| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masahide Yoshida, Yuki Takayanagi, Kiyoshi Inoue, Tadashi Kimura, Larry J Young, Tatsushi Onaka, Katsuhiko Nishimor. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 7. 2009-04-16. PMID:19228979. |
these results also have important implications for psychiatric disorders such as autism and depression in which both the oxytocin and serotonin systems have been implicated. |
2009-04-16 |
2023-08-12 |
mouse |
| Ana M D Carneiro, David C Airey, Brent Thompson, Chong-Bin Zhu, Lu Lu, Elissa J Chesler, Keith M Erikson, Randy D Blakel. Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 6. 2009-03-10. PMID:19179283. |
the human serotonin (5-hydroxytryptamine, 5-ht) transporter (hsert, slc6a4) figures prominently in the etiology and treatment of many prevalent neurobehavioral disorders including anxiety, alcoholism, depression, autism, and obsessive-compulsive disorder (ocd). |
2009-03-10 |
2023-08-12 |
mouse |
| Harish C Prasad, Jennifer A Steiner, James S Sutcliffe, Randy D Blakel. Enhanced activity of human serotonin transporter variants associated with autism. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 364. issue 1514. 2009-03-03. PMID:18957375. |
enhanced activity of human serotonin transporter variants associated with autism. |
2009-03-03 |
2023-08-12 |
human |
| Harish C Prasad, Jennifer A Steiner, James S Sutcliffe, Randy D Blakel. Enhanced activity of human serotonin transporter variants associated with autism. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 364. issue 1514. 2009-03-03. PMID:18957375. |
rare, functional, non-synonymous variants in the human serotonin (5-hydroxytryptamine, 5-ht) transporter (hsert) gene (slc6a4) have been identified in both autism and obsessive-compulsive disorder (ocd). |
2009-03-03 |
2023-08-12 |
human |
| Harish C Prasad, Jennifer A Steiner, James S Sutcliffe, Randy D Blakel. Enhanced activity of human serotonin transporter variants associated with autism. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 364. issue 1514. 2009-03-03. PMID:18957375. |
within autism, rare hsert coding variants associate with rigid-compulsive traits, suggesting both phenotypic overlap with ocd and a shared relationship with disrupted 5-ht signalling. |
2009-03-03 |
2023-08-12 |
human |
| Subhrangshu Guhathakurta, Swagata Sinha, Saurabh Ghosh, Anindita Chatterjee, Shabina Ahmed, Prasanta Kumar Gangopadhyay, Rajamma Ush. Population-based association study and contrasting linkage disequilibrium pattern reveal genetic association of SLC6A4 with autism in the Indian population from West Bengal. Brain research. vol 1240. 2009-02-17. PMID:18804097. |
serotonin transporter gene (slc6a4) that regulates synaptic serotonin level has been investigated as a candidate gene for autism, but consensus opinion on possible association is still lacking. |
2009-02-17 |
2023-08-12 |
human |
| Kazuhiko Nakamura, Ayyappan Anitha, Kazuo Yamada, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Shiro Suda, Noriyoshi Takei, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji J Tsuchiya, Gen-Ichi Sugihara, Yasuomi Ouchi, Toshiro Sugiyama, Takeo Yoshikawa, Norio Mor. Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism. The international journal of neuropsychopharmacology. vol 11. issue 8. 2009-01-26. PMID:18593506. |
serotonin transporter (5-htt), which modulates serotonin levels, is a major therapeutic target in autism. |
2009-01-26 |
2023-08-12 |
Not clear |
| Christine Winter, Teri J Reutiman, Timothy D Folsom, Reinhard Sohr, Rainer J Wolf, Georg Juckel, S Hossein Fatem. Dopamine and serotonin levels following prenatal viral infection in mouse--implications for psychiatric disorders such as schizophrenia and autism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 10. 2009-01-26. PMID:18693086. |
dopamine and serotonin levels following prenatal viral infection in mouse--implications for psychiatric disorders such as schizophrenia and autism. |
2009-01-26 |
2023-08-12 |
mouse |
| Christine H Huang, Susan L Santangel. Autism and serotonin transporter gene polymorphisms: a systematic review and meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 6. 2008-12-04. PMID:18286633. |
autism and serotonin transporter gene polymorphisms: a systematic review and meta-analysis. |
2008-12-04 |
2023-08-12 |
Not clear |
| Christine H Huang, Susan L Santangel. Autism and serotonin transporter gene polymorphisms: a systematic review and meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 6. 2008-12-04. PMID:18286633. |
the serotonin transporter gene (5-htt) plays a crucial role in serotonergic neurotransmission and has been found to be associated, with varying degrees of significance, with many diseases, including autism. |
2008-12-04 |
2023-08-12 |
Not clear |
| A Anitha, Kazuhiko Nakamura, Kazuo Yamada, Shiro Suda, Ismail Thanseem, Masatsugu Tsujii, Yoshimi Iwayama, Eiji Hattori, Tomoko Toyota, Taishi Miyachi, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Masayoshi Kawai, Yoshimoto Sekine, Kenji Tsuchiya, Gen-Ichi Sugihara, Yasuomi Ouchi, Toshiro Sugiyama, Keita Koizumi, Haruhiro Higashida, Nori Takei, Takeo Yoshikawa, Norio Mor. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18270976. |
serotonin transporter (sert) modulates serotonin levels, and is a major therapeutic target in autism. |
2008-11-17 |
2023-08-12 |
drosophila_melanogaster |
| Soo-Jeong Kim, Camille W Brune, Emily O Kistner, Susan L Christian, Eric H Courchesne, Nancy J Cox, Edwin H Coo. Transmission disequilibrium testing of the chromosome 15q11-q13 region in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18361419. |
evidence implicates the serotonin transporter gene (slc6a4) and the 15q11-q13 genes as candidates for autism as well as restricted repetitive behavior (rrb). |
2008-11-17 |
2023-08-12 |
Not clear |
| Lea K Davis, Heather C Hazlett, Amy L Librant, Peggy Nopoulos, Val C Sheffield, Joesph Piven, Thomas H Wassin. Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18361446. |
abnormalities of serotonin neurotransmission have long been implicated in the psychopathology of autism. |
2008-11-17 |
2023-08-12 |
Not clear |
| Lea K Davis, Heather C Hazlett, Amy L Librant, Peggy Nopoulos, Val C Sheffield, Joesph Piven, Thomas H Wassin. Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18361446. |
individuals with autism often exhibit elevated serotonin levels. |
2008-11-17 |
2023-08-12 |
Not clear |
| Christopher J McDougl. Serotonin and dopamine transporter binding in children with autism. Developmental medicine and child neurology. vol 50. issue 8. 2008-09-26. PMID:18754890. |
serotonin and dopamine transporter binding in children with autism. |
2008-09-26 |
2023-08-12 |
Not clear |
| Ismo Makkonen, Raili Riikonen, Hannu Kokki, Mauno M Airaksinen, Jyrki T Kuikk. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental medicine and child neurology. vol 50. issue 8. 2008-09-26. PMID:18754896. |
serotonin and dopamine transporter binding in children with autism determined by spect. |
2008-09-26 |
2023-08-12 |
Not clear |
| Ismo Makkonen, Raili Riikonen, Hannu Kokki, Mauno M Airaksinen, Jyrki T Kuikk. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental medicine and child neurology. vol 50. issue 8. 2008-09-26. PMID:18754896. |
to investigate the association between serotonin and dopamine transporters and autism, we studied 15 children (14 males, one female; mean age 8 y 8 mo [sd 3 y 10 mo]) with autism and 10 non-autistic comparison children (five males, five females; mean age 9 y 10 mo [sd 2 y 8 mo]) using single-photon emission computed tomography (spect) with [123 i] nor-beta-cit. |
2008-09-26 |
2023-08-12 |
Not clear |
| Ismo Makkonen, Raili Riikonen, Hannu Kokki, Mauno M Airaksinen, Jyrki T Kuikk. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Developmental medicine and child neurology. vol 50. issue 8. 2008-09-26. PMID:18754896. |
the low sert binding reported here and the low serotonin synthesis capacity shown elsewhere may indicate maturation of a lesser number of serotonergic nerve terminals in individuals with autism. |
2008-09-26 |
2023-08-12 |
Not clear |
| Jan Croonenberghs, Kristien Spaas, Annick Wauters, Robert Verkerk, Simon Scharpe, Dirk Deboutte, Michael Mae. Faulty serotonin--DHEA interactions in autism: results of the 5-hydroxytryptophan challenge test. Neuro endocrinology letters. vol 29. issue 3. 2008-09-08. PMID:18580847. |
faulty serotonin--dhea interactions in autism: results of the 5-hydroxytryptophan challenge test. |
2008-09-08 |
2023-08-12 |
Not clear |
| Jan Croonenberghs, Kristien Spaas, Annick Wauters, Robert Verkerk, Simon Scharpe, Dirk Deboutte, Michael Mae. Faulty serotonin--DHEA interactions in autism: results of the 5-hydroxytryptophan challenge test. Neuro endocrinology letters. vol 29. issue 3. 2008-09-08. PMID:18580847. |
autism is accompanied by peripheral and central disorders in the metabolism of serotonin (5-ht). |
2008-09-08 |
2023-08-12 |
Not clear |