| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hugo C Monroy-Ramírez, Gustavo Basurto-Islas, Raul Mena, Bulmaro Cisneros, Lester I Binder, Jesús Avila, Francisco Garcia-Sierr. Alterations in the nuclear architecture produced by the overexpression of tau protein in neuroblastoma cells. Journal of Alzheimer's disease : JAD. vol 36. issue 3. 2014-02-17. PMID:23635409. |
abnormal intracellular aggregation of tau protein is a pathological condition leading to neuronal death in alzheimer's disease. |
2014-02-17 |
2023-08-12 |
Not clear |
| Gayathri Ramachandran, Jayant B Udgaonka. Difference in fibril core stability between two tau four-repeat domain proteins: a hydrogen-deuterium exchange coupled to mass spectrometry study. Biochemistry. vol 52. issue 49. 2014-02-14. PMID:24256615. |
one of the signatures of alzheimer's disease and tauopathies is fibrillization of the microtubule-associated protein tau. |
2014-02-14 |
2023-08-12 |
Not clear |
| Shaowu Cheng, Dongfeng Cao, David A Hottman, LiLian Yuan, Martin O Bergo, Ling L. Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. The Journal of biological chemistry. vol 288. issue 50. 2014-02-13. PMID:24136196. |
isoprenoids and prenylated proteins have been implicated in the pathophysiology of alzheimer disease (ad), including amyloid-β precursor protein metabolism, tau phosphorylation, synaptic plasticity, and neuroinflammation. |
2014-02-13 |
2023-08-12 |
mouse |
| S Serizawa, J K Chambers, Y Un. Beta amyloid deposition and neurofibrillary tangles spontaneously occur in the brains of captive cheetahs (Acinonyx jubatus). Veterinary pathology. vol 49. issue 2. 2014-02-11. PMID:21712514. |
immunostaining (at8) revealed abnormal intracellular tau immunoreactivity in 10 of the cheetahs with aβ deposits, and they were mainly distributed in the parahippocampal cortex and ca1 in a fashion similar to that in human patients with alzheimer disease. |
2014-02-11 |
2023-08-12 |
human |
| Li Lin, Qiong-Xia Huang, Shu-Sheng Yang, Jiang Chu, Jian-Zhi Wang, Qing Tia. Melatonin in Alzheimer's disease. International journal of molecular sciences. vol 14. issue 7. 2014-02-11. PMID:23857055. |
alzheimer's disease (ad), an age-related neurodegenerative disorder with progressive cognition deficit, is characterized by extracellular senile plaques (sp) of aggregated β-amyloid (aβ) and intracellular neurofibrillary tangles, mainly containing the hyperphosphorylated microtubule-associated protein tau. |
2014-02-11 |
2023-08-12 |
Not clear |
| Herman van der Putten, Gregor P Lot. Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseases. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 10. issue 3. 2014-02-10. PMID:23536253. |
in alzheimer's disease, these are comprised of amyloid-β and tau as opposed to α-synuclein in parkinson's disease and n-terminal fragments of mutant huntingtin in huntington's disease. |
2014-02-10 |
2023-08-12 |
Not clear |
| Patrick Barré, David Elieze. Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation. Protein science : a publication of the Protein Society. vol 22. issue 8. 2014-02-07. PMID:23740819. |
the protein tau is found in an aggregated filamentous state in the intraneuronal paired helical filament deposits characteristic of alzheimer's disease and other related dementias and mutations in tau protein and mrna cause frontotemproal dementia. |
2014-02-07 |
2023-08-12 |
Not clear |
| Nilüfer Ertekin-Tane. Alzheimer disease: the quest for Alzheimer disease genes--focus on CSF tau. Nature reviews. Neurology. vol 9. issue 7. 2014-02-07. PMID:23752907. |
alzheimer disease: the quest for alzheimer disease genes--focus on csf tau. |
2014-02-07 |
2023-08-12 |
Not clear |
| Saranya Jayapalan, Jeyakumar Nataraja. The role of CDK5 and GSK3B kinases in hyperphosphorylation of microtubule associated protein tau (MAPT) in Alzheimer's disease. Bioinformation. vol 9. issue 20. 2014-02-05. PMID:24497730. |
the role of cdk5 and gsk3b kinases in hyperphosphorylation of microtubule associated protein tau (mapt) in alzheimer's disease. |
2014-02-05 |
2023-08-12 |
Not clear |
| Saranya Jayapalan, Jeyakumar Nataraja. The role of CDK5 and GSK3B kinases in hyperphosphorylation of microtubule associated protein tau (MAPT) in Alzheimer's disease. Bioinformation. vol 9. issue 20. 2014-02-05. PMID:24497730. |
abnormal hyperphosphorylation of microtubule associated protein tau (mapt) is one of the hallmarks of alzheimer's disease and related tau pathies. |
2014-02-05 |
2023-08-12 |
Not clear |
| Seung-Eon Roh, Jung A Woo, Madepalli K Lakshmana, Courtney Uhlar, Vinishaa Ankala, Taylor Boggess, Tian Liu, Yun-Hwa Hong, Inhee Mook-Jung, Sang Jeong Kim, David E Kan. Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 12. 2014-02-04. PMID:23982146. |
mitochondrial dysfunction and synaptic damage are important features of alzheimer's disease (ad) associated with amyloid β (aβ) and tau. |
2014-02-04 |
2023-08-12 |
mouse |
| Olga A Morozova, Zachary M March, Anne S Robinson, David W Colb. Conformational features of tau fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant protein. Biochemistry. vol 52. issue 40. 2014-02-03. PMID:24033133. |
conformational features of tau fibrils from alzheimer's disease brain are faithfully propagated by unmodified recombinant protein. |
2014-02-03 |
2023-08-12 |
Not clear |
| Olga A Morozova, Zachary M March, Anne S Robinson, David W Colb. Conformational features of tau fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant protein. Biochemistry. vol 52. issue 40. 2014-02-03. PMID:24033133. |
fibrils composed of tau protein are a pathological hallmark of several neurodegenerative disorders including alzheimer's disease (ad). |
2014-02-03 |
2023-08-12 |
Not clear |
| Muneaki Takahashi, Yo Chin, Takashi Nonaka, Masato Hasegawa, Nobuo Watanabe, Takao Ara. Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells. Neuroscience letters. vol 510. issue 1. 2014-01-31. PMID:22249117. |
presence of cytoplasmic tau aggregates is a hallmark of brains in patients with tauopathies such as alzheimer's disease. |
2014-01-31 |
2023-08-12 |
human |
| Masha G Savelieff, Sanghyun Lee, Yuzhong Liu, Mi Hee Li. Untangling amyloid-β, tau, and metals in Alzheimer's disease. ACS chemical biology. vol 8. issue 5. 2014-01-29. PMID:23506614. |
untangling amyloid-β, tau, and metals in alzheimer's disease. |
2014-01-29 |
2023-08-12 |
Not clear |
| Alaa H Abuznait, Hisham Qosa, Belnaser A Busnena, Khalid A El Sayed, Amal Kaddoum. Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies. ACS chemical neuroscience. vol 4. issue 6. 2014-01-28. PMID:23414128. |
oleocanthal, a phenolic component of extra-virgin olive oil, has been recently linked to reduced risk of alzheimer's disease (ad), a neurodegenerative disease that is characterized by accumulation of β-amyloid (aβ) and tau proteins in the brain. |
2014-01-28 |
2023-08-12 |
mouse |
| Harald Lund, Richard F Cowburn, Elin Gustafsson, Kia Strömberg, Anne Svensson, Leif Dahllund, David Malinowsky, Dan Sunnemar. Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain. Brain pathology (Zurich, Switzerland). vol 23. issue 4. 2014-01-27. PMID:23088643. |
tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-ser422 tau in the alzheimer's disease brain. |
2014-01-27 |
2023-08-12 |
human |
| Harald Lund, Richard F Cowburn, Elin Gustafsson, Kia Strömberg, Anne Svensson, Leif Dahllund, David Malinowsky, Dan Sunnemar. Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain. Brain pathology (Zurich, Switzerland). vol 23. issue 4. 2014-01-27. PMID:23088643. |
recent reports have implicated tau-tubulin kinase 1 (ttbk1) in the pathological phosphorylation of tau that occurs in alzheimer's disease (ad). |
2014-01-27 |
2023-08-12 |
human |
| Panagiotis Alexopoulos, Liang-Hao Guo, Meizi Jiang, Hideaki Bujo, Timo Grimmer, Stefan Förster, Alexander Drzezga, Alexander Kurz, Robert Perneczk. Amyloid cascade and tau pathology cerebrospinal fluid markers in mild cognitive impairment with regards to Alzheimer's disease cerebral metabolic signature. Journal of Alzheimer's disease : JAD. vol 36. issue 2. 2014-01-27. PMID:23609762. |
amyloid cascade and tau pathology cerebrospinal fluid markers in mild cognitive impairment with regards to alzheimer's disease cerebral metabolic signature. |
2014-01-27 |
2023-08-12 |
Not clear |
| Rita Selvatici, Luca Marani, Silvia Marino, Anna Siniscalch. In vitro mitochondrial failure and oxidative stress mimic biochemical features of Alzheimer disease. Neurochemistry international. vol 63. issue 2. 2014-01-27. PMID:23722080. |
the effects of such treatment on a series of parameters useful in characterizing neuronal damage were investigated: (i) the basal release of glutamate, evaluated as (3)h-d-aspartate efflux, was sharply, concentration-dependently, increased; (ii) the phosphorylation status of intracellular markers known to be involved in the neurodegenerative processes, in particular in alzheimer disease: tau and gsk3β were increased, as well as the protein level of β-secretase (bace1) and p35/25 evaluated by western blotting, while (iii) the cell metabolic activity, measured with the mtt method, was reduced, in a concentration- and time-dependent manner. |
2014-01-27 |
2023-08-12 |
rat |