| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea M Allan, Xiaomin Liang, Yuping Luo, Changhui Pak, Xuekun Li, Keith E Szulwach, Dahua Chen, Peng Jin, Xinyu Zha. The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Human molecular genetics. vol 17. issue 13. 2008-07-23. PMID:18385101. |
here we show that mbd1 mutant (mbd1(-/-)) mice exhibit several core deficits frequently associated with autism, including reduced social interaction, learning deficits, anxiety, defective sensory motor gating, depression and abnormal brain serotonin activity. |
2008-07-23 |
2023-08-12 |
mouse |
| Dubravka Hranilović, Ruder Novak, Marina Babić, Mislav Novokmet, Zorana Bujas-Petković, Branimir Jerne. Hyperserotonemia in autism: the potential role of 5HT-related gene variants. Collegium antropologicum. vol 32 Suppl 1. 2008-05-01. PMID:18405062. |
suggested mechanisms for hyperserotonemia in autism have been increased synthesis of serotonin (5ht) by tryptophan hydroxylase (tph), increased uptake into platelets through 5ht transporter (5htt), diminished release from platelets through 5ht2a receptor (5ht2ar) and decreased metabolism by monoamine oxydase (maoa). |
2008-05-01 |
2023-08-12 |
human |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
dysregulation of brain serotonin (5-ht) neurotransmission is thought to underlie mental conditions as diverse as depression, anxiety disorders, bipolar disorder, autism, and schizophrenia. |
2008-02-25 |
2023-08-12 |
mouse |
| Sarah Cross, Soo-Jeong Kim, Lauren A Weiss, Ryan J Delahanty, James S Sutcliffe, Bennett L Leventhal, Edwin H Cook, Jeremy Veenstra-Vanderweel. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17406648. |
elevated platelet serotonin (5-hydroxytryptamine, 5-ht) is found in a subset of children with autism and in some of their first-degree relatives. |
2008-02-06 |
2023-08-12 |
human |
| Sarah Cross, Soo-Jeong Kim, Lauren A Weiss, Ryan J Delahanty, James S Sutcliffe, Bennett L Leventhal, Edwin H Cook, Jeremy Veenstra-Vanderweel. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17406648. |
indices of the platelet serotonin system, including whole blood 5-ht, 5-ht binding affinity for the serotonin transporter (k(m)), 5-ht uptake (v(max)), and lysergic acid diethylamide (lsd) receptor binding, were previously studied in 24 first-degree relatives of probands with autism, half of whom were selected for elevated whole blood 5-ht levels. |
2008-02-06 |
2023-08-12 |
human |
| Jan Croonenberghs, Annick Wauters, Dirk Deboutte, Robert Verkerk, Simon Scharpe, Michael Mae. Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test. Neuro endocrinology letters. vol 28. issue 4. 2008-01-24. PMID:17693983. |
in order to assess the central serotonergic turnover in autism, this study examines the cortisol and prolactin responses to administration of l-5-hydroxy-tryptophan (5-htp), the direct precursor of 5-ht in 18 male, post-pubertal, caucasian autistic patients (age 13-19 y.; i.q.>55) and 22 matched healthy volunteers. |
2008-01-24 |
2023-08-12 |
human |
| H Mei, M L Cuccaro, E R Marti. Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables. American journal of human genetics. vol 81. issue 6. 2007-12-13. PMID:17999363. |
finally, by applying mdr-phenomics to autism, a complex disease in which multiple genes are believed to confer risk, we attempted to identify multiple gene effects in two candidate genes of interest--the serotonin transporter gene (slc6a4) and the integrin beta 3 gene (itgb3) on chromosome 17. |
2007-12-13 |
2023-08-12 |
human |
| Ana M Coutinho, Inês Sousa, Madalena Martins, Catarina Correia, Teresa Morgadinho, Celeste Bento, Carla Marques, Assunção Ataíde, Teresa S Miguel, Jason H Moore, Guiomar Oliveira, Astrid M Vicent. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human genetics. vol 121. issue 2. 2007-07-20. PMID:17203304. |
evidence for epistasis between slc6a4 and itgb3 in autism etiology and in the determination of platelet serotonin levels. |
2007-07-20 |
2023-08-12 |
Not clear |
| Ana M Coutinho, Inês Sousa, Madalena Martins, Catarina Correia, Teresa Morgadinho, Celeste Bento, Carla Marques, Assunção Ataíde, Teresa S Miguel, Jason H Moore, Guiomar Oliveira, Astrid M Vicent. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human genetics. vol 121. issue 2. 2007-07-20. PMID:17203304. |
the role in autism etiology of seven candidate genes in the serotonin metabolic and neurotransmission pathways and mapping to autism linkage regions (slc6a4, htr1a, htr1d, htr2a, htr5a, tph1 and itgb3) was analyzed in a sample of 186 nuclear families. |
2007-07-20 |
2023-08-12 |
Not clear |
| Ana M Coutinho, Inês Sousa, Madalena Martins, Catarina Correia, Teresa Morgadinho, Celeste Bento, Carla Marques, Assunção Ataíde, Teresa S Miguel, Jason H Moore, Guiomar Oliveira, Astrid M Vicent. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human genetics. vol 121. issue 2. 2007-07-20. PMID:17203304. |
we further evaluated whether the effect of specific gene variants or gene interactions associated with autism etiology might be mediated by their influence on serotonin levels, using the quantitative transmission disequilibrium test (qtdt) and the restricted partition method (rpm), in a sample of 109 autistic children. |
2007-07-20 |
2023-08-12 |
Not clear |
| Ana M Coutinho, Inês Sousa, Madalena Martins, Catarina Correia, Teresa Morgadinho, Celeste Bento, Carla Marques, Assunção Ataíde, Teresa S Miguel, Jason H Moore, Guiomar Oliveira, Astrid M Vicent. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Human genetics. vol 121. issue 2. 2007-07-20. PMID:17203304. |
the overall results implicate slc6a4 and itgb3 gene interactions in autism etiology and in serotonin level determination, providing evidence for a common underlying genetic mechanism and a molecular explanation for the association of platelet hyperserotonemia with autism. |
2007-07-20 |
2023-08-12 |
Not clear |
| C Altamura, M L Dell'Acqua, R Moessner, D L Murphy, K P Lesch, Antonio M Persic. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 6. 2007-07-03. PMID:16905592. |
the neurotransmitter serotonin (5-ht) plays morphogenetic roles during development, and their alteration could contribute to autism pathogenesis in humans. |
2007-07-03 |
2023-08-12 |
mouse |
| Thomas H Wassink, Heather C Hazlett, Eric A Epping, Stephan Arndt, Stephen R Dager, Gerard D Schellenberg, Geraldine Dawson, Joseph Pive. Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism. Archives of general psychiatry. vol 64. issue 6. 2007-07-03. PMID:17548752. |
cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism. |
2007-07-03 |
2023-08-12 |
Not clear |
| Thomas H Wassink, Heather C Hazlett, Eric A Epping, Stephan Arndt, Stephen R Dager, Gerard D Schellenberg, Geraldine Dawson, Joseph Pive. Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism. Archives of general psychiatry. vol 64. issue 6. 2007-07-03. PMID:17548752. |
autism is a heritable neurodevelopmental disorder characterized biologically by enlargement of the head and brain and abnormalities of serotonin neurotransmission. |
2007-07-03 |
2023-08-12 |
Not clear |
| In Hee Cho, Hee Jeong Yoo, Mira Park, Young Sik Lee, Soon Ae Ki. Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios. Brain research. vol 1139. 2007-05-08. PMID:17280648. |
promoter region polymorphisms (5-httlpr) of the serotonin transporter gene (slc6a4) and the 5-ht2a receptor gene (htr2a) have been studied as potential candidate genes in autism spectrum disorder (asd). |
2007-05-08 |
2023-08-12 |
human |
| Christine F Hohmann, Ellen M Walker, Carolyn B Boylan, Mary E Blu. Neonatal serotonin depletion alters behavioral responses to spatial change and novelty. Brain research. vol 1139. 2007-05-08. PMID:17296168. |
these results may have significant implications for understanding brain disorders presenting with cortical morphogenetic abnormalities and altered serotonin neurotransmission, such as autism, schizophrenia and affective disorders. |
2007-05-08 |
2023-08-12 |
mouse |
| George M Anderso. Measurement of plasma serotonin in autism. Pediatric neurology. vol 36. issue 2. 2007-04-18. PMID:17275674. |
measurement of plasma serotonin in autism. |
2007-04-18 |
2023-08-12 |
Not clear |
| Naohisa Tsujino, Yasushi Nakatani, Yoshinari Seki, Akane Nakasato, Michiko Nakamura, Michiya Sugawara, Hideho Arit. Abnormality of circadian rhythm accompanied by an increase in frontal cortex serotonin in animal model of autism. Neuroscience research. vol 57. issue 2. 2007-04-17. PMID:17157402. |
abnormality of circadian rhythm accompanied by an increase in frontal cortex serotonin in animal model of autism. |
2007-04-17 |
2023-08-12 |
rat |
| Naohisa Tsujino, Yasushi Nakatani, Yoshinari Seki, Akane Nakasato, Michiko Nakamura, Michiya Sugawara, Hideho Arit. Abnormality of circadian rhythm accompanied by an increase in frontal cortex serotonin in animal model of autism. Neuroscience research. vol 57. issue 2. 2007-04-17. PMID:17157402. |
these results suggest that a higher brain 5-ht level might be responsible for the irregular sleep/awake rhythm in autism. |
2007-04-17 |
2023-08-12 |
rat |
| Lauren A Weiss, Carole Ober, Edwin H Coo. ITGB3 shows genetic and expression interaction with SLC6A4. Human genetics. vol 120. issue 1. 2007-04-16. PMID:16721604. |
the integrin beta3 (itgb3) and serotonin transporter (slc6a4) genes were both recently identified as male quantitative trait loci (qtls) for serotonin levels and alleles of each have been associated with autism. |
2007-04-16 |
2023-08-12 |
human |