| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Viganò, M Pinti, M Nasi, L Moretti, F Balli, C Mussini, D Bricalli, N Sala, R Bugarini, S Vella, N Principi, A Cossarizz. Markers of cell death-activation in lymphocytes of vertically HIV-infected children naive to highly active antiretroviral therapy: the role of age. The Journal of allergy and clinical immunology. vol 108. issue 3. 2001-10-11. PMID:11544465. |
apoptosis plays a major role in depleting cd4(+) lymphocytes during infection with hiv-1. |
2001-10-11 |
2023-08-12 |
Not clear |
| A V Evans, B P Wood, J J Scarisbrick, E A Fraser-Andrews, S Chinn, A Dean, P Watkins, S J Whittaker, R Russell-Jone. Extracorporeal photopheresis in Sézary syndrome: hematologic parameters as predictors of response. Blood. vol 98. issue 5. 2001-10-04. PMID:11520774. |
these data show that the modest falls in cd4, cd8, and sézary cell counts were seen in all patients and might have resulted from lymphocyte apoptosis. |
2001-10-04 |
2023-08-12 |
human |
| J J Bleesing, M R Brown, J K Dale, S E Straus, M J Lenardo, J M Puck, T P Atkinson, T A Fleishe. TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clinical immunology (Orlando, Fla.). vol 100. issue 3. 2001-09-20. PMID:11513545. |
autoimmune lymphoproliferative syndrome (alps), caused by inherited defects in apoptosis secondary to mutations in genes encoding fas/cd95/apo-1 and fas ligand (fasl)/cd95l, is characterized by nonmalignant lymphadenopathy and splenomegaly, increased t cell receptor alpha/beta(+) cd4(-)cd8(-) t cells (alpha/beta(+) double-negative t cells [alpha/beta(+)-dnt cells]), autoimmunity, hypergammaglobulinemia, and cytokine abnormalities. |
2001-09-20 |
2023-08-12 |
mouse |
| J Strong, Q Wang, N Killee. Impaired survival of T helper cells in the absence of CD4. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 5. 2001-09-13. PMID:11226279. |
t helper cells that lack cd4 expression are prone to apoptosis and show diminished survival after adoptive transfer to irradiated recipients. |
2001-09-13 |
2023-08-12 |
Not clear |
| G J Wiegers, M Knoflach, G Böck, H Niederegger, H Dietrich, A Falus, R Boyd, G Wic. CD4(+)CD8(+)TCR(low) thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis. European journal of immunology. vol 31. issue 8. 2001-09-13. PMID:11477541. |
cd4(+)cd8(+)tcr(low) thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis. |
2001-09-13 |
2023-08-12 |
Not clear |
| G J Wiegers, M Knoflach, G Böck, H Niederegger, H Dietrich, A Falus, R Boyd, G Wic. CD4(+)CD8(+)TCR(low) thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis. European journal of immunology. vol 31. issue 8. 2001-09-13. PMID:11477541. |
while signaling by either the tcr or glucocorticoid receptor (gr) can induce apoptosis in thymocytes, recent studies have shown that combining these signals results in survival of cd4(+)cd8(+) thymocytes. |
2001-09-13 |
2023-08-12 |
Not clear |
| G J Wiegers, M Knoflach, G Böck, H Niederegger, H Dietrich, A Falus, R Boyd, G Wic. CD4(+)CD8(+)TCR(low) thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis. European journal of immunology. vol 31. issue 8. 2001-09-13. PMID:11477541. |
interestingly, the latter population, although expressing less than half the gr density of cd4(-)cd8(-)tcr(-) cells, is the most sensitive subset to gc-induced apoptosis. |
2001-09-13 |
2023-08-12 |
Not clear |
| N Selliah, T H Finke. HIV-1 NL4-3, but not IIIB, inhibits JAK3/STAT5 activation in CD4(+) T cells. Virology. vol 286. issue 2. 2001-09-06. PMID:11485409. |
we have also shown that while some strains of hiv-1, such as nl4-3, induce apoptosis of infected cd4(+) t cells, other strains, such as hiv-1 iiib, do not. |
2001-09-06 |
2023-08-12 |
Not clear |
| S Casares, C A Bona, T D Brumean. Enzymatically mediated engineering of multivalent MHC class II-peptide chimeras. Protein engineering. vol 14. issue 3. 2001-08-23. PMID:11342717. |
using this method, we generated covalently stabilized tetravalent and octavalent mhc ii-peptide ligands which bound stably and specifically to cognate tcr and preserved their structural integrity in blood and lymphoid organs for 72 h. depending on the tcr/cd4 occupancy and degree of tcr/cd4 co-clustering, the multivalent mhc ii-peptide ligands polarized efficiently the antigen-specific cd4(+) t-cells toward type 2 cell differentiation or induced t-cell anergy and apoptosis. |
2001-08-23 |
2023-08-12 |
Not clear |
| S Hamasaki, T Nakamura, T Furuya, A Kawakami, K Ichinose, T Nakashima, Y Nishiura, S Shirabe, K Eguch. Resistance of CD4-positive T lymphocytes to etoposide-induced apoptosis mediated by upregulation of Bcl-xL expression in patients with HTLV-I-associated myelopathy. Journal of neuroimmunology. vol 117. issue 1-2. 2001-08-23. PMID:11431014. |
our results indicate that peripheral blood cd4(+) t lymphocytes of ham patients are resistant to apoptosis triggered through mitochondrial death pathway through upregulation of expression of anti-apoptotic protein, bcl-xl. |
2001-08-23 |
2023-08-12 |
human |
| R Roggero, V Robert-Hebmann, S Harrington, J Roland, L Vergne, S Jaleco, C Devaux, M Biard-Piechaczy. Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of Fas signaling. Journal of virology. vol 75. issue 16. 2001-08-23. PMID:11462036. |
apoptosis of cd4(+) t lymphocytes, induced by contact between human immunodeficiency virus type 1 (hiv-1) envelope glycoprotein (gp120) and its receptors, could contribute to the cell depletion observed in hiv-infected individuals. |
2001-08-23 |
2023-08-12 |
human |
| R Roggero, V Robert-Hebmann, S Harrington, J Roland, L Vergne, S Jaleco, C Devaux, M Biard-Piechaczy. Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of Fas signaling. Journal of virology. vol 75. issue 16. 2001-08-23. PMID:11462036. |
to get insight into the signal transduction pathways connecting cxcr4 to apoptosis following gp120 binding, we used different cell lines expressing wild-type cxcr4 and a truncated form of cd4 that binds gp120 but lacks the ability to transduce signals. |
2001-08-23 |
2023-08-12 |
human |
| R Roggero, V Robert-Hebmann, S Harrington, J Roland, L Vergne, S Jaleco, C Devaux, M Biard-Piechaczy. Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of Fas signaling. Journal of virology. vol 75. issue 16. 2001-08-23. PMID:11462036. |
in addition, following coculture with cells expressing gp120, a fas-independent apoptosis involving mitochondria and caspase activation is also observed in primary umbilical cord blood cd4(+) t lymphocytes expressing high levels of cxcr4. |
2001-08-23 |
2023-08-12 |
human |
| H Bassiri, S R Cardin. A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 10. 2001-08-09. PMID:11342609. |
by using nontransgenic and transgenic il-2-sufficient and -deficient animal model systems, we have shown that during tcr-mediated thymocyte apoptosis, il-2 protein is expressed in situ in the thymus, and apoptotic thymocytes up-regulate expression of il-2rs: il-2r(+) double-positive and cd4 single-positive thymocytes undergoing activation-induced cell death bind and internalize il-2. |
2001-08-09 |
2023-08-12 |
mouse |
| M Wolf, A Schimpl, T Hüni. Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms. European journal of immunology. vol 31. issue 6. 2001-08-09. PMID:11385607. |
il-2 deficiency therefore may upset t cell homeostasis by two distinct mechanisms: the failure to program expanding t cells for apoptosis, and the failure to generate functional cd4(+)cd25(+) regulatory cells. |
2001-08-09 |
2023-08-12 |
mouse |
| D L Pitrak, J Bolaños, R Hershow, R M Nova. Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis. AIDS (London, England). vol 15. issue 10. 2001-08-09. PMID:11426081. |
discordant cd4 t lymphocyte responses to antiretroviral therapy for hiv infection are associated with ex-vivo rates of apoptosis. |
2001-08-09 |
2023-08-12 |
Not clear |
| D L Pitrak, J Bolaños, R Hershow, R M Nova. Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis. AIDS (London, England). vol 15. issue 10. 2001-08-09. PMID:11426081. |
our purpose was to determine if changes in cd4 cell counts in hiv-infected patients with good viral suppression on stable antiretroviral regimens could be predicted by ex-vivo rates of apoptosis of peripheral blood mononuclear cells (pbmc). |
2001-08-09 |
2023-08-12 |
Not clear |
| S E Straus, E S Jaffe, J M Puck, J K Dale, K B Elkon, A Rösen-Wolff, A M Peters, M C Sneller, C W Hallahan, J Wang, R E Fischer, C E Jackson, A Y Lin, C Bäumler, E Siegert, A Marx, A K Vaishnaw, T Grodzicky, T A Fleisher, M J Lenard. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood. vol 98. issue 1. 2001-07-26. PMID:11418480. |
lymphoma phenotype was determined by immunohistochemistry, frequency of cd3(+)cd4(-)cd8(-) t-cell-receptor alpha/beta cells by flow cytometry, nucleotide sequences of the gene encoding fas (apt1, tnfrsf6), and the percentage of lymphocytes undergoing apoptosis in vitro. |
2001-07-26 |
2023-08-12 |
Not clear |
| V Daniel, C Süsal, R Weimer, R Zimmermann, A Huth-Kühne, G Opel. Increased soluble Fas in HIV-infected hemophilia patients with CD4+ and CD8+ cell count increases and viral load and immune complex decreases. AIDS research and human retroviruses. vol 17. issue 4. 2001-07-12. PMID:11242519. |
previous studies interpreted increases of soluble fas (sfas) in the plasma during disease progression in hiv-infected patients as evidence of increased apoptosis of cd4(+) lymphocytes. |
2001-07-12 |
2023-08-12 |
Not clear |
| A M Steff, S Trop, M Maira, J Drouin, P Hug. Opposite ability of pre-TCR and alpha beta TCR to induce apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 8. 2001-06-28. PMID:11290785. |
in this work, we directly compared the capability of pre-tcr and alphabetatcr to induce apoptosis in a cd4(-)cd8(-) thymoma cell line following receptor cross-linking with mabs. |
2001-06-28 |
2023-08-12 |
Not clear |