| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramesh Kandimalla, Vani Thirumala, P Hemachandra Redd. Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 5. 2018-11-26. PMID:27567931. |
recently researchers proposed the term 'type-3-diabetes' for alzheimer's disease (ad) because of the shared molecular and cellular features among type-1-diabetes, type-2-diabetes and insulin resistance associated with memory deficits and cognitive decline in elderly individuals. |
2018-11-26 |
2023-08-13 |
Not clear |
| Zhangyu Guo, Yanxing Chen, Yan-Fang Mao, Tingting Zheng, Yasi Jiang, Yaping Yan, Xinzhen Yin, Baorong Zhan. Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model. Scientific reports. vol 7. 2018-11-16. PMID:28382978. |
long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced alzheimer's rat model. |
2018-11-16 |
2023-08-13 |
human |
| Zhangyu Guo, Yanxing Chen, Yan-Fang Mao, Tingting Zheng, Yasi Jiang, Yaping Yan, Xinzhen Yin, Baorong Zhan. Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model. Scientific reports. vol 7. 2018-11-16. PMID:28382978. |
recent evidence reveals that aberrant brain insulin signaling plays an important role in the pathology of alzheimer's disease (ad). |
2018-11-16 |
2023-08-13 |
human |
| Cesar L Moreno, Lucio Della Guardia, Valeria Shnyder, Maitane Ortiz-Virumbrales, Ilya Kruglikov, Bin Zhang, Eric E Schadt, Rudolph E Tanzi, Scott Noggle, Christoph Buettner, Sam Gand. iPSC-derived familial Alzheimer's PSEN2 Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29945658. |
one link between t2d and ci might involve decreased insulin signaling in brain and/or neurons in either animal or postmortem human brains as has been reported as a feature of alzheimer's disease (ad). |
2018-11-09 |
2023-08-13 |
human |
| Bae Kun Shin, Suna Kang, Da Sol Kim, Sunmin Par. Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer's disease-induced estrogen deficient rats. Experimental biology and medicine (Maywood, N.J.). vol 243. issue 4. 2018-11-06. PMID:29307281. |
alzheimer's disease and intermittent fasting deteriorated insulin resistance in the fasting state but intermittent fasting decreased serum glucose levels after oral glucose challenge by increasing insulin secretion. |
2018-11-06 |
2023-08-13 |
rat |
| Bae Kun Shin, Suna Kang, Da Sol Kim, Sunmin Par. Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer's disease-induced estrogen deficient rats. Experimental biology and medicine (Maywood, N.J.). vol 243. issue 4. 2018-11-06. PMID:29307281. |
intermittent fasting protected against the deterioration of these metabolic parameters, but it exacerbated bone mineral density loss and insulin resistance at fasting in alzheimer's disease-induced estrogen-deficient rats. |
2018-11-06 |
2023-08-13 |
rat |
| Antonella Caccamo, Ramona Belfiore, Salvatore Odd. Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 68. 2018-10-16. PMID:29729422. |
genetically reducing mtor signaling rescues central insulin dysregulation in a mouse model of alzheimer's disease. |
2018-10-16 |
2023-08-13 |
mouse |
| Konstantinos Ioannis Avgerinos, Grigorios Kalaitzidis, Antonia Malli, Dimitrios Kalaitzoglou, Pavlos Gr Myserlis, Vasileios-Arsenios Liouta. Intranasal insulin in Alzheimer's dementia or mild cognitive impairment: a systematic review. Journal of neurology. vol 265. issue 7. 2018-10-04. PMID:29392460. |
intranasal insulin in alzheimer's dementia or mild cognitive impairment: a systematic review. |
2018-10-04 |
2023-08-13 |
Not clear |
| Konstantinos Ioannis Avgerinos, Grigorios Kalaitzidis, Antonia Malli, Dimitrios Kalaitzoglou, Pavlos Gr Myserlis, Vasileios-Arsenios Liouta. Intranasal insulin in Alzheimer's dementia or mild cognitive impairment: a systematic review. Journal of neurology. vol 265. issue 7. 2018-10-04. PMID:29392460. |
due to common pathophysiological findings of alzheimer's disease (ad) with diabetes mellitus (dm), insulin has been suggested as a possible treatment of ad or mild cognitive impairment (mci). |
2018-10-04 |
2023-08-13 |
Not clear |
| Yi Zhang, Peichang Wan. Age-Related Increase of Insulin-Degrading Enzyme Is Inversely Correlated with Cognitive Function in APPswe/PS1dE9 Mice. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-28. PMID:29680859. |
although it is indispensable in removing plaques related to onset alzheimer's disease (ad) and in degrading insulin related to diabetes, there have been few studies on the dynamic level of ide in different stages of ad. |
2018-09-28 |
2023-08-13 |
mouse |
| Manuela Bomba, Alberto Granzotto, Vanessa Castelli, Noemi Massetti, Elena Silvestri, Lorella M T Canzoniero, Annamaria Cimini, Stefano L Sens. Exenatide exerts cognitive effects by modulating the BDNF-TrkB neurotrophic axis in adult mice. Neurobiology of aging. vol 64. 2018-09-27. PMID:29331730. |
altered brain insulin signaling participates in the cognitive decline seen in alzheimer's disease patients and the aging brain. |
2018-09-27 |
2023-08-13 |
mouse |
| E V Surkov. [Diabetes mellitus and the central nervous system]. Terapevticheskii arkhiv. vol 88. issue 10. 2018-08-22. PMID:28635855. |
the current views on the function of insulin in the cns and the relationship of central insulin resistance to alzheimer's disease are outlined. |
2018-08-22 |
2023-08-13 |
Not clear |
| Huajie Li, Jian Wu, Linfeng Zhu, Luolin Sha, Song Yang, Jiang Wei, Lei Ji, Xiaochun Tang, Keshi Mao, Liping Cao, Ning Wei, Wei Xie, Zhilong Yan. Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD. Bioscience reports. vol 38. issue 1. 2018-08-16. PMID:29222348. |
insulin degrading enzyme contributes to the pathology in a mixed model of type 2 diabetes and alzheimer's disease: possible mechanisms of ide in t2d and ad. |
2018-08-16 |
2023-08-13 |
mouse |
| Huajie Li, Jian Wu, Linfeng Zhu, Luolin Sha, Song Yang, Jiang Wei, Lei Ji, Xiaochun Tang, Keshi Mao, Liping Cao, Ning Wei, Wei Xie, Zhilong Yan. Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD. Bioscience reports. vol 38. issue 1. 2018-08-16. PMID:29222348. |
insulin degrading enzyme (ide) is believed to act as a junction point of type 2 diabetes (t2d) and alzheimer's disease (ad); however, the underlying mechanism was not completely clear yet. |
2018-08-16 |
2023-08-13 |
mouse |
| Stefan L C Geijselaers, Pauline Aalten, Inez H G B Ramakers, Peter Paul De Deyn, Annemieke C Heijboer, Huiberdina L Koek, Marcel G M OldeRikkert, Janne M Papma, Fransje E Reesink, Lieke L Smits, Coen D A Stehouwer, Charlotte E Teunissen, Frans R J Verhey, Wiesje M van der Flier, Geert Jan Biessel. Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29154275. |
association of cerebrospinal fluid (csf) insulin with cognitive performance and csf biomarkers of alzheimer's disease. |
2018-07-13 |
2023-08-13 |
Not clear |
| Stefan L C Geijselaers, Pauline Aalten, Inez H G B Ramakers, Peter Paul De Deyn, Annemieke C Heijboer, Huiberdina L Koek, Marcel G M OldeRikkert, Janne M Papma, Fransje E Reesink, Lieke L Smits, Coen D A Stehouwer, Charlotte E Teunissen, Frans R J Verhey, Wiesje M van der Flier, Geert Jan Biessel. Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29154275. |
abnormal insulin signaling in the brain has been linked to alzheimer's disease (ad). |
2018-07-13 |
2023-08-13 |
Not clear |
| N Rajasekar, Chandishwar Nath, Kashif Hanif, Rakesh Shukl. Intranasal Insulin Administration Ameliorates Streptozotocin (ICV)-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Memory Impairment in Rats. Molecular neurobiology. vol 54. issue 8. 2018-07-09. PMID:27730514. |
alzheimer's disease (ad) is associated with reduced insulin level and impairment of insulin receptor (ir) signaling in the brain, which correlates to amyloid pathology, neuroinflammation, and synaptic neurotoxicity. |
2018-07-09 |
2023-08-13 |
rat |
| E Candeias, A I Duarte, I Sebastião, M A Fernandes, A I Plácido, C Carvalho, S Correia, R X Santos, R Seiça, M S Santos, C R Oliveira, P I Moreir. Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology. Molecular neurobiology. vol 54. issue 8. 2018-07-09. PMID:27730513. |
among the several features shared between t2d and some neurodegenerative disorders (e.g., alzheimer disease (ad)), the impairment of insulin signaling may be a key link. |
2018-07-09 |
2023-08-13 |
rat |
| Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qi. Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29138799. |
studies have indicated that type ii diabetes mellitus (t2dm) and alzheimer's disease (ad) share common biological mechanisms including insulin resistance, impaired glucose metabolism, β‑amyloid (aβ) formation, oxidative stress and presence of advanced glycation end products (ages). |
2018-07-09 |
2023-08-13 |
rat |
| Ângela G Batista, Edilene S Soares, Monique C P Mendonça, Juliana K da Silva, Ana Paula Dionísio, Cesar R Sartori, Maria Alice da Cruz-Höfling, Mário R Maróstica Júnio. Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. Molecular nutrition & food research. vol 61. issue 10. 2018-07-02. PMID:28544198. |
the hyperphosphorylation of microtubule-associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance and these alterations are related to the development of tauopathies, such as alzheimer's disease. |
2018-07-02 |
2023-08-13 |
mouse |