| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Grzegorz M Rdzak, Osama Abdelghan. Does insulin therapy for type 1 diabetes mellitus protect against Alzheimer's disease? Pharmacotherapy. vol 34. issue 12. 2015-07-15. PMID:25280207. |
does insulin therapy for type 1 diabetes mellitus protect against alzheimer's disease? |
2015-07-15 |
2023-08-13 |
Not clear |
| Grzegorz M Rdzak, Osama Abdelghan. Does insulin therapy for type 1 diabetes mellitus protect against Alzheimer's disease? Pharmacotherapy. vol 34. issue 12. 2015-07-15. PMID:25280207. |
in recent years, there has been a growing interest in the possible links between insulin and alzheimer's disease. |
2015-07-15 |
2023-08-13 |
Not clear |
| Grzegorz M Rdzak, Osama Abdelghan. Does insulin therapy for type 1 diabetes mellitus protect against Alzheimer's disease? Pharmacotherapy. vol 34. issue 12. 2015-07-15. PMID:25280207. |
excess exogenous insulin may also play a role in overcoming the decreased utilization and transport of glucose in patients with alzheimer's disease. |
2015-07-15 |
2023-08-13 |
Not clear |
| Grzegorz M Rdzak, Osama Abdelghan. Does insulin therapy for type 1 diabetes mellitus protect against Alzheimer's disease? Pharmacotherapy. vol 34. issue 12. 2015-07-15. PMID:25280207. |
intranasal insulin therapy may have beneficial effects on cognition and function in patients with alzheimer's disease, as well as having only minor adverse effects, and this route of administration been the focus in clinical trials. |
2015-07-15 |
2023-08-13 |
Not clear |
| Grzegorz M Rdzak, Osama Abdelghan. Does insulin therapy for type 1 diabetes mellitus protect against Alzheimer's disease? Pharmacotherapy. vol 34. issue 12. 2015-07-15. PMID:25280207. |
these data support the mechanistic pathways that might link excess exogenous insulin administered to patients with type 1 diabetes mellitus to possible protection from alzheimer's disease and provide a rationale for using insulin to prevent the disease in high-risk patients. |
2015-07-15 |
2023-08-13 |
Not clear |
| Qingqing Yin, Yingjuan Ma, Yan Hong, Xunyao Hou, Jian Chen, Chao Shen, Menghan Sun, Yuying Shang, Siqin Dong, Ziling Zeng, Jin-Jing Pei, Xueping Li. Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats. Neuropharmacology. vol 86. 2015-07-14. PMID:25110828. |
fructose intake is linked with the increasing prevalence of insulin resistance, and insulin resistance links alzheimer's disease with impaired insulin signaling, oxidative damage, neuroinflammation, and cognitive impairment. |
2015-07-14 |
2023-08-13 |
rat |
| N Rajasekar, Subhash Dwivedi, Chandishwar Nath, Kashif Hanif, Rakesh Shukl. Protection of streptozotocin induced insulin receptor dysfunction, neuroinflammation and amyloidogenesis in astrocytes by insulin. Neuropharmacology. vol 86. 2015-07-14. PMID:25158313. |
impaired insulin signaling, amyloid pathology and neuroinflammation are closely associated with neurodegenerative disorder like alzheimer's disease (ad). |
2015-07-14 |
2023-08-13 |
rat |
| Mubashir Hassan, Sheikh A Sehgal, Sajid Rashi. Regulatory cascade of neuronal loss and glucose metabolism. CNS & neurological disorders drug targets. vol 13. issue 7. 2015-07-13. PMID:25230224. |
d2m is linked with alzheimer's disease through deregulation of calcium ions thereby leading to metabolic fluctuations of glucose and insulin. |
2015-07-13 |
2023-08-13 |
Not clear |
| Gaurav Bedse, Fabio Di Domenico, Gaetano Serviddio, Tommaso Cassan. Aberrant insulin signaling in Alzheimer's disease: current knowledge. Frontiers in neuroscience. vol 9. 2015-07-03. PMID:26136647. |
aberrant insulin signaling in alzheimer's disease: current knowledge. |
2015-07-03 |
2023-08-13 |
Not clear |
| Mark Yarchoan, Jon B Toledo, Edward B Lee, Zoe Arvanitakis, Hala Kazi, Li-Ying Han, Natalia Louneva, Virginia M-Y Lee, Sangwon F Kim, John Q Trojanowski, Steven E Arnol. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta neuropathologica. vol 128. issue 5. 2015-06-15. PMID:25107476. |
neuronal insulin signaling abnormalities have been associated with alzheimer's disease (ad). |
2015-06-15 |
2023-08-13 |
mouse |
| Gumpeny R Sridhar, Gumpeny Lakshmi, Gumpeny Nagaman. Emerging links between type 2 diabetes and Alzheimer's disease. World journal of diabetes. vol 6. issue 5. 2015-06-13. PMID:26069723. |
common pathogenic factors in both conditions span a broad sweep including chronic hyperglycemia per se, hyperinsulinemia, insulin resistance, acute hypoglycemic episodes, especially in the elderly, microvascular disease, fibrillar deposits (in brain in alzheimer's disease and in pancreas in type 2 diabetes), altered insulin processing, inflammation, obesity, dyslipidemia, altered levels of insulin like growth factor and occurrence of variant forms of the protein butyrylcholinesterase. |
2015-06-13 |
2023-08-13 |
Not clear |
| Gumpeny R Sridhar, Gumpeny Lakshmi, Gumpeny Nagaman. Emerging links between type 2 diabetes and Alzheimer's disease. World journal of diabetes. vol 6. issue 5. 2015-06-13. PMID:26069723. |
of interest not only do lifestyle measures have a protective effect against the development of cognitive impairment due to alzheimer's disease, but so do some of the pharmacological agents used in the treatment of diabetes such as insulin (especially when delivered intranasally), metformin, peroxisome proliferator-activated receptors γ agonists, glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. |
2015-06-13 |
2023-08-13 |
Not clear |
| Christian Hölsche. Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases. Biochemical Society transactions. vol 42. issue 2. 2015-06-05. PMID:24646283. |
insulin, incretins and other growth factors as potential novel treatments for alzheimer's and parkinson's diseases. |
2015-06-05 |
2023-08-12 |
Not clear |
| Christian Hölsche. Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases. Biochemical Society transactions. vol 42. issue 2. 2015-06-05. PMID:24646283. |
recently, it has been shown that in patients with ad (alzheimer's disease) and, to some degree, in patients with pd (parkinson's disease) insulin signalling is impaired. |
2015-06-05 |
2023-08-12 |
Not clear |
| M F Whit. IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity. Diabetes, obesity & metabolism. vol 16 Suppl 1. 2015-06-01. PMID:25200290. |
insulin resistance and type 2 diabetes are associated with clinical alzheimer's disease, whereas study in lower organisms shows that reduced insulin-like signalling slows the progressive neurodegeneration and increases life span. |
2015-06-01 |
2023-08-13 |
mouse |
| Dema Najem, Michelle Bamji-Mirza, Nina Chang, Qing Yan Liu, Wandong Zhan. Insulin resistance, neuroinflammation, and Alzheimer's disease. Reviews in the neurosciences. vol 25. issue 4. 2015-05-26. PMID:24622783. |
insulin resistance, neuroinflammation, and alzheimer's disease. |
2015-05-26 |
2023-08-12 |
Not clear |
| Tatsuya Ikenoue, Young-Ho Lee, József Kardos, Miyu Saiki, Hisashi Yagi, Yasushi Kawata, Yuji Got. Cold denaturation of α-synuclein amyloid fibrils. Angewandte Chemie (International ed. in English). vol 53. issue 30. 2015-05-13. PMID:24920162. |
meanwhile, the fibrils of β2-microglobulin, alzheimer's aβ1-40/aβ1-42 peptides, and insulin exhibited only heat denaturation, although they showed a decrease in stability at low temperature. |
2015-05-13 |
2023-08-13 |
Not clear |
| Dimitrios Kapogiannis, Adam Boxer, Janice B Schwartz, Erin L Abner, Arya Biragyn, Umesh Masharani, Lynda Frassetto, Ronald C Petersen, Bruce L Miller, Edward J Goetz. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 2. 2015-04-01. PMID:25342129. |
insulin resistance causes diminished glucose uptake in similar regions of the brain in alzheimer's disease (ad) and type 2 diabetes mellitus (dm2). |
2015-04-01 |
2023-08-13 |
human |
| George S Zubenko, Hugh B Hughes, Rick M Jordan, James Lyons-Weiler, Bruce M Cohe. Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 165B. issue 6. 2015-03-30. PMID:25059218. |
pathway analyses highlighted 11 kegg pathways: the phosphatidylinositol signaling system, which has been widely implicated in mdd, bipolar disorder, and the action of mood stabilizers; gap junction and long-term potentiation, which mediate cognition and memory functions often impaired in mdd; cardiac muscle contraction, insulin signaling pathway, and three neurodegenerative brain disorders (alzheimer's, parkinson's, and huntington's diseases) that are associated with mdd; ribosome and proteasome pathways affecting protein synthesis/degradation; and the oxidative phosphorylation pathway that is key to energy production. |
2015-03-30 |
2023-08-13 |
mouse |
| Hye Jeong Yang, Dae Young Kwon, Min Jung Kim, Suna Kang, Na Rang Moon, James W Daily, Sunmin Par. Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer's disease. Nutrition & metabolism. vol 12. 2015-03-10. PMID:25755673. |
red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with alzheimer's disease. |
2015-03-10 |
2023-08-13 |
rat |