| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Tural, N Altan, C Irkec, D Sahin, H Z Batur Caglaya. The probable role of insulin resistance and SIRT1 proteins in the Alzheimer's disease. Bratislavske lekarske listy. vol 121. issue 11. 2021-01-19. PMID:33164543. |
recent evidence suggests that insulin resistance may play an important role in the pathogenesis of alzheimer's disease (ad). |
2021-01-19 |
2023-08-13 |
Not clear |
| Tomohiro Imamura, Yuki T Yanagihara, Yasumasa Ohyagi, Norimichi Nakamura, Kyoko M Iinuma, Ryo Yamasaki, Hirohide Asai, Masahiro Maeda, Kazuma Murakami, Kazuhiro Irie, Jun-Ichi Kir. Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model. Neurobiology of disease. vol 137. 2021-01-15. PMID:31927145. |
insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an alzheimer's disease model. |
2021-01-15 |
2023-08-13 |
mouse |
| Elizabeth M Rhea, Jacob Raber, William A Bank. ApoE and cerebral insulin: Trafficking, receptors, and resistance. Neurobiology of disease. vol 137. 2021-01-15. PMID:31978603. |
central nervous system (cns) insulin resistance is associated with alzheimer's disease (ad). |
2021-01-15 |
2023-08-13 |
Not clear |
| Antonella Tramutola, Chiara Lanzillotta, Fabio Di Domenico, Elizabeth Head, D Allan Butterfield, Marzia Perluigi, Eugenio Baron. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiology of disease. vol 137. 2021-01-15. PMID:31987911. |
brain insulin resistance triggers early onset alzheimer disease in down syndrome. |
2021-01-15 |
2023-08-13 |
Not clear |
| Antonella Tramutola, Chiara Lanzillotta, Fabio Di Domenico, Elizabeth Head, D Allan Butterfield, Marzia Perluigi, Eugenio Baron. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiology of disease. vol 137. 2021-01-15. PMID:31987911. |
dysregulation of insulin signaling pathway with reduced downstream neuronal survival and plasticity mechanisms is a fundamental abnormality observed in alzheimer's disease (ad) brain. |
2021-01-15 |
2023-08-13 |
Not clear |
| Rohith N Thota, Jessica I Rosato, Cintia B Dias, Tracy L Burrows, Ralph N Martins, Manohar L Gar. Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer's Disease. Nutrients. vol 12. issue 4. 2021-01-11. PMID:32283762. |
dietary supplementation with curcumin has been previously reported to have beneficial effects in people with insulin resistance, type 2 diabetes (t2d) and alzheimer's disease (ad). |
2021-01-11 |
2023-08-13 |
human |
| Jong Ryeal Hahm, Myeung Hoon Jo, Rahat Ullah, Min Woo Kim, Myeong Ok Ki. Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer's Like Pathology in Mice Brain. Cells. vol 9. issue 1. 2021-01-06. PMID:31963819. |
oxidative stress and insulin resistance play major roles in numerous neurodegenerative diseases, including alzheimer's disease (ad). |
2021-01-06 |
2023-08-13 |
mouse |
| Jong Ryeal Hahm, Myeung Hoon Jo, Rahat Ullah, Min Woo Kim, Myeong Ok Ki. Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer's Like Pathology in Mice Brain. Cells. vol 9. issue 1. 2021-01-06. PMID:31963819. |
taken together, our findings suggest that excessive consumption of an hfd has a profound impact on brain function, which involves the acceleration of cognitive impairment due to increased obesity-associated oxidative stress, insulin resistance, and neuroinflammation, which ultimately may cause early onset of alzheimer's pathology via the suppression of adipor1 signaling in the brain. |
2021-01-06 |
2023-08-13 |
mouse |
| Ari B Cuperfain, James L Kennedy, Vanessa F Gonçalve. Overlapping mechanisms linking insulin resistance with cognition and neuroprogression in bipolar disorder. Neuroscience and biobehavioral reviews. vol 111. 2021-01-05. PMID:31978440. |
the relationship between insulin resistance in diabetes and the risk of developing major neurocognitive disorders such as alzheimer's disease has been well described. |
2021-01-05 |
2023-08-13 |
Not clear |
| Jared M Fine, Benjamin M Stroebel, Katherine A Faltesek, Kaoru Terai, Lucas Haase, Kristin E Knutzen, Jacob Kosyakovsky, Tate J Bowe, Austin K Fuller, William H Frey, Leah R Hanso. Intranasal delivery of low-dose insulin ameliorates motor dysfunction and dopaminergic cell death in a 6-OHDA rat model of Parkinson's Disease. Neuroscience letters. vol 714. 2021-01-04. PMID:31629033. |
intranasally administered insulin has already shown promise as a memory-enhancing therapy in patients with alzheimer's and animal models of the disease. |
2021-01-04 |
2023-08-13 |
human |
| Zoe Arvanitakis, Hoau-Yan Wang, Ana W Capuano, Amber Khan, Bouchra Taïb, Frederick Anokye-Danso, Julie A Schneider, David A Bennett, Rexford S Ahima, Steven E Arnol. Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function. Annals of neurology. vol 88. issue 3. 2021-01-04. PMID:32557841. |
brain insulin signaling, alzheimer disease pathology, and cognitive function. |
2021-01-04 |
2023-08-13 |
Not clear |
| Zoe Arvanitakis, Hoau-Yan Wang, Ana W Capuano, Amber Khan, Bouchra Taïb, Frederick Anokye-Danso, Julie A Schneider, David A Bennett, Rexford S Ahima, Steven E Arnol. Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function. Annals of neurology. vol 88. issue 3. 2021-01-04. PMID:32557841. |
to examine associations of molecular markers of brain insulin signaling with alzheimer disease (ad) and cognition among older persons with or without diabetes. |
2021-01-04 |
2023-08-13 |
Not clear |
| Therese S Salameh, Elizabeth M Rhea, Konrad Talbot, William A Bank. Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics. Biochemical pharmacology. vol 180. 2020-12-31. PMID:32755557. |
among the more promising treatments proposed for alzheimer's disease (ad) and parkinson's disease (pd) are those reducing brain insulin resistance. |
2020-12-31 |
2023-08-13 |
Not clear |
| Jonathan Chang-Cheng Shieh, Pai-Tsang Huang, Yung-Feng Li. Alzheimer's Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies. Molecular neurobiology. vol 57. issue 4. 2020-12-29. PMID:31900863. |
alzheimer's disease and diabetes: insulin signaling as the bridge linking two pathologies. |
2020-12-29 |
2023-08-13 |
Not clear |
| Jill K Morris, Casey S John, Zachary D Green, Heather M Wilkins, Xiaowan Wang, Ashwini Kamat, Russell S Swerdlow, Eric D Vidoni, Melissa E Petersen, Sid E O'Bryant, Robyn A Honea, Jeffrey M Burn. Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-12-18. PMID:33328877. |
individuals with alzheimer's disease (ad) are often characterized by systemic markers of insulin resistance; however, the broader effects of ad on other relevant metabolic hormones, such as incretins that affect insulin secretion and food intake, remains less clear. |
2020-12-18 |
2023-08-13 |
Not clear |
| Salinee Jantrapirom, Wutigri Nimlamool, Nipon Chattipakorn, Siriporn Chattipakorn, Piya Temviriyanukul, Woorawee Inthachat, Piyarat Govitrapong, Saranyapin Potikanon. Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity. International journal of molecular sciences. vol 21. issue 5. 2020-12-08. PMID:32138327. |
neuronal insulin resistance is a significant feature of alzheimer's disease (ad). |
2020-12-08 |
2023-08-13 |
human |
| Salinee Jantrapirom, Wutigri Nimlamool, Nipon Chattipakorn, Siriporn Chattipakorn, Piya Temviriyanukul, Woorawee Inthachat, Piyarat Govitrapong, Saranyapin Potikanon. Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity. International journal of molecular sciences. vol 21. issue 5. 2020-12-08. PMID:32138327. |
however, the neuronal effect of liraglutide on the model of neuronal insulin resistance with alzheimer's formation has not been thoroughly investigated. |
2020-12-08 |
2023-08-13 |
human |
| Salinee Jantrapirom, Wutigri Nimlamool, Nipon Chattipakorn, Siriporn Chattipakorn, Piya Temviriyanukul, Woorawee Inthachat, Piyarat Govitrapong, Saranyapin Potikanon. Liraglutide Suppresses Tau Hyperphosphorylation, Amyloid Beta Accumulation through Regulating Neuronal Insulin Signaling and BACE-1 Activity. International journal of molecular sciences. vol 21. issue 5. 2020-12-08. PMID:32138327. |
this indicated that liraglutide can reverse the defect of phosphorylation status of insulin signal transduction but also inhibit the formation of pathogenic alzheimer's proteins like aβ in neuronal cells. |
2020-12-08 |
2023-08-13 |
human |
| Vivek Kumar Sharma, Thakur Gurjeet Sing. Insulin resistance and bioenergetic manifestations: Targets and approaches in Alzheimer's disease. Life sciences. vol 262. 2020-12-04. PMID:32926928. |
insulin resistance and bioenergetic manifestations: targets and approaches in alzheimer's disease. |
2020-12-04 |
2023-08-13 |
Not clear |
| Vijay Hegde, Nikhil V Dhurandhar, P Hemachandra Redd. Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer's Disease? Journal of Alzheimer's disease : JAD. vol 72. issue s1. 2020-11-30. PMID:31744006. |
hyperinsulinemia or insulin resistance: what impacts the progression of alzheimer's disease? |
2020-11-30 |
2023-08-13 |
Not clear |