| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingchao Shi, Fengna Chu, Feiqi Zhu, Jie Zh. Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer's Disease: A Focus on Aducanumab and Lecanemab. Frontiers in aging neuroscience. vol 14. 2022-05-02. PMID:35493943. |
alzheimer's disease (ad) is the most prevalent form of age-related dementia in the world, and its main pathological features consist of amyloid-β (aβ) plaque deposits and neurofibrillary tangles formed by hyperphosphorylated tau protein. |
2022-05-02 |
2023-08-13 |
Not clear |
| Rebeca Lapresa, Jesus Agulla, Sonia Gonzalez-Guerrero, Juan P Bolaños, Angeles Almeid. Amyloid-β Induces Cdh1-Mediated Rock2 Stabilization Causing Neurodegeneration. Frontiers in pharmacology. vol 13. 2022-05-02. PMID:35496276. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by progressive cognitive decline, which is causally related to the accumulation of abnormally folded amyloid-β (aβ) peptide and hyperphosphorylated tau protein aggregates. |
2022-05-02 |
2023-08-13 |
mouse |
| Lulu Schulz, Paulino Ramirez, Adrienne Lemieux, Elias Gonzalez, Travis Thomson, Bess Fros. Tau-induced elevation of the activity-regulated cytoskeleton associated protein Arc1 causally mediates neurodegeneration in the adult Drosophila brain. Neuroscience. 2022-04-29. PMID:35487302. |
alzheimer's disease and other tauopathies are neurodegenerative disorders pathologically defined by aggregated forms of tau protein in the brain. |
2022-04-29 |
2023-08-13 |
human |
| Lulu Schulz, Paulino Ramirez, Adrienne Lemieux, Elias Gonzalez, Travis Thomson, Bess Fros. Tau-induced elevation of the activity-regulated cytoskeleton associated protein Arc1 causally mediates neurodegeneration in the adult Drosophila brain. Neuroscience. 2022-04-29. PMID:35487302. |
taken together, our results suggest that arc elevation in human alzheimer's disease is a consequence of tau pathology and is a causal factor contributing to neuronal death. |
2022-04-29 |
2023-08-13 |
human |
| Lei Liu, Yuqi Cai, Bianca M Lauro, Angela L Meunier, Jasmeer Chhatwal, Dennis J Selko. Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration. Biochemical and biophysical research communications. vol 611. 2022-04-28. PMID:35483223. |
evidence suggests that plasma levels of tau protein phosphorylated at specific residues such as p-t181, p-t217, and p-t231 can be used as biomarkers for alzheimer's disease (ad) diagnosis and prognosis. |
2022-04-28 |
2023-08-13 |
Not clear |
| Qiang Xie, Ming Ni, Feng Gao, Lin-Bin Dai, Xin-Yi Lv, Yi-Fan Zhang, Qin Shi, Xing-Xing Zhu, Ji-Kui Xie, Yong Shen, Shi-Cun Wan. Correlation between Cerebrospinal Fluid Core Alzheimer's Disease Biomarkers and β-Amyloid PET in Chinese Dementia Population. ACS chemical neuroscience. 2022-04-27. PMID:35476397. |
the current diagnoses of alzheimer's disease (ad) mainly rely on such measures as amyloid-β (aβ) and tau neuropathology biomarkers in vivo via cerebrospinal fluid (csf) and positron emission tomography (pet) imaging, which had been systematically studied in caucasian individuals, whereas diagnostic performances of these approaches in chinese dementia population still remain unclear. |
2022-04-27 |
2023-08-13 |
Not clear |
| Phuong H Nguyen, Philippe Derreumau. Molecular Dynamics Simulations of the Tau R3-R4 Domain Monomer in the Bulk Solution and at the Surface of a Lipid Bilayer Model. The journal of physical chemistry. B. 2022-04-27. PMID:35476504. |
the aggregation of the tau protein plays a significant role in alzheimer's disease, and the tau r3-r4 domain spanning residues 306-378 was shown to form the amyloid fibril core of a full-length tau. |
2022-04-27 |
2023-08-13 |
Not clear |
| Maryam Bazrgar, Pariya Khodabakhsh, Leila Dargahi, Fatemeh Mohagheghi, Abolhassan Ahmadian. MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid βeta oligomer induced Alzheimer's like rat model. Experimental gerontology. 2022-04-27. PMID:35476966. |
substantial evidence indicates that imbalance in the expression of mir-132-3p, mir-181b-5p, mir-125b-5p, mir-26a-5p, mir-124-3p, mir-146a-5p, mir-29a-3p, and mir-30a-5p in the ad brain are associated with amyloid-beta (aβ) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of alzheimer's disease)ad(. |
2022-04-27 |
2023-08-13 |
rat |
| Zarin Tabassum, Jui-Heng Tseng, Camryn Isemann, Xu Tian, Youjun Chen, Laura E Herring, Todd J Cohe. Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase. The Journal of biological chemistry. 2022-04-26. PMID:35469920. |
here, we describe the reciprocal regulation of a kinase, the microtubule affinity-regulating kinase 2 (mark2), and an acetyltransferase, creb-binding protein (cbp), two enzymes known to extensively modify tau proteins in the progression of alzheimer's disease (ad). |
2022-04-26 |
2023-08-13 |
Not clear |
| Jaime Ramos-Cejudo, Andrew D Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S Berger, Nathanael R Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A Ardekani, Pomara Nunzio, Omonigho M Bubu, Ankit Parekh, Antonio Convit, Rebecca A Betensky, Thomas M Wisniewski, Ricardo S Osori. Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study. Journal of the American Heart Association. 2022-04-26. PMID:35470685. |
background vascular function is compromised in alzheimer disease (ad) years before amyloid and tau pathology are detected and a substantial body of work shows abnormal platelet activation states in patients with ad. |
2022-04-26 |
2023-08-13 |
human |
| Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahash. Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer's disease mice synapse model. eLife. vol 11. 2022-04-26. PMID:35471147. |
microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in alzheimer's disease mice synapse model. |
2022-04-26 |
2023-08-13 |
mouse |
| Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahash. Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer's disease mice synapse model. eLife. vol 11. 2022-04-26. PMID:35471147. |
elevation of soluble wild-type (wt) tau occurs in synaptic compartments in alzheimer's disease. |
2022-04-26 |
2023-08-13 |
mouse |
| Qin-Yuan Yu, Ling-Qi Ye, Hong-Lei L. Molecular interaction of stress granules with Tau and autophagy in Alzheimer's disease. Neurochemistry international. 2022-04-24. PMID:35461975. |
molecular interaction of stress granules with tau and autophagy in alzheimer's disease. |
2022-04-24 |
2023-08-13 |
Not clear |
| Eleonora Virgilio, Fabiola De Marchi, Elena Contaldi, Umberto Dianzani, Roberto Cantello, Letizia Mazzini, Cristoforo Com. The Role of Tau beyond Alzheimer's Disease: A Narrative Review. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453510. |
the role of tau beyond alzheimer's disease: a narrative review. |
2022-04-23 |
2023-08-13 |
Not clear |
| Eleonora Virgilio, Fabiola De Marchi, Elena Contaldi, Umberto Dianzani, Roberto Cantello, Letizia Mazzini, Cristoforo Com. The Role of Tau beyond Alzheimer's Disease: A Narrative Review. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453510. |
in recent years, tau protein has been progressively recognized as a valuable neuronal biomarker in several neurological conditions, not only alzheimer's disease (ad). |
2022-04-23 |
2023-08-13 |
Not clear |
| Renato X Santos, Valeria Melis, Elizabeth A Goatman, Michael Leith, Thomas C Baddeley, John M D Storey, Gernot Riedel, Claude M Wischik, Charles R Harringto. HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453617. |
the tau protein aggregation inhibitor hydromethylthionine mesylate (hmtm) was shown recently to have concentration-dependent pharmacological activity in delaying cognitive decline and brain atrophy in phase 3 alzheimer's disease (ad) clinical trials; the activity was reduced in patients receiving symptomatic therapies. |
2022-04-23 |
2023-08-13 |
mouse |
| Xiaoxiao Fu, Jing Wang, Huaying Cai, Hong Jiang, Shu Ha. C16 Peptide and Ang-1 Improve Functional Disability and Pathological Changes in an Alzheimer's Disease Model Associated with Vascular Dysfunction. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455468. |
alzheimer's disease (ad) is a neurological disorder characterized by neuronal cell death, tau pathology, and excessive inflammatory responses. |
2022-04-23 |
2023-08-13 |
rat |
| Andrea González, Sandeep Kumar Singh, Macarena Churruca, Ricardo B Maccion. Alzheimer's Disease and Tau Self-Assembly: In the Search of the Missing Link. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457009. |
alzheimer's disease and tau self-assembly: in the search of the missing link. |
2022-04-23 |
2023-08-13 |
Not clear |
| Tazeen Qureshi, Subashchandrabose Chinnathamb. Histone deacetylase-6 modulates Tau function in Alzheimer's disease. Biochimica et biophysica acta. Molecular cell research. 2022-04-22. PMID:35452751. |
histone deacetylase-6 modulates tau function in alzheimer's disease. |
2022-04-22 |
2023-08-13 |
Not clear |
| Lukasz Samluk, Piotr Ostapczuk, Magdalena Dziembowsk. Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis. Molecular biology of the cell. 2022-04-21. PMID:35446108. |
however, still unknown are the specific defects of mitochondrial biology that play a critical role in the development of alzheimer's disease, in which tau protein aggregates are observed in some patients' brains. |
2022-04-21 |
2023-08-13 |
Not clear |