| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri A Sakya, Sophie Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Chris Green, Lise Skov, Sanne S Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James B Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwa. Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models. Science (New York, N.Y.). vol 379. issue 6639. 2023-03-30. PMID:36996217. |
aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative diseases. |
2023-03-30 |
2023-08-14 |
mouse |
| Lauren H Fairley, Imane Lejri, Amandine Grimm, Anne Ecker. Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982371. |
abnormal tau build-up is a hallmark of alzheimer's disease (ad) and more than 20 other serious neurodegenerative diseases. |
2023-03-29 |
2023-08-14 |
human |
| Prechiel A Barredo, Mannix P Balana. Recent Advances in Molecular Dynamics Simulations of Tau Fibrils and Oligomers. Membranes. vol 13. issue 3. 2023-03-29. PMID:36984665. |
the study of tau protein aggregation and interactions with other molecules or solvents using molecular dynamics simulations (mds) is of interest to many researchers to propose new mechanism-based therapeutics for neurodegenerative diseases such as alzheimer's disease, pick's disease, chronic traumatic encephalopathy, and other tauopathies. |
2023-03-29 |
2023-08-14 |
Not clear |
| Haruaki Sato, Kensaku Kasuga, Noriko Isoo, Toshihiro Hayashi, Takeshi Ikeuchi, Yukiko Hori, Taisuke Tomit. Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion. Neuroscience research. 2023-03-26. PMID:36967088. |
extracellular tau has been highlighted in the pathogenesis of alzheimer disease (ad), which is the most common neurodegenerative disease. |
2023-03-26 |
2023-08-14 |
mouse |
| Dailu Chen, Sofia Bali, Ruhar Singh, Aleksandra Wosztyl, Vishruth Mullapudi, Jaime Vaquer-Alicea, Parvathy Jayan, Shamiram Melhem, Harro Seelaar, John C van Swieten, Marc I Diamond, Lukasz A Joachimia. FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation. Nature communications. vol 14. issue 1. 2023-03-24. PMID:36959205. |
amyloid deposition of the microtubule-associated protein tau is associated with neurodegenerative diseases. |
2023-03-24 |
2023-08-14 |
Not clear |
| Carlo Condello, Jacob I Ayers, Clifton L Dalgard, M Madhy Garcia Garcia, Brianna M Rivera, William W Seeley, Daniel P Perl, Stanley B Prusine. Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 13. 2023-03-23. PMID:36952379. |
the amyotrophic lateral sclerosis-parkinsonism dementia complex (als-pdc) of guam is an endemic neurodegenerative disease that features widespread tau tangles, occasional α-synuclein lewy bodies, and sparse β-amyloid (aβ) plaques distributed in the central nervous system. |
2023-03-23 |
2023-08-14 |
Not clear |
| Jingjing Liu, Xin Zhang, Hui Wan. The cGAS-STING-mediated NLRP3 inflammasome is involved in the neurotoxicity induced by manganese exposure. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 154. 2023-03-21. PMID:36942606. |
inflammation and tau hyperphosphorylation are prominent hallmarks of neurodegenerative diseases induced by mn exposure. |
2023-03-21 |
2023-08-14 |
Not clear |
| Yu-Qing Liu, Chu-Qiao Liang, Zhi-Wei Chen, Jun Hu, Jin-Jian Hu, Yun-Yi Luo, Yong-Xiang Chen, Yan-Mei L. 14-3-3ζ Participates in the Phase Separation of Phosphorylated and Glycated Tau and Modulates the Physiological and Pathological Functions of Tau. ACS chemical neuroscience. 2023-03-20. PMID:36939323. |
tau plays a major role in alzheimer's disease (ad) and several other neurodegenerative diseases. |
2023-03-20 |
2023-08-14 |
Not clear |
| Fernando Gonzalez-Ortiz, Przemysław R Kac, Wagner S Brum, Henrik Zetterberg, Kaj Blennow, Thomas K Karikar. Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications. Molecular neurodegeneration. vol 18. issue 1. 2023-03-17. PMID:36927491. |
one such promising biomarker is plasma phosphorylated tau (p-tau), which has demonstrated specificity to ad versus non-ad neurodegenerative diseases, and will be extremely important to inform on clinical diagnosis and eligibility for therapies that have recently been approved. |
2023-03-17 |
2023-08-14 |
human |
| Suying Duan, Jing Yang, Zheqing Cui, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Lu Zhao, Yangyang Wang, Haiyang Luo, Yuming X. Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases. Translational neurodegeneration. vol 12. issue 1. 2023-03-16. PMID:36922862. |
in neurodegenerative diseases, nasal swab tests are currently being explored using seed amplification assay (saa) of pathogenic misfolded proteins, such as prion, α-synuclein, and tau. |
2023-03-16 |
2023-08-14 |
Not clear |
| Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake, Mikita Suyama, Takashi Saito, Takaomi C Saido, Minako It. Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease. Inflammation and regeneration. vol 43. issue 1. 2023-03-16. PMID:36922861. |
alzheimer's disease (ad) is one of the neurodegenerative diseases and characterized by the appearance and accumulation of amyloid-β (aβ) aggregates and phosphorylated tau with aging. |
2023-03-16 |
2023-08-14 |
mouse |
| Ha-Lim Song, Na-Young Kim, Jaewan Park, Meong Il Kim, Yu-Na Jeon, Se-Jong Lee, Kwangmin Cho, Young-Lim Shim, Kyoung-Hye Lee, Yeon-Seon Mun, Jung-A Song, Min-Seok Kim, Chan-Gi Pack, Minkyo Jung, Hyemin Jang, Duk L Na, Minsun Hong, Dong-Hou Kim, Seung-Yong Yoo. Monoclonal antibody Y01 prevents tauopathy progression induced by lysine280-acetylated tau in cell and mouse models. The Journal of clinical investigation. 2023-03-14. PMID:36917188. |
however, the mechanism that links tau acetylated on lysine 280 (tau-ack280) to subsequent progression to neurodegenerative disease remains unclear. |
2023-03-14 |
2023-08-14 |
mouse |
| Erika Cecon, Atsuro Oishi, Marine Luka, Delphine Ndiaye-Lobry, Arnaud François, Mathias Lescuyer, Fany Panayi, Julie Dam, Patricia Machado, Ralf Jocker. Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells. eLife. vol 12. 2023-03-14. PMID:36917493. |
aggregates of the tau protein are a well-known hallmark of several neurodegenerative diseases, collectively referred to as tauopathies, including frontal temporal dementia and alzheimer's disease (ad). |
2023-03-14 |
2023-08-14 |
Not clear |
| Evan Lester, Roy Parke. Tau, RNA, and RNA-Binding Proteins: Complex Interactions in Health and Neurodegenerative Diseases. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2023-03-09. PMID:36892034. |
tau, rna, and rna-binding proteins: complex interactions in health and neurodegenerative diseases. |
2023-03-09 |
2023-08-14 |
Not clear |
| Evan Lester, Roy Parke. Tau, RNA, and RNA-Binding Proteins: Complex Interactions in Health and Neurodegenerative Diseases. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2023-03-09. PMID:36892034. |
the tau protein is a key contributor to multiple neurodegenerative diseases. |
2023-03-09 |
2023-08-14 |
Not clear |
| Masaomi Miyamoto, Chio Okuyama, Shinya Kagawa, Kuninori Kusano, Masaaki Takahashi, Keisuke Takahata, Ming-Kuei Jang, Hiroshi Yamauch. Radiation dosimetry and pharmacokinetics of the tau PET tracer florzolotau (18F) in healthy Japanese subjects. Annals of nuclear medicine. 2023-03-08. PMID:36890399. |
abnormal aggregation of tau in the brain is a major contributing factor in various neurodegenerative diseases. |
2023-03-08 |
2023-08-14 |
human |
| Lizanne Arnoldy, Sarah Gauci, Lauren M Young, Wolfgang Marx, Helen Macpherson, Andrew Pipingas, Oren Civier, David J Whit. The association of dietary and nutrient patterns on neurocognitive decline: a systematic review of MRI and PET studies. Ageing research reviews. 2023-03-06. PMID:36878405. |
the inclusion criteria for the articles comprised studies reporting on the association between dietary patterns and neuroimaging outcomes, which includes both specific pathological hallmarks of neurodegenerative diseases such as aβ and tau and nonspecific markers such as structural mri and glucose metabolism. |
2023-03-06 |
2023-08-14 |
Not clear |
| b' Daniel Alcolea, Michal Schnaider Beeri, Julio C Rojas, Raquel C Gardner, Alberto Lle\\xc3\\xb. Blood Biomarkers in Neurodegenerative Diseases: Implications for the Clinical Neurologist. Neurology. 2023-03-06. PMID:36878698.' |
currently, research studies have reported robust assays of blood markers for the detection of amyloid and tau pathologies specific to alzheimer's disease (aß peptides, p-tau), as well as non-specific blood markers of neuronal (neurofilament light, ß-synuclein, ubiquitin-c-terminal-hydrolase-l1) and glial degeneration (glial fibrillary acidic protein) that can measure key pathophysiological processes in several neurodegenerative diseases. |
2023-03-06 |
2023-08-14 |
Not clear |
| Narendran Annadurai, Jiří Hrubý, Agáta Kubíčková, Lukáš Malina, Marián Hajdúch, Viswanath Da. Time- and dose-dependent seeding tendency of exogenous tau R2 and R3 aggregates in cells. Biochemical and biophysical research communications. vol 653. 2023-03-02. PMID:36863211. |
tauopathies are a group of neurodegenerative diseases categorised into three types, 3r, 4r, or 3r+4r (mixed) tauopathies, based on the tau isoforms that make up the aberrant filaments. |
2023-03-02 |
2023-08-14 |
Not clear |
| Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolise. Imaging Methods Applicable in the Diagnostics of Alzheimer's Disease, Considering the Involvement of Insulin Resistance. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834741. |
alzheimer's disease (ad) is an incurable neurodegenerative disease and the most frequently diagnosed type of dementia, characterized by (1) perturbed cerebral perfusion, vasculature, and cortical metabolism; (2) induced proinflammatory processes; and (3) the aggregation of amyloid beta and hyperphosphorylated tau proteins. |
2023-02-25 |
2023-08-14 |
Not clear |