| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Predrag Serbedžija, Douglas N Ishi. Insulin and insulin-like growth factor prevent brain atrophy and cognitive impairment in diabetic rats. Indian journal of endocrinology and metabolism. vol 16. issue Suppl 3. 2013-04-09. PMID:23565496. |
these findings have important implications for late-onset alzheimer's disease (load) where diabetes is a major risk factor, and concomitant decline in insulin and igf activity suggest a similar pathogenesis for brain atrophy and dementia. |
2013-04-09 |
2023-08-12 |
rat |
| Jill K Morris, Jeffrey M Burn. Insulin: an emerging treatment for Alzheimer's disease dementia? Current neurology and neuroscience reports. vol 12. issue 5. 2013-04-03. PMID:22791280. |
insulin: an emerging treatment for alzheimer's disease dementia? |
2013-04-03 |
2023-08-12 |
Not clear |
| Xin Liu, Yi-Na Zhang, Li-Hong Jiang, Zong-Yan Ten. [Study of the correlation about IGF-I receptor and β-amyloid in Alzheimer's disease]. Zhonghua yi xue za zhi. vol 92. issue 15. 2013-03-20. PMID:22781651. |
to detect the expression of igf-i receptor in the hippocampus neuron of rat treated by aβ(1-42), and thus from the receptor level explore the disorder of central nervous insulin signaling and the possible molecular mechanism of alzheimer disease. |
2013-03-20 |
2023-08-12 |
rat |
| John G Menting, Jonathan Whittaker, Mai B Margetts, Linda J Whittaker, Geoffrey K-W Kong, Brian J Smith, Christopher J Watson, Lenka Záková, Emília Kletvíková, Jiří Jiráček, Shu Jin Chan, Donald F Steiner, Guy G Dodson, Andrzej M Brzozowski, Michael A Weiss, Colin W Ward, Michael C Lawrenc. How insulin engages its primary binding site on the insulin receptor. Nature. vol 493. issue 7431. 2013-02-26. PMID:23302862. |
insulin resistance contributes to the pathogenesis of type 2 diabetes mellitus and the onset of alzheimer's disease; aberrant signalling occurs in diverse cancers, exacerbated by cross-talk with the homologous type 1 insulin-like growth factor receptor (igf1r). |
2013-02-26 |
2023-08-12 |
Not clear |
| Ian Clark, Craig Atwood, Richard Bowen, Gilberto Paz-Filho, Bryce Visse. Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales. Pharmacological reviews. vol 64. issue 4. 2013-02-21. PMID:22966039. |
tumor necrosis factor-induced cerebral insulin resistance in alzheimer's disease links numerous treatment rationales. |
2013-02-21 |
2023-08-12 |
Not clear |
| Ian Clark, Craig Atwood, Richard Bowen, Gilberto Paz-Filho, Bryce Visse. Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales. Pharmacological reviews. vol 64. issue 4. 2013-02-21. PMID:22966039. |
the key link in this chain presently absent is a recognition by alzheimer's research community of the long-neglected history of tnf induction of insulin resistance. |
2013-02-21 |
2023-08-12 |
Not clear |
| Ian Clark, Craig Atwood, Richard Bowen, Gilberto Paz-Filho, Bryce Visse. Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales. Pharmacological reviews. vol 64. issue 4. 2013-02-21. PMID:22966039. |
thus the inflammation, insulin resistance, gsk-3, and mitochondrial dysfunction hypotheses are not opposing ideas but stages of the same fundamental, overarching, pathway of alzheimer's disease pathogenesis. |
2013-02-21 |
2023-08-12 |
Not clear |
| Xiaohong Sun, Haihua Shao, Danmei Yu, Decai Wan. [Analysis of correlation between insulin resistance, blood lipids and Alzheimer's disease]. Wei sheng yan jiu = Journal of hygiene research. vol 39. issue 5. 2013-01-31. PMID:21033433. |
[analysis of correlation between insulin resistance, blood lipids and alzheimer's disease]. |
2013-01-31 |
2023-08-12 |
Not clear |
| Xiaohong Sun, Haihua Shao, Danmei Yu, Decai Wan. [Analysis of correlation between insulin resistance, blood lipids and Alzheimer's disease]. Wei sheng yan jiu = Journal of hygiene research. vol 39. issue 5. 2013-01-31. PMID:21033433. |
to investigate the relationship between alzheimer' s disease(ad) and insulin resistance and blood lipids. |
2013-01-31 |
2023-08-12 |
Not clear |
| Helgi B Schiöth, Suzanne Craft, Samantha J Brooks, William H Frey, Christian Benedic. Brain insulin signaling and Alzheimer's disease: current evidence and future directions. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22205300. |
brain insulin signaling and alzheimer's disease: current evidence and future directions. |
2013-01-31 |
2023-08-12 |
Not clear |
| Helgi B Schiöth, Suzanne Craft, Samantha J Brooks, William H Frey, Christian Benedic. Brain insulin signaling and Alzheimer's disease: current evidence and future directions. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22205300. |
since alzheimer's disease (ad) is linked to cns insulin resistance, decreased expression of insulin and insulin receptor genes and attenuated permeation of blood-borne insulin across the blood-brain barrier, impaired brain insulin signaling could partially account for the cognitive deficits associated with this disease. |
2013-01-31 |
2023-08-12 |
Not clear |
| Takayuki Nemoto, Toshihiko Yanagita, Shinya Satoh, Toyoaki Maruta, Tasuku Kanai, Manabu Murakami, Akihiko Wad. Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase~mammalian target of rapamycin pathway. Neurochemistry international. vol 59. issue 6. 2013-01-29. PMID:21854819. |
both insulin and tau, promoting neuronal differentiation (neurite outgrowth, neuronal polarity, and myelination) and cell survival, are associated with neurodegenerative disease (e.g., alzheimer's disease). |
2013-01-29 |
2023-08-12 |
cattle |
| Sung Min Son, Hyundong Song, Jayoung Byun, Kyong Soo Park, Hak Chul Jang, Young Joo Park, Inhee Mook-Jun. Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway. Diabetes. vol 61. issue 12. 2013-01-25. PMID:22829447. |
insulin resistance, one of the major components of type 2 diabetes mellitus (t2dm), is a known risk factor for alzheimer's disease (ad), which is characterized by an abnormal accumulation of intra- and extracellular amyloid β peptide (aβ). |
2013-01-25 |
2023-08-12 |
mouse |
| Sirisha Nandipati, Xiaodong Luo, Corbett Schimming, Hillel T Grossman, Mary San. Cognition in non-demented diabetic older adults. Current aging science. vol 5. issue 2. 2013-01-08. PMID:22023096. |
evidence links diabetes mellitus to cognitive impairment and increased risk of alzheimer's disease (ad) and suggests that insulin therapy improves cognition. |
2013-01-08 |
2023-08-12 |
human |
| William A Banks, Joshua B Owen, Michelle A Erickso. Insulin in the brain: there and back again. Pharmacology & therapeutics. vol 136. issue 1. 2013-01-04. PMID:22820012. |
cns insulin resistance is associated with alzheimer's disease, depression, and impaired baroreceptor gain in pregnancy. |
2013-01-04 |
2023-08-12 |
Not clear |
| Paula I Moreir. Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin. Journal of Alzheimer's disease : JAD. vol 30 Suppl 2. 2012-12-12. PMID:22269163. |
alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin. |
2012-12-12 |
2023-08-12 |
Not clear |
| Suzanne M de la Monte, Edward Re, Lisa Longato, Ming Ton. Dysfunctional pro-ceramide, ER stress, and insulin/IGF signaling networks with progression of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 30 Suppl 2. 2012-12-12. PMID:22297646. |
in alzheimer's disease (ad), brain insulin and insulin-like growth factor (igf) resistance and deficiency begin early, and worsen with severity of disease. |
2012-12-12 |
2023-08-12 |
human |
| Suzanne M de la Mont. Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed. Journal of Alzheimer's disease : JAD. vol 30 Suppl 2. 2012-12-12. PMID:22337830. |
triangulated mal-signaling in alzheimer's disease: roles of neurotoxic ceramides, er stress, and insulin resistance reviewed. |
2012-12-12 |
2023-08-12 |
Not clear |
| B Cholerton, L D Baker, S Craf. Insulin resistance and pathological brain ageing. Diabetic medicine : a journal of the British Diabetic Association. vol 28. issue 12. 2012-12-10. PMID:21974744. |
with more extreme pathology, brain insulin resistance may be associated with neurogenerative diseases such as alzheimer's disease, and the condition which precedes alzheimer's disease, known as amnestic mild cognitive impairment. |
2012-12-10 |
2023-08-12 |
Not clear |
| Cora O'Neill, Aoife P Kiely, Meghan F Coakley, Sean Manning, Caitriona M Long-Smit. Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817723. |
insulin and igf-1 signalling: longevity, protein homoeostasis and alzheimer's disease. |
2012-12-07 |
2023-08-12 |
Not clear |