| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Priyadarshi Prajjwal, Shahnaz Asharaf, Dhruvi Makhanasa, Aishwarya Yamparala, Halla Tariq, Soumya Aleti, Srikanth Gadam, Neel Vor. Association of Alzheimer's dementia with oral bacteria, vitamin B12, folate, homocysteine levels, and insulin resistance along with its pathophysiology, genetics, imaging, and biomarkers. Disease-a-month : DM. 2023-03-17. PMID:36931946. |
there could be derangement in the insulin signaling further causing disruption in glucose metabolism within the brain, suggesting that alzheimer's disease may represent a form of type 2 diabetes mellitus associated with the brain, commonly known as type 3 diabetes. |
2023-03-17 |
2023-08-14 |
Not clear |
| Licong Yang, Yabin Wang, Zhiwei Li, Xiaohua Wu, Jingtao Mei, Guodong Zhen. Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease. Carbohydrate polymers. vol 310. 2023-03-16. PMID:36925241. |
brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: impact on insulin resistance and gut microbiota in obesity-related alzheimer's disease. |
2023-03-16 |
2023-08-14 |
mouse |
| Licong Yang, Yabin Wang, Zhiwei Li, Xiaohua Wu, Jingtao Mei, Guodong Zhen. Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease. Carbohydrate polymers. vol 310. 2023-03-16. PMID:36925241. |
the pathology of alzheimer's disease (ad) is highly correlated with obesity-induced insulin resistance. |
2023-03-16 |
2023-08-14 |
mouse |
| Zheng Shen, Zheng-Yang Li, Meng-Ting Yu, Kai-Leng Tan, Si Che. Metabolic perspective of astrocyte dysfunction in Alzheimer's disease and type 2 diabetes brains. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2023-03-14. PMID:36916433. |
the term type iii diabetes (t3dm) has been proposed for alzheimer's disease (ad) due to the shared molecular and cellular features between type 2 diabetes (t2dm) and insulin resistance-associated memory deficits and cognitive decline in elderly individuals. |
2023-03-14 |
2023-08-14 |
Not clear |
| Amaia Ezkurdia, María J Ramírez, Maite Sola. Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: A Focus on Insulin Resistance. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901787. |
metabolic syndrome as a risk factor for alzheimer's disease: a focus on insulin resistance. |
2023-03-11 |
2023-08-14 |
Not clear |
| M Omidi-Shahsavandi, P Yaghmaei, S Ahmadian, A Ebrahim-Habib. Effect of silibinin and trans-chalcone in an Alzheimer's disease-like model generated by insulin amyloids. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 56. 2023-03-01. PMID:36856252. |
effect of silibinin and trans-chalcone in an alzheimer's disease-like model generated by insulin amyloids. |
2023-03-01 |
2023-08-14 |
rat |
| Cristina Carvalho, Paula I Moreir. Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria. Current opinion in neurobiology. vol 79. 2023-02-26. PMID:36842275. |
type 2 diabetes (t2d) and alzheimer's disease (ad) are two global epidemics that share several metabolic defects, such as insulin resistance, impaired glucose metabolism, and mitochondrial defects. |
2023-02-26 |
2023-08-14 |
Not clear |
| Oksana Fihurka, Yanhong Wang, Yuzhu Hong, Xiaoyang Lin, Ning Shen, Haiqiang Yang, Breanna Brown, Marcus Mommer, Tarek Zieneldien, Yitong Li, Janice Kim, Minghua Li, Jianfeng Cai, Qingyu Zhou, Chuanhai Ca. Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830601. |
melatonin, insulin, and Δ9-tetrahydrocannabinol (thc) have been shown to reverse cognitive deficits and attenuate neuropathologies in transgenic mouse models of alzheimer's disease (ad) when used individually. |
2023-02-25 |
2023-08-14 |
mouse |
| Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolise. Imaging Methods Applicable in the Diagnostics of Alzheimer's Disease, Considering the Involvement of Insulin Resistance. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834741. |
imaging methods applicable in the diagnostics of alzheimer's disease, considering the involvement of insulin resistance. |
2023-02-25 |
2023-08-14 |
Not clear |
| Ji Hye Yoon, JooHyun Hwang, Sung Un Son, Junhyuk Choi, Seung-Won You, Hyunwoo Park, Seung-Yun Cha, Sungho Maen. How Can Insulin Resistance Cause Alzheimer's Disease? International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834911. |
how can insulin resistance cause alzheimer's disease? |
2023-02-25 |
2023-08-14 |
Not clear |
| Oxana V Galzitskaya, Sergei Y Grishin, Anna V Glyakina, Nikita V Dovidchenko, Anastasiia V Konstantinova, Sergey V Kravchenko, Alexey K Suri. The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835194. |
some of these proteins are known to cause a number of degenerative diseases in humans, such as amyloid-beta (aβ) in alzheimer's disease (ad), α-synuclein in parkinson's disease (pd), and insulin and its analogues in insulin-derived amyloidosis. |
2023-02-25 |
2023-08-14 |
Not clear |
| Azam Abedi, Tahereh Foroutan, Leila Mohaghegh Shalmani, Leila Dargah. Sex-specific effects of high-fat diet on rat brain glucose metabolism and early-onset dementia symptoms. Mechanisms of ageing and development. 2023-02-24. PMID:36828273. |
also, the expression of brain insulin resistance markers and alzheimer's pathology-related genes was assessed by qpcr. |
2023-02-24 |
2023-08-14 |
rat |
| Russell H Swerdlo. The Alzheimer's Disease Mitochondrial Cascade Hypothesis: A Current Overview. Journal of Alzheimer's disease : JAD. 2023-02-22. PMID:36806512. |
viable alzheimer's disease (ad) hypotheses must account for its age-dependence; commonality; association with amyloid precursor protein, tau, and apolipoprotein e biology; connection with vascular, inflammation, and insulin signaling changes; and systemic features. |
2023-02-22 |
2023-08-14 |
Not clear |
| Bo Pang, Lu-Lu Zhang, Bin Li, Feng-Xian Sun, Zhi-Da Wan. The sodium glucose co-transporter 2 inhibitor ertugliflozin for Alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. Physiology & behavior. 2023-02-22. PMID:36809844. |
the sodium glucose co-transporter 2 inhibitor ertugliflozin for alzheimer's disease: inhibition of brain insulin signaling disruption-induced tau hyperphosphorylation. |
2023-02-22 |
2023-08-14 |
rat |
| Sini Toppala, Laura L Ekblad, Matti Viitanen, Juha O Rinne, Antti Jul. Impaired Early Insulin Response to Glucose Load Predicts Episodic Memory Decline: A 10-Year Population-Based Cohort Follow-Up of 45-74-Year-Old Men and Women. Journal of Alzheimer's disease : JAD. 2023-02-06. PMID:36744339. |
impaired early insulin secretion in elderly men and insulin resistance, both of which are pathophysiological features of type 2 diabetes, have previously been linked to alzheimer's disease. |
2023-02-06 |
2023-08-14 |
Not clear |
| Estefania Fuentes, Berenice Venegas, Guadalupe Muñoz-Arenas, Carolina Moran, Rubén A Vazquez-Roque, Gonzalo Flores, Samuel Treviño, Alfonso Diaz, Jorge Guevar. HIGH-CARBOHYDRATE AND FAT DIET CONSUMPTION CAUSES METABOLIC DETERIORATION, NEURONAL DAMAGE, AND LOSS OF RECOGNITION MEMORY IN RATS. Journal of chemical neuroanatomy. 2023-02-03. PMID:36736441. |
in recent years, it has been reported that alterations in insulin at the brain level could have an impact on the appearance of neurodegenerative diseases such as alzheimer's disease, parkinson's disease, dementia, depression, and other types of disorders that compromise brain function. |
2023-02-03 |
2023-08-14 |
rat |
| Aashutosh U Shetti, Abhirami Ramakrishnan, Liudmila Romanova, Wenping Li, Khanh Vo, Ipsita Volety, Ishara Ratnayake, Terilyn Stephen, Richard D Minshall, Stephanie M Cologna, Orly Lazaro. Reduced endothelial caveolin-1 underlies deficits in brain insulin signalling in type 2 diabetes. Brain : a journal of neurology. 2023-02-02. PMID:36731883. |
patients with type 2 diabetes exhibit severe impairments in insulin signaling in the brain and are 5-times more likely to develop alzheimer's disease. |
2023-02-02 |
2023-08-14 |
mouse |
| N Villalobos, E Ramírez-Sánchez, A Mondragón-García, J Garduño, D Castillo-Rolón, S Trujeque-Ramos, S Hernández-Lópe. Insulin decreases epileptiform activity in rat layer 5/6 prefrontal cortex in vitro. Synapse (New York, N.Y.). 2023-02-02. PMID:36732015. |
alterations to insulin signaling are associated with the development of neurological disorders including alzheimer's disease and parkinson's disease. |
2023-02-02 |
2023-08-14 |
rat |
| Eloi Gagnon, Patricia L Mitchell, Hasanga D Manikpurage, Erik Abner, Nele Taba, Tõnu Esko, Nooshin Ghodsian, Sébastien Thériault, Patrick Mathieu, Benoit J Arsenaul. Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study. Journal of translational medicine. vol 21. issue 1. 2023-01-31. PMID:36717893. |
we included as outcomes nine cardiometabolic traits (fasting glucose, fasting insulin, systolic blood pressure, diastolic blood pressure, hdl cholesterol, ldl cholesterol, triglycerides, estimated glomerular filtration rate, body mass index [bmi]), eight chronic diseases previously linked with the gut microbiota in observational studies (alzheimer's disease, depression, type 2 diabetes, non-alcoholic fatty liver disease, coronary artery disease (cad), stroke, osteoporosis and chronic kidney disease), as well as parental lifespan and longevity. |
2023-01-31 |
2023-08-14 |
human |
| Muhammad Afzal, Khalid Saad Alharbi, Sami I Alzarea, Najiah M Alyamani, Imran Kazmi, Emine Güve. Revealing genetic links of Type 2 diabetes that lead to the development of Alzheimer's disease. Heliyon. vol 9. issue 1. 2023-01-30. PMID:36711310. |
a factor leading to alzheimer's disease (ad), portrayed by peripheral insulin resistance, is type 2 diabetes mellitus (t2d). |
2023-01-30 |
2023-08-14 |
Not clear |