| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Y Guo, C Mizzen, Y Wang, J M Larne. Histone H1 and H3 dephosphorylation are differentially regulated by radiation-induced signal transduction pathways. Cancer research. vol 60. issue 20. 2000-11-08. PMID:11059758. |
we recently demonstrated that linker histone h1, which is thought to have a fundamental role in higher-order chromatin structure, becomes transiently dephosphorylated after ionizing radiation (ir) in a mutated ataxia telangiectasia (atm) dependent manner. |
2000-11-08 |
2023-08-12 |
Not clear |
| M A Johnson, P E Bryant, N J Jone. Isolation of camptothecin-sensitive chinese hamster cell mutants: phenotypic heterogeneity within the ataxia telangiectasia-like XRCC8 (irs2) complementation group. Mutagenesis. vol 15. issue 4. 2000-11-03. PMID:10887218. |
hamster xrcc8 mutants show phenotypic similarities to cultured cells from ataxia telangiectasia and nijmegen break syndrome (nbs) patients and are likely to be defective in the same pathway in which the atm (ataxia telangiectasia-mutated) and the nbs genes operate. |
2000-11-03 |
2023-08-12 |
Not clear |
| K Laake, L Jansen, J M Hahnemann, K Brondum-Nielsen, T Lönnqvist, H Kääriäinen, R Sankila, A Lähdesmäki, L Hammarström, J Yuen, S Tretli, A Heiberg, J H Olsen, M Tucker, R Kleinerman, A L Børresen-Dal. Characterization of ATM mutations in 41 Nordic families with ataxia telangiectasia. Human mutation. vol 16. issue 3. 2000-10-30. PMID:10980530. |
characterization of atm mutations in 41 nordic families with ataxia telangiectasia. |
2000-10-30 |
2023-08-12 |
Not clear |
| K Laake, L Jansen, J M Hahnemann, K Brondum-Nielsen, T Lönnqvist, H Kääriäinen, R Sankila, A Lähdesmäki, L Hammarström, J Yuen, S Tretli, A Heiberg, J H Olsen, M Tucker, R Kleinerman, A L Børresen-Dal. Characterization of ATM mutations in 41 Nordic families with ataxia telangiectasia. Human mutation. vol 16. issue 3. 2000-10-30. PMID:10980530. |
the ataxia telangiectasia mutation (atm) gene is mutated in the rare recessive syndrome ataxia telangiectasia (at), which is characterized by cerebellar degeneration, immunodeficiency, and cancer predisposition. |
2000-10-30 |
2023-08-12 |
Not clear |
| H Scherthan, M Jerratsch, S Dhar, Y A Wang, S P Goff, T K Pandit. Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Molecular and cellular biology. vol 20. issue 20. 2000-10-30. PMID:11003672. |
the ataxia telangiectasia mutant (atm) protein is an intrinsic part of the cell cycle machinery that surveys genomic integrity and responses to genotoxic insult. |
2000-10-30 |
2023-08-12 |
mouse |
| H Scherthan, M Jerratsch, S Dhar, Y A Wang, S P Goff, T K Pandit. Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Molecular and cellular biology. vol 20. issue 20. 2000-10-30. PMID:11003672. |
individuals with ataxia telangiectasia as well as atm(-/-) mice are predisposed to cancer and are infertile due to spermatogenesis disruption during first meiotic prophase. |
2000-10-30 |
2023-08-12 |
mouse |
| M Liyanage, Z Weaver, C Barlow, A Coleman, D G Pankratz, S Anderson, A Wynshaw-Boris, T Rie. Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice. Blood. vol 96. issue 5. 2000-10-18. PMID:10961898. |
atm-deficient mice (atm(-/-)) recapitulate many aspects of the ataxia telangiectasia (at) syndrome, including the susceptibility to tumors of lymphoid origin. |
2000-10-18 |
2023-08-12 |
mouse |
| T O'Neill, A J Dwyer, Y Ziv, D W Chan, S P Lees-Miller, R H Abraham, J H Lai, D Hill, Y Shiloh, L C Cantley, G A Rathbu. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. The Journal of biological chemistry. vol 275. issue 30. 2000-08-31. PMID:10801797. |
the ataxia telangiectasia mutated (atm) gene encodes a serine/threonine protein kinase that plays a critical role in genomic surveillance and development. |
2000-08-31 |
2023-08-12 |
Not clear |
| T K Pandita, S Dha. Influence of ATM function on interactions between telomeres and nuclear matrix. Radiation research. vol 154. issue 2. 2000-08-11. PMID:10931683. |
the atm (ataxia telangiectasia mutated) gene product has been implicated in mitogenic signal transduction, chromosome condensation, meiotic recombination, and cell cycle control. |
2000-08-11 |
2023-08-12 |
mouse |
| T K Pandita, S Dha. Influence of ATM function on interactions between telomeres and nuclear matrix. Radiation research. vol 154. issue 2. 2000-08-11. PMID:10931683. |
recently, we have shown that the atm gene product, which is defective in the cancer-prone disorder ataxia telangiectasia (at), influences chromosome end associations and telomere length. |
2000-08-11 |
2023-08-12 |
mouse |
| S Li, N S Ting, L Zheng, P L Chen, Y Ziv, Y Shiloh, E Y Lee, W H Le. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature. vol 406. issue 6792. 2000-08-08. PMID:10910365. |
this phosphorylation event requires the protein kinase (atm) that is mutated in the disease ataxia telangiectasia. |
2000-08-08 |
2023-08-12 |
mouse |
| J P Vit, E Moustacchi, F Rossell. ATM protein is required for radiation-induced apoptosis and acts before mitochondrial collapse. International journal of radiation biology. vol 76. issue 6. 2000-08-02. PMID:10902739. |
to define the role of the ataxia telangiectasia (a-t) mutated gene (atm) in activation and progress of apoptosis. |
2000-08-02 |
2023-08-12 |
Not clear |
| C Jhappan, T M Yusufzai, S Anderson, M R Anver, G Merlin. The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Molecular and cellular biology. vol 20. issue 11. 2000-07-06. PMID:10805749. |
together, these data demonstrate that the p53-mediated response to dna damage is intact in cells devoid of dna-pk activity and suggest that other kinases, such as the product of the gene (atm) mutated in ataxia telangiectasia, are better candidates for regulating ir-induced phosphorylation and accumulation of p53. |
2000-07-06 |
2023-08-12 |
mouse |
| P N Toni. Genes implicated in hereditary breast cancer syndromes. Seminars in surgical oncology. vol 18. issue 4. 2000-06-21. PMID:10805949. |
other hereditary syndromes that feature breast cancer are li-fraumeni syndrome, cowden disease, and ataxia telangiectasia, whose carriers have been shown to harbor germ-line mutations in tp53, pten, and atm, respectively. |
2000-06-21 |
2023-08-12 |
Not clear |
| S Angèle, J Hal. The ATM gene and breast cancer: is it really a risk factor? Mutation research. vol 462. issue 2-3. 2000-06-16. PMID:10767628. |
in such cases genes frequently altered in the general population, such as the gene mutated in ataxia telangiectasia (at), atm may be important risk factors. |
2000-06-16 |
2023-08-12 |
Not clear |
| X Wu, V Ranganathan, D S Weisman, W F Heine, D N Ciccone, T B O'Neill, K E Crick, K A Pierce, W S Lane, G Rathbun, D M Livingston, D T Weave. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature. vol 405. issue 6785. 2000-06-16. PMID:10839545. |
the phenotypes are similar to those of ataxia telangiectasia mutated (atm) disease, where there is a deficiency in a protein kinase that is activated by dna damage, indicating that the nbs and atm proteins may participate in common pathways. |
2000-06-16 |
2023-08-12 |
human |
| b' A Hotti, K J\\xc3\\xa4rvinen, P Siivola, E H\\xc3\\xb6ltt\\xc3\\xa. Caspases and mitochondria in c-Myc-induced apoptosis: identification of ATM as a new target of caspases. Oncogene. vol 19. issue 19. 2000-06-07. PMID:10822387.' |
we further found that the atm (ataxia telangiectasia mutated)--protein is a novel key substrate of caspases. |
2000-06-07 |
2023-08-12 |
Not clear |
| V Garcia, M Salanoubat, N Choisne, A Tissie. An ATM homologue from Arabidopsis thaliana: complete genomic organisation and expression analysis. Nucleic acids research. vol 28. issue 8. 2000-06-06. PMID:10734187. |
atm is a gene mutated in the human disease ataxia telangiectasia with reported homologues in yeast, drosophila, xenopus and mouse. |
2000-06-06 |
2023-08-12 |
mouse |
| N Takao, Y Li, K Yamamot. Protective roles for ATM in cellular response to oxidative stress. FEBS letters. vol 472. issue 1. 2000-06-02. PMID:10781820. |
atm (ataxia telangiectasia mutated), the gene mutated in ataxia telangiectasia, is related to a family of large phosphatidylinositol 3-kinase domain-containing proteins involved in cell cycle control and dna repair. |
2000-06-02 |
2023-08-12 |
Not clear |
| A de Klein, M Muijtjens, R van Os, Y Verhoeven, B Smit, A M Carr, A R Lehmann, J H Hoeijmaker. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Current biology : CB. vol 10. issue 8. 2000-06-02. PMID:10801416. |
checkpoints of dna integrity are conserved throughout evolution, as are the kinases atm (ataxia telangiectasia mutated) and atr (ataxia- and rad-related), which are related to phosphatidylinositol (pi) 3-kinase [1] [2] [3]. |
2000-06-02 |
2023-08-12 |
mouse |