| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Büşra Delikkaya, Natalia Moriel, Ming Tong, Gina Gallucci, Suzanne M de la Mont. Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-ε4-associated Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2020-09-30. PMID:31193223. |
this study assesses insulin-degrading enzyme (ide) and regulator of calcineurin 1 (rcan1) as potential mediators of brain insulin deficiency and neurodegeneration in experimental and human alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
human |
| Sami Gabbouj, Simo Ryhänen, Mikael Marttinen, Rebekka Wittrahm, Mari Takalo, Susanna Kemppainen, Henna Martiskainen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen, Teemu Natune. Altered Insulin Signaling in Alzheimer's Disease Brain - Special Emphasis on PI3K-Akt Pathway. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31275108. |
altered insulin signaling in alzheimer's disease brain - special emphasis on pi3k-akt pathway. |
2020-09-30 |
2023-08-13 |
mouse |
| Jaume Folch, Jordi Olloquequi, Miren Ettcheto, Oriol Busquets, Elena Sánchez-López, Amanda Cano, Triana Espinosa-Jiménez, Maria Luisa García, Carlos Beas-Zarate, Gemma Casadesús, Mónica Bulló, Carme Auladell, Antoni Camin. The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31551756. |
the involvement of peripheral and brain insulin resistance in late onset alzheimer's dementia. |
2020-09-30 |
2023-08-13 |
human |
| Irina Krasil'nikova, Alexander Surin, Elena Sorokina, Andrei Fisenko, Dmitry Boyarkin, Maxim Balyasin, Anna Demchenko, Igor Pomytkin, Vsevolod Pineli. Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31611766. |
glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and alzheimer's disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be a promising therapy. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jim R Fadel, Lawrence P Reaga. Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits. Current opinion in behavioral sciences. vol 9. 2020-09-29. PMID:26955646. |
the concept that insulin regulates hippocampal neuroplasticity is further supported from animal models of type 2 diabetes (t2dm) and alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Guohong Jiang, Changming Wang, Jun Zhang, Haijun Li. Mediation of insulin growth factor-1 in Alzheimer's disease and the mechanism of PRNP genetic expression and the PI3K/Akt signaling pathway. Experimental and therapeutic medicine. vol 13. issue 6. 2020-09-29. PMID:28587338. |
mediation of insulin growth factor-1 in alzheimer's disease and the mechanism of prnp genetic expression and the pi3k/akt signaling pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| Guohong Jiang, Changming Wang, Jun Zhang, Haijun Li. Mediation of insulin growth factor-1 in Alzheimer's disease and the mechanism of PRNP genetic expression and the PI3K/Akt signaling pathway. Experimental and therapeutic medicine. vol 13. issue 6. 2020-09-29. PMID:28587338. |
the aim of the study was to examine the mediation of insulin growth factor-1 (igf-1) in alzheimer's disease (ad), as well as the underlying mechanism of the prnp genetic expression and pi3k/akt signaling pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| Bryan J Neth, Suzanne Craf. Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages. Frontiers in aging neuroscience. vol 9. 2020-09-29. PMID:29163128. |
insulin resistance and alzheimer's disease: bioenergetic linkages. |
2020-09-29 |
2023-08-13 |
Not clear |
| Laís S S Ferreira, Caroline S Fernandes, Marcelo N N Vieira, Fernanda G De Felic. Insulin Resistance in Alzheimer's Disease. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30542257. |
insulin resistance in alzheimer's disease. |
2020-09-29 |
2023-08-13 |
Not clear |
| Laís S S Ferreira, Caroline S Fernandes, Marcelo N N Vieira, Fernanda G De Felic. Insulin Resistance in Alzheimer's Disease. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30542257. |
the key intersection among the three diseases is insulin resistance, which has been classically described to occur in peripheral tissues in diabetes and obesity and has recently been shown to develop in alzheimer's disease (ad) brains. |
2020-09-29 |
2023-08-13 |
Not clear |
| Elizabeth M Rhea, William A Bank. Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31213970. |
we also summarize how insulin can regulate levels of the pathological hallmarks of alzheimer's disease, including amyloid beta (aβ) and tau within each cell type. |
2020-09-29 |
2023-08-13 |
Not clear |
| A M Fernandez, A Santi, I Torres Alema. Insulin Peptides as Mediators of the Impact of Life Style in Alzheimer's disease. Brain plasticity (Amsterdam, Netherlands). vol 4. issue 1. 2020-09-28. PMID:30564544. |
insulin peptides as mediators of the impact of life style in alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Zeleke Geto, Meseret Derbew Molla, Feyissa Challa, Yohannes Belay, Tigist Getahu. Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases. Journal of inflammation research. vol 13. 2020-09-28. PMID:32110085. |
chronic inflammation due to oxidative damage is thought to trigger numerous chronic diseases including cardiac, liver and kidney disorders, neurodegenerative diseases (parkinson's disease and alzheimer's disease), cardiovascular diseases/atherosclerosis, obesity, insulin resistance, and type 2 diabetes mellitus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Nawar Muneer Aljanabi, Sahil Mamtani, Muthanna Mohammed Hasan Al-Ghuraibawi, Sunita Yadav, Lubna Nas. Alzheimer's and Hyperglycemia: Role of the Insulin Signaling Pathway and GSK-3 Inhibition in Paving a Path to Dementia. Cureus. vol 12. issue 2. 2020-09-28. PMID:32190448. |
alzheimer's and hyperglycemia: role of the insulin signaling pathway and gsk-3 inhibition in paving a path to dementia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Nawar Muneer Aljanabi, Sahil Mamtani, Muthanna Mohammed Hasan Al-Ghuraibawi, Sunita Yadav, Lubna Nas. Alzheimer's and Hyperglycemia: Role of the Insulin Signaling Pathway and GSK-3 Inhibition in Paving a Path to Dementia. Cureus. vol 12. issue 2. 2020-09-28. PMID:32190448. |
in this project, we are trying to review the articles that discuss the relationship between insulin signaling and alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Nawar Muneer Aljanabi, Sahil Mamtani, Muthanna Mohammed Hasan Al-Ghuraibawi, Sunita Yadav, Lubna Nas. Alzheimer's and Hyperglycemia: Role of the Insulin Signaling Pathway and GSK-3 Inhibition in Paving a Path to Dementia. Cureus. vol 12. issue 2. 2020-09-28. PMID:32190448. |
we used pubmed database to collect our data and used the following keywords: alzheimer's disease, insulin signaling pathway, type 3 diabetes, type 2 diabetes, insulin, and insulin resistance in our revision; we included free articles that were published in the last 10 years and excluded articles that were written in any language other than english. |
2020-09-28 |
2023-08-13 |
Not clear |
| b' Velid Unsal, Tahir Dalk\\xc4\\xb1ran, Mustafa \\xc3\\x87i\\xc3\\xa7ek, Engin K\\xc3\\xb6l\\xc3\\xbck\\xc3\\xa7\\xc3\\xb. The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review. Advanced pharmaceutical bulletin. vol 10. issue 2. 2020-09-28. PMID:32373487.' |
these include cancer, hypertension, ischemia/perfusion, cardiovascular diseases, chronic obstructive pulmonary disease, diabetes, insulin resistance, acute respiratory distress syndrome, idiopathic pulmonary fibrosis, asthma, skin diseases, chronic kidney disease, eye diseases, neurodegenerative diseases (amyotrophic lateral sclerosis, parkinson's disease, alzheimer's disease, and huntington disease). |
2020-09-28 |
2023-08-13 |
Not clear |
| Silvia Rea, David Della-Morte, Francesca Pacifici, Barbara Capuani, Donatella Pastore, Andrea Coppola, Roberto Arriga, Aikaterini Andreadi, Giulia Donadel, Nicola Di Daniele, Alfonso Bellia, Davide Laur. Insulin and Exendin-4 Reduced Mutated Huntingtin Accumulation in Neuronal Cells. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32547392. |
furthermore, it has also been reported that intranasal insulin (ins) administration improved cognitive function in patients with neurodegenerative disorders such as alzheimer disease, and that exendin-4 (ex-4) enhanced lifespan and ameliorated glucose homeostasis in a mouse model of hd. |
2020-09-28 |
2023-08-13 |
mouse |
| Demi C Galindo, William A Banks, Elizabeth M Rhe. The impact of acute rosiglitazone on insulin pharmacokinetics at the blood-brain barrier. Endocrinology, diabetes & metabolism. vol 3. issue 3. 2020-09-28. PMID:32704569. |
cns insulin levels are decreased and insulin receptor signalling is dampened in alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Athanasia K Papazafiropoulou, Chris Koros, Andreas Melidonis, Stavros Antonopoulo. Diabetes and dementia - the two faces of Janus. Archives of medical sciences. Atherosclerotic diseases. vol 5. 2020-09-28. PMID:32832719. |
despite the limited data on the possible pathogenetic mechanisms, evidence suggests that cognitive decline, and thus dementia and alzheimer's disease, might arise from a complex interplay between type 2 diabetes and the aging brain, including decreased insulin signalling and glucose metabolism, mitochondrial dysfunction, neuroinflammation, and vascular disease. |
2020-09-28 |
2023-08-13 |
Not clear |