| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Ingelsson, Karunya Ramasamy, Carsten Russ, Stefanie H Freeman, Jennifer Orne, Susan Raju, Toshifumi Matsui, John H Growdon, Matthew P Frosch, Bernardino Ghetti, Robert H Brown, Michael C Irizarry, Bradley T Hyma. Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains. Acta neuropathologica. vol 114. issue 5. 2008-02-19. PMID:17721707. |
we assessed tau mrna and protein levels in frontal cortex from 15 sporadic ftld, 21 psp, 5 cbd, 15 alzheimer's disease (ad) and 16 control brains. |
2008-02-19 |
2023-08-12 |
human |
| D Singer, N Herth, J Kuhlmann, K Holland-Nell, A G Beck-Sickinger, R Hoffman. Mapping of phosphorylation-dependent anti-tau monoclonal antibodies in immunoblots using human tau-constructs synthesized by native chemical ligation. Biochemical and biophysical research communications. vol 367. issue 2. 2008-02-15. PMID:18162172. |
in alzheimer's disease (ad) neurofibrillary tangles (nft) are formed by hyperphosphorylated microtubule-associated tau protein. |
2008-02-15 |
2023-08-12 |
human |
| Jakob-A Tschäpe, Tobias Hartman. Therapeutic perspectives in Alzheimer's disease. Recent patents on CNS drug discovery. vol 1. issue 1. 2008-02-15. PMID:18221198. |
main characteristics of alzheimer's disease (ad) are massive cerebral accumulation of amyloid, composed of fibrillary aggregates of the amyloid beta peptide (abeta) and intracellular accumulation of abnormally phosphorylated tau protein associated with widespread neurodegeneration. |
2008-02-15 |
2023-08-12 |
Not clear |
| Tristan Bolmont, Florence Clavaguera, Melanie Meyer-Luehmann, Martin C Herzig, Rebecca Radde, Matthias Staufenbiel, Jada Lewis, Mike Hutton, Markus Tolnay, Mathias Jucke. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. The American journal of pathology. vol 171. issue 6. 2008-02-08. PMID:18055549. |
alzheimer's disease presents morphologically with senile plaques, primarily made of extracellular amyloid-beta (a beta) deposits, and neurofibrillary lesions, which consist of intracellular aggregates of hyperphosphorylated tau protein. |
2008-02-08 |
2023-08-12 |
mouse |
| Tristan Bolmont, Florence Clavaguera, Melanie Meyer-Luehmann, Martin C Herzig, Rebecca Radde, Matthias Staufenbiel, Jada Lewis, Mike Hutton, Markus Tolnay, Mathias Jucke. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. The American journal of pathology. vol 171. issue 6. 2008-02-08. PMID:18055549. |
the observation that infused a beta can trigger the tau pathology in the absence of a beta deposits provides an explanation for the discrepancy between the neuroanatomical location of a beta deposits and the development and spreading of tau lesions in alzheimer's disease brain. |
2008-02-08 |
2023-08-12 |
mouse |
| Maria-Magdalena Mocanu, Astrid Nissen, Katrin Eckermann, Inna Khlistunova, Jacek Biernat, Dagmar Drexler, Olga Petrova, Kai Schönig, Hermann Bujard, Eckhard Mandelkow, Lepu Zhou, Gabriele Rune, Eva-Maria Mandelko. The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 3. 2008-02-08. PMID:18199773. |
we describe two new transgenic mouse lines for studying pathological changes of tau protein related to alzheimer's disease. |
2008-02-08 |
2023-08-12 |
mouse |
| Virginie Rhein, Anne Ecker. Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial function -- role of glucose metabolism and insulin signalling. Archives of physiology and biochemistry. vol 113. issue 3. 2008-02-05. PMID:17922309. |
effects of alzheimer's amyloid-beta and tau protein on mitochondrial function -- role of glucose metabolism and insulin signalling. |
2008-02-05 |
2023-08-12 |
Not clear |
| Virginie Rhein, Anne Ecker. Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial function -- role of glucose metabolism and insulin signalling. Archives of physiology and biochemistry. vol 113. issue 3. 2008-02-05. PMID:17922309. |
alzheimer's disease (ad) is the most frequent form of dementia among the elderly and is characterized by neuropathological hallmarks of extracellular amyloid-beta (abeta) plaques and intracellular neurofibrillary tangles composed of abnormally hyperphosphorylated microtubular protein tau in the brains of ad patients. |
2008-02-05 |
2023-08-12 |
Not clear |
| Yasuji Matsuoka, Audrey J Gray, Chiho Hirata-Fukae, S Sakura Minami, Emily Graeme Waterhouse, Mark P Mattson, Frank M LaFerla, Illana Gozes, Paul S Aise. Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. Journal of molecular neuroscience : MN. vol 31. issue 2. 2008-02-04. PMID:17478890. |
intranasal nap administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of alzheimer's disease at early pathological stage. |
2008-02-04 |
2023-08-12 |
mouse |
| Yasuji Matsuoka, Audrey J Gray, Chiho Hirata-Fukae, S Sakura Minami, Emily Graeme Waterhouse, Mark P Mattson, Frank M LaFerla, Illana Gozes, Paul S Aise. Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. Journal of molecular neuroscience : MN. vol 31. issue 2. 2008-02-04. PMID:17478890. |
accumulation of beta-amyloid (abeta) peptide and hyperphosphorylation of tau in the brain are pathological hallmarks of alzheimer's disease (ad). |
2008-02-04 |
2023-08-12 |
mouse |
| Sachin Patil, Joseph Melrose, Christina Cha. Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. The European journal of neuroscience. vol 26. issue 8. 2008-02-01. PMID:17908174. |
a high-fat diet has been shown to significantly increase the risk of the development of alzheimer's disease (ad), a neurodegenerative disease histochemically characterized by the accumulation of amyloid beta (abeta) protein in senile plaques and hyperphosphorylated tau in neurofibrillary tangles. |
2008-02-01 |
2023-08-12 |
rat |
| Seungyong Yoon, Jungeun Choi, Juhee Haam, Han Choe, DongHou Ki. Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons. Neuroreport. vol 18. issue 18. 2008-01-25. PMID:18007179. |
treatment of neurons with okadaic acid, a protein phosphatase-2a inhibitor, has been used to induce tau phosphorylation and neuronal death, and to create a research model of alzheimer's disease. |
2008-01-25 |
2023-08-12 |
Not clear |
| Ling-Feng Jiang, Tian-Ming Yao, Zhi-Liang Zhu, Chong Wang, Liang-Nian J. Impacts of Cd(II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain. Biochimica et biophysica acta. vol 1774. issue 11. 2008-01-24. PMID:17920001. |
impacts of cd(ii) on the conformation and self-aggregation of alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain. |
2008-01-24 |
2023-08-12 |
Not clear |
| Ling-Feng Jiang, Tian-Ming Yao, Zhi-Liang Zhu, Chong Wang, Liang-Nian J. Impacts of Cd(II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain. Biochimica et biophysica acta. vol 1774. issue 11. 2008-01-24. PMID:17920001. |
for the first time, we investigated the impacts of cd(ii) on the conformation and self-aggregation of alzheimer's tau peptide r3, corresponding to the third repeat of microtubule-binding domain. |
2008-01-24 |
2023-08-12 |
Not clear |
| Wagner B Dias, Gerald W Har. O-GlcNAc modification in diabetes and Alzheimer's disease. Molecular bioSystems. vol 3. issue 11. 2008-01-24. PMID:17940659. |
with respect to alzheimer's disease, several proteins involved in the etiology of the disease, including tau, neurofilaments, beta-amyloid precursor protein, and synaptosomal proteins are glcnacylated in normal brain. |
2008-01-24 |
2023-08-12 |
Not clear |
| Emmanuel Planel, Yoshitaka Tatebayashi, Tomohiro Miyasaka, Li Liu, Lili Wang, Mathieu Herman, W Haung Yu, Jose A Luchsinger, Brian Wadzinski, Karen E Duff, Akihiko Takashim. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 50. 2008-01-22. PMID:18077675. |
hyperphosphorylated tau is the major component of paired helical filaments in neurofibrillary tangles found in alzheimer's disease (ad) brains, and tau hyperphosphorylation is thought to be a critical event in the pathogenesis of the disease. |
2008-01-22 |
2023-08-12 |
mouse |
| M Ewers, K Buerger, S J Teipel, P Scheltens, J Schröder, R P Zinkowski, F H Bouwman, P Schönknecht, N S M Schoonenboom, N Andreasen, A Wallin, J F DeBernardis, D J Kerkman, B Heindl, K Blennow, H Hampe. Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI. Neurology. vol 69. issue 24. 2008-01-14. PMID:18071141. |
the measurement of hyperphosphorylated tau (p-tau) in csf has been proposed as a biomarker candidate for the prediction of alzheimer disease (ad) in patients with mild cognitive impairment (mci). |
2008-01-14 |
2023-08-12 |
Not clear |
| Wenkai Li, Virginia M-Y Le. Characterization of two VQIXXK motifs for tau fibrillization in vitro. Biochemistry. vol 45. issue 51. 2008-01-11. PMID:17176091. |
tau proteins are building blocks of the filaments that form neurofibrillary tangles of alzheimer's disease (ad) and related neurodegenerative tauopathies. |
2008-01-11 |
2023-08-12 |
human |
| Stéphanie Boutillier, Béatrice Lannes, Luc Buée, André Delacourte, Caroline Rouaux, Michel Mohr, Jean-Pierre Bellocq, François Sellal, Yves Larmet, Anne-Laurence Boutillier, Jean-Philippe Loeffle. Sp3 and sp4 transcription factor levels are increased in brains of patients with Alzheimer's disease. Neuro-degenerative diseases. vol 4. issue 6. 2008-01-09. PMID:17934324. |
alzheimer's disease (ad) is characterized by extracellular abeta peptide deposition originating from amyloid precursor protein cleavage and intracellular neurofibrillary tangles resulting from pathological tau protein aggregation. |
2008-01-09 |
2023-08-12 |
Not clear |
| Jesús Avila, Félix Hernánde. GSK-3 inhibitors for Alzheimer's disease. Expert review of neurotherapeutics. vol 7. issue 11. 2008-01-02. PMID:17997701. |
glycogen synthase kinase (gsk)-3 has been proposed as the link between the two histopathological hallmarks of alzheimer's disease, the extracellular senile plaques made of beta-amyloid and the intracellular neurofibrillary tangles made of hyperphosphorylated tau. |
2008-01-02 |
2023-08-12 |
Not clear |