| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Ye, Ning Hou, Lu Xiao, Yifan Xu, Haodong Xu, Faqian L. Dynamic monitoring of oxidative DNA double-strand break and repair in cardiomyocytes. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 25. issue 2. 2016-12-13. PMID:26764141. |
after 30 min, 200 μmol/l of h2o2 treatment, γ-h2ax levels were highest within the first hour and then gradually declined during the recovery and returned to basal levels at 48 h. among dna damage transducer kinases, ataxia telangiectasia mutated (atm) was significantly activated by h2o2 in contrast to mild activation of atr (atm and rad3-related). |
2016-12-13 |
2023-08-13 |
rat |
| Zhen Yang, Yi Shen, Hisashi Oishi, Eric L Matteson, Lu Tian, Jörg J Goronzy, Cornelia M Weyan. Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis. Science translational medicine. vol 8. issue 331. 2016-12-13. PMID:27009267. |
with surplus reductive equivalents, ra t cells insufficiently activated the redox-sensitive kinase ataxia telangiectasia mutated (atm), bypassed the g2/m cell cycle checkpoint, and hyperproliferated. |
2016-12-13 |
2023-08-13 |
Not clear |
| E Datan, S G Roy, G Germain, N Zali, J E McLean, G Golshan, S Harbajan, R A Lockshin, Z Zaker. Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation. Cell death & disease. vol 7. 2016-11-14. PMID:26938301. |
in this study, we evaluate how it does so; we show that dengue upregulates host pathways that increase autophagy, namely endoplasmic reticulum (er) stress and ataxia telangiectasia mutated (atm) signaling followed by production of reactive oxygen species (ros). |
2016-11-14 |
2023-08-13 |
Not clear |
| Frank P Vendetti, Alan Lau, Sandra Schamus, Thomas P Conrads, Mark J O'Connor, Christopher J Bakkenis. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. vol 6. issue 42. 2016-11-07. PMID:26517239. |
atm has been widely studied since ataxia telangiectasia individuals who express no atm protein are the most radiosensitive patients identified. |
2016-11-07 |
2023-08-13 |
mouse |
| Chiou-Feng Lin, Shun-Yi Chien, Chia-Ling Chen, Chia-Yuan Hsieh, Po-Chun Tseng, Yu-Chih Wan. IFN-γ Induces Mimic Extracellular Trap Cell Death in Lung Epithelial Cells Through Autophagy-Regulated DNA Damage. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 36. issue 2. 2016-11-04. PMID:26540174. |
following caspase-mediated lamin degradation, ifn-γ caused dna damage-associated ataxia telangiectasia and rad3-related protein (atr)/ataxia telangiectasia mutated (atm)-regulated mimic etosis. |
2016-11-04 |
2023-08-13 |
human |
| Emily A Resseguie, Rhonda J Staversky, Paul S Brookes, Michael A O'Reill. Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction. Redox biology. vol 5. 2016-11-01. PMID:25967673. |
ataxia telangiectasia mutated (atm) kinase is activated by nuclear dna double strand breaks and delays hyperoxia-induced cell death through downstream targets p53 and p21. |
2016-11-01 |
2023-08-13 |
Not clear |
| Ashay D Bhatwadekar, Yaqian Duan, Harshini Chakravarthy, Maria Korah, Sergio Caballero, Julia V Busik, Maria B Gran. Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy. Stem cells (Dayton, Ohio). vol 34. issue 2. 2016-10-31. PMID:26502796. |
ataxia telangiectasia mutated (atm) acts as a defense against a variety of bone marrow (bm) stressors. |
2016-10-31 |
2023-08-13 |
human |
| Ayushi Guleria, Sudhir Chandn. ATM kinase: Much more than a DNA damage responsive protein. DNA repair. vol 39. 2016-10-28. PMID:26777338. |
atm, mutation of which causes ataxia telangiectasia, has emerged as a cardinal multifunctional protein kinase during past two decades as evidenced by various studies from around the globe. |
2016-10-28 |
2023-08-13 |
Not clear |
| Xuting Shen, Jianmin Chen, Jiali Li, Julia Kofler, Karl Herru. Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling. eNeuro. vol 3. issue 1. 2016-10-27. PMID:27022623. |
ataxia telangiectasia (a-t) is a multisystemic disease caused by mutations in the atm (a-t mutated) gene. |
2016-10-27 |
2023-08-13 |
mouse |
| Hongrui Guo, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Bangyuan Wu, Kejie Chen, Jie Den. Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney. Oncotarget. vol 6. issue 34. 2016-10-25. PMID:26440151. |
the g2/m cell cycle arrest was accompanied by up-regulation of phosphorylated ataxia telangiectasia mutated (p-atm), p53, p-chk1, p-chk2, p21 protein expression and atm, p53, p21, chk1, chk2 mrna expression, and down-regulation of p-cdc25c, cdc2, cyclinb and proliferating cell nuclear antigen (pcna) protein expression and the cdc25, cdc2, cyclinb, pcna mrna expression. |
2016-10-25 |
2023-08-13 |
Not clear |
| Yu-Wei Chou, Gopal Chandru Senadi, Chung-Yu Chen, Kung-Kai Kuo, Ying-Ting Lin, Jeh-Jeng Wang, Jia-Hau Lee, Ya-Ching Wang, Wan-Ping H. Design and synthesis of pyrrolobenzodiazepine-gallic hybrid agents as p53-dependent and -independent apoptogenic signaling in melanoma cells. European journal of medicinal chemistry. vol 109. 2016-10-21. PMID:26756315. |
these pbd conjugates caused s phase arrest for the a375 cell line via increased reactive oxygen species (ros) generation, deoxyribonucleic acid (dna) damage, ataxia telangiectasia mutated (atm)/atm-rad3-related (atr) and checkpoint kinases 1 (chk1) activation. |
2016-10-21 |
2023-08-13 |
mouse |
| Wen-Jian Meng, Surajit Pathak, Zhen-Yu Ding, Hong Zhang, Gunnar Adell, Birgitta Holmlund, Yuan Li, Zong-Guang Zhou, Xiao-Feng Su. Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer. Cancer biology & therapy. vol 16. issue 12. 2016-10-20. PMID:26528635. |
satb1 negatively correlated with ataxia telangiectasia mutated (atm) and prb2/p130, and positively with ki-67 and survivin in rt patients, and their potential interaction through different canonical pathways was identified in network ideogram. |
2016-10-20 |
2023-08-13 |
human |
| Donatella Vecchio, Guido Frosin. Targeting the Ataxia Telangiectasia Mutated Protein in Cancer Therapy. Current drug targets. vol 17. issue 2. 2016-10-13. PMID:25382204. |
ataxia telangiectasia mutated (atm) protein plays a central role in this response: activated by dna damage, atm phosphorylates itself and downstream effectors that arrest cell cycle allowing for dna repair or, should dna damage be too severe and not retrievable, inducing apoptosis. |
2016-10-13 |
2023-08-13 |
Not clear |
| Stephane Tarrade, Tanya Bhardwaj, Matthew Flegal, Lindsey Bertrand, Ilya Velegzhaninov, Alexey Moskalev, Dmitry Kloko. Histone H2AX Is Involved in FoxO3a-Mediated Transcriptional Responses to Ionizing Radiation to Maintain Genome Stability. International journal of molecular sciences. vol 16. issue 12. 2016-10-05. PMID:26694365. |
it is downstream of ataxia telangiectasia mutated (atm) damage signaling pathway and there is an emerging role of the transcription factor foxo3a, a regulator of a variety of other pathways, in activating this signaling. |
2016-10-05 |
2023-08-13 |
mouse |
| Suzanne M Maho. Management of Individuals With a Mutation in the Ataxia Telangiectasia Mutated Gene. Oncology nursing forum. vol 43. issue 1. 2016-09-29. PMID:26679451. |
one such gene is the ataxia telangiectasia mutated (atm) gene, which is available on many genetic panels offered to individuals with suspected hereditary risk. |
2016-09-29 |
2023-08-13 |
Not clear |
| Lara Barazzuol, Nicole Rickett, Limei Ju, Penny A Jegg. Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells. Journal of cell science. vol 128. issue 19. 2016-09-16. PMID:26303202. |
we used mice with a hypomorphic mutation in dna ligase iv (lig4(y288c)), ataxia telangiectasia mutated (atm(-/-)) and double mutant atm(-/-)/lig4(y288c) mice. |
2016-09-16 |
2023-08-13 |
mouse |
| Rosanna Beraldi, Chun-Hung Chan, Christopher S Rogers, Attila D Kovács, David K Meyerholz, Constantin Trantzas, Allyn M Lambertz, Benjamin W Darbro, Krystal L Weber, Katherine A M White, Richard V Rheeden, Michael C Kruer, Brian A Dacken, Xiao-Jun Wang, Bryan T Davis, Judy A Rohret, Jason T Struzynski, Frank A Rohret, Jill M Weimer, David A Pearc. A novel porcine model of ataxia telangiectasia reproduces neurological features and motor deficits of human disease. Human molecular genetics. vol 24. issue 22. 2016-09-12. PMID:26374845. |
ataxia telangiectasia (at) is a progressive multisystem disorder caused by mutations in the at-mutated (atm) gene. |
2016-09-12 |
2023-08-13 |
human |
| In-geun Ryoo, Sang-hwan Lee, Mi-Kyoung Kwa. Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance. Oxidative medicine and cellular longevity. vol 2016. 2016-09-12. PMID:26682001. |
current literatures demonstrate that the activation of ataxia telangiectasia mutated (atm) and forkhead box o3 (foxo3) is associated with the maintenance of low ros levels in normal stem cells such as hematopoietic stem cells. |
2016-09-12 |
2023-08-13 |
Not clear |
| Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, Béatrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, Jason S Iacovoni, Alejandro Álvarez-Quilón, Felipe Cortés-Ledesma, Gaëlle Legub. Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks. Cell reports. vol 13. issue 8. 2016-09-07. PMID:26586426. |
dna double-strand breaks (dsbs) elicit the so-called dna damage response (ddr), largely relying on ataxia telangiectasia mutated (atm) and dna-dependent protein kinase (dna-pkcs), two members of the pi3k-like kinase family, whose respective functions during the sequential steps of the ddr remains controversial. |
2016-09-07 |
2023-08-13 |
Not clear |
| Jayadev Mavuluri, Swarnalatha Beesetti, Rohan Surabhi, Joachim Kremerskothen, Ganesh Venkatraman, Suresh K Rayal. Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Molecular and cellular biology. vol 36. issue 9. 2016-09-06. PMID:26929199. |
in this report, we show that kibra is a physiologically interacting reversible substrate of ataxia telangiectasia mutated (atm) kinase. |
2016-09-06 |
2023-08-13 |
Not clear |