| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A de Klein, M Muijtjens, R van Os, Y Verhoeven, B Smit, A M Carr, A R Lehmann, J H Hoeijmaker. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Current biology : CB. vol 10. issue 8. 2000-06-02. PMID:10801416. |
the atm gene is not essential, but mutations lead to ataxia telangiectasia (at), a pleiotropic disorder characterised by radiation sensitivity and cellular checkpoint defects in response to ionising radiation [4] [5] [6]. |
2000-06-02 |
2023-08-12 |
mouse |
| S Kovalev, A Mateen, A I Zaika, B J O'Hea, U M Mol. Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines. International journal of oncology. vol 16. issue 4. 2000-05-11. PMID:10717253. |
homozygous mutations of the gene mutated in ataxia telangiectasia (atm) causes the at syndrome, a pleiotropic phenotype that includes an increased risk of cancer. |
2000-05-11 |
2023-08-12 |
Not clear |
| S Boulton, S Kyle, B W Durkac. Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin. European journal of cancer (Oxford, England : 1990). vol 36. issue 4. 2000-05-04. PMID:10717533. |
these data suggest that wm inhibits in intact cells both dna-pk and either or both the ataxia telangiectasia (at) and at-related gene products atm and atr. |
2000-05-04 |
2023-08-12 |
Not clear |
| N Chiesa, C Barlow, A Wynshaw-Boris, P Strata, F Tempi. Atm-deficient mice Purkinje cells show age-dependent defects in calcium spike bursts and calcium currents. Neuroscience. vol 96. issue 3. 2000-04-27. PMID:10717437. |
ataxia telangiectasia in humans results from homozygous loss-of-function mutations in atm. |
2000-04-27 |
2023-08-12 |
mouse |
| C Schaffner, I Idler, S Stilgenbauer, H Döhner, P Lichte. Mantle cell lymphoma is characterized by inactivation of the ATM gene. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10706620. |
the deleted segment contains the atm (ataxia telangiectasia mutated) gene. |
2000-04-25 |
2023-08-12 |
Not clear |
| C Schaffner, I Idler, S Stilgenbauer, H Döhner, P Lichte. Mantle cell lymphoma is characterized by inactivation of the ATM gene. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10706620. |
atm is an interesting candidate as a tumor suppressor gene because constitutive inactivation of the gene predisposes ataxia telangiectasia patients to lymphoid malignancies. |
2000-04-25 |
2023-08-12 |
Not clear |
| D W Chan, S C Son, W Block, R Ye, K K Khanna, M S Wold, P Douglas, A A Goodarzi, J Pelley, Y Taya, M F Lavin, S P Lees-Mille. Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase. The Journal of biological chemistry. vol 275. issue 11. 2000-04-12. PMID:10713094. |
atm is mutated in the human genetic disorder ataxia telangiectasia, which is characterized by ataxia, immune defects, and cancer predisposition. |
2000-04-12 |
2023-08-12 |
human |
| M A Haidar, H Kantarjian, T Manshouri, C Y Chang, S O'Brien, E Freireich, M Keating, M Albita. ATM gene deletion in patients with adult acute lymphoblastic leukemia. Cancer. vol 88. issue 5. 2000-04-07. PMID:10699895. |
loss of heterozygosity (loh) at the atm gene (mutated in ataxia telangiectasia [at] patients) and atm protein deficiency occur in 14% and 34%, respectively, of patients with chronic lymphocytic leukemia (cll). |
2000-04-07 |
2023-08-12 |
Not clear |
| T Souss. [Card no. 32: ATM (Ataxia Telangiectasia Mutated)]. Bulletin du cancer. vol 87. issue 2. 2000-04-05. PMID:10705278. |
32: atm (ataxia telangiectasia mutated)]. |
2000-04-05 |
2023-08-12 |
Not clear |
| S Sanlioglu, P Benson, J F Engelhard. Loss of ATM function enhances recombinant adeno-associated virus transduction and integration through pathways similar to UV irradiation. Virology. vol 268. issue 1. 2000-03-29. PMID:10683328. |
ataxia telangiectasia is caused by a genetic defect in the atm gene that results in altered cellular sensitivity to dna-damaging agents such as gamma-irradiation. |
2000-03-29 |
2023-08-12 |
Not clear |
| M O Sikpi, Y Wan. Ionizing radiation enhances double-strand-break repair in rapamycin-treated ataxia telangiectasia lymphoblasts. International journal of radiation biology. vol 76. issue 2. 2000-03-23. PMID:10716639. |
ataxia telangiectasia mutated (atm) protein, the mutated protein in a-t cells, is homologous to members of the p13-kinase, including the rapamycin target frap. |
2000-03-23 |
2023-08-12 |
Not clear |
| C Morrison, E Sonoda, N Takao, A Shinohara, K Yamamoto, S Taked. The controlling role of ATM in homologous recombinational repair of DNA damage. The EMBO journal. vol 19. issue 3. 2000-03-10. PMID:10654944. |
the human genetic disorder ataxia telangiectasia (a-t), caused by mutation in the atm gene, is characterized by chromosomal instability, radiosensitivity and defective cell cycle checkpoint activation. |
2000-03-10 |
2023-08-12 |
human |
| M J Chong, M R Murray, E C Gosink, H R Russell, A Srinivasan, M Kapsetaki, S J Korsmeyer, P J McKinno. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 2. 2000-03-02. PMID:10639175. |
ataxia-telangiectasia is a hereditary multisystemic disease resulting from mutations of ataxia telangiectasia, mutated (atm) and is characterized by neurodegeneration, cancer, immune defects, and hypersensitivity to ionizing radiation. |
2000-03-02 |
2023-08-12 |
mouse |
| A J Bishop, C Barlow, A J Wynshaw-Boris, R H Schiest. Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice. Cancer research. vol 60. issue 2. 2000-02-28. PMID:10667593. |
ataxia telangiectasia (at) patients have inactivating mutations in both copies of the atm gene. |
2000-02-28 |
2023-08-12 |
mouse |
| N Takao, R Mori, H Kato, A Shinohara, K i Yamamot. c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance. The Journal of biological chemistry. vol 275. issue 2. 2000-02-18. PMID:10625600. |
c-abl is activated by dna damage in an ataxia telangiectasia mutated (atm)-dependent manner and plays important roles in growth arrest and apoptosis induced by dna damage. |
2000-02-18 |
2023-08-12 |
chicken |
| S T Kim, D S Lim, C E Canman, M B Kasta. Substrate specificities and identification of putative substrates of ATM kinase family members. The Journal of biological chemistry. vol 274. issue 53. 2000-02-08. PMID:10608806. |
ataxia telangiectasia mutated (atm) phosphorylates p53 protein in response to ionizing radiation, but the complex phenotype of at cells suggests that it must have other cellular substrates as well. |
2000-02-08 |
2023-08-12 |
Not clear |
| M A Basrai, V E Velculescu, K W Kinzler, P Hiete. NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae. Molecular and cellular biology. vol 19. issue 10. 2000-02-03. PMID:10490641. |
transcription of one of these, norf5/hug1 (hydroxyurea and uv and gamma radiation induced), is induced by dna damage, and this induction requires mec1, a homolog of the ataxia telangiectasia mutated (atm) gene. |
2000-02-03 |
2023-08-12 |
Not clear |
| P S Bradshaw, R Hamoudi, T Min, D Catovsky, R S Houlston, M R Yuill. Fluorescent BAT-25 and BAT-26 analysis of T cell prolymphocytic leukaemia. Leukemia. vol 13. issue 12. 2000-01-06. PMID:10602436. |
this is supported by the recent finding that the ataxia telangiectasia gene, atm, which contributes to maintaining genomic integrity, is frequently mutated in this disease. |
2000-01-06 |
2023-08-12 |
Not clear |
| K Robertson, C Hensey, J Gautie. Isolation and characterization of Xenopus ATM (X-ATM): expression, localization, and complex formation during oogenesis and early development. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597308. |
atm, the gene product mutated in ataxia telangiectasia (a-t) encodes a 350-kda protein involved in the regulation of several cellular responses to dna breaks. |
2000-01-04 |
2023-08-12 |
human |
| D R Schmidt, S L Schreibe. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. Biochemistry. vol 38. issue 44. 1999-12-22. PMID:10545197. |
ataxia telangiectasia mutated (atm)- and rad3-related protein (atr) is a phosphatidylinositol-kinase (pik)-related kinase that has been implicated in the response of human cells to multiple forms of dna damage and may play a role in the dna replication checkpoint. |
1999-12-22 |
2023-08-12 |
human |