| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji Yeon Chung, Hyung-Seok Kim, Juhyun Son. Iron metabolism in diabetes-induced Alzheimer's disease: a focus on insulin resistance in the brain. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 31. issue 5. 2019-08-19. PMID:30043289. |
iron metabolism in diabetes-induced alzheimer's disease: a focus on insulin resistance in the brain. |
2019-08-19 |
2023-08-13 |
Not clear |
| Wenchang Chang, Dawei Huang, Y Martin Lo, Qinqiao Tee, Poling Kuo, James Swibea Wu, Wenchung Huang, Szuchuan She. Protective Effect of Caffeic Acid against Alzheimer's Disease Pathogenesis via Modulating Cerebral Insulin Signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats. Journal of agricultural and food chemistry. vol 67. issue 27. 2019-08-12. PMID:31203623. |
protective effect of caffeic acid against alzheimer's disease pathogenesis via modulating cerebral insulin signaling, β-amyloid accumulation, and synaptic plasticity in hyperinsulinemic rats. |
2019-08-12 |
2023-08-13 |
rat |
| Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsub. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease. Molecular neurodegeneration. vol 14. issue 1. 2019-08-07. PMID:30975165. |
differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of alzheimer's disease. |
2019-08-07 |
2023-08-13 |
mouse |
| Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsub. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease. Molecular neurodegeneration. vol 14. issue 1. 2019-08-07. PMID:30975165. |
based on epidemiological and experimental studies, type 2 diabetes mellitus (t2dm), especially insulin resistance that comprises the core mechanism of t2dm, has been recognized as a significant risk factor for alzheimer's disease (ad). |
2019-08-07 |
2023-08-13 |
mouse |
| Yusaku Nakabepp. Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer's Disease Brain. Advances in experimental medicine and biology. vol 1128. 2019-08-07. PMID:31062324. |
molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in alzheimer's disease brain. |
2019-08-07 |
2023-08-13 |
Not clear |
| Yusaku Nakabepp. Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer's Disease Brain. Advances in experimental medicine and biology. vol 1128. 2019-08-07. PMID:31062324. |
accumulating clinical data indicates that insulin resistance and diabetes mellitus (dm) are major risk factors for alzheimer's disease (ad); however, the exact mechanisms on how insulin resistance and dm act as risk factors for ad remain unclear. |
2019-08-07 |
2023-08-13 |
Not clear |
| Cristina Carvalho, Susana M Cardoso, Sónia C Correia, Paula I Moreir. Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1128. 2019-08-07. PMID:31062330. |
tortuous paths of insulin signaling and mitochondria in alzheimer's disease. |
2019-08-07 |
2023-08-13 |
Not clear |
| Hanyu Liang, Jia Nie, Candice E Van Skike, Joseph M Valentine, Miranda E Or. Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes. Advances in experimental medicine and biology. vol 1128. 2019-08-07. PMID:31062331. |
type 2 diabetes mellitus is especially notable as the disease shares many overlapping pathologies observed in patients with alzheimer's disease, including hyperglycemia, hyperinsulinemia, insulin resistance, glucose intolerance, dyslipidemia, inflammation, and cognitive dysfunction, as described in chap. |
2019-08-07 |
2023-08-13 |
Not clear |
| Eugenio Barone, Antonella Tramutola, Francesca Triani, Silvio Calcagnini, Fabio Di Domenico, Cristian Ripoli, Silvana Gaetani, Claudio Grassi, D Allan Butterfield, Tommaso Cassano, Marzia Perluig. Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30073505. |
biliverdin reductase-a mediates the beneficial effects of intranasal insulin in alzheimer disease. |
2019-08-06 |
2023-08-13 |
mouse |
| Yaqiong Dong, Tessandra Stewart, Yue Zhang, Min Shi, Chang Tan, Xue Li, Lan Yuan, Aanchal Mehrotra, Jing Zhang, Xiaoda Yan. Anti-diabetic vanadyl complexes reduced Alzheimer's disease pathology independent of amyloid plaque deposition. Science China. Life sciences. vol 62. issue 1. 2019-07-29. PMID:30136058. |
association of alzheimer's disease (ad) with cerebral glucose hypometabolism, likely due to impairments of insulin signaling, has been reported recently, with encouraging results when additional insulin is provided to ad patients. |
2019-07-29 |
2023-08-13 |
mouse |
| Heather Woo. Alzheimer disease: Is p-tau the missing link between insulin resistance and AD? Nature reviews. Neurology. vol 13. issue 12. 2019-07-25. PMID:29104290. |
alzheimer disease: is p-tau the missing link between insulin resistance and ad? |
2019-07-25 |
2023-08-13 |
Not clear |
| Maud Gratuze, Jacinthe Julien, Franck R Petry, Françoise Morin, Emmanuel Plane. Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology. Scientific reports. vol 7. 2019-07-17. PMID:28402338. |
insulin deprivation induces pp2a inhibition and tau hyperphosphorylation in htau mice, a model of alzheimer's disease-like tau pathology. |
2019-07-17 |
2023-08-13 |
mouse |
| Sami Gabbouj, Teemu Natunen, Hennariikka Koivisto, Kimmo Jokivarsi, Mari Takalo, Mikael Marttinen, Rebekka Wittrahm, Susanna Kemppainen, Reyhaneh Naderi, Adrián Posado-Fernández, Simo Ryhänen, Petra Mäkinen, Kaisa M A Paldanius, Gonçalo Doria, Pekka Poutiainen, Orfeu Flores, Annakaisa Haapasalo, Heikki Tanila, Mikko Hiltune. Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice. Neurobiology of aging. vol 75. 2019-07-11. PMID:30554086. |
intranasal insulin activates akt2 signaling pathway in the hippocampus of wild-type but not in app/ps1 alzheimer model mice. |
2019-07-11 |
2023-08-13 |
mouse |
| Pegah Javadpour, Leila Dargahi, Abolhassan Ahmadiani, Rasoul Ghasem. To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling. Cellular and molecular life sciences : CMLS. vol 76. issue 12. 2019-06-24. PMID:30874837. |
thereafter, we discussed the latest findings about pp2a dysregulation in alzheimer and parkinson diseases and possible interplay between this phosphatase and insulin signaling pathways. |
2019-06-24 |
2023-08-13 |
Not clear |
| Jung Hyun Lee, Jordan B Jahrling, Larry Denner, Kelly T Dinele. Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29710715. |
targeting insulin for alzheimer's disease: mechanisms, status and potential directions. |
2019-06-11 |
2023-08-13 |
human |
| Jung Hyun Lee, Jordan B Jahrling, Larry Denner, Kelly T Dinele. Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29710715. |
in the brain, insulin manages glucose metabolism in regions such as the hippocampus and plays a key role in directly regulating erk, a kinase required for the type of memory compromised in early alzheimer's disease (ad). |
2019-06-11 |
2023-08-13 |
human |
| Valentina Sposato, Nadia Canu, Elena Fico, Salvatore Fusco, Giulia Bolasco, Maria Teresa Ciotti, Matteo Spinelli, Delio Mercanti, Claudio Grassi, Viviana Triaca, Pietro Calissan. The Medial Septum Is Insulin Resistant in the AD Presymptomatic Phase: Rescue by Nerve Growth Factor-Driven IRS Molecular neurobiology. vol 56. issue 1. 2019-06-11. PMID:29736736. |
impaired neuronal metabolism and reduced insulin signaling, known as insulin resistance, has been reported in the early phase of alzheimer's disease (ad), which has been suggested to be "type 3 diabetes." |
2019-06-11 |
2023-08-13 |
mouse |
| Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Andrew Wang, Mara Farcasanu, Virgil A Woods, Lauren A McCord, David Lee, Weifeng Shang, Rebecca Deprez-Poulain, Benoit Deprez, David R Liu, Akiko Koide, Shohei Koide, Anthony A Kossiakoff, Sheng Li, Bridget Carragher, Clinton S Potter, Wei-Jen Tan. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. eLife. vol 7. 2019-06-03. PMID:29596046. |
insulin degrading enzyme (ide) plays key roles in degrading peptides vital in type two diabetes, alzheimer's, inflammation, and other human diseases. |
2019-06-03 |
2023-08-13 |
human |
| Ari Robinson, Irit Lubitz, Dana Atrakchi-Baranes, Avital Licht-Murava, Pavel Katsel, Derek Leroith, Sigal Liraz-Zaltsman, Vahram Haroutunian, Michal Schnaider Beer. Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 67. issue 4. 2019-05-29. PMID:30635783. |
combination of insulin with a glp1 agonist is associated with better memory and normal expression of insulin receptor pathway genes in a mouse model of alzheimer's disease. |
2019-05-29 |
2023-08-13 |
mouse |
| Ari Robinson, Irit Lubitz, Dana Atrakchi-Baranes, Avital Licht-Murava, Pavel Katsel, Derek Leroith, Sigal Liraz-Zaltsman, Vahram Haroutunian, Michal Schnaider Beer. Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 67. issue 4. 2019-05-29. PMID:30635783. |
disruption of brain insulin signaling may explain the higher alzheimer's disease (ad) risk among type 2 diabetic (t2d) patients. |
2019-05-29 |
2023-08-13 |
mouse |