| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy Claxton, Laura D Baker, Angela Hanson, Emily H Trittschuh, Brenna Cholerton, Amy Morgan, Maureen Callaghan, Matthew Arbuckle, Colin Behl, Suzanne Craf. Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. Journal of Alzheimer's disease : JAD. vol 44. issue 3. 2015-10-26. PMID:25374101. |
previous trials have shown promising effects of intranasally administered insulin for adults with alzheimer's disease dementia (ad) or amnestic mild cognitive impairment (mci). |
2015-10-26 |
2023-08-13 |
human |
| Erika Calvo-Ochoa, Clorinda Aria. Cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer's disease: studies in animal models. Diabetes/metabolism research and reviews. vol 31. issue 1. 2015-10-01. PMID:24464982. |
cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and alzheimer's disease: studies in animal models. |
2015-10-01 |
2023-08-12 |
Not clear |
| Erika Calvo-Ochoa, Clorinda Aria. Cellular and metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer's disease: studies in animal models. Diabetes/metabolism research and reviews. vol 31. issue 1. 2015-10-01. PMID:24464982. |
a growing body of animal and epidemiological studies suggest that metabolic diseases such as obesity, insulin resistance, metabolic syndrome and type 2 diabetes mellitus are associated with the development of cognitive impairment, dementia and alzheimer's disease, particularly in aging. |
2015-10-01 |
2023-08-12 |
Not clear |
| João M N Duart. Metabolic Alterations Associated to Brain Dysfunction in Diabetes. Aging and disease. vol 6. issue 5. 2015-10-01. PMID:26425386. |
moreover, cognitive impairment and alzheimer's disease (ad) are also accompanied by impaired glucose homeostasis and insulin signalling. |
2015-10-01 |
2023-08-13 |
Not clear |
| Lilian Calderón-Garcidueñas, Maricela Franco-Lira, Amedeo D'Angiulli, Joel Rodríguez-Díaz, Eleonore Blaurock-Busch, Yvette Busch, Chih-kai Chao, Charles Thompson, Partha S Mukherjee, Ricardo Torres-Jardón, George Perr. Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease. Environmental research. vol 140. 2015-09-25. PMID:26037109. |
these changes could signal the future trajectory of urban children towards the development of insulin resistance, obesity, type ii diabetes, premature cardiovascular disease, addiction-like behavior, cognitive impairment and alzheimer's disease. |
2015-09-25 |
2023-08-13 |
Not clear |
| Hye Jeong Yang, Dae Young Kwon, Hyun Jin Kim, Min Jung Kim, Do Yeon Jung, Hee Joo Kang, Da Sol Kim, Suna Kang, Na Rang Moon, Bae Keun Shin, Sunmin Par. Fermenting soybeans with Bacillus licheniformis potentiates their capacity to improve cognitive function and glucose homeostaisis in diabetic rats with experimental Alzheimer's type dementia. European journal of nutrition. vol 54. issue 1. 2015-09-15. PMID:24700374. |
brain insulin resistance is related to both diabetes and alzheimer's disease. |
2015-09-15 |
2023-08-13 |
rat |
| Akinori Futamura, Yukiko Mori, Mitsuru Kawamur. [Diabetes and Dementia]. Brain and nerve = Shinkei kenkyu no shinpo. vol 67. issue 6. 2015-09-08. PMID:26062587. |
anti-diabetic drugs and insulin may protect and improve cognitive dysfunction in alzheimer's disease and dm-mci, but more studies are needed to verify this claim. |
2015-09-08 |
2023-08-13 |
Not clear |
| Elizabeth Rose Mayeda, Rachel A Whitmer, Kristine Yaff. Diabetes and cognition. Clinics in geriatric medicine. vol 31. issue 1. 2015-09-04. PMID:25453304. |
proposed mechanisms through which t2d could cause dementia include the effects of insulin dysregulation and chronic hyperglycemia on features of alzheimer's disease and macrovascular and microvascular disorders in the brain. |
2015-09-04 |
2023-08-13 |
Not clear |
| M Del Campo, A Stargardt, R Veerhuis, E Reits, C E Teunisse. Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease. Neuroscience letters. vol 589. 2015-08-27. PMID:25597881. |
accumulation of bri2-brichos ectodomain correlates with a decreased clearance of aβ by insulin degrading enzyme (ide) in alzheimer's disease. |
2015-08-27 |
2023-08-13 |
human |
| Husam Ghanim, Paresh Dandon. Comment on Vandal et al. Insulin Reverses the High-Fat Diet-Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease. Diabetes 2014;63:4291-4301. Diabetes. vol 64. issue 7. 2015-08-27. PMID:26106201. |
insulin reverses the high-fat diet-induced increase in brain aβ and improves memory in an animal model of alzheimer disease. |
2015-08-27 |
2023-08-13 |
Not clear |
| Milene Vandal, Frederic Calo. Response to Comment on Vandal et al. Insulin Reverses the High-Fat Diet-Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease. Diabetes 2014;63:4291-4301. Diabetes. vol 64. issue 7. 2015-08-27. PMID:26106202. |
insulin reverses the high-fat diet-induced increase in brain aβ and improves memory in an animal model of alzheimer disease. |
2015-08-27 |
2023-08-13 |
Not clear |
| Weijie Xu, Yan Yang, Gang Yuan, Wenjun Zhu, Delin Ma, Shuhong H. Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 63. issue 2. 2015-08-25. PMID:25479064. |
impaired insulin signaling pathway in the brain in type 2 diabetes (t2d) is a risk factor for alzheimer disease (ad). |
2015-08-25 |
2023-08-13 |
rat |
| Rosa Luciano, Gloria Maria Barraco, Maurizio Muraca, Simonetta Ottino, Maria Rita Spreghini, Rita Wietrzykowska Sforza, Carmela Rustico, Giuseppe Stefano Morino, Melania Manc. Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood. Pediatrics. vol 135. issue 6. 2015-08-20. PMID:25963004. |
biomarkers of alzheimer disease, insulin resistance, and obesity in childhood. |
2015-08-20 |
2023-08-13 |
Not clear |
| Rosa Luciano, Gloria Maria Barraco, Maurizio Muraca, Simonetta Ottino, Maria Rita Spreghini, Rita Wietrzykowska Sforza, Carmela Rustico, Giuseppe Stefano Morino, Melania Manc. Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood. Pediatrics. vol 135. issue 6. 2015-08-20. PMID:25963004. |
to answer the question of whether onset of insulin resistance (ir) early in life enhances the risk of developing dementia and alzheimer disease (ad), serum levels of 2 molecules that are likely associated with development of ad, the amyloid β-protein 42 (aβ42) and presenilin 1 (psen1), were estimated in 101 preschoolers and 309 adolescents of various bmi. |
2015-08-20 |
2023-08-13 |
Not clear |
| Auriel A Willette, Nina Modanlo, Dimitrios Kapogianni. Insulin resistance predicts medial temporal hypermetabolism in mild cognitive impairment conversion to Alzheimer disease. Diabetes. vol 64. issue 6. 2015-08-19. PMID:25576061. |
insulin resistance predicts medial temporal hypermetabolism in mild cognitive impairment conversion to alzheimer disease. |
2015-08-19 |
2023-08-13 |
human |
| Amy Claxton, Laura D Baker, Angela Hanson, Emily H Trittschuh, Brenna Cholerton, Amy Morgan, Maureen Callaghan, Matthew Arbuckle, Colin Behl, Suzanne Craf. Long Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia. Journal of Alzheimer's disease : JAD. vol 45. issue 4. 2015-08-14. PMID:25869922. |
long acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage alzheimer's disease dementia. |
2015-08-14 |
2023-08-13 |
Not clear |
| Kelly T Dineley, Jordan B Jahrling, Larry Denne. Insulin resistance in Alzheimer's disease. Neurobiology of disease. vol 72 Pt A. 2015-07-28. PMID:25237037. |
insulin resistance in alzheimer's disease. |
2015-07-28 |
2023-08-13 |
human |
| Kelly T Dineley, Jordan B Jahrling, Larry Denne. Insulin resistance in Alzheimer's disease. Neurobiology of disease. vol 72 Pt A. 2015-07-28. PMID:25237037. |
since insulin has a key role in learning and memory as well as directly regulating erk, a kinase required for the type of learning and memory compromised in early alzheimer's disease (ad), insulin resistance has been identified as a major risk factor for the onset of ad. |
2015-07-28 |
2023-08-13 |
human |
| Michael H Rosenbloom, Terry R Barclay, Maria Pyle, Brian L Owens, Amanda B Cagan, Christopher P Anderson, William H Frey, Leah R Hanso. A single-dose pilot trial of intranasal rapid-acting insulin in apolipoprotein E4 carriers with mild-moderate Alzheimer's disease. CNS drugs. vol 28. issue 12. 2015-07-22. PMID:25373630. |
a single-dose pilot trial of intranasal rapid-acting insulin in apolipoprotein e4 carriers with mild-moderate alzheimer's disease. |
2015-07-22 |
2023-08-13 |
Not clear |
| Ewan McNa. Your Brain on Insulin: From Heresy to Dogma. Perspectives on psychological science : a journal of the Association for Psychological Science. vol 9. issue 1. 2015-07-17. PMID:26173246. |
brain insulin signaling is a target for therapeutic intervention in patients with neuropsychological conditions such as alzheimer's disease. |
2015-07-17 |
2023-08-13 |
Not clear |