| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyung Ho Kim, Sung Min Son, Inhee Mook-Jun. Contributions of microglia to structural synaptic plasticity. Journal of experimental neuroscience. vol 7. 2014-08-26. PMID:25157211. |
because of their special role in the brain's immune response, microglia are involved in the pathological progression of neurodegenerative disorders such as alzheimer's disease (ad). |
2014-08-26 |
2023-08-13 |
Not clear |
| Jacqueline Hofrichter, Markus Krohn, Toni Schumacher, Cathleen Lange, Björn Feistel, Bernd Walbroel, Hans-Jochen Heinze, Sara Crockett, Timothy F Sharbel, Jens Pahnk. Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice. Current Alzheimer research. vol 10. issue 10. 2014-08-05. PMID:24156265. |
reduced alzheimer's disease pathology by st. john's wort treatment is independent of hyperforin and facilitated by abcc1 and microglia activation in mice. |
2014-08-05 |
2023-08-12 |
mouse |
| Xin Zhou, Linhong Yuan, Xia Zhao, Chengcheng Hou, Weiwei Ma, Huanling Yu, Rong Xia. Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB. Nutrition (Burbank, Los Angeles County, Calif.). vol 30. issue 1. 2014-07-17. PMID:24290604. |
microglia activation and neuroinflammation have been associated with the pathogenesis of neurodegenerative disorders such as alzheimer's disease (ad). |
2014-07-17 |
2023-08-12 |
Not clear |
| Arnaud François, Faraj Terro, Thierry Janet, Agnès Rioux Bilan, Marc Paccalin, Guylène Pag. Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer's disease. Journal of neuroinflammation. vol 10. 2014-06-25. PMID:24330807. |
involvement of interleukin-1β in the autophagic process of microglia: relevance to alzheimer's disease. |
2014-06-25 |
2023-08-12 |
Not clear |
| Xin Yi Choo, Lobna Alukaidey, Anthony R White, Alexandra Grubma. Neuroinflammation and copper in Alzheimer's disease. International journal of Alzheimer's disease. vol 2013. 2014-06-24. PMID:24369524. |
the presence of activated microglia and astrocytes in the vicinity of amyloid plaques in the brains of alzheimer's disease (ad) patients and mouse models implicates inflammation as a contributor to ad pathogenesis. |
2014-06-24 |
2023-08-12 |
mouse |
| Hansang Cho, Tadafumi Hashimoto, Elisabeth Wong, Yukiko Hori, Levi B Wood, Lingzhi Zhao, Kevin M Haigis, Bradley T Hyman, Daniel Irimi. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation. Scientific reports. vol 3. 2014-06-23. PMID:23665843. |
progressive microglial accumulation at amyloid-β (aβ) plaques is a well-established signature of the pathology of alzheimer's disease, but how and why microglia accumulate in the vicinity of aβ plaques is unknown. |
2014-06-23 |
2023-08-12 |
human |
| Yang Yu, Jin Liu, Shu-Qin Li, Lei Peng, Richard D Y. Serum amyloid a differentially activates microglia and astrocytes via the PI3K pathway. Journal of Alzheimer's disease : JAD. vol 38. issue 1. 2014-06-17. PMID:23948927. |
microglia and astrocytes in the brain play an important role in the development and progression of alzheimer's disease (ad). |
2014-06-17 |
2023-08-12 |
Not clear |
| Ye Jin, Koichi Sato, Ayaka Tobo, Chihiro Mogi, Masayuki Tobo, Naoya Murata, Satoshi Ishii, Dong-Soon Im, Fumikazu Okajim. Inhibition of interleukin-1β production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia. Journal of neurochemistry. vol 129. issue 4. 2014-06-15. PMID:24447140. |
interleukin-1β (il-1β) is released from activated microglia and involved in the neurodegeneration of acute and chronic brain disorders, such as stroke and alzheimer's disease, in which extracellular acidification has been shown to occur. |
2014-06-15 |
2023-08-12 |
mouse |
| Silvia De Astis, Irene Corradini, Raffaella Morini, Simona Rodighiero, Romana Tomasoni, Cristina Lenardi, Claudia Verderio, Paolo Milani, Michela Matteol. Nanostructured TiO2 surfaces promote polarized activation of microglia, but not astrocytes, toward a proinflammatory profile. Nanoscale. vol 5. issue 22. 2014-06-06. PMID:24065287. |
activation of glial cells, including astrocytes and microglia, has been implicated in the inflammatory responses underlying brain injury and neurodegenerative diseases including alzheimer's and parkinson's diseases. |
2014-06-06 |
2023-08-12 |
Not clear |
| Fushan Shi, Lifeng Yang, Jihong Wang, Mohammed Kouadir, Yang Yang, Yongyao Fu, Xiangmei Zhou, Xiaomin Yin, Deming Zha. Inhibition of phagocytosis reduced the classical activation of BV2 microglia induced by amyloidogenic fragments of beta-amyloid and prion proteins. Acta biochimica et biophysica Sinica. vol 45. issue 11. 2014-05-27. PMID:24055815. |
the inflammatory responses in alzheimer's disease and prion diseases are dominated by microglia activation. |
2014-05-27 |
2023-08-12 |
Not clear |
| Suzanne E Hickman, Joseph El Khour. TREM2 and the neuroimmunology of Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24355566. |
microglia can be protective and promote phagocytosis, degradation and ultimately clearance of aβ, the pathogenic protein deposited in the brains of alzheimer's patients. |
2014-05-19 |
2023-08-12 |
Not clear |
| Suzanne E Hickman, Joseph El Khour. TREM2 and the neuroimmunology of Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24355566. |
here we propose that the mechanism(s) by which trem2 variants cause alzheimer's disease are via down regulation of the aβ phagocytic ability of microglia and by dysregulation of the pro-inflammatory response of these cells. |
2014-05-19 |
2023-08-12 |
Not clear |
| Eiron Cudaback, Nikolas L Jorstad, Yue Yang, Thomas J Montine, C Dirk Keen. Therapeutic implications of the prostaglandin pathway in Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24434190. |
an important pathologic hallmark of alzheimer's disease (ad) is neuroinflammation, a process characterized in ad by disproportionate activation of cells (microglia and astrocytes, primarily) of the non-specific innate immune system within the cns. |
2014-05-19 |
2023-08-12 |
Not clear |
| Kira Irving Mosher, Tony Wyss-Cora. Microglial dysfunction in brain aging and Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24445162. |
microglia, the immune cells of the central nervous system, have long been a subject of study in the alzheimer's disease (ad) field due to their dramatic responses to the pathophysiology of the disease. |
2014-05-19 |
2023-08-12 |
human |
| Isaac M Chiu, Emiko T A Morimoto, Hani Goodarzi, Jennifer T Liao, Sean O'Keeffe, Hemali P Phatnani, Michael Muratet, Michael C Carroll, Shawn Levy, Saeed Tavazoie, Richard M Myers, Tom Maniati. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell reports. vol 4. issue 2. 2014-05-16. PMID:23850290. |
we found that sod1(g93a) microglia are not derived from infiltrating monocytes, and that both potentially neuroprotective and toxic factors, including alzheimer's disease genes, are concurrently upregulated. |
2014-05-16 |
2023-08-12 |
mouse |
| J J Rodríguez, H N Noristani, T Hilditch, M Olabarria, C Y Yeh, J Witton, A Verkhratsk. Increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the CA1 subfield of the hippocampus in the triple transgenic model of Alzheimer's disease. Neuroscience letters. vol 552. 2014-05-15. PMID:23827221. |
increased densities of resting and activated microglia in the dentate gyrus follow senile plaque formation in the ca1 subfield of the hippocampus in the triple transgenic model of alzheimer's disease. |
2014-05-15 |
2023-08-12 |
mouse |
| Marina A Lync. The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease. Immunology. vol 141. issue 3. 2014-05-15. PMID:23876085. |
this review will discuss the modulatory effect of t cells on microglia and the impact of infiltration of t cells into the brain with a focus on alzheimer's disease, and will propose that infiltration of interferon-γ-producing cells may be an important factor in triggering inflammation that is pathogenic and destructive. |
2014-05-15 |
2023-08-12 |
Not clear |
| Sameh K Wasseff, Steven S Schere. Activated microglia do not form functional gap junctions in vivo. Journal of neuroimmunology. vol 269. issue 1-2. 2014-05-15. PMID:24582000. |
we investigated whether microglia form gap junctions with themselves, or with astrocytes, oligodendrocytes, or neurons in vivo in normal mouse brains, and in pathological conditions that induce microglial activation - brain injury and a model of alzheimer's disease. |
2014-05-15 |
2023-08-12 |
mouse |
| Yuanhui Ma, Jintao Bao, Xuyang Zhao, Hongyan Shen, Junniao Lv, Shuaipeng Ma, Xuefei Zhang, Zeyang Li, Shuxin Wang, Qingsong Wang, Jianguo J. Activated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expression. Molecular & cellular proteomics : MCP. vol 12. issue 10. 2014-05-09. PMID:23816988. |
phagocytosis of fibrillar β-amyloid (aβ) by activated microglia is essential for aβ clearance in alzheimer disease. |
2014-05-09 |
2023-08-12 |
mouse |
| Yuanhui Ma, Jintao Bao, Xuyang Zhao, Hongyan Shen, Junniao Lv, Shuaipeng Ma, Xuefei Zhang, Zeyang Li, Shuxin Wang, Qingsong Wang, Jianguo J. Activated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar β-amyloid by up-regulating lipoprotein lipase expression. Molecular & cellular proteomics : MCP. vol 12. issue 10. 2014-05-09. PMID:23816988. |
in summary, our findings reveal a potential role of the cdk5/p25-lpl signaling pathway in aβ phagocytosis by microglia and provide a new insight into the molecular pathogenesis of alzheimer disease. |
2014-05-09 |
2023-08-12 |
mouse |