| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cyntia Tremblay, Mireille Pilote, Alix Phivilay, Vincent Emond, David A Bennett, Frédéric Calo. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198424. |
biochemical characterization of abeta and tau pathologies in mild cognitive impairment and alzheimer's disease. |
2008-03-25 |
2023-08-12 |
human |
| Cyntia Tremblay, Mireille Pilote, Alix Phivilay, Vincent Emond, David A Bennett, Frédéric Calo. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198424. |
we report a post mortem biochemical analysis of amyloid-beta (abeta) (elisa) and tau (western immunoblots) in the temporo-parietal neocortex of subjects with a clinical diagnosis of mild cognitive impairment (mci, n=12), alzheimer's disease (ad, n=12) or no cognitive impairment (nci, n=12). |
2008-03-25 |
2023-08-12 |
human |
| Inna Khlistunova, Marcus Pickhardt, Jacek Biernat, Yipeng Wang, Eva-Maria Mandelkow, Eckhard Mandelko. Inhibition of tau aggregation in cell models of tauopathy. Current Alzheimer research. vol 4. issue 5. 2008-03-21. PMID:18220518. |
the pathological aggregation of tau into paired helical filaments is a hallmark of several neurodegenerative diseases, including alzheimer's disease. |
2008-03-21 |
2023-08-12 |
Not clear |
| Marcie A Glicksman, Gregory D Cuny, Min Liu, Brittany Dobson, Kenneth Auerbach, Ross L Stein, Kenneth S Kosi. New approaches to the discovery of cdk5 inhibitors. Current Alzheimer research. vol 4. issue 5. 2008-03-21. PMID:18220519. |
among its attractions is the possibility that inhibitors will prevent the pathological phosphorylation of tau and neurofibrillary pathology in both alzheimer's disease and tauopathies. |
2008-03-21 |
2023-08-12 |
Not clear |
| Michelle L Steinhilb, Dora Dias-Santagata, Tudor A Fulga, Daniel L Felch, Mel B Fean. Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Molecular biology of the cell. vol 18. issue 12. 2008-03-19. PMID:17928404. |
tau is a microtubule binding protein implicated in a number of human neurodegenerative disorders, including alzheimer's disease. |
2008-03-19 |
2023-08-12 |
human |
| S Mondragón-Rodríguez, R Mena, L I Binder, M A Smith, G Perry, F García-Sierr. Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology. Neuropathology and applied neurobiology. vol 34. issue 1. 2008-03-18. PMID:17971079. |
conformational changes and cleavage of tau in pick bodies parallel the early processing of tau found in alzheimer pathology. |
2008-03-18 |
2023-08-12 |
Not clear |
| K Schindowski, K Belarbi, A Bretteville, K Ando, L Bué. Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation. Genes, brain, and behavior. vol 7 Suppl 1. 2008-03-12. PMID:18184373. |
this mouse displays all alzheimer disease features of neurodegeneration and a broad timely resolution of tau pathology with hyperphosphorylation of tau at younger age (up to 6 months) and abnormal tau phosphorylation and tau aggregation in aged mice (by 10 months). |
2008-03-12 |
2023-08-12 |
mouse |
| Joao P Lopes, Catarina R Oliveira, Paula Agostinh. Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies. Cellular and molecular neurobiology. vol 27. issue 7. 2008-03-10. PMID:17965932. |
tau hyperphosphorylation, amyloid plaques, and neuronal death are major neuropathological features of alzheimer's disease (ad) and prion-related encephalopathies (pre). |
2008-03-10 |
2023-08-12 |
rat |
| Tetsuya Kimura, Shunji Yamashita, Tetsuya Fukuda, Jun-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashim. Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. The EMBO journal. vol 26. issue 24. 2008-03-07. PMID:18007595. |
thus, the accumulation of hyperphosphorylated tau that occurs before nft formation in entorhinal cortex may contribute to the memory problems seen in alzheimer's disease (ad). |
2008-03-07 |
2023-08-12 |
mouse |
| Edward Chang, Jeff Kure. Detection and quantification of tau aggregation using a membrane filter assay. Analytical biochemistry. vol 373. issue 2. 2008-03-06. PMID:17949677. |
aggregation of the microtubule-associated protein tau contributes to the formation of neurofibrillary lesions in alzheimer's disease and is a useful marker of disease progression. |
2008-03-06 |
2023-08-12 |
Not clear |
| Fei Liu, Bin Li, E-Jan Tung, Inge Grundke-Iqbal, Khalid Iqbal, Cheng-Xin Gon. Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation. The European journal of neuroscience. vol 26. issue 12. 2008-03-06. PMID:18052981. |
microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains with alzheimer's disease. |
2008-03-06 |
2023-08-12 |
Not clear |
| Jozef Sevcik, Rostislav Skrabana, Radovan Dvorsky, Natalia Csokova, Khalid Iqbal, Michal Nova. X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease. FEBS letters. vol 581. issue 30. 2008-03-05. PMID:18061582. |
x-ray structure of the phf core c-terminus: insight into the folding of the intrinsically disordered protein tau in alzheimer's disease. |
2008-03-05 |
2023-08-12 |
Not clear |
| Jozef Sevcik, Rostislav Skrabana, Radovan Dvorsky, Natalia Csokova, Khalid Iqbal, Michal Nova. X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease. FEBS letters. vol 581. issue 30. 2008-03-05. PMID:18061582. |
the major constituent of alzheimer's disease paired helical filaments (phf) core is intrinsically disordered protein (idp) tau. |
2008-03-05 |
2023-08-12 |
Not clear |
| Jozef Sevcik, Rostislav Skrabana, Radovan Dvorsky, Natalia Csokova, Khalid Iqbal, Michal Nova. X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease. FEBS letters. vol 581. issue 30. 2008-03-05. PMID:18061582. |
it is reasonable to expect that this approach will help to reveal the structural principles underlying the tau protein assembly into phf and possibly will facilitate rationale drug design for inhibition of alzheimer neurofibrillary changes. |
2008-03-05 |
2023-08-12 |
Not clear |
| Jennifer M Ogar, Nina F Dronkers, Simona M Brambati, Bruce L Miller, Maria Luisa Gorno-Tempin. Progressive nonfluent aphasia and its characteristic motor speech deficits. Alzheimer disease and associated disorders. vol 21. issue 4. 2008-02-28. PMID:18090419. |
postmortem histopathologic evidence has shown that pnfa is usually associated with tau pathology, although focal alzheimer disease pathology and tau-negative, ubiquitin-tdp-43 inclusions also have been reported in association with this clinical syndrome. |
2008-02-28 |
2023-08-12 |
Not clear |
| Aidong Yuan, Asok Kumar, Corrinne Peterhoff, Karen Duff, Ralph A Nixo. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 7. 2008-02-25. PMID:18272688. |
elevated tau expression has been proposed as a possible basis for impaired axonal transport in alzheimer's disease. |
2008-02-25 |
2023-08-12 |
mouse |
| Louis Segu, Arnaud Pascaud, Pierre Costet, Michel Darmon, Marie-Christine Buho. Impairment of spatial learning and memory in ELKL Motif Kinase1 (EMK1/MARK2) knockout mice. Neurobiology of aging. vol 29. issue 2. 2008-02-21. PMID:17196307. |
the hyperphosphorylation of tau protein is one of the hallmarks of alzheimer's disease (ad) and of the associated cognitive decline. |
2008-02-21 |
2023-08-12 |
mouse |
| Evan Elliott, Peter Tsvetkov, Irith Ginzbur. BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. The Journal of biological chemistry. vol 282. issue 51. 2008-02-20. PMID:17954934. |
intraneuronal accumulation of phosphorylated tau protein is a molecular pathology found in many forms of dementia, including alzheimer disease. |
2008-02-20 |
2023-08-12 |
mouse |
| Evan Elliott, Peter Tsvetkov, Irith Ginzbur. BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. The Journal of biological chemistry. vol 282. issue 51. 2008-02-20. PMID:17954934. |
finally, bag-1 is highly expressed in neurons bearing tau tangles in a mouse model of alzheimer disease. |
2008-02-20 |
2023-08-12 |
mouse |
| Evan Elliott, Peter Tsvetkov, Irith Ginzbur. BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. The Journal of biological chemistry. vol 282. issue 51. 2008-02-20. PMID:17954934. |
this data suggests a molecular mechanism through which tau protein levels are regulated in the cell and possible consequences for the pathology and treatment of alzheimer disease. |
2008-02-20 |
2023-08-12 |
mouse |