| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
the development of intraneuronal lesions as a result of the progressive deposition of hyperphosphorylated tau at specific brain regions (such as hippocampus and cortex) plays a key role in the pathological process of alzheimer's disease. |
2008-09-30 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
both somatostatin and cortistatin induce tau phosphorylation at ser262, a site modified in alzheimer's disease, although with different kinetics in cortex. |
2008-09-30 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
our results suggest an important role for cortistatin in the regulation of tau phosphorylation that may be associated with the pathophysiology of alzheimer's disease in regions such as the cerebral cortex. |
2008-09-30 |
2023-08-12 |
mouse |
| Binbin Wang, Sirui Zhou, Ze Yang, Yan-Chen Xie, Jing Wang, Peng Zhang, Zeping Lv, Chenguang Zheng, Xu M. Genetic analysis of tumor necrosis factor-alpha (TNF-alpha) G-308A and Saitohin Q7R polymorphisms with Alzheimer's disease. Journal of the neurological sciences. vol 270. issue 1-2. 2008-09-24. PMID:18396294. |
neuroinflammation and abnormal phosphorylation of tau proteins have been implicated in the etiology of alzheimer's disease (ad). |
2008-09-24 |
2023-08-12 |
Not clear |
| Inmaculada Cuchillo-Ibanez, Anjan Seereeram, Helen L Byers, Kit-Yi Leung, Malcolm A Ward, Brian H Anderton, Diane P Hange. Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 9. 2008-09-24. PMID:18511549. |
we investigated the effect of phosphorylation on the axonal transport of tau, a neuronal protein that stabilizes microtubules and is hyperphosphorylated and mislocalized in alzheimer's disease. |
2008-09-24 |
2023-08-12 |
rat |
| Inmaculada Cuchillo-Ibanez, Anjan Seereeram, Helen L Byers, Kit-Yi Leung, Malcolm A Ward, Brian H Anderton, Diane P Hange. Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 9. 2008-09-24. PMID:18511549. |
hyperphosphorylated tau in alzheimer's disease appearing first in distal portions of axons may result from aberrant axonal transport of phosphorylated tau reported here. |
2008-09-24 |
2023-08-12 |
rat |
| J A P van de Nes, R Nafe, W Schlot. Non-tau based neuronal degeneration in Alzheimer's disease -- an immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex. Brain research. vol 1213. 2008-09-19. PMID:18455153. |
in alzheimer's disease (ad), cortical neurons develop neurofibrillary tangles (nfts) consisting of hyperphosphorylated tau. |
2008-09-19 |
2023-08-12 |
human |
| Kavon Rezai-Zadeh, Gary W Arendash, Huayan Hou, Frank Fernandez, Maren Jensen, Melissa Runfeldt, R Douglas Shytle, Jun Ta. Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain research. vol 1214. 2008-09-19. PMID:18457818. |
green tea epigallocatechin-3-gallate (egcg) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in alzheimer transgenic mice. |
2008-09-19 |
2023-08-12 |
mouse |
| Quan-Guang Zhang, Ruimin Wang, Mohammad Khan, Virendra Mahesh, Darrell W Bran. Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 34. 2008-09-16. PMID:18716201. |
tau hyperphosphorylation has been implicated to have a prodeath role in alzheimer's disease and cerebral ischemia, and e2 attenuates tau hyperphosphorylation. |
2008-09-16 |
2023-08-12 |
Not clear |
| Min Hu, Jeffrey F Waring, Murali Gopalakrishnan, Jinhe L. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18485099. |
beta-amyloid peptide 1-42 (abeta(1-42)) and hyperphosphorylated tau are associated with neurodegeneration in alzheimer's disease. |
2008-09-15 |
2023-08-12 |
mouse |
| Min Hu, Jeffrey F Waring, Murali Gopalakrishnan, Jinhe L. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. Journal of neurochemistry. vol 106. issue 3. 2008-09-15. PMID:18485099. |
this study provides evidence of nachr mechanisms underlying abeta(1-42) toxicity and tau phosphorylation, which, if translated in vivo, could provide additional basis for the utility of alpha7 nachr ligands in the treatment of alzheimer's disease. |
2008-09-15 |
2023-08-12 |
mouse |
| Mohamed Ali Smach, Bassem Charfeddine, Turkia Lammouchi, Imed Harrabi, Leila Ben Othman, Hedi Dridi, Soufien Bennamou, Khalifa Lime. CSF beta-amyloid 1-42 and tau in Tunisian patients with Alzheimer's disease: the effect of APOE epsilon4 allele. Neuroscience letters. vol 440. issue 2. 2008-09-15. PMID:18555606. |
csf beta-amyloid 1-42 and tau in tunisian patients with alzheimer's disease: the effect of apoe epsilon4 allele. |
2008-09-15 |
2023-08-12 |
human |
| Huiping Ding, Gail V W Johnso. New application of beta-galactosidase complementation to monitor tau self-association. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18498442. |
neurofibrillary tangles composed of hyperphosphorylated and aberrantly cleaved microtubule-associated protein tau are a major neuropathological hallmark of alzheimer's disease. |
2008-09-12 |
2023-08-12 |
human |
| Chun-Hui Yu, Tong Si, Wei-Hui Wu, Jia Hu, Jin-Tang Du, Yu-Fen Zhao, Yan-Mei L. O-GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau. Biochemical and biophysical research communications. vol 375. issue 1. 2008-09-09. PMID:18671940. |
in alzheimer's disease (ad), tau protein is abnormally hyperphosphorylated and aggregated into paired helical filaments (phfs). |
2008-09-09 |
2023-08-12 |
human |
| Chiho Hirata-Fukae, Hui-Fang Li, Hyang-Sook Hoe, Audrey J Gray, S Sakura Minami, Katsuyoshi Hamada, Takako Niikura, Fang Hua, Hiroe Tsukagoshi-Nagai, Yuko Horikoshi-Sakuraba, Mohamed Mughal, G William Rebeck, Frank M LaFerla, Mark P Mattson, Nobuhisa Iwata, Takaomi C Saido, William L Klein, Karen E Duff, Paul S Aisen, Yasuji Matsuok. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain research. vol 1216. 2008-09-08. PMID:18486110. |
females exhibit more extensive amyloid, but not tau, pathology in an alzheimer transgenic model. |
2008-09-08 |
2023-08-12 |
mouse |
| Min Liu, Sungwoon Choi, Gregory D Cuny, Kai Ding, Brittany C Dobson, Marcie A Glicksman, Ken Auerbach, Ross L Stei. Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. Biochemistry. vol 47. issue 32. 2008-09-02. PMID:18636751. |
cdk5/p25 is a member of the family of cyclin-dependent, ser/thr kinases and is thought to play a causal role in alzheimer's disease (ad) due to its ability to phosphorylate the protein tau, and thus promote the latter's aggregation into intraneuronal tangles. |
2008-09-02 |
2023-08-12 |
Not clear |
| Mun'delanji Vestergaard, Kagan Kerman, Do-Kyun Kim, Minh Hiep Ha, Eiichi Tamiy. Detection of Alzheimer's tau protein using localised surface plasmon resonance-based immunochip. Talanta. vol 74. issue 4. 2008-08-26. PMID:18371746. |
detection of alzheimer's tau protein using localised surface plasmon resonance-based immunochip. |
2008-08-26 |
2023-08-12 |
cattle |
| Lewis H Kuller, Oscar L Lope. Dementia: is it time for a change in focus? Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 4. issue 1 Suppl 1. 2008-08-26. PMID:18632006. |
ad and dementia research has matured since the inception of the alzheimer's disease center program from a primary social service problem to clinical-pathologic correlates and better definition of disease to evaluation of measures of cognition, in vivo images of the brain, and then to measures of beta amyloid and tau in vivo and relationship to clinical dementia. |
2008-08-26 |
2023-08-12 |
Not clear |
| Masaki Hattori, Etsuko Sugino, Katsuhiko Minoura, Yasuko In, Miho Sumida, Taizo Taniguchi, Koji Tomoo, Toshimasa Ishid. Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain. Biochemical and biophysical research communications. vol 374. issue 1. 2008-08-25. PMID:18619417. |
one of the priorities in alzheimer research is to develop a compound that inhibits the filament formation of tau protein. |
2008-08-25 |
2023-08-12 |
Not clear |
| H Zetterberg, U Rüetschi, E Portelius, G Brinkmalm, U Andreasson, K Blennow, A Brinkmal. Clinical proteomics in neurodegenerative disorders. Acta neurologica Scandinavica. vol 118. issue 1. 2008-08-21. PMID:18279484. |
a triplet of biomarkers for alzheimer's disease (ad), total and hyperphosphorylated tau and the 42 amino acid isoform of beta-amyloid, has already been established for early detection of ad before the onset of dementia. |
2008-08-21 |
2023-08-12 |
Not clear |