| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Elizabeth De Sousa Rodrigues, Madelyn C Houser, Douglas I Walker, Dean P Jones, Jianjun Chang, Christopher J Barnum, Malú G Tanse. Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer's disease associated with obesity, metabolic syndrome, and type 2 diabetes. Alzheimer's research & therapy. vol 12. issue 1. 2020-08-03. PMID:31892368. |
insulin impairment and inflammation are two features common to type 2 diabetes and alzheimer's disease; however, the molecular and signaling interactions underlying this relationship are not well understood. |
2020-08-03 |
2023-08-13 |
Not clear |
| Maria Elizabeth De Sousa Rodrigues, Madelyn C Houser, Douglas I Walker, Dean P Jones, Jianjun Chang, Christopher J Barnum, Malú G Tanse. Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer's disease associated with obesity, metabolic syndrome, and type 2 diabetes. Alzheimer's research & therapy. vol 12. issue 1. 2020-08-03. PMID:31892368. |
mounting evidence point to the associations between the disruption of metabolite processing in insulin impairment and neurodegenerative conditions such as alzheimer's. |
2020-08-03 |
2023-08-13 |
Not clear |
| Farzana Parveen, Daniel Bender, Shi-Hui Law, Vineet Kumar Mishra, Chih-Chieh Chen, Liang-Yin K. Role of Ceramidases in Sphingolipid Metabolism and Human Diseases. Cells. vol 8. issue 12. 2020-07-31. PMID:31817238. |
human pathologies such as alzheimer's disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular diseases have altered lipid homeostasis. |
2020-07-31 |
2023-08-13 |
human |
| Bhumsoo Kim, Sarah E Elzinga, Rosemary E Henn, Lisa M McGinley, Eva L Feldma. The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease. Neurobiology of disease. vol 132. 2020-07-27. PMID:31349033. |
the effects of insulin and insulin-like growth factor i on amyloid precursor protein phosphorylation in in vitro and in vivo models of alzheimer's disease. |
2020-07-27 |
2023-08-13 |
mouse |
| Suzanne M de la Monte, Ming Tong, Lori A Daiello, Brian R Ot. Early-Stage Alzheimer's Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-22. PMID:30775986. |
brain insulin resistance is a well-recognized abnormality in alzheimer's disease (ad) and the likely mediator of impaired glucose utilization that emerges early and progresses with disease severity. |
2020-07-22 |
2023-08-13 |
Not clear |
| Ewan C McNay, Jiah Pearson-Lear. GluT4: A central player in hippocampal memory and brain insulin resistance. Experimental neurology. vol 323. 2020-07-21. PMID:31614121. |
impairments to insulin signaling, such as those seen in type 2 diabetes and alzheimer's disease, are associated with brain hypometabolism and cognitive impairment, but the mechanisms of insulin's central effects are not determined. |
2020-07-21 |
2023-08-13 |
Not clear |
| Shijiao Tian, Wenming Jia, Mei Lu, Juan Zhao, Xiulian Su. Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression. The Journal of biological chemistry. vol 294. issue 52. 2020-06-22. PMID:31723029. |
insulin resistance in the brain is a pathological mechanism that is shared between alzheimer's disease (ad) and type 2 diabetes mellitus (t2dm). |
2020-06-22 |
2023-08-13 |
Not clear |
| Smriti Gupta, Nitin Kumar Singhal, Subramaniam Ganesh, Rajat Sandhi. Extending Arms of Insulin Resistance from Diabetes to Alzheimer's Disease: Identification of Potential Therapeutic Targets. CNS & neurological disorders drug targets. vol 18. issue 3. 2020-06-17. PMID:30430949. |
extending arms of insulin resistance from diabetes to alzheimer's disease: identification of potential therapeutic targets. |
2020-06-17 |
2023-08-13 |
Not clear |
| Smriti Gupta, Nitin Kumar Singhal, Subramaniam Ganesh, Rajat Sandhi. Extending Arms of Insulin Resistance from Diabetes to Alzheimer's Disease: Identification of Potential Therapeutic Targets. CNS & neurological disorders drug targets. vol 18. issue 3. 2020-06-17. PMID:30430949. |
type 3 diabetes (t3d) is chronic insulin resistant state of brain which shares pathology with sporadic alzheimer's disease (sad). |
2020-06-17 |
2023-08-13 |
Not clear |
| Smriti Gupta, Nitin Kumar Singhal, Subramaniam Ganesh, Rajat Sandhi. Extending Arms of Insulin Resistance from Diabetes to Alzheimer's Disease: Identification of Potential Therapeutic Targets. CNS & neurological disorders drug targets. vol 18. issue 3. 2020-06-17. PMID:30430949. |
although insulin is primarily studied as a key molecule in diabetes mellitus, its role has recently been implicated in the development of alzheimer's disease (ad). |
2020-06-17 |
2023-08-13 |
Not clear |
| Boe-Hyun Kim, Jennifer Kelschenbach, Alejandra Borjabad, Eran Hadas, Hongxia He, Mary Jane Potash, Michael T Nedelcovych, Rana Rais, Norman J Haughey, Justin C McArthur, Barbara S Slusher, David J Volsk. Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice. AIDS (London, England). vol 33. issue 6. 2020-06-04. PMID:30946151. |
intranasal insulin therapy improves cognition in alzheimer's disease and diabetes. |
2020-06-04 |
2023-08-13 |
mouse |
| Anand Kamal Sachdeva, Ravinder Naik Dharavath, Kanwaljit Chopr. Time-response studies on development of cognitive deficits in an experimental model of insulin resistance. Clinical nutrition (Edinburgh, Scotland). vol 38. issue 3. 2020-06-01. PMID:30037709. |
alzheimer's disease is suggested to be primarily metabolic, mainly characterized by brain insulin resistance. |
2020-06-01 |
2023-08-13 |
rat |
| Sunil Kumar Dubey, K K Lakshmi, Kowthavarapu Venkata Krishna, Mukta Agrawal, Gautam Singhvi, Ranendra Narayana Saha, Swarnlata Saraf, Shailendra Saraf, Rahul Shukla, Amit Alexande. Insulin mediated novel therapies for the treatment of Alzheimer's disease. Life sciences. vol 249. 2020-05-27. PMID:32165212. |
insulin mediated novel therapies for the treatment of alzheimer's disease. |
2020-05-27 |
2023-08-13 |
Not clear |
| Hala Attia, Shaykhah Albuhayri, Sadeem Alaraidh, Amirah Alotaibi, Hazar Yacoub, Raeesa Mohamad, Maha Al-Ami. Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride-induced Alzheimer's disease via attenuating neuroinflammation and improving brain insulin signaling. Journal of biochemical and molecular toxicology. 2020-05-08. PMID:32383521. |
biotin, coenzyme q10, and their combination ameliorate aluminium chloride-induced alzheimer's disease via attenuating neuroinflammation and improving brain insulin signaling. |
2020-05-08 |
2023-08-13 |
Not clear |
| Hala Attia, Shaykhah Albuhayri, Sadeem Alaraidh, Amirah Alotaibi, Hazar Yacoub, Raeesa Mohamad, Maha Al-Ami. Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride-induced Alzheimer's disease via attenuating neuroinflammation and improving brain insulin signaling. Journal of biochemical and molecular toxicology. 2020-05-08. PMID:32383521. |
in alzheimer's disease (ad), oxidative stress and accumulation of amyloid beta (aβ) induce neuroinflammation, which augments pser-irs-1 and reduces ptyr-irs-1 disturbing insulin signaling pathway. |
2020-05-08 |
2023-08-13 |
Not clear |
| Yunpeng Huang, Zhihui Wan, Zhiqing Wang, Bing Zho. Insulin signaling in Communications biology. vol 2. 2020-05-05. PMID:30652125. |
insulin signaling in alzheimer's disease (ad) and diabetes are clinically positively correlated. |
2020-05-05 |
2023-08-13 |
Not clear |
| Chaitanya Chakravarthi Gali, Elham Fanaee-Danesh, Martina Zandl-Lang, Nicole Maria Albrecher, Carmen Tam-Amersdorfer, Anika Stracke, Vinay Sachdev, Florian Reichmann, Yidan Sun, Afrim Avdili, Marielies Reiter, Dagmar Kratky, Peter Holzer, Achim Lass, Karunya K Kandimalla, Ute Panzenboec. Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice. Molecular and cellular neurosciences. vol 99. 2020-05-05. PMID:31276749. |
aberrant insulin signaling constitutes an early change in alzheimer's disease (ad). |
2020-05-05 |
2023-08-13 |
mouse |
| J Patrick O'Grady, Douglas C Dean, Kao Lee Yang, Cristybelle-Marie Canda, Siobhan M Hoscheidt, Erika J Starks, Andrew Merluzzi, Samuel Hurley, Nancy J Davenport, Ozioma C Okonkwo, Rozalyn M Anderson, Sanjay Asthana, Sterling C Johnson, Andrew L Alexander, Barbara B Bendli. Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle-Aged Adults. Obesity (Silver Spring, Md.). vol 27. issue 9. 2020-04-23. PMID:31314172. |
insulin resistance (ir) and type ii diabetes have been identified as risk factors for alzheimer disease (ad). |
2020-04-23 |
2023-08-13 |
Not clear |
| Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Mario Riverol, Irene Marcilla, Carlos E de Andrea, Juan Antonio Sánchez-Arias, Maria Del Mar Carmona-Abellan, Gloria Marti, Maria-Elena Erro, Eduardo Martínez-Vila, Maria-Teresa Tuñon, Maria-Rosario Luqui. Amylin as a potential link between type 2 diabetes and alzheimer disease. Annals of neurology. vol 86. issue 4. 2020-04-20. PMID:31376172. |
alzheimer disease (ad) is the leading cause of dementia, and although its etiology remains unclear, it seems that type 2 diabetes mellitus (t2dm) and other prediabetic states of insulin resistance could contribute to the appearance of sporadic ad. |
2020-04-20 |
2023-08-13 |
human |
| Rajeev Taliyan, Sarathlal K Chandran, Violina Kakot. Therapeutic Approaches to Alzheimer's Type of Dementia: A Focus on FGF21 Mediated Neuroprotection. Current pharmaceutical design. vol 25. issue 23. 2020-04-16. PMID:31333086. |
with the identification of insulin and insulin receptors in some parts of the brain, it has become evident that certain metabolic conditions associated with insulin dysfunction like type 2 diabetes mellitus (t2dm), dyslipidemia, obesity etc., are also known to contribute to neurodegeneration mainly alzheimer's disease (ad). |
2020-04-16 |
2023-08-13 |
Not clear |