| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreea Nissenkorn, Bruria Ben-Zee. Ataxia telangiectasia. Handbook of clinical neurology. vol 132. 2016-08-22. PMID:26564081. |
ataxia telangiectasia (at) is an autosomal recessive multisystem genetic disorder caused by a mutation in the atm gene encoding for the atm protein. |
2016-08-22 |
2023-08-13 |
Not clear |
| Shane M Harding, Jonathan A Boiarsky, Roger A Greenber. ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition. Cell reports. vol 13. issue 2. 2016-08-04. PMID:26440899. |
dsb repair in transcriptionally active genomic regions represents a unique challenge that is associated with ataxia telangiectasia mutated (atm) kinase-mediated transcriptional silencing. |
2016-08-04 |
2023-08-13 |
Not clear |
| Shiyuan Hong, Shouqiang Cheng, Andre Iovane, Laimonis A Laimin. STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication. mBio. vol 6. issue 6. 2016-08-04. PMID:26695634. |
the ataxia telangiectasia (atm) pathway repairs double-strand breaks in dna, while the ataxia telangiectasia and rad3-related (atr) pathway targets single-strand breaks. |
2016-08-04 |
2023-08-13 |
human |
| Lin Feng, Nan Li, Yujing Li, Jiadong Wang, Min Gao, Wenqi Wang, Junjie Che. Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1. Cell discovery. vol 1. 2016-07-27. PMID:27462418. |
53bp1 protects dna broken ends from resection by recruiting two downstream factors, rif1 (rap1-interacting factor 1) and ptip (pax transactivation domain-interacting protein), to double-stranded breaks (dsbs) via atm (ataxia telangiectasia mutated)-mediated 53bp1 phosphorylation, and competes with brca1-mediated homologous recombination (hr) repair in g1 phase. |
2016-07-27 |
2023-08-13 |
Not clear |
| Naoto Tatewaki, Tetsuya Konishi, Yuki Nakajima, Miyako Nishida, Masafumi Saito, Takahiro Eitsuka, Toshiyuki Sakamaki, Nobuo Ikekawa, Hiroshi Nishid. Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase. PloS one. vol 11. issue 1. 2016-07-26. PMID:26824362. |
ataxia telangiectasia mutated (atm) kinase plays a crucial role as a master controller in the cellular dna damage response. |
2016-07-26 |
2023-08-13 |
Not clear |
| Yao-Cheng Lu, Meng-Liang Lin, Hong-Lin Su, Shih-Shun Che. ER-Dependent Ca++-mediated Cytosolic ROS as an Effector for Induction of Mitochondrial Apoptotic and ATM-JNK Signal Pathways in Gallic Acid-treated Human Oral Cancer Cells. Anticancer research. vol 36. issue 2. 2016-07-12. PMID:26851027. |
small interfering rna-mediated suppression of protein kinase rna-like endoplasmic reticulum kinase inhibited tunicamycin-induced induction of 78 kda glucose-regulated protein, c/ebp homologous protein, pro-caspase-12 cleavage, cytosolic ca(++) increase and apoptosis, but did not attenuate the increase in cytosolic ca(++) level and apoptosis induced by ga. ataxia telangiectasia mutated (atm)-mediated c-jun n-terminal kinase (jnk) phosphorylation and apoptosis by ga was blocked by dantrolene. |
2016-07-12 |
2023-08-13 |
human |
| Akihiro Watari, Maki Hasegawa, Kiyohito Yagi, Masuo Kondo. Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression. PloS one. vol 11. issue 1. 2016-06-27. PMID:26727128. |
caffeine, which is an inhibitor of ataxia telangiectasia mutated protein (atm) and ataxia telangiectasia mutated and rad3-related protein (atr), and the chk1 inhibitor inhibited the ter increases induced by daunorubicin and rebeccamycin, whereas a chk2 inhibitor did not. |
2016-06-27 |
2023-08-13 |
human |
| Ammad Ahmad Farooqi, Shyh-Jong Wu, Yung-Ting Chang, Jen-Yang Tang, Kun-Tzu Li, Muhammad Ismail, Chih-Chuang Liaw, Ruei-Nian Li, Hsueh-Wei Chan. Activation and Inhibition of ATM by Phytochemicals: Awakening and Sleeping the Guardian Angel Naturally. Archivum immunologiae et therapiae experimentalis. vol 63. issue 5. 2016-06-20. PMID:26089209. |
increasing understanding of dna damage signaling has provided an ever-expanding list of modulators reported to orchestrate dna damage repair and ataxia telangiectasia mutated (atm) is the master regulator and main transducer of the dsb response. |
2016-06-20 |
2023-08-13 |
Not clear |
| Anamaria G Zavala, John M O'Dowd, Elizabeth A Fortunat. Infection of a Single Cell Line with Distinct Strains of Human Cytomegalovirus Can Result in Large Variations in Virion Production and Facilitate Efficient Screening of Virus Protein Function. Journal of virology. vol 90. issue 5. 2016-06-20. PMID:26676783. |
previously, we reported that the absence of the ataxia telangiectasia mutated (atm) kinase, a critical dna damage response (ddr) signaling component for double-strand breaks, caused no change in hcmv towne virion production. |
2016-06-20 |
2023-08-13 |
human |
| Jeffrey M Sifford, James A Stahl, Eduardo Salinas, J Craig Forres. Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication. Journal of virology. vol 90. issue 5. 2016-06-20. PMID:26676792. |
here, we demonstrate that mhv68 lytic infection induces p53 phosphorylation and stabilization in a manner that is dependent on the dna damage response (ddr) kinase ataxia telangiectasia mutated (atm). |
2016-06-20 |
2023-08-13 |
mouse |
| Marwan Kwok, Nicholas Davies, Angelo Agathanggelou, Edward Smith, Ceri Oldreive, Eva Petermann, Grant Stewart, Jeff Brown, Alan Lau, Guy Pratt, Helen Parry, Malcolm Taylor, Paul Moss, Peter Hillmen, Tatjana Stankovi. ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells. Blood. vol 127. issue 5. 2016-06-17. PMID:26563132. |
tp53 and ataxia telangiectasia mutated (atm) defects are associated with genomic instability, clonal evolution, and chemoresistance in chronic lymphocytic leukemia (cll). |
2016-06-17 |
2023-08-13 |
Not clear |
| Tina M Thornton, Pilar Delgado, Liang Chen, Beatriz Salas, Dimitry Krementsov, Miriam Fernandez, Santiago Vernia, Roger J Davis, Ruth Heimann, Cory Teuscher, Michael S Krangel, Almudena R Ramiro, Mercedes Rincó. Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response. Nature communications. vol 7. 2016-06-17. PMID:26822034. |
here we show that phosphorylation of gsk3β on ser(389) by p38 mapk (mitogen-activated protein kinase) is induced selectively by dsbs through atm (ataxia telangiectasia mutated) as a unique mechanism to attenuate the activity of nuclear gsk3β and promote survival of cells undergoing dsbs. |
2016-06-17 |
2023-08-13 |
mouse |
| Francois Aymard, Gaëlle Legub. A TAD closer to ATM. Molecular & cellular oncology. vol 3. issue 3. 2016-06-17. PMID:27314089. |
ataxia telangiectasia mutated (atm) has been known for decades as the main kinase mediating the dna double-strand break response. |
2016-06-17 |
2023-08-13 |
Not clear |
| HaiYang Wang, YiBo Luo, ZiLi Lin, In-Won Lee, Jeongwoo Kwon, Xiang-Shun Cui, Nam-Hyung Ki. Effect of ATM and HDAC Inhibition on Etoposide-Induced DNA Damage in Porcine Early Preimplantation Embryos. PloS one. vol 10. issue 11. 2016-06-16. PMID:26556501. |
caffeine, which is an atm (ataxia telangiectasia mutated) and atr (ataxia telangiectasia and rad3-related protein) kinase inhibitor, and ku55933, which is an atm kinase inhibitor, were equally effective in rescuing the etoposide-induced cell-cycle blocks. |
2016-06-16 |
2023-08-13 |
Not clear |
| Monica M Olcina, Roger Ja Grand, Ester M Hammon. ATM activation in hypoxia - causes and consequences. Molecular & cellular oncology. vol 1. issue 1. 2016-06-16. PMID:27308313. |
the integral role of ataxia telangiectasia mutated (atm) kinase in the response to dna damaging agents is well characterized; however, atm can also be activated by non-dna damaging agents. |
2016-06-16 |
2023-08-13 |
Not clear |
| Andreas Kakarougkas, Jessica A Downs, Penny A Jegg. The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks. Molecular & cellular oncology. vol 2. issue 1. 2016-06-16. PMID:27308404. |
transcription in the vicinity of dna double-strand breaks (dsbs) is suppressed via a process involving ataxia telangiectasia mutated protein (atm) and h2ak119 ubiquitylation. |
2016-06-16 |
2023-08-13 |
Not clear |
| Gwenola Manic, Florine Obrist, Antonella Sistigu, Ilio Vital. Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy. Molecular & cellular oncology. vol 2. issue 4. 2016-06-16. PMID:27308506. |
the ataxia telangiectasia mutated serine/threonine kinase (atm)/checkpoint kinase 2 (chek2, best known as chk2) and the atm and rad3-related serine/threonine kinase (atr)/chek1 (best known as chk1) cascades are the 2 major signaling pathways driving the dna damage response (ddr), a network of processes crucial for the preservation of genomic stability that act as a barrier against tumorigenesis and tumor progression. |
2016-06-16 |
2023-08-13 |
Not clear |
| Nuala McCabe, Steven M Walker, Richard D Kenned. When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers. Molecular & cellular oncology. vol 3. issue 1. 2016-06-16. PMID:27308567. |
ataxia telangiectasia mutated (atm) is an important signaling molecule in the dna damage response and inhibitors of atm are under clinical development. |
2016-06-16 |
2023-08-13 |
Not clear |
| Wuli Zhao, Caixia Zhang, Chongwen Bi, Cheng Ye, Danqing Song, Xiujun Liu, Rongguang Sha. Sophoridinol derivative 05D induces tumor cells apoptosis by topoisomerase1-mediated DNA breakage. OncoTargets and therapy. vol 9. 2016-06-09. PMID:27274276. |
05d suppressed the ataxia telangiectasia mutated (atm) and atm and rad3-related (atr) activation and decreased 53bp level, which contributed to dna damage repair, suggesting that the novel compound 05d might be helpful to improve the antitumor activity of dna damaging agent by repressing atm and atr activation and 53bp level. |
2016-06-09 |
2023-08-13 |
Not clear |
| Manbok Ki. Naturally occurring reoviruses for human cancer therapy. BMB reports. vol 48. issue 8. 2016-06-03. PMID:26058397. |
many tumor suppressor genes such as p53, ataxia telangiectasia mutated (atm), and retinoblastoma associated (rb) are known to play important roles in genomic fidelity/maintenance. |
2016-06-03 |
2023-08-13 |
human |