| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Benedict, Claudia A Grill. Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29743868. |
insulin resistance as a therapeutic target in the treatment of alzheimer's disease: a state-of-the-art review. |
2020-10-01 |
2023-08-13 |
Not clear |
| Christian Benedict, Claudia A Grill. Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29743868. |
research in animals and humans has shown that type 2 diabetes and its prodromal state, insulin resistance, promote major pathological hallmarks of alzheimer's disease (ad), such as the formation of amyloid plaques and neurofibrillary tangles (nft). |
2020-10-01 |
2023-08-13 |
Not clear |
| Ian James Martin. Heat Shock Gene Inactivation and Protein Aggregation with Links to Chronic Diseases. Diseases (Basel, Switzerland). vol 6. issue 2. 2020-10-01. PMID:29783682. |
defective circadian rhythm alterations are connected to inactivation of the peripheral sink amyloid beta clearance pathway and related to insulin resistance, protein aggregation, and autoimmune disease in non-alcoholic fatty liver disease (nafld) and various neurodegenerative diseases such as alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ping Sun, Gabriela Ortega, Yan Tan, Qian Hua, Peter F Riederer, Jürgen Deckert, Angelika G Schmitt-Böhre. Streptozotocin Impairs Proliferation and Differentiation of Adult Hippocampal Neural Stem Cells Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29867451. |
streptozotocin impairs proliferation and differentiation of adult hippocampal neural stem cells rats intracerebroventricularily (icv) treated with streptozotocin (stz), shown to generate an insulin resistant brain state, were used as an animal model for the sporadic form of alzheimer's disease (sad). |
2020-10-01 |
2023-08-13 |
rat |
| Lan Cao, Zigao Wang, Wenbin Wa. Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer's Disease. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29973864. |
suppressor of cytokine signaling 3: emerging role linking central insulin resistance and alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Parisa Iloun, Zahra Abbasnejad, Mahyar Janahmadi, Abolhassan Ahmadiani, Rasoul Ghasem. Investigating the role of P38, JNK and ERK in LPS induced hippocampal insulin resistance and spatial memory impairment: effects of insulin treatment. EXCLI journal. vol 17. 2020-10-01. PMID:30233281. |
despite the consensus that neuro-inflammation and insulin resistance (ir) are two hallmarks of alzheimer disease (ad), the molecular mechanisms responsible for the development of ir remain uncharacterized. |
2020-10-01 |
2023-08-13 |
rat |
| Yanhui Lu, Xinjun Jiang, Shuling Liu, Mingzi L. Changes in Cerebrospinal Fluid Tau and β-Amyloid Levels in Diabetic and Prediabetic Patients: A Meta-Analysis. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30364261. |
increased risks for alzheimer's disease (ad) are a well-recognized consequence of diabetes, insulin resistance (ir), and hyperinsulinemia. |
2020-10-01 |
2023-08-13 |
human |
| Young-Kook Kim, Juhyun Son. The Role of Long Noncoding RNAs in Diabetic Alzheimer's Disease. Journal of clinical medicine. vol 7. issue 11. 2020-10-01. PMID:30469430. |
among the various neurodegenerative diseases, diabetic alzheimer's disease (ad) has been recently emerging as an important issue due to several unexpected reports suggesting that metabolic issues in the brain, such as insulin resistance and glucose dysregulation, could be important risk factors for ad. |
2020-10-01 |
2023-08-13 |
Not clear |
| Abdalla M Albeely, Scott D Ryan, Melissa L Perreaul. Pathogenic Feed-Forward Mechanisms in Alzheimer's and Parkinson's Disease Converge on GSK-3. Brain plasticity (Amsterdam, Netherlands). vol 4. issue 2. 2020-10-01. PMID:30598867. |
alzheimer's disease (ad) and parkinson's disease (pd) share many commonalities ranging from signaling deficits such as altered cholinergic activity, neurotrophin and insulin signaling to cell stress cascades that result in proteinopathy, mitochondrial dysfunction and neuronal cell death. |
2020-10-01 |
2023-08-13 |
Not clear |
| D Reich, G Gallucci, M Tong, S M de la Mont. Therapeutic Advantages of Dual Targeting of PPAR-δ and PPAR-γ in an Experimental Model of Sporadic Alzheimer's Disease. Journal of Parkinson's disease and Alzheimer's disease. vol 5. issue 1. 2020-10-01. PMID:30705969. |
alzheimer's disease (ad) is associated with progressive impairments in brain responsiveness to insulin and insulin-like growth factor (igf). |
2020-10-01 |
2023-08-13 |
Not clear |
| Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E Fraser, Fernanda G De Felic. The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30804755. |
the link between tau and insulin signaling: implications for alzheimer's disease and other tauopathies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E Fraser, Fernanda G De Felic. The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30804755. |
we further highlight the deleterious consequences of tau pathology-induced insulin resistance to the brain and/or peripheral tissues, suggesting that these are key events mediating cognitive decline in alzheimer's disease (ad) and other tauopathies. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tushar Kanti Das, Swarup Kumar Chakrabarti, Ihsan Nazurah Zulkipli, Mas R W Abdul Hami. Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer's Disease in Rats. Journal of Alzheimer's disease reports. vol 3. issue 1. 2020-10-01. PMID:31025030. |
curcumin ameliorates the impaired insulin signaling involved in the pathogenesis of alzheimer's disease in rats. |
2020-10-01 |
2023-08-13 |
rat |
| Tushar Kanti Das, Swarup Kumar Chakrabarti, Ihsan Nazurah Zulkipli, Mas R W Abdul Hami. Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer's Disease in Rats. Journal of Alzheimer's disease reports. vol 3. issue 1. 2020-10-01. PMID:31025030. |
to date, dysregulation of the insulin signaling pathway in the brain has not been demonstrated unequivocally in alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
rat |
| Elena Sanguinetti, Maria Angela Guzzardi, Daniele Panetta, Maria Tripodi, Vincenzo De Sena, Mauro Quaglierini, Silvia Burchielli, Piero A Salvadori, Patricia Iozz. Combined Effect of Fatty Diet and Cognitive Decline on Brain Metabolism, Food Intake, Body Weight, and Counteraction by Intranasal Insulin Therapy in 3×Tg Mice. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31130848. |
we used control (c) and triple transgenic mice (3×tg, a model of alzheimer's pathology) to measure cerebral mass, glucose metabolism, and the metabolic response to acute ini administration (cerebral insulin sensitivity). |
2020-10-01 |
2023-08-13 |
mouse |
| Yoshiki Takamatsu, Gilbert Ho, Wakako Koike, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Jianshe Wei, Kazunari Sekiyama, Makoto Hashimot. Combined immunotherapy with "anti-insulin resistance" therapy as a novel therapeutic strategy against neurodegenerative diseases. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:28649604. |
meanwhile, type ii diabetes mellitus has been associated with an increased risk of neurodegenerative disease, such as alzheimer's disease and parkinson's disease, and studies have shown that metabolic dysfunction and abnormalities surrounding insulin signaling may underlie disease progression. |
2020-09-30 |
2023-08-13 |
Not clear |
| Shama Parween, Divya S Varghese, Mustafa T Ardah, Ashok D Prabakaran, Eric Mensah-Brown, Bright Starling Emerald, Suraiya A Ansar. Higher O-GlcNAc Levels Are Associated with Defects in Progenitor Proliferation and Premature Neuronal Differentiation during Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29311838. |
hyperglycemia mediated increase in protein o-glcnacylation has been shown to be responsible for various pathologies including insulin resistance and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
human |
| Sebastiaan Dalle, Lenka Rossmeislova, Katrien Kopp. The Role of Inflammation in Age-Related Sarcopenia. Frontiers in physiology. vol 8. 2020-09-30. PMID:29311975. |
this condition has already been shown to be interrelated with several (sub)clinical conditions, such as insulin resistance, atherosclerosis and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Paul Denver, Paula L McClea. Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition. Neural regeneration research. vol 13. issue 10. 2020-09-30. PMID:30136683. |
distinguishing normal brain aging from the development of alzheimer's disease: inflammation, insulin signaling and cognition. |
2020-09-30 |
2023-08-13 |
Not clear |
| Christian Hölsche. Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31068799. |
insulin signaling impairment in the brain as a risk factor in alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |