| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mar Hernandez-Guillamon, Stephanie Mawhirt, Steven Blais, Joan Montaner, Thomas A Neubert, Agueda Rostagno, Jorge Ghis. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. The Journal of biological chemistry. vol 290. issue 24. 2015-09-10. PMID:25897080. |
matrix metalloproteases (mmps) mmp-2 and mmp-9 have been implicated in the physiological catabolism of alzheimer's amyloid-β (aβ). |
2015-09-10 |
2023-08-13 |
human |
| Markus Morawski, Mikhail Filippov, Athina Tzinia, Effie Tsilibary, Lydia Vargov. ECM in brain aging and dementia. Progress in brain research. vol 214. 2015-08-19. PMID:25410360. |
age-related changes in the extracellular matrix composition and the extracellular space volume and permissivity are major determinants of the onset and development of the most common neurodegenerative disorder, alzheimer's disease. |
2015-08-19 |
2023-08-13 |
Not clear |
| Vladimir Berezin, Peter S Walmod, Mikhail Filippov, Alexander Dityate. Targeting of ECM molecules and their metabolizing enzymes and receptors for the treatment of CNS diseases. Progress in brain research. vol 214. 2015-08-19. PMID:25410365. |
extracellular matrix (ecm) molecules, their receptors at the cell surface, and cell adhesion molecules (cams) involved in cell-cell or cell-ecm interactions are implicated in processes related to major diseases of the central nervous system including alzheimer's disease (ad), epilepsy, schizophrenia, addiction, multiple sclerosis, parkinson's disease, and cancer. |
2015-08-19 |
2023-08-13 |
Not clear |
| Suresh Ponnayyan Sulochana, Kuldeep Sharma, Ramesh Mullangi, Sathesh Kumar Sukumara. Review of the validated HPLC and LC-MS/MS methods for determination of drugs used in clinical practice for Alzheimer's disease. Biomedical chromatography : BMC. vol 28. issue 11. 2015-06-22. PMID:24515838. |
in addition, this review collates various considerations such as internal standard selection, extraction schemes, matrix effect, selectivity evaluation and optimization of mass spectrometric conditions to enable the development of sound bioanalytical methods for quantitation of alzheimer's drugs. |
2015-06-22 |
2023-08-12 |
Not clear |
| Marlene J Végh, Céline M Heldring, Willem Kamphuis, Sara Hijazi, Arie J Timmerman, Ka Wan Li, Pim van Nierop, Huibert D Mansvelder, Elly M Hol, August B Smit, Ronald E van Kestere. Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:24974208. |
reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of alzheimer's disease. |
2015-05-29 |
2023-08-13 |
mouse |
| Marlene J Végh, Céline M Heldring, Willem Kamphuis, Sara Hijazi, Arie J Timmerman, Ka Wan Li, Pim van Nierop, Huibert D Mansvelder, Elly M Hol, August B Smit, Ronald E van Kestere. Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:24974208. |
these findings indicate an important role for the extracellular matrix in causing early memory loss in alzheimer's disease. |
2015-05-29 |
2023-08-13 |
mouse |
| Wei Kong, Juan Wang, Xiaoyang Mo. [Significant genes extraction and analysis of gene expression data based on matrix factorization techniques]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 31. issue 3. 2015-05-19. PMID:25219254. |
in our study, two unsupervised matrix factorization methods, independent component analysis (ica) and nonnegative matrix factorization (nmf), were proposed to identify significant genes and model the regulatory network using the microarray gene expression data of alzheimer's disease (ad). |
2015-05-19 |
2023-08-13 |
Not clear |
| Wei Kong, Xiaoyang Mou, Xing Zhi, Xin Zhang, Yang Yan. Dynamic regulatory network reconstruction for Alzheimer's disease based on matrix decomposition techniques. Computational and mathematical methods in medicine. vol 2014. 2015-03-30. PMID:25024739. |
dynamic regulatory network reconstruction for alzheimer's disease based on matrix decomposition techniques. |
2015-03-30 |
2023-08-13 |
Not clear |
| Xiang-Xiang Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Ta. Matrix metalloproteinases and their multiple roles in Alzheimer's disease. BioMed research international. vol 2014. 2015-03-30. PMID:25050378. |
matrix metalloproteinases and their multiple roles in alzheimer's disease. |
2015-03-30 |
2023-08-13 |
Not clear |
| Barbara Mroczko, Magdalena Groblewska, Marzena Zboch, Agnieszka Kulczyńska, Olga M Koper, Maciej Szmitkowski, Johannes Kornhuber, Piotr Lewczu. Concentrations of matrix metalloproteinases and their tissue inhibitors in the cerebrospinal fluid of patients with Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 40. issue 2. 2015-01-15. PMID:24448781. |
concentrations of matrix metalloproteinases and their tissue inhibitors in the cerebrospinal fluid of patients with alzheimer's disease. |
2015-01-15 |
2023-08-12 |
Not clear |
| Cecilia E Hanzel, M Florencia Iulita, Helga Eyjolfsdottir, Erik Hjorth, Marianne Schultzberg, Maria Eriksdotter, A Claudio Cuell. Analysis of matrix metallo-proteases and the plasminogen system in mild cognitive impairment and Alzheimer's disease cerebrospinal fluid. Journal of Alzheimer's disease : JAD. vol 40. issue 3. 2014-12-17. PMID:24531161. |
analysis of matrix metallo-proteases and the plasminogen system in mild cognitive impairment and alzheimer's disease cerebrospinal fluid. |
2014-12-17 |
2023-08-12 |
human |
| Cecilia E Hanzel, M Florencia Iulita, Helga Eyjolfsdottir, Erik Hjorth, Marianne Schultzberg, Maria Eriksdotter, A Claudio Cuell. Analysis of matrix metallo-proteases and the plasminogen system in mild cognitive impairment and Alzheimer's disease cerebrospinal fluid. Journal of Alzheimer's disease : JAD. vol 40. issue 3. 2014-12-17. PMID:24531161. |
the expression of matrix metallo-proteases (mmp-2, mmp-3, mmp-7, and mmp-9), plasminogen and their regulators (timp-1, tissue plasminogen activator and neuroserpin) was investigated in cerebrospinal fluid (csf) from subjective cognitive impairment (sci) subjects, mild cognitive impairment (mci), and alzheimer's disease (ad) cases. |
2014-12-17 |
2023-08-12 |
human |
| Victor N Ierusalimsky, Elena P Kuleshova, Pavel M Balaba. Expression of the type 1 metalloproteinase in the rat hippocampus after the intracerebroventricular injection of β-amyloid peptide (25-35). Acta neurobiologiae experimentalis. vol 73. issue 4. 2014-11-21. PMID:24457647. |
the expression of matrix metalloproteinase of the first type was studied in frontal sections of the adult rat brain one month after a single intracerebroventricular injection of beta-amyloid peptide (25-35), which is known to be a well-known model of the development of alzheimer's disease. |
2014-11-21 |
2023-08-12 |
rat |
| Pedro Cisternas, Juan P Henriquez, Enrique Brandan, Nibaldo C Inestros. Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:24014138. |
in addition, based on previous evidence showing that wnt pathways are linked to several diseases, such as alzheimer's and cancer, we address recent studies indicating that wnt signaling plays a key role in skeletal muscle fibrosis, a disease characterized by an increase in the extracellular matrix components leading to failure in muscle regeneration, tissue disorganization and loss of muscle activity. |
2014-10-27 |
2023-08-12 |
Not clear |
| Sally Hunter, Thomas Arendt, Carol Brayn. The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD. Molecular neurobiology. vol 48. issue 3. 2014-06-18. PMID:23546742. |
the senescence hypothesis of disease progression in alzheimer disease: an integrated matrix of disease pathways for fad and sad. |
2014-06-18 |
2023-08-12 |
Not clear |
| Micha M M Wilhelmus, John G J M Bol, Sjoerd G van Duinen, Benjamin Drukarc. Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type. Experimental gerontology. vol 48. issue 2. 2013-07-08. PMID:23267843. |
extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--dutch type. |
2013-07-08 |
2023-08-12 |
Not clear |
| Dávid Lendvai, Markus Morawski, László Négyessy, Georgina Gáti, Carsten Jäger, Gábor Baksa, Tibor Glasz, Johannes Attems, Heikki Tanila, Thomas Arendt, Tibor Harkany, Alán Alpá. Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease. Acta neuropathologica. vol 125. issue 2. 2013-06-25. PMID:22961619. |
neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in alzheimer's disease. |
2013-06-25 |
2023-08-12 |
mouse |
| Dávid Lendvai, Markus Morawski, László Négyessy, Georgina Gáti, Carsten Jäger, Gábor Baksa, Tibor Glasz, Johannes Attems, Heikki Tanila, Thomas Arendt, Tibor Harkany, Alán Alpá. Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease. Acta neuropathologica. vol 125. issue 2. 2013-06-25. PMID:22961619. |
we hypothesized that (1) the cellular expression sites of chondroitin sulphate proteoglycan-containing extracellular matrix associate with specific neuronal identities, reflecting network dynamics, and (2) the regional distribution and molecular composition of axonal coats must withstand alzheimer's disease-related modifications to protect functional synapses. |
2013-06-25 |
2023-08-12 |
mouse |
| Tanja Hochstrasser, Daniela Ehrlich, Josef Marksteiner, Barbara Sperner-Unterweger, Christian Humpe. Matrix metalloproteinase-2 and epidermal growth factor are decreased in platelets of Alzheimer patients. Current Alzheimer research. vol 9. issue 8. 2013-06-21. PMID:21875409. |
matrix metalloproteinase-2 and epidermal growth factor are decreased in platelets of alzheimer patients. |
2013-06-21 |
2023-08-12 |
Not clear |
| Bianca Da Costa Dias, Katarina Jovanovic, Danielle Gonsalves, Stefan F T Weis. Structural and mechanistic commonalities of amyloid-β and the prion protein. Prion. vol 5. issue 3. 2013-04-11. PMID:21862871. |
furthermore, comparisons are drawn between alzheimer disease and prion disorders and the role of laminin, an extracellular matrix protein, glycosaminoglycans and the 37 kda/67 kda laminin receptor (lrp/lr) have been highlighted with regards to both neurodegenerative diseases. |
2013-04-11 |
2023-08-12 |
Not clear |