| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Li, Chao Quan, Rachel Toth, David G Campbell, Carol MacKintosh, Hong Yu Wang, Shuai Che. Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders. The Journal of biological chemistry. vol 290. issue 50. 2016-05-10. PMID:26499801. |
our findings reveal novel mechanisms linking peripheral insulin sensitivity with cytoskeletal remodeling in neurons, which may help to explain the association of diabetes with neurological disorders such as alzheimer disease. |
2016-05-10 |
2023-08-13 |
mouse |
| A Popa-Wagner, Ana-Maria Buga, B Popescu, D Muresan. Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle. Journal of neural transmission (Vienna, Austria : 1996). vol 122 Suppl 1. 2016-04-29. PMID:24337666. |
alzheimer, aging and diabetes are also influenced by insulin/insulin-like growth factor-1 signaling, and accumulated evidence indicates sporadic ad is associated with disturbed brain insulin metabolism. |
2016-04-29 |
2023-08-12 |
Not clear |
| Katherine J Fishwick, R Jane Rylet. Insulin Regulates the Activity of the High-Affinity Choline Transporter CHT. PloS one. vol 10. issue 7. 2016-04-19. PMID:26161852. |
studies in humans and animal models show that neuronal insulin resistance increases the risk of developing alzheimer's disease (ad), and that insulin treatment may promote memory function. |
2016-04-19 |
2023-08-13 |
Not clear |
| Shaniya Maimaiti, Katie L Anderson, Chris DeMoll, Lawrence D Brewer, Benjamin A Rauh, John C Gant, Eric M Blalock, Nada M Porter, Olivier Thibaul. Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 71. issue 1. 2016-04-14. PMID:25659889. |
recent studies suggest that insulin resistance may be a factor in brain aging and alzheimer's disease (ad) whereby intranasal insulin therapy, which delivers insulin to the brain, improves cognition and memory in ad patients. |
2016-04-14 |
2023-08-13 |
rat |
| Zhiyou Cai, Ming Xiao, Liying Chang, Liang-Jun Ya. Role of insulin resistance in Alzheimer's disease. Metabolic brain disease. vol 30. issue 4. 2016-04-08. PMID:25399337. |
role of insulin resistance in alzheimer's disease. |
2016-04-08 |
2023-08-13 |
Not clear |
| Zhiyou Cai, Ming Xiao, Liying Chang, Liang-Jun Ya. Role of insulin resistance in Alzheimer's disease. Metabolic brain disease. vol 30. issue 4. 2016-04-08. PMID:25399337. |
a critical role of insulin resistance (ir) in alzheimer's disease (ad) includes beta-amyloid (aβ) production and accumulation, the formation of neurofibrillary tangles (nfts), failure of synaptic transmission and neuronal degeneration. |
2016-04-08 |
2023-08-13 |
Not clear |
| Gemma McGregor, Yasaman Malekizadeh, Jenni Harve. Minireview: Food for thought: regulation of synaptic function by metabolic hormones. Molecular endocrinology (Baltimore, Md.). vol 29. issue 1. 2016-03-24. PMID:25470238. |
the hippocampal formation is also a prime site for the neurodegenerative processes that occur during alzheimer's disease, and impairments in either leptin or insulin function have been linked to central nervous system-driven diseases like alzheimer's disease. |
2016-03-24 |
2023-08-13 |
Not clear |
| V Schöpf, K Kollndorfer, M Pollak, C A Mueller, J Freiher. Intranasal insulin influences the olfactory performance of patients with smell loss, dependent on the body mass index: A pilot study. Rhinology. vol 53. issue 4. 2016-03-24. PMID:26275583. |
there has also been some correlation between the morbidities associated with central nervous system (cns) insulin resistance, such as type ii diabetes mellitus, alzheimer's disease, obesity, and impaired odour recognition. |
2016-03-24 |
2023-08-13 |
Not clear |
| Edy Kornelius, Chih-Li Lin, Hsiu-Han Chang, Hsin-Hua Li, Wen-Nung Huang, Yi-Sun Yang, Ying-Li Lu, Chiung-Huei Peng, Chien-Ning Huan. DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells. CNS neuroscience & therapeutics. vol 21. issue 7. 2016-03-17. PMID:26010513. |
dysregulation of brain insulin signaling has been linked to neurodegenerative disease, particularly alzheimer's disease (ad). |
2016-03-17 |
2023-08-13 |
Not clear |
| Kourosh Negintaji, Asadollah Zarifkar, Rasoul Ghasemi, Maryam Moosav. Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment. Journal of molecular neuroscience : MN. vol 56. issue 2. 2016-03-14. PMID:25744099. |
intraventricularly administered streptozotocin (stz) disrupts insulin signaling pathway which leads to behavioral and biochemical changes resemble to early signs of ad; therefore, stz model has been proposed as a model for sporadic alzheimer's disease (sad). |
2016-03-14 |
2023-08-13 |
rat |
| Giuseppe Grasso, Cristina Satriano, Danilo Milard. A neglected modulator of insulin-degrading enzyme activity and conformation: The pH. Biophysical chemistry. vol 203-204. 2016-03-14. PMID:26025789. |
insulin-degrading enzyme (ide), a ubiquitously expressed zinc metalloprotease, has multiple activities in addition to insulin degradation and its malfunction is believed to connect type 2 diabetes with alzheimer's disease. |
2016-03-14 |
2023-08-13 |
Not clear |
| Shanshan Gao, Chunli Duan, Ge Gao, Xiaoming Wang, Hui Yan. Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling. The international journal of biochemistry & cell biology. vol 64. 2016-03-11. PMID:25813876. |
insulin receptor substrate (irs)-1 is a docking protein linking irs to downstream signaling pathways such as phosphatidylinositol 3-kinase/akt and mammalian target of rapamycin (mtor)/ribosomal protein s6 kinase (s6k)1; the latter exerts negative feedback control on insulin signaling, which is impaired in alzheimer's disease. |
2016-03-11 |
2023-08-13 |
mouse |
| Huawei Cheng, Lin Wang, Tianlu Shi, Yuping Shang, Ling Jian. Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis. The International journal of neuroscience. vol 125. issue 5. 2016-03-07. PMID:25105907. |
association of insulin degrading enzyme gene polymorphisms with alzheimer's disease: a meta-analysis. |
2016-03-07 |
2023-08-13 |
Not clear |
| Fiammetta Monacelli, Roberta Borghi, Sergio Cammarata, Alessio Nencioni, Alessandra Piccini, Massimo Tabaton, Patrizio Odett. Amnestic mild cognitive impairment and conversion to Alzheimer's disease: insulin resistance and glycoxidation as early biomarker clusters. Journal of Alzheimer's disease : JAD. vol 45. issue 1. 2016-02-29. PMID:25471189. |
amnestic mild cognitive impairment and conversion to alzheimer's disease: insulin resistance and glycoxidation as early biomarker clusters. |
2016-02-29 |
2023-08-13 |
human |
| Mahmood Bahmani, Hedayatollah Shirzad, Samira Rafieian, Mahmoud Rafieian-Kopae. Silybum marianum: Beyond Hepatoprotection. Journal of evidence-based complementary & alternative medicine. vol 20. issue 4. 2016-02-25. PMID:25686616. |
most of documented data with silybum marianum are about liver disorders; however, recently several beneficial properties on a wide variety of other disorders such as renal protection, hypolipidemic and anti-atherosclerosis activities, cardiovascular protection, prevention of insulin resistance, especially in cirrhotic patients, cancer, and alzheimer prevention. |
2016-02-25 |
2023-08-13 |
Not clear |
| A O Shpako. [FUNCTIONAL ACTIVITY OF THE BRAIN INSULIN SIGNALING SYS TEM IN NORM AND IN TYPE 2 DIABETES MELLITUS]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 101. issue 10. 2016-02-11. PMID:26827491. |
the disturbances in the brain insulin system lead to central insulin resistance, which is one of the primary causes of type 2 diabetes mellitus (dm), metabolic syndrome and alzheimer's disease. |
2016-02-11 |
2023-08-13 |
Not clear |
| Kenji Fukui, Heather A Ferris, C Ronald Kah. Effect of cholesterol reduction on receptor signaling in neurons. The Journal of biological chemistry. vol 290. issue 44. 2016-02-04. PMID:26370080. |
together, these data indicate that a reduction in neuron-derived cholesterol content, similar to that observed in diabetic brain, creates a state of insulin and growth factor resistance that could contribute to cns-related complications of diabetes, including increased risk of neurodegenerative diseases, such as alzheimer disease. |
2016-02-04 |
2023-08-13 |
Not clear |
| Zhi Li, Hang Li, Chunhui Zhao, Cui Lv, Changjia Zhong, Wenfeng Xin, Wensheng Zhan. Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation. CNS & neurological disorders drug targets. vol 14. issue 3. 2016-02-01. PMID:25714973. |
protective effect of notoginsenoside r1 on an app/ps1 mouse model of alzheimer's disease by up-regulating insulin degrading enzyme and inhibiting aβ accumulation. |
2016-02-01 |
2023-08-13 |
mouse |
| Auriel A Willette, Sterling C Johnson, Alex C Birdsill, Mark A Sager, Bradley Christian, Laura D Baker, Suzanne Craft, Jennifer Oh, Eric Statz, Bruce P Hermann, Erin M Jonaitis, Rebecca L Koscik, Asenath La Rue, Sanjay Asthana, Barbara B Bendli. Insulin resistance predicts brain amyloid deposition in late middle-aged adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 5. 2016-01-28. PMID:25043908. |
insulin resistance (ir) increases alzheimer's disease (ad) risk. |
2016-01-28 |
2023-08-13 |
human |
| V R Bitra, Deepthi Rapaka, Annapurna Akul. Prediabetes and Alzheimer's Disease. Indian journal of pharmaceutical sciences. vol 77. issue 5. 2016-01-22. PMID:26798163. |
emerging evidences demonstrate the role of brain insulin resistance, which is a key mediator in prediabetes and diabetes mellitus that may lead to alzheimer's disease. |
2016-01-22 |
2023-08-13 |
Not clear |