| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V R Bitra, Deepthi Rapaka, Annapurna Akul. Prediabetes and Alzheimer's Disease. Indian journal of pharmaceutical sciences. vol 77. issue 5. 2016-01-22. PMID:26798163. |
hence, the endogenous brain specific insulin impairments and signaling account for the majority of alzheimer's abnormalities. |
2016-01-22 |
2023-08-13 |
Not clear |
| Rüdiger Hardeland, Daniel P Cardinali, Gregory M Brown, Seithikurippu R Pandi-Peruma. Melatonin and brain inflammaging. Progress in neurobiology. vol 127-128. 2016-01-15. PMID:25697044. |
it is levels tend to decrease in the course of senescence and are more strongly reduced in several neurodegenerative disorders, especially alzheimer's disease, and in diseases related to insulin resistance such as diabetes type 2. |
2016-01-15 |
2023-08-13 |
Not clear |
| Kole D Meeker, James S Meabon, David G Coo. Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 2. 2016-01-14. PMID:25589729. |
partial loss of the glutamate transporter glt-1 alters brain akt and insulin signaling in a mouse model of alzheimer's disease. |
2016-01-14 |
2023-08-13 |
mouse |
| Farida Chentli, Said Azzoug, Souad Mahgou. Diabetes mellitus in elderly. Indian journal of endocrinology and metabolism. vol 19. issue 6. 2015-12-22. PMID:26693423. |
alzheimer disease seems to share the same risk factors as dm, which means insulin resistance due to lack of physical activity and eating disorders. |
2015-12-22 |
2023-08-13 |
Not clear |
| Lutz Frölich, Walter E Müller, Peter Riedere. Editorial: Siegfried Hoyer's concept of Alzheimer pathophysiology. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25616721. |
the concept of central insulin resistance and dysfunctional insulin signaling in alzheimer's disease (ad) has been developed by siegfried hoyer in 1985-2000. |
2015-12-16 |
2023-08-13 |
Not clear |
| Lutz Frölich, Walter E Müller, Peter Riedere. Editorial: Siegfried Hoyer's concept of Alzheimer pathophysiology. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25616721. |
finally, the insulin hypothesis of alzheimer's disease has currently advanced into a potential therapeutic avenue. |
2015-12-16 |
2023-08-13 |
Not clear |
| Katrin Morgen, Lutz Frölic. The metabolism hypothesis of Alzheimer's disease: from the concept of central insulin resistance and associated consequences to insulin therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25673434. |
the metabolism hypothesis of alzheimer's disease: from the concept of central insulin resistance and associated consequences to insulin therapy. |
2015-12-16 |
2023-08-13 |
Not clear |
| Katrin Morgen, Lutz Frölic. The metabolism hypothesis of Alzheimer's disease: from the concept of central insulin resistance and associated consequences to insulin therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25673434. |
the concept of central insulin resistance and dysfunctional insulin signaling in alzheimer's disease (ad) has been developed by siegfried hoyer in 1985-2000. |
2015-12-16 |
2023-08-13 |
Not clear |
| Katrin Morgen, Lutz Frölic. The metabolism hypothesis of Alzheimer's disease: from the concept of central insulin resistance and associated consequences to insulin therapy. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25673434. |
insulin and insulin receptors are widely distributed in the brain and are impaired in the post-mortem alzheimer brain. |
2015-12-16 |
2023-08-13 |
Not clear |
| Sergio Rosales-Corral, Dun-Xian Tan, Lucien Manchester, Russel J Reite. Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress. Oxidative medicine and cellular longevity. vol 2015. 2015-12-15. PMID:25815110. |
alzheimer's pathology by itself may lead to insulin resistance in brain, insulin resistance being an intervening variable in the neurodegenerative disorder. |
2015-12-15 |
2023-08-13 |
Not clear |
| Sergio Rosales-Corral, Dun-Xian Tan, Lucien Manchester, Russel J Reite. Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress. Oxidative medicine and cellular longevity. vol 2015. 2015-12-15. PMID:25815110. |
hyperglycemia and insulin resistance from diabetes, overlapping with the alzheimer's pathology, aggravate the progression of the neurodegenerative processes, indeed. |
2015-12-15 |
2023-08-13 |
Not clear |
| Ruishan Wang, Shaoya Chen, Yingchun Liu, Shiyong Diao, Yueqiang Xue, Xiaoqing You, Edwards A Park, Francesca-Fang Lia. All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor κB (NFκB) signaling. The Journal of biological chemistry. vol 290. issue 37. 2015-12-04. PMID:26240147. |
insulin resistance and neuroinflammation have emerged as two likely key contributors in the pathogenesis of alzheimer disease (ad), especially in those sporadic ad cases compromised by diabetes or cardiovascular disease. |
2015-12-04 |
2023-08-13 |
mouse |
| Hemi Malkk. Alzheimer disease: Insulin resistance could be linked to risk of AD via reduced glucose uptake. Nature reviews. Neurology. vol 11. issue 9. 2015-12-03. PMID:26260658. |
alzheimer disease: insulin resistance could be linked to risk of ad via reduced glucose uptake. |
2015-12-03 |
2023-08-13 |
Not clear |
| Auriel A Willette, Barbara B Bendlin, Erika J Starks, Alex C Birdsill, Sterling C Johnson, Bradley T Christian, Ozioma C Okonkwo, Asenath La Rue, Bruce P Hermann, Rebecca L Koscik, Erin M Jonaitis, Mark A Sager, Sanjay Asthan. Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease. JAMA neurology. vol 72. issue 9. 2015-12-02. PMID:26214150. |
association of insulin resistance with cerebral glucose uptake in late middle-aged adults at risk for alzheimer disease. |
2015-12-02 |
2023-08-13 |
Not clear |
| Auriel A Willette, Barbara B Bendlin, Erika J Starks, Alex C Birdsill, Sterling C Johnson, Bradley T Christian, Ozioma C Okonkwo, Asenath La Rue, Bruce P Hermann, Rebecca L Koscik, Erin M Jonaitis, Mark A Sager, Sanjay Asthan. Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease. JAMA neurology. vol 72. issue 9. 2015-12-02. PMID:26214150. |
converging evidence suggests that alzheimer disease (ad) involves insulin signaling impairment. |
2015-12-02 |
2023-08-13 |
Not clear |
| Thiruchelvam Kariharan, Gayani Nanayakkara, Kodeeswaran Parameshwaran, Inseyah Bagasrawala, Manuj Ahuja, Engy Abdel-Rahman, Arin T Amin, Murali Dhanasekaran, Vishnu Suppiramaniam, Rajesh H Ami. Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression. Neurobiology of aging. vol 36. issue 3. 2015-11-24. PMID:25510319. |
pharmacologic agonist of the nuclear receptor, peroxisomal proliferator-activating receptor gamma (pparγ), that is, rosiglitazone (rosi), are insulin sensitizing agents that improve memory in alzheimer's disease. |
2015-11-24 |
2023-08-13 |
mouse |
| Oliver Takach, Trevor B Gill, Michael A Silverma. Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons. Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25543463. |
defective brain insulin signaling contributes to the cognitive deficits in alzheimer's disease (ad). |
2015-11-12 |
2023-08-13 |
mouse |
| Hao Gong, Zihao He, Anlin Peng, Xin Zhang, Biao Cheng, Yue Sun, Ling Zheng, Kun Huan. Effects of several quinones on insulin aggregation. Scientific reports. vol 4. 2015-10-28. PMID:25008537. |
in this study, we used insulin as an amyloid model to test the anti-amyloid effects of four simple quinones and four natural anthraquinone derivatives from rhubarb, a traditional herbal medicine used for treating alzheimer's disease. |
2015-10-28 |
2023-08-13 |
Not clear |
| Hugo Gutiérrez-Hermosillo, Enrique Díaz De León-González, Rebeca Palacios-Corona, Javier Armando Cedillo-Rodríguez, Abelardo Camacho-Luis, Miguel Arturo Reyes-Romero, Juan Humberto Medina-Chávez, Pedro A Blandó. C allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and Alzheimer's disease in type 2 diabetes, a case control study. Medicina clinica. vol 144. issue 4. 2015-10-26. PMID:24355596. |
c allele of the rs2209972 single nucleotide polymorphism of the insulin degrading enzyme gene and alzheimer's disease in type 2 diabetes, a case control study. |
2015-10-26 |
2023-08-12 |
Not clear |
| Amy Claxton, Laura D Baker, Angela Hanson, Emily H Trittschuh, Brenna Cholerton, Amy Morgan, Maureen Callaghan, Matthew Arbuckle, Colin Behl, Suzanne Craf. Long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage Alzheimer's disease dementia. Journal of Alzheimer's disease : JAD. vol 44. issue 3. 2015-10-26. PMID:25374101. |
long-acting intranasal insulin detemir improves cognition for adults with mild cognitive impairment or early-stage alzheimer's disease dementia. |
2015-10-26 |
2023-08-13 |
human |