| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mingjuan Yan, Chengyuan Tang, Zhengwei Ma, Shuang Huang, Zheng Don. DNA damage response in nephrotoxic and ischemic kidney injury. Toxicology and applied pharmacology. vol 313. 2017-05-24. PMID:27984128. |
in ischemic aki, ddr seems more complex and involves at least the ataxia telangiectasia mutated (atm), a member of the phosphatidylinositol 3-kinase-related kinase (pikk) family, and p53; however, while atm may promote dna repair, p53 may trigger cell death. |
2017-05-24 |
2023-08-13 |
Not clear |
| Zhenyou Zou, Mengjie Ni, Jing Zhang, Yongfeng Chen, Hongyu Ma, Shihan Qian, Longhua Tang, Jiamei Tang, Hailun Yao, Chengbin Zhao, Xiongwen Lu, Hongyang Sun, Jue Qian, Xiaoting Mao, Xulin Lu, Qun Liu, Juping Zen, Hanbing Wu, Zhaosheng Bao, Shudan Lin, Hongyu Sheng, Yunlong Li, Yong Liang, Zhiqiang Chen, Dan Zon. miR-30a can inhibit DNA replication by targeting RPA1 thus slowing cancer cell proliferation. The Biochemical journal. vol 473. issue 14. 2017-05-15. PMID:27208176. |
furthermore, ataxia telangiectasia mutated (atm) and checkpoint kinase 2 (chk2) were phosphorylated after dna damage, which induced p53 expression, thus triggering the s-phase checkpoint, arresting cell cycle progression and ultimately initiating cancer cell apoptosis. |
2017-05-15 |
2023-08-13 |
Not clear |
| Thomas J Kucharski, Timothy F Ng, David M Sharon, Pedram Navid-Azarbaijani, Mahvash Tavassoli, Jose G Teodor. Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral Replication. Journal of virology. vol 90. issue 20. 2017-05-09. PMID:27512067. |
we have previously demonstrated that dna damage signaling through the ataxia telangiectasia mutated (atm) pathway induces the translocation of apoptin from the cytoplasm to the nucleus, where it induces apoptosis. |
2017-05-09 |
2023-08-13 |
chicken |
| Yongmei Qi, Qian Qiu, Xueyan Gu, Yihong Tian, Yingmei Zhan. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Scientific reports. vol 6. 2017-05-01. PMID:27089984. |
the atm (ataxia telangiectasia mutated) protein has recently been proposed to play critical roles in the response to mitochondrial dysfunction by initiating mitophagy. |
2017-05-01 |
2023-08-13 |
human |
| Marcelo R Luizon, Walter L Eckalbar, Yao Wang, Stacy L Jones, Robin P Smith, Megan Laurance, Lawrence Lin, Paul J Gallins, Amy S Etheridge, Fred Wright, Yihui Zhou, Cliona Molony, Federico Innocenti, Sook Wah Yee, Kathleen M Giacomini, Nadav Ahitu. Genomic Characterization of Metformin Hepatic Response. PLoS genetics. vol 12. issue 11. 2017-04-28. PMID:27902686. |
these include an enhancer in an ataxia telangiectasia mutated (atm) intron that has snps in linkage disequilibrium with a metformin treatment response gwas lead snp (rs11212617) that showed increased enhancer activity for the associated haplotype. |
2017-04-28 |
2023-08-13 |
human |
| Senlin Huang, Yuzhao Zhang, Tao Zen. Effect of ATM-111 (G>A) Polymorphism on Cancer Risk: A Meta-Analysis. Genetic testing and molecular biomarkers. vol 20. issue 7. 2017-04-04. PMID:27227554. |
to assess the relationship between the ataxia telangiectasia mutated (atm) gene-111 (g>a) polymorphism and cancer risk. |
2017-04-04 |
2023-08-13 |
Not clear |
| Hiroshi Ureshino, Momoka Tanabe, Kazuya Kurogi, Masaharu Miyahara, Shinya Kimur. Acute Megakaryoblastic Leukemia with Myelodysplasia-related Changes Associated with ATM Gene Deletion. Internal medicine (Tokyo, Japan). vol 55. issue 12. 2017-03-27. PMID:27301517. |
ataxia telangiectasia mutated (atm) is a tumor suppressor gene, and its somatic inactivation plays a role in the pathogenesis of lymphoid malignancies. |
2017-03-27 |
2023-08-13 |
Not clear |
| Enea Gino Di Domenico, Luigi Toma, Valentina Bordignon, Elisabetta Trento, Giovanna D'Agosto, Paola Cordiali-Fei, Fabrizio Ensol. Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus. International journal of molecular sciences. vol 17. issue 6. 2017-03-23. PMID:27258263. |
during both the latent and the lytic cycle, kshv is programmed to express genes which selectively modulate the dna damage response (ddr) through the activation of the ataxia telangiectasia mutated (atm) pathway and by phosphorylating factors associated with the ddr, including the major tumor suppressor protein p53 tumor suppressor p53. |
2017-03-23 |
2023-08-13 |
human |
| S V Khoronenkov. Mechanisms of Non-canonical Activation of Ataxia Telangiectasia Mutated. Biochemistry. Biokhimiia. vol 81. issue 13. 2017-03-07. PMID:28260489. |
noncanonical atm activation may be important for the pathology of the multisystemic disease ataxia telangiectasia. |
2017-03-07 |
2023-08-13 |
Not clear |
| Ping Zhou, Nan Jiang, Guo-Xia Zhang, Qing Su. MiR-203 inhibits tumor invasion and metastasis in gastric cancer by ATM. Acta biochimica et biophysica Sinica. vol 48. issue 8. 2017-02-13. PMID:27542403. |
our results showed that mir-203 was significantly downregulated in gastric cancer tissues and cells, while ataxia telangiectasia mutated kinase (atm) was upregulated in gastric cancer tissues and cells and was directly regulated by mir-203. |
2017-02-13 |
2023-08-13 |
Not clear |
| Ipsita Pal, Kaushik Kumar Dey, Madhuri Chaurasia, Sheetal Parida, Subhayan Das, Y Rajesh, Kulbhushan Sharma, Tamohan Chowdhury, Mahitosh Manda. Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26631035. |
here, we suggest that the combination of bi-69a11 and celecoxib inhibits the phosphorylation of ataxia telangiectasia mutated (atm) kinase and dna-pk responsible for ionizing radiation (ir)-induced double-strand break (dsb) repair. |
2017-02-06 |
2023-08-13 |
Not clear |
| Prashant Rai, Fang He, Jimmy Kwang, Bevin P Engelward, Vincent T K Cho. Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest. Scientific reports. vol 6. 2017-01-30. PMID:27026501. |
here, we show that pneumolysin, which is released during bacterial lysis, induces dna double strand breaks (dsbs), as indicated by ataxia telangiectasia mutated (atm)-mediated h2ax phosphorylation (γh2ax). |
2017-01-30 |
2023-08-13 |
Not clear |
| Yi-Li Feng, Ji-Feng Xiang, Na Kong, Xiu-Jun Cai, An-Yong Xi. Buried territories: heterochromatic response to DNA double-strand breaks. Acta biochimica et biophysica Sinica. vol 48. issue 7. 2017-01-30. PMID:27151295. |
this review will focus on the functions of the ataxia telangiectasia mutated (atm) signaling cascade involving atm, heterochromatin protein 1 (hp1), krüppel-associated box (krab)-associated protein-1 (kap-1), tat-interacting protein 60 (tip60), and many other protein factors in dsb-induced decondensation of heterochromatin and subsequent repair of heterochromatic dsbs. |
2017-01-30 |
2023-08-13 |
Not clear |
| Manjula Gorre, Prajitha Edathara Mohandas, Sailaja Kagita, Anuradha Cingeetham, Sugunakar Vuree, Sarika Jarjapu, Santhoshirani Nanchari, Phanni Bhushann Meka, Sandhya Annamaneni, Nageswara Rao Dunna, Raghunadharao Digumarti, Vishnupriya Satt. Significance of ATM Gene Polymorphisms in Chronic Myeloid Leukemia - a Case Control Study from India. Asian Pacific journal of cancer prevention : APJCP. vol 17. issue 2. 2017-01-19. PMID:26925685. |
development of chronic myeloid leukemia (cml) involves formation of double strand breaks (dsbs) which are initially sensed by the ataxia telangiectasia mutated (atm) signal kinase to induce a dna damage response (ddr). |
2017-01-19 |
2023-08-13 |
Not clear |
| Tsutomu Shimura, Junya Kobayashi, Kenshi Komatsu, Naoki Kunugit. Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells. Cell cycle (Georgetown, Tex.). vol 15. issue 8. 2017-01-06. PMID:26940879. |
to identify the small effects of low-dose radiation, we investigated how mitochondria respond to low-dose radiation in radiosensitive human ataxia telangiectasia mutated (atm)- and nijmegen breakage syndrome (nbs)1-deficient cell lines compared with corresponding cell lines expressing atm and nbs1. |
2017-01-06 |
2023-08-13 |
human |
| Paulina Tokarz, Kai Kaarniranta, Janusz Blasia. Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases. Rejuvenation research. vol 19. issue 2. 2017-01-02. PMID:26214710. |
dna damage activates ataxia telangiectasia mutated (atm), ataxia telangiectasia and rad3-related (atr), breast cancer 1 (brca1), e2f transcription factor 1 (e2f1), and other proteins that regulate the cell cycle, dna damage repair, and apoptosis. |
2017-01-02 |
2023-08-13 |
Not clear |
| Hong Zhan, Kenichi Aizawa, Junqing Sun, Shota Tomida, Kinya Otsu, Simon J Conway, Peter J Mckinnon, Ichiro Manabe, Issei Komuro, Kiyoshi Miyagawa, Ryozo Nagai, Toru Suzuk. Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity. Cardiovascular research. vol 110. issue 1. 2016-12-30. PMID:26862121. |
ataxia telangiectasia mutated (atm) kinase is thought to play a role in mediating the actions of oxidative stress. |
2016-12-30 |
2023-08-13 |
Not clear |
| Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wan. PTEN enhances G2/M arrest in etoposide-treated MCF‑7 cells through activation of the ATM pathway. Oncology reports. vol 35. issue 5. 2016-12-29. PMID:26986476. |
the dna damage-induced g2/m arrest results from the activation of protein kinase ataxia telangiectasia mutated (atm), followed by the activation of chk2 that subsequently inactivates cdc25c, resulting in g2/m arrest. |
2016-12-29 |
2023-08-13 |
Not clear |
| P J Connelly, N Smith, R Chadwick, A R Exley, J M Shneerson, E R Pearso. Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance. Diabetic medicine : a journal of the British Diabetic Association. vol 33. issue 3. 2016-12-13. PMID:26606753. |
recessive mutations in the cancer gene ataxia telangiectasia mutated (atm), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance. |
2016-12-13 |
2023-08-13 |
human |
| Sanjeev Choudhary, Istvan Boldogh, Allan R Brasie. Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity. Journal of innate immunity. vol 8. issue 2. 2016-12-13. PMID:26756522. |
in parallel, nuclear ros are detected by ataxia telangiectasia mutated (atm), a pi3 kinase activated by ros, triggering its nuclear export. |
2016-12-13 |
2023-08-13 |
Not clear |