| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberto Sacco, Veruska Papaleo, Jorg Hager, Francis Rousseau, Rainald Moessner, Roberto Militerni, Carmela Bravaccio, Simona Trillo, Cindy Schneider, Raun Melmed, Maurizio Elia, Paolo Curatolo, Barbara Manzi, Tiziana Pascucci, Stefano Puglisi-Allegra, Karl-Ludvig Reichelt, Antonio M Persic. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC medical genetics. vol 8. 2007-04-12. PMID:17346350. |
stereotypic and repetitive behaviors are influenced by 5-ht, and initial studies report an association of tph2 alleles with childhood-onset obsessive-compulsive disorder (ocd) and with autism. |
2007-04-12 |
2023-08-12 |
Not clear |
| Edward S Brodki. BALB/c mice: low sociability and other phenotypes that may be relevant to autism. Behavioural brain research. vol 176. issue 1. 2007-03-01. PMID:16890300. |
balb/c mice also show other phenotypes with possible relevance to autism, including relatively high levels of anxiety and aggressive behaviors, large brain size, underdevelopment of the corpus callosum, and low levels of brain serotonin. |
2007-03-01 |
2023-08-12 |
mouse |
| Carolyn B Boylan, Mary E Blue, Christine F Hohman. Modeling early cortical serotonergic deficits in autism. Behavioural brain research. vol 176. issue 1. 2007-03-01. PMID:17034875. |
we report here on a selective serotonin (5-ht) depletion model of this disorder in neonatal mice that mimics neurochemical and structural changes in cortex and, in addition, displays a behavioral phenotype consistent with autism. |
2007-03-01 |
2023-08-12 |
mouse |
| Camille W Brune, Soo-Jeong Kim, Jeff Salt, Bennett L Leventhal, Catherine Lord, Edwin H Coo. 5-HTTLPR Genotype-Specific Phenotype in Children and Adolescents With Autism. The American journal of psychiatry. vol 163. issue 12. 2007-02-16. PMID:17151167. |
the serotonin transporter gene (slc6a4) is a strong autism candidate gene because of its association with anxiety, aggression and attention, and the effectiveness of selective serotonin reuptake inhibitors (ssris) in treating certain behavioral symptoms. |
2007-02-16 |
2023-08-12 |
Not clear |
| Camille W Brune, Soo-Jeong Kim, Jeff Salt, Bennett L Leventhal, Catherine Lord, Edwin H Coo. 5-HTTLPR Genotype-Specific Phenotype in Children and Adolescents With Autism. The American journal of psychiatry. vol 163. issue 12. 2007-02-16. PMID:17151167. |
in families with individuals with autism, several reports of biased transmission of both alleles (short, long) at the serotonin transporter gene promotor polymorphism (5-httlpr) locus of slc6a4 now exist. |
2007-02-16 |
2023-08-12 |
Not clear |
| Nicolas Ramoz, Guiqing Cai, Jennifer G Reichert, Thomas E Corwin, Lauren A Kryzak, Christopher J Smith, Jeremy M Silverman, Eric Hollander, Joseph D Buxbau. Family-based association study of TPH1 and TPH2 polymorphisms in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 8. 2007-02-13. PMID:16958027. |
the tph1 and tph2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. |
2007-02-13 |
2023-08-12 |
Not clear |
| Nancy K Burgess, Thayne L Sweeten, William M McMahon, Robert S Fujinam. Hyperserotoninemia and altered immunity in autism. Journal of autism and developmental disorders. vol 36. issue 5. 2007-01-03. PMID:16614791. |
one of the most consistent biological findings in autism is elevated whole blood serotonin (5-ht) levels found in about 1/3 of cases. |
2007-01-03 |
2023-08-12 |
Not clear |
| Nancy K Burgess, Thayne L Sweeten, William M McMahon, Robert S Fujinam. Hyperserotoninemia and altered immunity in autism. Journal of autism and developmental disorders. vol 36. issue 5. 2007-01-03. PMID:16614791. |
given 5-ht's role as an immunomodulator, possible connections between 5-ht and immune abnormalities in autism are explored in this review. |
2007-01-03 |
2023-08-12 |
Not clear |
| Skirmantas Janusonis, George M Anderson, Ilya Shifrovich, Pasko Raki. Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autism. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16981893. |
ontogeny of brain and blood serotonin levels in 5-ht receptor knockout mice: potential relevance to the neurobiology of autism. |
2006-12-20 |
2023-08-12 |
mouse |
| Skirmantas Janusonis, George M Anderson, Ilya Shifrovich, Pasko Raki. Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autism. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16981893. |
the most consistent neurochemical finding in autism has been elevated group mean levels of blood platelet 5-hydroxytryptamine (5-ht, serotonin). |
2006-12-20 |
2023-08-12 |
mouse |
| Skirmantas Janusonis, George M Anderson, Ilya Shifrovich, Pasko Raki. Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autism. Journal of neurochemistry. vol 99. issue 3. 2006-12-20. PMID:16981893. |
the results are discussed in relation to the possible role of 5-ht in the ontogeny of autism. |
2006-12-20 |
2023-08-12 |
mouse |
| Lauren A Weiss, Gülüm Kosova, Ryan J Delahanty, Lan Jiang, Edwin H Cook, Carole Ober, James S Sutcliff. Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility. European journal of human genetics : EJHG. vol 14. issue 8. 2006-11-21. PMID:16724005. |
variation in itgb3 is associated with whole-blood serotonin level and autism susceptibility. |
2006-11-21 |
2023-08-12 |
Not clear |
| Susan L Connors, Karla J Matteson, Gary A Sega, Carmen B Lozzio, Roger C Carroll, Andrew W Zimmerma. Plasma serotonin in autism. Pediatric neurology. vol 35. issue 3. 2006-11-21. PMID:16939857. |
plasma serotonin in autism. |
2006-11-21 |
2023-08-12 |
rat |
| Susan L Connors, Karla J Matteson, Gary A Sega, Carmen B Lozzio, Roger C Carroll, Andrew W Zimmerma. Plasma serotonin in autism. Pediatric neurology. vol 35. issue 3. 2006-11-21. PMID:16939857. |
low maternal plasma serotonin may contribute to abnormal brain development in autism. |
2006-11-21 |
2023-08-12 |
rat |
| Susan L Connors, Karla J Matteson, Gary A Sega, Carmen B Lozzio, Roger C Carroll, Andrew W Zimmerma. Plasma serotonin in autism. Pediatric neurology. vol 35. issue 3. 2006-11-21. PMID:16939857. |
in this study, plasma serotonin levels in autism mothers and control mothers of typically developing children were compared, and plasma serotonin levels in children with autism (n = 17) and their family members were measured. |
2006-11-21 |
2023-08-12 |
rat |
| Susan L Connors, Karla J Matteson, Gary A Sega, Carmen B Lozzio, Roger C Carroll, Andrew W Zimmerma. Plasma serotonin in autism. Pediatric neurology. vol 35. issue 3. 2006-11-21. PMID:16939857. |
plasma serotonin levels in autism mothers were significantly lower than in mothers of normal children (p = 0.002). |
2006-11-21 |
2023-08-12 |
rat |
| Susan L Connors, Karla J Matteson, Gary A Sega, Carmen B Lozzio, Roger C Carroll, Andrew W Zimmerma. Plasma serotonin in autism. Pediatric neurology. vol 35. issue 3. 2006-11-21. PMID:16939857. |
plasma serotonin levels correlated between autism mothers and their children, but differed between autistic children and their fathers (p = 0.028) and siblings (p = 0.063). |
2006-11-21 |
2023-08-12 |
rat |
| Susan L Connors, Karla J Matteson, Gary A Sega, Carmen B Lozzio, Roger C Carroll, Andrew W Zimmerma. Plasma serotonin in autism. Pediatric neurology. vol 35. issue 3. 2006-11-21. PMID:16939857. |
low maternal plasma serotonin may be a risk factor for autism through effects on fetal brain development. |
2006-11-21 |
2023-08-12 |
rat |
| Kristen S L Lam, Michael G Aman, L Eugene Arnol. Neurochemical correlates of autistic disorder: a review of the literature. Research in developmental disabilities. vol 27. issue 3. 2006-10-25. PMID:16002261. |
overall, serotonin appears to have the most empirical evidence for a role in autism, but this requires further investigation and replication. |
2006-10-25 |
2023-08-12 |
human |
| Subhrangshu Guhathakurta, Sagarmoy Ghosh, Swagata Sinha, Anindita Chatterjee, Shabina Ahmed, Susanta Roy Chowdhury, Prasanta Kumar Gangopadhyay, Saurabh Ghosh, Manoranjan Singh, Rajamma Ush. Serotonin transporter promoter variants: Analysis in Indian autistic and control population. Brain research. vol 1092. issue 1. 2006-09-19. PMID:16674932. |
with the finding of efficacy of serotonin reuptake inhibitors in ameliorating ritualistic behavior in autistic disorder, 5-htt emerged as a putative candidate gene for autism and association studies have been carried out in different ethnic populations. |
2006-09-19 |
2023-08-12 |
Not clear |