| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianfeng Li, Wenyan Li, Jialin Su, Weimin Liu, Bella T Altura, Burton M Altur. Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. Brain research bulletin. vol 62. issue 2. 2004-02-06. PMID:14638383. |
apoptosis has been suggested to play an important role in neurodegenerative diseases, traumatic brain injury and strokes. |
2004-02-06 |
2023-08-12 |
Not clear |
| David L Vaux, John Silk. HtrA2/Omi, a sheep in wolf's clothing. Cell. vol 115. issue 3. 2004-01-30. PMID:14636553. |
mammalian mitochondrial htra2/omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant htra2/omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. |
2004-01-30 |
2023-08-12 |
mouse |
| Zoltán Urbányi, Lajos László, Thomas B Tomasi, Erzsébet Tóth, Eva Mekes, Miklós Sass, Tamás Pázmán. Serum amyloid P component induces neuronal apoptosis and beta-amyloid immunoreactivity. Brain research. vol 988. issue 1-2. 2003-12-10. PMID:14519527. |
this study supports the thesis that sap plays an important role in the pathomechanism of neurodegenerative diseases, including alzheimer's disease by inducing neuronal apoptosis. |
2003-12-10 |
2023-08-12 |
rat |
| A Cristina Rego, Catarina R Oliveir. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochemical research. vol 28. issue 10. 2003-11-18. PMID:14570402. |
mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. |
2003-11-18 |
2023-08-12 |
Not clear |
| Jianfeng Li, Jialin Su, Wenyan Li, Weimin Liu, Bella T Altura, Burton M Altur. Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. Neuroscience letters. vol 350. issue 3. 2003-11-10. PMID:14550922. |
peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. |
2003-11-10 |
2023-08-12 |
Not clear |
| Manisha Sonee, Johanna R Martens, Meredith R Evers, Suman K Mukherje. The effect of tertiary butylhydroperoxide and nicotinamide on human cortical neurons. Neurotoxicology. vol 24. issue 3. 2003-09-02. PMID:12782109. |
it is well known that the generation of oxygen radicals can cause neuronal death by both apoptosis and necrosis, which may lead to the onset of neurodegenerative diseases. |
2003-09-02 |
2023-08-12 |
human |
| Lucyna Antkiewicz-Michalu. Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866710. |
since pd is a slowly progressing neurodegenerative disease, it has been suggested that it could be connected with excitotoxicity and apoptosis. |
2003-08-15 |
2023-08-12 |
monkey |
| M Castedo, J-L Perfettini, T Roumier, G Kroeme. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478465. |
an unscheduled cdk1 activation may contribute to neuronal apoptosis occurring in neurodegenerative diseases. |
2003-07-30 |
2023-08-12 |
Not clear |
| M Jiménez del Rio, C Vélez-Pard. [Apoptosis in neurodegenerative diseases: facts and controversies]. Revista de neurologia. vol 32. issue 9. 2003-07-28. PMID:11424038. |
[apoptosis in neurodegenerative diseases: facts and controversies]. |
2003-07-28 |
2023-08-12 |
Not clear |
| Joseph F Sanchez, Lynn F Sniderhan, Andrea L Williamson, Shongshan Fan, Shikha Chakraborty-Sett, Sanjay B Maggirwa. Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling. Molecular and cellular biology. vol 23. issue 13. 2003-07-22. PMID:12808104. |
recent studies have revealed a positive correlation between astrocyte apoptosis and rapid disease progression in persons with neurodegenerative diseases. |
2003-07-22 |
2023-08-12 |
Not clear |
| A Tempestini, N Schiavone, L Papucci, E Witort, A Lapucci, M Cutrì, M Donnini, S Capacciol. The mechanisms of apoptosis in biology and medicine: a new focus for ophthalmology. European journal of ophthalmology. vol 13 Suppl 3. 2003-07-03. PMID:12749672. |
for instance, excesses of apoptosis lead to cell loss that accompanies neurodegenerative diseases, whereas genetically determined defects of apoptosis lead to the deregulated cell proliferation typical of cancer. |
2003-07-03 |
2023-08-12 |
human |
| Jennifer L Mazzola, Michael A Sirove. Subcellular alteration of glyceraldehyde-3-phosphate dehydrogenase in Alzheimer's disease fibroblasts. Journal of neuroscience research. vol 71. issue 2. 2003-06-25. PMID:12503091. |
the regulation of glyceraldehyde-3-phosphate dehydrogenase (gapdh) has been implicated both in age-related neurodegenerative disease and in apoptosis. |
2003-06-25 |
2023-08-12 |
Not clear |
| Mark D Berry, Alan A Boulto. Apoptosis and human neurodegenerative diseases. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 2. 2003-05-29. PMID:12657359. |
apoptosis and human neurodegenerative diseases. |
2003-05-29 |
2023-08-12 |
human |
| Peter C Waldmeie. Prospects for antiapoptotic drug therapy of neurodegenerative diseases. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 2. 2003-05-29. PMID:12657369. |
the evidence for a role of apoptosis in the neurodegenerative diseases, alzheimer's disease (ad), parkinson's disease (pd) and amyotrophic lateral sclerosis (als), and in the more acute conditions of cerebral ischemia, traumatic brain injury (tbi), and spinal cord injury (sci) is reviewed with regard to potential intervention by means of small antiapoptotic molecules. |
2003-05-29 |
2023-08-12 |
mouse |
| Myriam Roussigne, Corinne Cayrol, Thomas Clouaire, François Amalric, Jean-Philippe Girar. THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies. Oncogene. vol 22. issue 16. 2003-05-23. PMID:12717420. |
here, we report that thap1 is a novel nuclear proapoptotic factor associated with pml nbs, which potentiates both serum withdrawal- and tnf alpha-induced apoptosis, and interacts with prostate-apoptosis-response-4 (par-4), a well characterized proapoptotic factor, previously linked to prostate cancer and neurodegenerative diseases. |
2003-05-23 |
2023-08-12 |
Not clear |
| Sonia Medina, Marcos Martínez, Angel Hernan. Antioxidants inhibit the human cortical neuron apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42. Free radical research. vol 36. issue 11. 2003-04-28. PMID:12592670. |
several substances related to the neurodegenerative diseases of alzheimer and parkinson, such as hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42, have been shown to induce apoptosis in tumoral cell lines and rat neurons but not in human neurons. |
2003-04-28 |
2023-08-12 |
human |
| Jung-Chul Seo, Sang-Won Han, Chang-Sik Yin, Hyung-Kyun Koh, Chang-Hwan Kim, Ee-Hwa Kim, Kang-Hyun Leem, Hyang-Sook Lee, Hi-Joon Park, Soon-Ae Kim, Bong-Keun Choe, Hee-Jae Lee, Sung-Vin Yim, Chang-Ju Kim, Joo-Ho Chun. Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients. Experimental & molecular medicine. vol 34. issue 4. 2003-04-11. PMID:12515395. |
apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and alzheimer's disease. |
2003-04-11 |
2023-08-12 |
Not clear |
| Jun-Sub Choi, Jeong-A Kim, Choun-Ki Jo. Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve. Investigative ophthalmology & visual science. vol 44. issue 4. 2003-04-10. PMID:12657617. |
neuronal cells undergo apoptosis when the supply of neurotrophic factor is limited by injury, trauma, or neurodegenerative disease. |
2003-04-10 |
2023-08-12 |
Not clear |
| Robert M Friedlande. Apoptosis and caspases in neurodegenerative diseases. The New England journal of medicine. vol 348. issue 14. 2003-04-09. PMID:12672865. |
apoptosis and caspases in neurodegenerative diseases. |
2003-04-09 |
2023-08-12 |
Not clear |
| Seiji Kikuchi, Kazuyoshi Shinpo, Sachiko Tsuji, Ichiro Yabe, Masaaki Niino, Kunio Tashir. Brefeldin A-induced neurotoxicity in cultured spinal cord neurons. Journal of neuroscience research. vol 71. issue 4. 2003-04-01. PMID:12548716. |
brefeldin a (bfa) is a fungus metabolite that is known to cause the disassembly of the golgi complex and apoptosis in exposed cells, both of which have been suggested as playing roles in the pathogenesis of neurodegenerative diseases, particularly amyotrophic lateral sclerosis (als). |
2003-04-01 |
2023-08-12 |
rat |