| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Delphine Boche, Alexander Gerhard, Elena Rodriguez-Vieite. Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 46. issue 13. 2020-09-23. PMID:31396666. |
the present review describes the recent advancements in microglia and astrocyte biology in the context of health, ageing, and alzheimer's disease, the most common dementia worldwide. |
2020-09-23 |
2023-08-13 |
human |
| Lucia Batzu, Eric Westman, Joana B Pereir. Cerebrospinal fluid progranulin is associated with increased cortical thickness in early stages of Alzheimer's disease. Neurobiology of aging. vol 88. 2020-09-23. PMID:31980280. |
progranulin plays an important role in neuroinflammation in alzheimer's disease (ad) pathophysiology, being upregulated by activated microglia. |
2020-09-23 |
2023-08-13 |
human |
| James Keaney, Julien Gasser, Gaëlle Gillet, Diana Scholz, Irena Kadi. Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 3. 2020-09-18. PMID:30758770. |
using potent btk inhibitors and small interfering rna (sirna) against btk, we observed that blockade of btk activity decreased activation of phospholipase gamma 2, a recently identified genetic risk factor in alzheimer's disease (ad), and reduced phagocytosis in rodent microglia and human monocyte-derived macrophages. |
2020-09-18 |
2023-08-13 |
mouse |
| Dominic M Walsh, Dennis J Selko. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current opinion in neurobiology. vol 61. 2020-09-15. PMID:32197217. |
basic research on the biological mechanism of alzheimer's disease has focused for decades on the age-related aggregation of the amyloid β-protein and its apparent downstream effects on microglia, astrocytes and neurons, including the posttranslational modification of the tau protein that seems necessary for symptom expression. |
2020-09-15 |
2023-08-13 |
Not clear |
| Zachery Moore, Juliet M Taylor, Peter J Crac. The involvement of microglia in Alzheimer's disease: a new dog in the fight. British journal of pharmacology. vol 176. issue 18. 2020-09-14. PMID:30445661. |
the involvement of microglia in alzheimer's disease: a new dog in the fight. |
2020-09-14 |
2023-08-13 |
dog |
| Ramon Velazquez, Eric Ferreira, Sara Knowles, Chaya Fux, Alexis Rodin, Wendy Winslow, Salvatore Odd. Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. Aging cell. vol 18. issue 6. 2020-09-14. PMID:31560162. |
lifelong choline supplementation ameliorates alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. |
2020-09-14 |
2023-08-13 |
mouse |
| Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webbe. A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders. Nature communications. vol 11. issue 1. 2020-09-14. PMID:32826893. |
unlike alzheimer's disease (ad), we find no association between pd risk and microglia or astrocytes, suggesting that neuroinflammation plays a less causal role in pd than ad. |
2020-09-14 |
2023-08-13 |
human |
| Arsalan Hashemiaghdam, Magdalena Mrocze. Microglia heterogeneity and neurodegeneration: The emerging paradigm of the role of immunity in Alzheimer's disease. Journal of neuroimmunology. vol 341. 2020-09-03. PMID:32045774. |
microglia heterogeneity and neurodegeneration: the emerging paradigm of the role of immunity in alzheimer's disease. |
2020-09-03 |
2023-08-13 |
human |
| Arsalan Hashemiaghdam, Magdalena Mrocze. Microglia heterogeneity and neurodegeneration: The emerging paradigm of the role of immunity in Alzheimer's disease. Journal of neuroimmunology. vol 341. 2020-09-03. PMID:32045774. |
dysregulated immunoactivity in ad has been broadly studied, and current research on animal models enabled us to identify a new cluster of microglia (disease-associated microglia) alongside previously detected glial populations (e.g., plaque-associated microglia, dark microglia, human alzheimer's microglia) associated with neuroinflammation and with macrophagic activity. |
2020-09-03 |
2023-08-13 |
human |
| Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H Schuchman, Hee Kyung Jin, Jae-Sung Ba. N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-08-31. PMID:32398649. |
n-as-triggered spms are direct regulators of microglia in a model of alzheimer's disease. |
2020-08-31 |
2023-08-13 |
mouse |
| José M Castellano, Silvia Garcia-Rodriguez, Juan M Espinosa, María C Millan-Linares, Mirela Rada, Javier S Peron. Oleanolic Acid Exerts a Neuroprotective Effect Against Microglial Cell Activation by Modulating Cytokine Release and Antioxidant Defense Systems. Biomolecules. vol 9. issue 11. 2020-08-25. PMID:31683841. |
these findings advocate considering oa as a novel neuroprotective agent to inhibit oxidative stress and inflammatory response in activated microglia associated with alzheimer's disease. |
2020-08-25 |
2023-08-13 |
Not clear |
| Erik C B Johnson, Eric B Dammer, Duc M Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A Higginbotham, Andrew Guajardo, Bartholomew White, Juan C Troncoso, Madhav Thambisetty, Thomas J Montine, Edward B Lee, John Q Trojanowski, Thomas G Beach, Eric M Reiman, Vahram Haroutunian, Minghui Wang, Eric Schadt, Bin Zhang, Dennis W Dickson, Nilüfer Ertekin-Taner, Todd E Golde, Vladislav A Petyuk, Philip L De Jager, David A Bennett, Thomas S Wingo, Srikant Rangaraju, Ihab Hajjar, Joshua M Shulman, James J Lah, Allan I Levey, Nicholas T Seyfrie. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature medicine. vol 26. issue 5. 2020-08-24. PMID:32284590. |
large-scale proteomic analysis of alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. |
2020-08-24 |
2023-08-13 |
Not clear |
| Sung Hoon Baik, Seokjo Kang, Woochan Lee, Hayoung Choi, Sunwoo Chung, Jong-Il Kim, Inhee Mook-Jun. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell metabolism. vol 30. issue 3. 2020-08-21. PMID:31257151. |
a breakdown in metabolic reprogramming causes microglia dysfunction in alzheimer's disease. |
2020-08-21 |
2023-08-13 |
mouse |
| Sung Hoon Baik, Seokjo Kang, Woochan Lee, Hayoung Choi, Sunwoo Chung, Jong-Il Kim, Inhee Mook-Jun. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell metabolism. vol 30. issue 3. 2020-08-21. PMID:31257151. |
reactive microglia are a major pathological feature of alzheimer's disease (ad). |
2020-08-21 |
2023-08-13 |
mouse |
| D T Ohm, G Kim, T Gefen, A Rademaker, S Weintraub, E H Bigio, M-M Mesulam, E Rogalski, C Geul. Prominent microglial activation in cortical white matter is selectively associated with cortical atrophy in primary progressive aphasia. Neuropathology and applied neurobiology. vol 45. issue 3. 2020-08-19. PMID:29679378. |
ppa is associated with alzheimer's disease (ad), frontotemporal lobar degeneration (ftld) and significant accumulation of activated microglia. |
2020-08-19 |
2023-08-13 |
Not clear |
| Alejandro Carrillo-Jimenez, Özgen Deniz, Maria Victoria Niklison-Chirou, Rocio Ruiz, Karina Bezerra-Salomão, Vassilis Stratoulias, Rachel Amouroux, Ping Kei Yip, Anna Vilalta, Mathilde Cheray, Alexander Michael Scott-Egerton, Eloy Rivas, Khadija Tayara, Irene García-Domínguez, Juan Garcia-Revilla, Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Xianli Shen, Peter St George-Hyslop, Guy Charles Brown, Petra Hajkova, Bertrand Joseph, Jose Luis Venero, Miguel Ramos Branco, Miguel Angel Burguillo. TET2 Regulates the Neuroinflammatory Response in Microglia. Cell reports. vol 29. issue 3. 2020-08-18. PMID:31618637. |
we observed that microglia associated with amyloid β plaques expressed tet2 in brain tissue from individuals with alzheimer's disease (ad) and in 5xfad mice. |
2020-08-18 |
2023-08-13 |
mouse |
| Kate M Onusk. The Dual Role of Microglia in the Progression of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 8. 2020-08-07. PMID:32075949. |
the dual role of microglia in the progression of alzheimer's disease. |
2020-08-07 |
2023-08-13 |
Not clear |
| Matteo Pedrazzoli, Morris Losurdo, Giovanna Paolone, Manuela Medelin, Lejdi Jaupaj, Barbara Cisterna, Anna Slanzi, Manuela Malatesta, Silvia Coco, Mario Buffell. Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease. Neurobiology of disease. vol 132. 2020-08-06. PMID:31394203. |
glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of alzheimer's disease. |
2020-08-06 |
2023-08-13 |
mouse |
| Malvindar K Singh-Bains, Vanessa Linke, Micah D R Austria, Adelie Y S Tan, Emma L Scotter, Nasim F Mehrabi, Richard L M Faull, Mike Draguno. Altered microglia and neurovasculature in the Alzheimer's disease cerebellum. Neurobiology of disease. vol 132. 2020-08-06. PMID:31454549. |
altered microglia and neurovasculature in the alzheimer's disease cerebellum. |
2020-08-06 |
2023-08-13 |
human |
| Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q Trojanowski, Leslie M Shaw, Michael W Weiner, Christian Haas. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science translational medicine. vol 11. issue 507. 2020-07-27. PMID:31462511. |
loss of function of trem2, a key receptor selectively expressed by microglia in the brain, contributes to the development of alzheimer's disease (ad). |
2020-07-27 |
2023-08-13 |
human |