| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natasha Deters, Lars M Ittner, Jürgen Göt. Substrate-specific reduction of PP2A activity exaggerates tau pathology. Biochemical and biophysical research communications. vol 379. issue 2. 2009-02-13. PMID:19126401. |
disturbance of this balance causes hyperphosphorylation of tau and neurofibrillary tangle formation in alzheimer's disease brain. |
2009-02-13 |
2023-08-12 |
mouse |
| b' Gorana Mandi\\xc4\\x87, Ivanka Markovi\\xc4\\x87, Marija Ostoji\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Sonja Misirli\\xc4\\x87-Denci\\xc4\\x87, Tatjana Zivanovi\\xc4\\x87-Radni\\xc4\\x87, Rodoljub Stefanovi\\xc4\\x87, Marko Bumbasirevi\\xc4\\x87, Elka Stefanova, Vladimir Kosti\\xc4\\x8. [Cerebrospinal fluid amyloid beta and tau protein: biomarkers for Alzheimer\'s disease]. Vojnosanitetski pregled. vol 65. issue 12. 2009-02-11. PMID:19160984.' |
[cerebrospinal fluid amyloid beta and tau protein: biomarkers for alzheimer's disease]. |
2009-02-11 |
2023-08-12 |
Not clear |
| b' Gorana Mandi\\xc4\\x87, Ivanka Markovi\\xc4\\x87, Marija Ostoji\\xc4\\x87, Tanja Stojkovi\\xc4\\x87, Sonja Misirli\\xc4\\x87-Denci\\xc4\\x87, Tatjana Zivanovi\\xc4\\x87-Radni\\xc4\\x87, Rodoljub Stefanovi\\xc4\\x87, Marko Bumbasirevi\\xc4\\x87, Elka Stefanova, Vladimir Kosti\\xc4\\x8. [Cerebrospinal fluid amyloid beta and tau protein: biomarkers for Alzheimer\'s disease]. Vojnosanitetski pregled. vol 65. issue 12. 2009-02-11. PMID:19160984.' |
introduction of acetylcholine esterase inhibitors as a symptomatic treatment of alzheimer's disease (ad) has additionally highlighted the importance of diagnostic markers in cerebrospinal fluid (csf) for early ad diagnosis: low level of 42 amino acid form of amyloid-beta peptide (abeta42), and levels of tau protein (t-tau) and phosphorylated tau protein (p-tau). |
2009-02-11 |
2023-08-12 |
Not clear |
| Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, José Luis Vázquez-Higuera, Inés García-Gorostiaga, José Berciano, Onofre Combarro. Synergistic effect of heme oxygenase-1 and tau genetic variants on Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 26. issue 4. 2009-02-09. PMID:18841019. |
synergistic effect of heme oxygenase-1 and tau genetic variants on alzheimer's disease risk. |
2009-02-09 |
2023-08-12 |
human |
| Ignacio Mateo, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Jon Infante, José Luis Vázquez-Higuera, Inés García-Gorostiaga, José Berciano, Onofre Combarro. Synergistic effect of heme oxygenase-1 and tau genetic variants on Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 26. issue 4. 2009-02-09. PMID:18841019. |
in alzheimer's disease (ad) brain, accumulation of hyperphosphorylated tau in nft is associated with the induction of heme oxygenase-1 (ho-1), a potent antioxidant that downregulates the production of tau. |
2009-02-09 |
2023-08-12 |
human |
| Ditte Zerlang Christensen, Sophie Luise Kraus, Antonius Flohr, Marie-Caroline Cotel, Oliver Wirths, Thomas A Baye. Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice. Acta neuropathologica. vol 116. issue 6. 2009-02-03. PMID:18974993. |
the accumulation of beta-amyloid (a beta) plaques and neurofibrillary tangles consisting of hyperphosphorylated tau protein are pathological features of alzheimer's disease (ad) commonly modeled in mice using known human familial mutations; however, the loss of neurons also found to occur in ad is rarely observed in such models. |
2009-02-03 |
2023-08-12 |
mouse |
| Chad Dickey, Clara Kraft, Umesh Jinwal, John Koren, Amelia Johnson, Laura Anderson, Lori Lebson, Daniel Lee, Dennis Dickson, Rohan de Silva, Lester I Binder, David Morgan, Jada Lewi. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. The American journal of pathology. vol 174. issue 1. 2009-02-03. PMID:19074615. |
moreover, we show that the active production of small amounts of abnormal tau protein facilitates dysfunction and accumulation of otherwise normal tau, a significant implication for the pathogenesis of patients with alzheimer's disease. |
2009-02-03 |
2023-08-12 |
mouse |
| Shreyasi Chatterjee, Tzu-Kang Sang, George M Lawless, George R Jackso. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Human molecular genetics. vol 18. issue 1. 2009-01-30. PMID:18930955. |
hyperphosphorylation of tau at multiple sites has been implicated in the formation of neurofibrillary tangles in alzheimer's disease; however, the relationship between toxicity and phosphorylation of tau has not been clearly elucidated. |
2009-01-30 |
2023-08-12 |
drosophila_melanogaster |
| Da-yu Yu, Li Tong, Gao-jie Song, Wei-lin Lin, Lai-qun Zhang, Wei Bai, He Gong, Yan-xia Yin, Qun We. Tau binds both subunits of calcineurin, and binding is impaired by calmodulin. Biochimica et biophysica acta. vol 1783. issue 12. 2009-01-27. PMID:18639592. |
they shed some light on how the interactions might control the phosphorylation state of tau under physiological conditions, and provide new insights into the treatment of tauopathies such as alzheimer's disease. |
2009-01-27 |
2023-08-12 |
Not clear |
| Emmanuel Planel, Pavan Krishnamurthy, Tomohiro Miyasaka, Li Liu, Mathieu Herman, Asok Kumar, Alexis Bretteville, Helen Y Figueroa, Wai Haung Yu, Robert A Whittington, Peter Davies, Akihiko Takashima, Ralph A Nixon, Karen E Duf. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 48. 2009-01-26. PMID:19036972. |
in alzheimer's disease, tau is hyperphosphorylated, which is thought to detach it from microtubules (mts), induce mt destabilization, and promote aggregation. |
2009-01-26 |
2023-08-12 |
mouse |
| G Giaccone, M Mangieri, R Capobianco, L Limido, J J Hauw, S Haïk, P Fociani, O Bugiani, F Tagliavin. Tauopathy in human and experimental variant Creutzfeldt-Jakob disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17560687. |
cerebral accumulation of hyperphosphorylated tau (phospho-tau) occurs in several neurodegenerative conditions including alzheimer disease. |
2009-01-23 |
2023-08-12 |
mouse |
| G Giaccone, M Mangieri, R Capobianco, L Limido, J J Hauw, S Haïk, P Fociani, O Bugiani, F Tagliavin. Tauopathy in human and experimental variant Creutzfeldt-Jakob disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17560687. |
these findings suggest that the abnormal forms of prp associated with vcjd trigger a tauopathy, and provide a paradigm for the early stages of tau pathology associated with cerebral amyloidoses, including alzheimer disease. |
2009-01-23 |
2023-08-12 |
mouse |
| Ramona Bravo, Muriel Arimon, Juan José Valle-Delgado, Raquel García, Núria Durany, Susanna Castel, Montserrat Cruz, Salvador Ventura, Xavier Fernàndez-Busquet. Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity. The Journal of biological chemistry. vol 283. issue 47. 2009-01-22. PMID:18819917. |
the histopathological hallmarks of alzheimer disease are the self-aggregation of the amyloid beta peptide (abeta) in extracellular amyloid fibrils and the formation of intraneuronal tau filaments, but a convincing mechanism connecting both processes has yet to be provided. |
2009-01-22 |
2023-08-12 |
Not clear |
| Ramona Bravo, Muriel Arimon, Juan José Valle-Delgado, Raquel García, Núria Durany, Susanna Castel, Montserrat Cruz, Salvador Ventura, Xavier Fernàndez-Busquet. Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity. The Journal of biological chemistry. vol 283. issue 47. 2009-01-22. PMID:18819917. |
in vitro assays indicate that such transient, local ca(2+) increases can have a direct effect in promoting the formation of tau filaments similar to those isolated from alzheimer disease brains. |
2009-01-22 |
2023-08-12 |
Not clear |
| C Haense, K Buerger, E Kalbe, A Drzezga, S J Teipel, P Markiewicz, K Herholz, W D Heiss, H Hampe. CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease. European journal of neurology. vol 15. issue 11. 2009-01-21. PMID:18803648. |
csf total and phosphorylated tau protein, regional glucose metabolism and dementia severity in alzheimer's disease. |
2009-01-21 |
2023-08-12 |
Not clear |
| C Haense, K Buerger, E Kalbe, A Drzezga, S J Teipel, P Markiewicz, K Herholz, W D Heiss, H Hampe. CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease. European journal of neurology. vol 15. issue 11. 2009-01-21. PMID:18803648. |
we investigated associations between severity of cognitive impairment, cerebrospinal fluid (csf) concentrations of total-tau (t-tau) protein and tau phosphorylated at threonin 181 (p-tau(181)) and regional glucose metabolism measured with 18f-fluorodeoxyglucose-positron emission tomography (18f-fdg-pet) in patients with probable alzheimer's disease (ad). |
2009-01-21 |
2023-08-12 |
Not clear |
| Scott A Small, Karen Duf. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron. vol 60. issue 4. 2009-01-16. PMID:19038212. |
linking abeta and tau in late-onset alzheimer's disease: a dual pathway hypothesis. |
2009-01-16 |
2023-08-12 |
Not clear |
| Scott A Small, Karen Duf. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron. vol 60. issue 4. 2009-01-16. PMID:19038212. |
alzheimer's disease is characterized by abnormal elevation of abeta peptide and abnormal hyperphosphorylation of the tau protein. |
2009-01-16 |
2023-08-12 |
Not clear |
| Scott A Small, Karen Duf. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron. vol 60. issue 4. 2009-01-16. PMID:19038212. |
the "amyloid hypothesis," which is based on molecular defects observed in autosomal-dominant early-onset alzheimer's disease (eoad), suggests a serial model of causality, whereby elevation of abeta drives other disease features including tau hyperphosphorylation. |
2009-01-16 |
2023-08-12 |
Not clear |
| N Sahara, S Maeda, A Takashim. Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration. Current Alzheimer research. vol 5. issue 6. 2009-01-16. PMID:19075586. |
intracellular accumulation of filamentous tau proteins is a defining feature of neurodegenerative diseases, including alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, pick's disease, and frontotemporal dementia with parkinsonism linked to chromosome 17, all known collectively as tauopathies. |
2009-01-16 |
2023-08-12 |
human |