| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P M Roger, L E Bermude. Infection of mice with Mycobacterium avium primes CD8+ lymphocytes for apoptosis upon exposure to macrophages. Clinical immunology (Orlando, Fla.). vol 99. issue 3. 2001-06-21. PMID:11358435. |
using a double staining tunel followed by anti-mouse cd4 or anti-mouse cd8 monoclonal antibodies, it was observed that only cd8+ t cells but not cd4+ t cells underwent apoptosis at 3 weeks of infection. |
2001-06-21 |
2023-08-12 |
mouse |
| A R Hamad, A Srikrishnan, P Mirmonsef, C P Broeren, C H June, D Pardoll, J P Schnec. Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunity. The Journal of experimental medicine. vol 193. issue 10. 2001-06-21. PMID:11369783. |
enhanced survival of cd4(-/-) t cells was due to decreased apoptosis rather than enhanced proliferation. |
2001-06-21 |
2023-08-12 |
mouse |
| J Estaquier, V Monceaux, M C Cumont, A M Aubertin, B Hurtrel, J C Ameise. Early changes in peripheral blood T cells during primary infection of rhesus macaques with a pathogenic SIV. Journal of medical primatology. vol 29. issue 3-4. 2001-06-07. PMID:11085574. |
the primary phase of infection was associated with changes in the t cells expressing cd25, cd69, or hla-dr and with a priming of the peripheral blood cd4 and cd8 t cells for a process of apoptosis in vitro that was enhanced by cd95 (fas) ligation, and was detected in two macaques as early as 7 days after infection. |
2001-06-07 |
2023-08-12 |
Not clear |
| J Estaquier, V Monceaux, M C Cumont, A M Aubertin, B Hurtrel, J C Ameise. Early changes in peripheral blood T cells during primary infection of rhesus macaques with a pathogenic SIV. Journal of medical primatology. vol 29. issue 3-4. 2001-06-07. PMID:11085574. |
our findings suggest the possibility that the early activation and priming for apoptosis of cd4 and cd8 t cells may involve indirect, host-related, mechanisms, or alternatively, that the t cells that remain in the peripheral blood during primary infection do not adequately reflect the viral-mediated changes in t cell activation and death that may occur in the lymphoid organs throughout the body. |
2001-06-07 |
2023-08-12 |
Not clear |
| C Cerdan, E Devilard, L Xerri, D Oliv. The C-class chemokine lymphotactin costimulates the apoptosis of human CD4(+) T cells. Blood. vol 97. issue 8. 2001-05-24. PMID:11290580. |
the c-class chemokine lymphotactin costimulates the apoptosis of human cd4(+) t cells. |
2001-05-24 |
2023-08-12 |
human |
| C Cerdan, E Devilard, L Xerri, D Oliv. The C-class chemokine lymphotactin costimulates the apoptosis of human CD4(+) T cells. Blood. vol 97. issue 8. 2001-05-24. PMID:11290580. |
this study demonstrates that the functional repertoire of lptn in the regulation of human cd4(+) t-lymphocyte activation includes the ability to costimulate apoptosis. |
2001-05-24 |
2023-08-12 |
human |
| J E Pearl, I M Orme, A M Coope. CD95 signaling is not required for the down regulation of cellular responses to systemic Mycobacterium tuberculosis infection. Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. vol 80. issue 6. 2001-05-10. PMID:11162768. |
there is a tendency among tuberculosis patients to have reduced cellular responses to mycobacterial antigens and this loss has been associated with apoptosis of cd4 t cells. |
2001-05-10 |
2023-08-12 |
mouse |
| L S Taams, J Smith, M H Rustin, M Salmon, L W Poulter, A N Akba. Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. European journal of immunology. vol 31. issue 4. 2001-05-10. PMID:11298337. |
isolated cd4(+)cd25(+) t cells are susceptible to apoptosis that is associated with low bcl-2 expression, but this death can be prevented by il-2 or fibroblast-secreted ifn-beta. |
2001-05-10 |
2023-08-12 |
human |
| C E Alexander, P M Kaye, C R Engwerd. CD95 is required for the early control of parasite burden in the liver of Leishmania donovani-infected mice. European journal of immunology. vol 31. issue 4. 2001-05-10. PMID:11298345. |
adoptive transfer of cd4(+) and cd8(+) t cells into recombinase activating gene 1 knockout (rag-1(- / -)) recipients, revealed that cd95l expressed on cd4(+) t cells contributes to early control of l. donovani infection in the liver via mechanisms that are independent of granuloma formation and induction of apoptosis. |
2001-05-10 |
2023-08-12 |
mouse |
| A Stallmach, T Giese, K Pfister, B M Wittig, S Künne, M Humphries, M Zeitz, S C Meue. Activation of beta(1) integrins mediates proliferation and inhibits apoptosis of intestinal CD4-positive lymphocytes. European journal of immunology. vol 31. issue 4. 2001-05-10. PMID:11298349. |
we demonstrated that beta(1) integrin costimulation restored cd3-induced proliferation of cd4(+) lpl and reduced activation-induced apoptosis. |
2001-05-10 |
2023-08-12 |
Not clear |
| C Deng, E Goluszko, P Christados. Fas/Fas ligand pathway, apoptosis, and clonal anergy involved in systemic acetylcholine receptor T cell epitope tolerance. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 5. 2001-04-26. PMID:11207304. |
the findings implicate the possible role of fas-/fas ligand-mediated apoptosis and the resulting clonal anergy as the mechanisms of high dose achr alpha 146--162 peptide-induced tolerance on cd4 cells. |
2001-04-26 |
2023-08-12 |
mouse |
| C Scheller, C Jasso. Syncytium formation amplifies apoptotic signals: a new view on apoptosis in HIV infection in vitro. Virology. vol 282. issue 1. 2001-04-26. PMID:11259189. |
this study demonstrates that apoptosis did not occur in single cells and was mediated neither by cd4 nor by coreceptor signaling, indicating that apoptosis was not induced by intra- or intercellular glycoprotein-receptor interaction. |
2001-04-26 |
2023-08-12 |
Not clear |
| M Nieda, A Nicol, Y Koezuka, A Kikuchi, N Lapteva, Y Tanaka, K Tokunaga, K Suzuki, N Kayagaki, H Yagita, H Hirai, T Juj. TRAIL expression by activated human CD4(+)V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells. Blood. vol 97. issue 7. 2001-04-26. PMID:11264173. |
trail expression by activated human cd4(+)v alpha 24nkt cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells. |
2001-04-26 |
2023-08-12 |
human |
| M Nieda, A Nicol, Y Koezuka, A Kikuchi, N Lapteva, Y Tanaka, K Tokunaga, K Suzuki, N Kayagaki, H Yagita, H Hirai, T Juj. TRAIL expression by activated human CD4(+)V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells. Blood. vol 97. issue 7. 2001-04-26. PMID:11264173. |
a nonobese diabetic-severe combined immunodeficient human leukemia (aml m4) model showed that human activated cd4(+)v alpha 24nkt cells induced apoptosis of human leukemia cells in vivo. |
2001-04-26 |
2023-08-12 |
human |
| D Andrew, R Aspinal. Il-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 3. 2001-04-19. PMID:11160192. |
because there is no age-associated decrease in the number of cd44(+)cd25(-)cd3(-)cd4(-)cd8(-) cells, this study investigated whether alterations in apoptosis within the tn pathway accounted for diminishing thymocyte numbers with age. |
2001-04-19 |
2023-08-12 |
mouse |
| J M Schwab, T D Nguyen, R Meyermann, H J Schluesene. Human focal cerebral infarctions induce differential lesional interleukin-16 (IL-16) expression confined to infiltrating granulocytes, CD8+ T-lymphocytes and activated microglia/macrophages. Journal of neuroimmunology. vol 114. issue 1-2. 2001-04-12. PMID:11240037. |
mature il-16 is an immunomodulatory cytokine, exerting cd4 dependent and independent effects and is characterized by chemotactic activity, induction of early gene phosphorylation, stimulation of pro-inflammatory il-1beta, il-6, tnfalpha expression in monocytic cells and also modulates apoptosis. |
2001-04-12 |
2023-08-12 |
human |
| C S Hirsch, Z Toossi, J L Johnson, H Luzze, L Ntambi, P Peters, M McHugh, A Okwera, M Joloba, P Mugyenyi, R D Mugerwa, P Terebuh, J J Ellne. Augmentation of apoptosis and interferon-gamma production at sites of active Mycobacterium tuberculosis infection in human tuberculosis. The Journal of infectious diseases. vol 183. issue 5. 2001-03-29. PMID:11181155. |
apoptosis of cd4 and non-cd4 t cells in the pleural space occurred in both hiv/tb and tb. |
2001-03-29 |
2023-08-12 |
human |
| P Ruiz, L Coleman, F Wang, J Ente. Differential kinetics of intracellular caspase-1-like and caspase-3-like enzyme activity in human alloreactive CD4(+) and CD8(+) T cells undergoing apoptosis. Clinical immunology (Orlando, Fla.). vol 98. issue 3. 2001-03-29. PMID:11237553. |
differential kinetics of intracellular caspase-1-like and caspase-3-like enzyme activity in human alloreactive cd4(+) and cd8(+) t cells undergoing apoptosis. |
2001-03-29 |
2023-08-12 |
human |
| T Niehues, T W McCloskey, J Ndagijimana, G Horneff, V Wahn, S Pahw. Apoptosis in T-lymphocyte subsets in human immunodeficiency virus-infected children measured immediately ex vivo and following in vitro activation. Clinical and diagnostic laboratory immunology. vol 8. issue 1. 2001-03-22. PMID:11139198. |
phosphatidylserine molecules are translocated to the outer plasma membrane of lymphocytes undergoing apoptosis and can be detected by the binding of fluorochrome-conjugated annexin v. using the annexin v assay, we examined cd4 and cd8 t cells from human immunodeficiency virus (hiv)-infected children for apoptosis upon isolation or following in vitro culture. |
2001-03-22 |
2023-08-12 |
human |
| T Niehues, T W McCloskey, J Ndagijimana, G Horneff, V Wahn, S Pahw. Apoptosis in T-lymphocyte subsets in human immunodeficiency virus-infected children measured immediately ex vivo and following in vitro activation. Clinical and diagnostic laboratory immunology. vol 8. issue 1. 2001-03-22. PMID:11139198. |
immediate ex vivo analysis or overnight culture showed significantly higher levels of apoptosis in cd8 cells than in cd4 cells. |
2001-03-22 |
2023-08-12 |
human |