| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vijay Hegde, Nikhil V Dhurandhar, P Hemachandra Redd. Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer's Disease? Journal of Alzheimer's disease : JAD. vol 72. issue s1. 2020-11-30. PMID:31744006. |
type 2 diabetes mellitus (t2d), which is often accompanied by hyperinsulinemia and insulin resistance, is associated with an increased risk for developing mild cognitive impairment and alzheimer's disease (ad); however, the underlying mechanisms for this association are still unclear. |
2020-11-30 |
2023-08-13 |
Not clear |
| Shreyasi Asthana, Bibekanand Mallick, Andrei T Alexandrescu, Suman Jh. IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies. Biochimica et biophysica acta. Biomembranes. vol 1860. issue 9. 2020-11-23. PMID:29518374. |
here we review aspects of the normal physiological function of iapp in glucose regulation together with insulin, and its misfolding which contributes to tiidm, and may also play roles in other pathologies such as alzheimer's and heart disease. |
2020-11-23 |
2023-08-13 |
Not clear |
| Hoda E Mohamed, Mervat E Asker, Nahla N Younis, Mohamed A Shaheen, Rana G Eiss. Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract. Nutritional neuroscience. vol 23. issue 1. 2020-11-23. PMID:29712510. |
modulation of brain insulin signaling in alzheimer's disease: new insight on the protective role of green coffee bean extract. |
2020-11-23 |
2023-08-13 |
Not clear |
| Robert J Pawlosky, Yoshihero Kashiwaya, M Todd King, Richard L Veec. A Dietary Ketone Ester Normalizes Abnormal Behavior in a Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 3. 2020-11-17. PMID:32033248. |
because of a decreased sensitivity toward insulin, a key regulator of pyruvate dehydrogenase (pdh), alzheimer's patients have lower brain glucose utilization with reductions in tricarboxylic acid (tca) cycle metabolites such as citrate, a precursor to n-acetyl-aspartate. |
2020-11-17 |
2023-08-13 |
mouse |
| Elizabeth M Rhea, Surabhi Nirkhe, Steven Nguyen, Sarah Pemberton, Theo K Bammler, Richard Beyer, Michael L Niehoff, John E Morley, Susan A Farr, William A Bank. Molecular Mechanisms of Intranasal Insulin in SAMP8 Mice. Journal of Alzheimer's disease : JAD. vol 71. issue 4. 2020-11-06. PMID:31561374. |
recent work has shown intranasal (inl) delivery of insulin improves memory and cognition in healthy subjects as well as patients with alzheimer's disease (ad) and in ad mouse models. |
2020-11-06 |
2023-08-13 |
mouse |
| Alex J T Yang, Scott Frendo-Cumbo, Rebecca E K MacPherso. Resveratrol and Metformin Recover Prefrontal Cortex AMPK Activation in Diet-Induced Obese Mice but Reduce BDNF and Synaptophysin Protein Content. Journal of Alzheimer's disease : JAD. vol 71. issue 3. 2020-11-05. PMID:31450493. |
obesity, insulin resistance, and type 2 diabetes are established risk factors for the development of alzheimer's disease (ad). |
2020-11-05 |
2023-08-13 |
mouse |
| David Bradle. Clusterin as a Potential Biomarker of Obesity-Related Alzheimer's Disease Risk. Biomarker insights. vol 15. 2020-10-30. PMID:33110346. |
in turn, excess adiposity increases the risk of multiple complications including type 2 diabetes (t2d), insulin resistance, and cardiovascular disease; yet, obesity also independently heightens risk of alzheimer's disease (ad), even after adjusting for other important confounding risk factors including blood pressure, sociodemographics, cholesterol levels, smoking status, and apolipoprotein e (apoe) genotype. |
2020-10-30 |
2023-08-13 |
Not clear |
| Michael Shaughness, Deanna Acs, Fiona Brabazon, Nicole Hockenbury, Kimberly R Byrne. Role of Insulin in Neurotrauma and Neurodegeneration: A Review. Frontiers in neuroscience. vol 14. 2020-10-28. PMID:33100956. |
this review will explore the literature to date on the role of insulin in neurotrauma and neurodegeneration, with a focus on traumatic brain injury (tbi), spinal cord injury (sci), alzheimer's disease (ad) and parkinson's disease (pd). |
2020-10-28 |
2023-08-13 |
Not clear |
| Nicholas Barlow, Philip E Thompso. IRAP Inhibitors: M1-Aminopeptidase Family Inspiration. Frontiers in pharmacology. vol 11. 2020-10-28. PMID:33101040. |
the insulin regulated aminopeptidase (irap) has been proposed as an important therapeutic target for indications including alzheimer's disease and immune disorders. |
2020-10-28 |
2023-08-13 |
Not clear |
| Lei Zhu, Zhen Zhang, Xiao-Jie Hou, Yong-Feng Wang, Jing-Yu Yang, Chun-Fu W. Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat model. Brain research. vol 1722. 2020-10-21. PMID:31344367. |
intracerebroventricular (icv) streptozotocin (stz) injection decreases cerebral insulin signal pathway function and produces multiple effects that resemble the molecular, pathological, and behavioural features of sporadic alzheimer's disease (sad). |
2020-10-21 |
2023-08-13 |
mouse |
| Antonio J López-Gambero, Carlos Sanjuan, Pedro Jesús Serrano-Castro, Juan Suárez, Fernando Rodríguez de Fonsec. The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases. Biomedicines. vol 8. issue 9. 2020-10-20. PMID:32825356. |
epi- and scyllo-inositol isomers are capable of stabilizing non-toxic forms of β-amyloid proteins, which are characteristic of alzheimer's disease and cognitive dementia in down's syndrome, both associated with brain insulin resistance. |
2020-10-20 |
2023-08-13 |
Not clear |
| Yaki Sett. eBrain: a Three Dimensional Simulation Tool to Study Drug Delivery in the Brain. Scientific reports. vol 9. issue 1. 2020-10-13. PMID:30992468. |
we discuss a representative implementation of ebrain that is inspired by clinical data in which insulin is intranasally administered to alzheimer patients. |
2020-10-13 |
2023-08-13 |
Not clear |
| Abuzer Ali, Amena Ali, Wasim Ahmad, Niyaz Ahmad, Sana Khan, Sheikh Md Nuruddin, Ibraheem Husai. Deciphering the Role of WNT Signaling in Metabolic Syndrome-Linked Alzheimer's Disease. Molecular neurobiology. vol 57. issue 1. 2020-10-07. PMID:31325024. |
deregulation of wnt signaling has been affiliated with numerous brain pathologies, including alzheimer's disease and insulin resistance. |
2020-10-07 |
2023-08-13 |
Not clear |
| Shize Li, Nini Wang, Jiyu Lou, Xiaoman Zhan. Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease. Experimental and therapeutic medicine. vol 9. issue 6. 2020-10-01. PMID:26136993. |
the aim of this study was to investigate the expression of β-site app-cleaving enzyme 1 (bace1) in the hippocampal tissue of an insulin-resistant rat model, and thereby explore the roles of bace1 and insulin resistance (ir) in the pathogenesis of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
rat |
| Suzanne M de la Mont. Early intranasal insulin therapy halts progression of neurodegeneration: progress in Alzheimer's disease therapeutics. Aging health. vol 8. issue 1. 2020-10-01. PMID:26855666. |
early intranasal insulin therapy halts progression of neurodegeneration: progress in alzheimer's disease therapeutics. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ming Tong, Cesar Dominguez, John Didsbury, Suzanne M de la Mont. Targeting Alzheimer's Disease Neuro-Metabolic Dysfunction with a Small Molecule Nuclear Receptor Agonist (T3D-959) Reverses Disease Pathologies. Journal of Alzheimer's disease & Parkinsonism. vol 6. issue 3. 2020-10-01. PMID:27525190. |
alzheimer's disease (ad) could be regarded as a brain form of diabetes since insulin resistance and deficiency develop early and progress with severity of neurodegeneration. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maria Niures P S Matioli, Ricardo Nitrin. Mechanisms linking brain insulin resistance to Alzheimer's disease. Dementia & neuropsychologia. vol 9. issue 2. 2020-10-01. PMID:29213950. |
mechanisms linking brain insulin resistance to alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Gregory Oxenkrug, Marieke van der Hart, Julien Roeser, Paul Summergra. Peripheral Tryptophan - Kynurenine Metabolism Associated with Metabolic Syndrome is Different in Parkinson's and Alzheimer's Diseases. Endocrinology, diabetes and metabolism journal. vol 1. issue 4. 2020-10-01. PMID:29292800. |
insulin resistance (ir), obesity and other components of metabolic syndrome [mets] are highly associated with alzheimer's (ad) and parkinson's (pd) diseases. |
2020-10-01 |
2023-08-13 |
Not clear |
| Liying Yang, Hongyan Wang, Lijun Liu, Anmu Xi. The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29515352. |
furthermore, previous studies have demonstrated that insulin treatment reduces amyloid plaques in alzheimer's disease (ad), and normalizes the production and functionality of dopamine and ameliorates motor impairments in 6-ohda-induced rat pd models. |
2020-10-01 |
2023-08-13 |
rat |
| Fabio Sonvico, Adryana Clementino, Francesca Buttini, Gaia Colombo, Silvia Pescina, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Sara Nicol. Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting. Pharmaceutics. vol 10. issue 1. 2020-10-01. PMID:29543755. |
recently, nasal administration of insulin showed promising results in clinical trials for the treatment of alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |