| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Sinclair, J A Lee, A Goldstein, D Xing, S Liu, R Ju, P W Tucker, E J Neufeld, R H Scheuerman. Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood. vol 98. issue 13. 2002-01-11. PMID:11739170. |
analysis of t lymphopoiesis demonstrated that cux/cdp(delta hd/delta hd) mice had dramatically reduced thymic cellularity due to enhanced apoptosis, with a preferential loss of cd4(+)cd8(+) thymocytes. |
2002-01-11 |
2023-08-12 |
mouse |
| B L Bennett, D T Sasaki, B W Murray, E C O'Leary, S T Sakata, W Xu, J C Leisten, A Motiwala, S Pierce, Y Satoh, S S Bhagwat, A M Manning, D W Anderso. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 24. 2002-01-08. PMID:11717429. |
in animal studies, sp600125 blocked (bacterial) lipopolysaccharide-induced expression of tumor necrosis factor-alpha and inhibited anti-cd3-induced apoptosis of cd4(+) cd8(+) thymocytes. |
2002-01-08 |
2023-08-12 |
human |
| M Radojcic, N E Crompto. Age dependence of T-lymphocyte apoptosis induced by high-energy proton exposure. Radiation and environmental biophysics. vol 40. issue 2. 2001-12-21. PMID:11484784. |
the data analysis revealed an age-dependent sensitivity to radiation-induced apoptosis by 300 kvp x-rays and 138 mev protons, for both cd4 and cd8 t-lymphocytes. |
2001-12-21 |
2023-08-12 |
Not clear |
| M Radojcic, N E Crompto. Age dependence of T-lymphocyte apoptosis induced by high-energy proton exposure. Radiation and environmental biophysics. vol 40. issue 2. 2001-12-21. PMID:11484784. |
radiation-induced apoptosis was about 4 times greater in cd4 lymphocytes from the youngest donor than the oldest donor and was about 2 times greater in cd8 t-lymphocytes, both after x-ray and proton exposures. |
2001-12-21 |
2023-08-12 |
Not clear |
| M Radojcic, N E Crompto. Age dependence of T-lymphocyte apoptosis induced by high-energy proton exposure. Radiation and environmental biophysics. vol 40. issue 2. 2001-12-21. PMID:11484784. |
it is concluded that radiation-induced apoptosis of cd4 and cd8 t-lymphocytes, which is already exploited to predict patient response in conventional radiotherapy, may also be used to predict response in proton treatment planning. |
2001-12-21 |
2023-08-12 |
Not clear |
| T Iida, M Kita, T Kuwata, T Miura, K Ibuki, M Ui, M Hayami, J Imanish. Apoptosis induced by in vitro infection with simian-human immunodeficiency chimeric virus in macaque and human peripheral blood mononuclear cells. AIDS research and human retroviruses. vol 17. issue 15. 2001-12-21. PMID:11679151. |
in macaque pbmcs, the extent of virus production and apoptosis induction in cd4(+) cells was much greater in 89.6p infection than in nm-3rn infection. |
2001-12-21 |
2023-08-12 |
human |
| W P Brooks, M A Lyne. Effects of hemizygous CD45 expression in the autoimmune Fasl(gld/gld) syndrome. Cellular immunology. vol 212. issue 1. 2001-12-20. PMID:11716526. |
mice homozygous for the fasl(gld/gld) mutation cannot initiate apoptosis via the fas/fasl pathway and develop an autoimmune disease characterized by the accumulation of cd4(-)/cd8(-) (dn) t cells and a progressive t cell anergy. |
2001-12-20 |
2023-08-12 |
mouse |
| T W Orlikowsky, Z Q Wang, A Dudhane, G E Dannecker, D Niethammer, G P Wormser, M K Hoffmann, H W Horowit. Dexamethasone inhibits CD4 T cell deletion mediated by macrophages from human immunodeficiency virus-infected persons. The Journal of infectious diseases. vol 184. issue 10. 2001-12-19. PMID:11679924. |
prednisolone slows the loss of cd4 t cells in individuals with human immunodeficiency virus (hiv) disease and inhibits antigen-induced apoptosis of recently hiv-infected cd4 cells in vitro. |
2001-12-19 |
2023-08-12 |
human |
| I Sereti, B Herpin, J A Metcalf, R Stevens, M W Baseler, C W Hallahan, J A Kovacs, R T Davey, H C Lan. CD4 T cell expansions are associated with increased apoptosis rates of T lymphocytes during IL-2 cycles in HIV infected patients. AIDS (London, England). vol 15. issue 14. 2001-12-14. PMID:11579237. |
cd4 t cell expansions are associated with increased apoptosis rates of t lymphocytes during il-2 cycles in hiv infected patients. |
2001-12-14 |
2023-08-12 |
Not clear |
| I Sereti, B Herpin, J A Metcalf, R Stevens, M W Baseler, C W Hallahan, J A Kovacs, R T Davey, H C Lan. CD4 T cell expansions are associated with increased apoptosis rates of T lymphocytes during IL-2 cycles in HIV infected patients. AIDS (London, England). vol 15. issue 14. 2001-12-14. PMID:11579237. |
in an attempt to determine the mechanisms underlying the cd4 t cell expansions in patients receiving intermittent interleukin (il)-2, a cohort of 10 hiv infected patients were studied during a 5-day cycle of il-2 to measure rates of apoptosis, the expression of activation markers in cd4 and cd8 t cell subsets and the serum levels of proinflammatory cytokines. |
2001-12-14 |
2023-08-12 |
Not clear |
| J Fishman-Lobell, P Tsui, M Reddy, R DiPrinzio, C Eichman, R W Sweet, A Trune. CD4 mAb induced apoptosis of peripheral T cells: multiparameter subpopulation analysis by flow cytometry using Attractors. Journal of immunological methods. vol 257. issue 1-2. 2001-12-14. PMID:11687240. |
cd4 mab induced apoptosis of peripheral t cells: multiparameter subpopulation analysis by flow cytometry using attractors. |
2001-12-14 |
2023-08-12 |
human |
| J Fishman-Lobell, P Tsui, M Reddy, R DiPrinzio, C Eichman, R W Sweet, A Trune. CD4 mAb induced apoptosis of peripheral T cells: multiparameter subpopulation analysis by flow cytometry using Attractors. Journal of immunological methods. vol 257. issue 1-2. 2001-12-14. PMID:11687240. |
studies describing the induction of apoptosis for cd4 mabs do not delineate between epitope-dependent and fc-driven epitope cross-linking induced cell death. |
2001-12-14 |
2023-08-12 |
human |
| J Fishman-Lobell, P Tsui, M Reddy, R DiPrinzio, C Eichman, R W Sweet, A Trune. CD4 mAb induced apoptosis of peripheral T cells: multiparameter subpopulation analysis by flow cytometry using Attractors. Journal of immunological methods. vol 257. issue 1-2. 2001-12-14. PMID:11687240. |
depletion of cd4 t cells in vivo by keliximab may reflect, in part, antibody-mediated apoptosis of these cells that is dependent on fcgamma receptors. |
2001-12-14 |
2023-08-12 |
human |
| Y Suzuki, M Rahman, H Mitsuy. Diverse transcriptional response of CD4+ T cells to stromal cell-derived factor SDF-1: cell survival promotion and priming effects of SDF-1 on CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 6. 2001-12-12. PMID:11544290. |
when examined using complementary dna microarray, up-regulation of genes which are associated with dna repair, detoxification, apoptosis, cell morphology, cell adhesion, and signal transduction was seen in cd4(+) t cells upon sdf-1 exposure. |
2001-12-12 |
2023-08-12 |
Not clear |
| J Wang, E Guan, G Roderiquez, M A Norcros. Synergistic induction of apoptosis in primary CD4(+) T cells by macrophage-tropic HIV-1 and TGF-beta1. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 6. 2001-12-12. PMID:11544326. |
synergistic induction of apoptosis in primary cd4(+) t cells by macrophage-tropic hiv-1 and tgf-beta1. |
2001-12-12 |
2023-08-12 |
Not clear |
| J Wang, E Guan, G Roderiquez, M A Norcros. Synergistic induction of apoptosis in primary CD4(+) T cells by macrophage-tropic HIV-1 and TGF-beta1. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 6. 2001-12-12. PMID:11544326. |
virus production by cells cultured in the presence of il-2 was inhibited by tgf-beta1, and this inhibition was accompanied by a loss of t cells from the culture and an increase in cd4(+) t cell apoptosis. |
2001-12-12 |
2023-08-12 |
Not clear |
| J Wang, E Guan, G Roderiquez, M A Norcros. Synergistic induction of apoptosis in primary CD4(+) T cells by macrophage-tropic HIV-1 and TGF-beta1. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 6. 2001-12-12. PMID:11544326. |
whereas r5x4 and x4 hiv-1 infection was sufficient to induce t cell apoptosis, r5 hiv-1 failed to induce apoptosis of pbls in the absence of tgf-beta1 despite the fact that r5 hiv-1 depletes cd4(+) t cells in vivo. |
2001-12-12 |
2023-08-12 |
Not clear |
| J Wang, E Guan, G Roderiquez, M A Norcros. Synergistic induction of apoptosis in primary CD4(+) T cells by macrophage-tropic HIV-1 and TGF-beta1. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 6. 2001-12-12. PMID:11544326. |
these results show that tgf-beta1 promotes depletion of cd4(+) t cells after r5 hiv-1 infection by inducing apoptosis and suggest that tgf-beta1 might contribute to the pathogenesis of hiv-1 infection in vivo. |
2001-12-12 |
2023-08-12 |
Not clear |
| b' A M Dyrhol-Riise, G Stent, B I R\\xc3\\xb8sok, P Voltersvik, J Olofsson, B Asj\\xc3\\xb. The Fas/FasL system and T cell apoptosis in HIV-1-infected lymphoid tissue during highly active antiretroviral therapy. Clinical immunology (Orlando, Fla.). vol 101. issue 2. 2001-12-07. PMID:11683576.' |
cd4 cell apoptosis was predominantly seen within the memory cd28+ fas+ fasl+ population. |
2001-12-07 |
2023-08-12 |
Not clear |
| b' A M Dyrhol-Riise, M Ohlsson, K Skarstein, S J Nygaard, J Olofsson, R Jonsson, B Asj\\xc3\\xb. T cell proliferation and apoptosis in HIV-1-infected lymphoid tissue: impact of highly active antiretroviral therapy. Clinical immunology (Orlando, Fla.). vol 101. issue 2. 2001-12-07. PMID:11683577.' |
prior to therapy, cd4 cell proliferation (%cd4+ ki67+) and apoptosis (%cd4+ tunel+) were increased in hiv-1-infected lt and both parameters correlated with tonsillar viral load. |
2001-12-07 |
2023-08-12 |
Not clear |