| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca J Smith, Matthew S Savoian, Lauren E Weber, Jeong Hyeon Par. Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response. BMC molecular biology. vol 17. issue 1. 2017-09-13. PMID:27814680. |
ataxia telangiectasia mutated (atm) interacts with p400 atpase for an efficient dna damage response. |
2017-09-13 |
2023-08-13 |
Not clear |
| Rebecca J Smith, Matthew S Savoian, Lauren E Weber, Jeong Hyeon Par. Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response. BMC molecular biology. vol 17. issue 1. 2017-09-13. PMID:27814680. |
ataxia telangiectasia mutated (atm) and trrap proteins belong to the phosphatidylinositol 3-kinase-related kinase family and are involved in dna damage repair and chromatin remodeling. |
2017-09-13 |
2023-08-13 |
Not clear |
| Esmaeil Mortaz, Sayed Mehran Marashian, Hosseinali Ghaffaripour, Mohammad Varahram, Payam Mehrian, Atosa Dorudinia, Johan Garssen, Ian M Adcock, Malcolm Taylor, Seyed Alireza Mahdavian. A new ataxia-telangiectasia mutation in an 11-year-old female. Immunogenetics. vol 69. issue 7. 2017-09-13. PMID:28488180. |
a-t is associated mainly with mutations in the ataxia telangiectasia mutated (atm) gene, which encodes a protein kinase that has a major role in the cellular response to dna damage. |
2017-09-13 |
2023-08-13 |
human |
| Lara Barazzuol, Limei Ju, Penny A Jegg. A coordinated DNA damage response promotes adult quiescent neural stem cell activation. PLoS biology. vol 15. issue 5. 2017-08-25. PMID:28489848. |
these 3 responses are ataxia telangiectasia mutated (atm)-dependent and promote quiescent nsc (qnsc) activation, which does not occur in the subdomains that lack progenitors. |
2017-08-25 |
2023-08-13 |
Not clear |
| Martyn K White, Anna Bellizzi, Gabriele Ibba, Valeria Pietropaolo, Anna T Palamara, Hassen S Wolleb. The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation. Virology journal. vol 14. issue 1. 2017-08-23. PMID:28202068. |
ddr is also known to stimulate nf-κb activity, a phenomenon known as nucleus to cytoplasm or "inside-out" nf-κb signaling, which is initiated by ataxia telangiectasia mutated (atm) protein, a serine/threonine kinase recruited and activated by dna double-strand breaks. |
2017-08-23 |
2023-08-13 |
human |
| Xiang Ding, Qiukui Hao, Ming Yang, Tie Chen, Shanping Chen, Jirong Yue, Sean X Leng, Birong Don. Polymorphism rs189037C > T in the promoter region of the ATM gene may associate with reduced risk of T2DM in older adults in China: a case control study. BMC medical genetics. vol 18. issue 1. 2017-08-21. PMID:28806901. |
recent evidence indicates that ataxia telangiectasia mutated (atm) is a cytoplasmic protein that involves in insulin signaling pathways. |
2017-08-21 |
2023-08-13 |
Not clear |
| Angelo Agathanggelou, Edward Smith, Nicholas J Davies, Marwan Kwok, Anastasia Zlatanou, Ceri E Oldreive, Jingwen Mao, David Da Costa, Sina Yadollahi, Tracey Perry, Pamela Kearns, Anna Skowronska, Elliot Yates, Helen Parry, Peter Hillmen, Celine Reverdy, Remi Delansorne, Shankara Paneesha, Guy Pratt, Paul Moss, A Malcolm R Taylor, Grant S Stewart, Tatjana Stankovi. USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status. Blood. vol 130. issue 2. 2017-08-15. PMID:28495793. |
to test this hypothesis, we studied the effect of usp7 inhibition in chronic lymphocytic leukemia (cll) where the ataxia telangiectasia mutated (atm)-p53 pathway is inactivated with relatively high frequency, leading to treatment resistance and poor clinical outcome. |
2017-08-15 |
2023-08-13 |
Not clear |
| Reut Yosef, Noam Pilpel, Nurit Papismadov, Hilah Gal, Yossi Ovadya, Ezra Vadai, Stav Miller, Ziv Porat, Shifra Ben-Dor, Valery Krizhanovsk. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling. The EMBO journal. vol 36. issue 15. 2017-08-11. PMID:28607003. |
upon p21 knockdown, senescent cells acquired multiple dna lesions that activated ataxia telangiectasia mutated (atm) and nuclear factor (nf)-κb kinase, leading to decreased cell survival. |
2017-08-11 |
2023-08-13 |
mouse |
| Kalpana Mujoo, Clayton R Hunt, Nobuo Horikoshi, Tej K Pandit. A multifaceted role for MOF histone modifying factor in genome maintenance. Mechanisms of ageing and development. vol 161. issue Pt A. 2017-08-07. PMID:27038808. |
for example, recent results indicate mof is an upstream regulator of the atm (ataxia-telangiectasia mutated) protein, the loss of which is responsible for ataxia telangiectasia (at). |
2017-08-07 |
2023-08-13 |
drosophila_melanogaster |
| Fernando Anjos-Afonso, Joanna I Loizou, Amy Bradburn, Nnennaya Kanu, Sukhveer Purewal, Clive Da Costa, Dominique Bonnet, Axel Behren. Perturbed hematopoiesis in mice lacking ATMIN. Blood. vol 128. issue 16. 2017-08-04. PMID:27581360. |
the ataxia telangiectasia mutated (atm)-interacting protein atmin mediates noncanonical atm signaling in response to oxidative and replicative stress conditions. |
2017-08-04 |
2023-08-13 |
mouse |
| Xiaofan Li, Eric M Burton, Sumita Bhaduri-McIntos. Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells. PLoS pathogens. vol 13. issue 3. 2017-08-03. PMID:28249048. |
specifically, chloroquine utilizes ataxia telangiectasia mutated (atm) to phosphorylate the universal transcriptional corepressor krüppel-associated box-associated protein 1/tripartite motif-containing protein 28 (kap1/trim28) at serine 824 -a mechanism that typically facilitates repair of double-strand breaks in heterochromatin, to instead activate ebv. |
2017-08-03 |
2023-08-13 |
Not clear |
| Vanessa Enriquez-Rios, Lavinia C Dumitrache, Susanna M Downing, Yang Li, Eric J Brown, Helen R Russell, Peter J McKinno. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123024. |
dna-pkcs (the catalytic subunit of the dna-dependent kinase, encoded by prkdc), atm (ataxia telangiectasia, mutated), and atr (atm and rad3-related) are related pi3k-like protein kinases and central regulators of the ddr. |
2017-08-01 |
2023-08-13 |
mouse |
| Sara Biagiotti, Michele Menotta, Sara Orazi, Chiara Spapperi, Serena Brundu, Alessandra Fraternale, Marzia Bianchi, Luigia Rossi, Luciana Chessa, Mauro Magnan. Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2-mediated antioxidant response. The FEBS journal. vol 283. issue 21. 2017-07-10. PMID:27636396. |
ataxia telangiectasia (a-t) is a rare incurable neurodegenerative disease caused by biallelic mutations in the gene for ataxia-telangiectasia mutated (atm). |
2017-07-10 |
2023-08-13 |
Not clear |
| Michael Choi, Thomas Kipps, Razelle Kurzroc. ATM Mutations in Cancer: Therapeutic Implications. Molecular cancer therapeutics. vol 15. issue 8. 2017-06-29. PMID:27413114. |
germ-line mutations of the ataxia telangiectasia mutated (atm) gene result in the well-characterized ataxia telangiectasia syndrome, which manifests with an increased cancer predisposition, including a 20% to 30% lifetime risk of lymphoid, gastric, breast, central nervous system, skin, and other cancers. |
2017-06-29 |
2023-08-13 |
Not clear |
| Vinod Vijay Subhash, Shi Hui Tan, Mei Shi Yeo, Fui Leng Yan, Praveen C Peethala, Natalia Liem, Vaidehi Krishnan, Wei Peng Yon. ATM Expression Predicts Veliparib and Irinotecan Sensitivity in Gastric Cancer by Mediating P53-Independent Regulation of Cell Cycle and Apoptosis. Molecular cancer therapeutics. vol 15. issue 12. 2017-06-15. PMID:27638859. |
the ataxia telangiectasia mutated (atm) kinase is a nuclear protein that plays a major role in the initiation of dna repair signaling and cell-cycle check points during dna damage. |
2017-06-15 |
2023-08-13 |
Not clear |
| Hyun Tae Kang, Joon Tae Park, Kobong Choi, Yongsub Kim, Hyo Jei Claudia Choi, Chul Won Jung, Young-Sam Lee, Sang Chul Par. Chemical screening identifies ATM as a target for alleviating senescence. Nature chemical biology. vol 13. issue 6. 2017-06-13. PMID:28346404. |
here, we performed high-throughput screening to identify compounds that alleviate senescence and identified the ataxia telangiectasia mutated (atm) inhibitor ku-60019 as an effective agent. |
2017-06-13 |
2023-08-13 |
Not clear |
| Sébastien L Degorce, Bernard Barlaam, Elaine Cadogan, Allan Dishington, Richard Ducray, Steven C Glossop, Lorraine A Hassall, Franck Lach, Alan Lau, Thomas M McGuire, Thorsten Nowak, Gilles Ouvry, Kurt G Pike, Andrew G Thomaso. Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase. Journal of medicinal chemistry. vol 59. issue 13. 2017-05-29. PMID:27259031. |
discovery of novel 3-quinoline carboxamides as potent, selective, and orally bioavailable inhibitors of ataxia telangiectasia mutated (atm) kinase. |
2017-05-29 |
2023-08-13 |
Not clear |
| Sébastien L Degorce, Bernard Barlaam, Elaine Cadogan, Allan Dishington, Richard Ducray, Steven C Glossop, Lorraine A Hassall, Franck Lach, Alan Lau, Thomas M McGuire, Thorsten Nowak, Gilles Ouvry, Kurt G Pike, Andrew G Thomaso. Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase. Journal of medicinal chemistry. vol 59. issue 13. 2017-05-29. PMID:27259031. |
a novel series of 3-quinoline carboxamides has been discovered and optimized as selective inhibitors of the ataxia telangiectasia mutated (atm) kinase. |
2017-05-29 |
2023-08-13 |
Not clear |
| Maria Piane, Anna Molinaro, Annarosa Soresina, Silvia Costa, Marianna Maffeis, Aldo Germani, Lorenzo Pinelli, Roberta Meschini, Alessandro Plebani, Luciana Chessa, Roberto Michel. Novel compound heterozygous mutations in a child with Ataxia-Telangiectasia showing unrelated cerebellar disorders. Journal of the neurological sciences. vol 371. 2017-05-26. PMID:27871447. |
the molecular analysis of atm (ataxia telangiectasia mutated) gene showed that the patient is compound heterozygote for two previously unreported mutations: c.3291delc (p.phe1097fs) at exon 25 and c.8198a>c (p.gln2733pro) at exon 58. |
2017-05-26 |
2023-08-13 |
Not clear |
| Maria Piane, Anna Molinaro, Annarosa Soresina, Silvia Costa, Marianna Maffeis, Aldo Germani, Lorenzo Pinelli, Roberta Meschini, Alessandro Plebani, Luciana Chessa, Roberto Michel. Novel compound heterozygous mutations in a child with Ataxia-Telangiectasia showing unrelated cerebellar disorders. Journal of the neurological sciences. vol 371. 2017-05-26. PMID:27871447. |
the role of the identified atm gene mutations in the pathogenesis of ataxia telangiectasia and the coexisting cerebellar disorders is discussed. |
2017-05-26 |
2023-08-13 |
Not clear |