| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Wang, M J Lenard. Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95. The Journal of experimental medicine. vol 186. issue 7. 1997-11-13. PMID:9314566. |
b cells are susceptible to fas ligand (fasl)+ cd4(+) th1 cell-mediated apoptosis. |
1997-11-13 |
2023-08-12 |
mouse |
| B D Jamieson, C H Uittenbogaart, I Schmid, J A Zac. High viral burden and rapid CD4+ cell depletion in human immunodeficiency virus type 1-infected SCID-hu mice suggest direct viral killing of thymocytes in vivo. Journal of virology. vol 71. issue 11. 1997-11-13. PMID:9343176. |
increased levels of apoptosis were observed during the later phase of thymocyte depletion; however, these apoptotic cells lacked cd4. |
1997-11-13 |
2023-08-12 |
mouse |
| A Samuelsson, A Sönnerborg, N Heuts, J Cöster, F Chiod. Progressive B cell apoptosis and expression of Fas ligand during human immunodeficiency virus type 1 infection. AIDS research and human retroviruses. vol 13. issue 12. 1997-10-10. PMID:9264290. |
apoptosis of both b cells and cd4+ cells correlated inversely with cd4 cell counts. |
1997-10-10 |
2023-08-12 |
human |
| C Guntermann, R Zheng, K E Ny. The effects of CD3, CD4 and CD28 signaling on lymphocytes during human immunodeficiency virus-1 infection. European journal of immunology. vol 27. issue 8. 1997-09-30. PMID:9295033. |
our data demonstrate the importance of appropriate cd3, cd4 and cd28 co-stimulatory function to prevent apoptosis. |
1997-09-30 |
2023-08-12 |
human |
| J Estaquier, M Marguerite, F Sahuc, N Bessis, C Auriault, J C Ameise. Interleukin-10-mediated T cell apoptosis during the T helper type 2 cytokine response in murine Schistosoma mansoni parasite infection. European cytokine network. vol 8. issue 2. 1997-09-29. PMID:9262964. |
here we report that the th2 cytokine response, which begins 6 weeks after infection, at the time of parasite egg laying (i) does not occur in the context of a genuine th1 to th2 cytokine switch, but is associated with a persistent capacity of th1 (or th0) cells to secrete il-2 and ifn-gamma in response to t cell receptor (tcr) stimulation; (ii) is associated, in vitro, with spontaneous death by apoptosis of a significant fraction of the cd4 and cd8 t cells, which is greatly enhanced by tcr stimulation; and (iii) is associated, in vivo, with numerous and large clusters of apoptotic cells in the spleen and in the inflammatory infiltrates surrounding the parasite egg deposits in the liver. |
1997-09-29 |
2023-08-12 |
mouse |
| E Milia, M M Di Somma, M B Majolini, C Ulivieri, F Somma, E Piccolella, J L Telford, C T Baldar. Gene activating and proapoptotic potential are independent properties of different CD4 epitopes. Molecular immunology. vol 34. issue 4. 1997-08-18. PMID:9244341. |
the outcome of cd4 engagement is t-cell commitment to alternative, dramatically different fates, such as activation and apoptosis. |
1997-08-18 |
2023-08-12 |
Not clear |
| E Milia, M M Di Somma, M B Majolini, C Ulivieri, F Somma, E Piccolella, J L Telford, C T Baldar. Gene activating and proapoptotic potential are independent properties of different CD4 epitopes. Molecular immunology. vol 34. issue 4. 1997-08-18. PMID:9244341. |
no correlation could be found between capacity of specific cd4 epitopes to deliver a gene activating signal and capacity to prime t-cells to apoptosis, suggesting that gene activating and proapoptotic potential are independent functions of cd4 epitopes. |
1997-08-18 |
2023-08-12 |
Not clear |
| S V Pakala, M O Kurrer, J D Kat. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. The Journal of experimental medicine. vol 186. issue 2. 1997-08-14. PMID:9221759. |
autoimmune diabetes is caused by the cd4(+), t helper 1 (th1) cell-mediated apoptosis of insulin-producing beta cells. |
1997-08-14 |
2023-08-12 |
mouse |
| F Hashimoto, N Oyaizu, V S Kalyanaraman, S Pahw. Modulation of Bcl-2 protein by CD4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2. Blood. vol 90. issue 2. 1997-08-07. PMID:9226175. |
modulation of bcl-2 protein by cd4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2. |
1997-08-07 |
2023-08-12 |
human |
| F Hashimoto, N Oyaizu, V S Kalyanaraman, S Pahw. Modulation of Bcl-2 protein by CD4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2. Blood. vol 90. issue 2. 1997-08-07. PMID:9226175. |
we have previously demonstrated that cd4 cross-linking (cd4xl) results in apoptosis of cd4+ t cells and augmentation of fas antigen (cd95, apo-1) expression in cd4+ and cd8+ t cells. |
1997-08-07 |
2023-08-12 |
human |
| F Hashimoto, N Oyaizu, V S Kalyanaraman, S Pahw. Modulation of Bcl-2 protein by CD4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2. Blood. vol 90. issue 2. 1997-08-07. PMID:9226175. |
these results support the hypothesis that cd4 ligation by hiv-1 envelope protein in vivo in hiv-infected patients selectively reduces bcl-2 protein in cd4+ t lymphocytes, thereby facilitating fas/fas-ligand triggered apoptosis; furthermore the findings reported expand the rationale for use of il-2 in hiv disease. |
1997-08-07 |
2023-08-12 |
human |
| M Ozsahin, H Ozsahin, Y Shi, B Larsson, F E Würgler, N E Crompto. Rapid assay of intrinsic radiosensitivity based on apoptosis in human CD4 and CD8 T-lymphocytes. International journal of radiation oncology, biology, physics. vol 38. issue 2. 1997-07-31. PMID:9226332. |
rapid assay of intrinsic radiosensitivity based on apoptosis in human cd4 and cd8 t-lymphocytes. |
1997-07-31 |
2023-08-12 |
human |
| M Ozsahin, H Ozsahin, Y Shi, B Larsson, F E Würgler, N E Crompto. Rapid assay of intrinsic radiosensitivity based on apoptosis in human CD4 and CD8 T-lymphocytes. International journal of radiation oncology, biology, physics. vol 38. issue 2. 1997-07-31. PMID:9226332. |
we have developed a rapid assay (about 24 h) able to predict intrinsic radiosensitivity of cd4 and cd8 t-lymphocytes based on radiation-induced apoptosis. |
1997-07-31 |
2023-08-12 |
human |
| S A Stewart, B Poon, J B Jowett, I S Che. Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest. Journal of virology. vol 71. issue 7. 1997-07-10. PMID:9188632. |
these studies indicate that vpr is capable of inducing apoptosis, and we propose that both the initial arrest of cells and subsequent apoptosis may contribute to cd4 cell depletion in hiv-1 disease. |
1997-07-10 |
2023-08-12 |
human |
| S J James, M Pogribna, B J Miller, B Bolon, L Muskhelishvil. Characterization of cellular response to silicone implants in rats: implications for foreign-body carcinogenesis. Biomaterials. vol 18. issue 9. 1997-07-09. PMID:9151998. |
endpoints included expression of leucocyte antigens cd4 (t helper/inducer), cd8 (t suppressor/cytotoxic) and cd11 b/c (macrophage), proliferating cell nuclear antigen (pcna) as an indicator of proliferation, and in situ end-labelling (isel) of 3'oh dna strand breaks as an indicator of dna damage and apoptosis. |
1997-07-09 |
2023-08-12 |
rat |
| S H Khoo, L Pepper, N Snowden, A H Hajeer, P Vallely, E G Wilkins, B K Mandal, W E Ollie. Tumour necrosis factor c2 microsatellite allele is associated with the rate of HIV disease progression. AIDS (London, England). vol 11. issue 4. 1997-07-08. PMID:9084788. |
tumour necrosis factor (tnf)-alpha and lymphotoxin stimulate hiv replication and may induce apoptosis of hiv-infected and uninfected lymphocytes in vitro, thus accelerating disease progression and cd4 depletion. |
1997-07-08 |
2023-08-12 |
human |
| N L Perillo, C H Uittenbogaart, J T Nguyen, L G Bau. Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. The Journal of experimental medicine. vol 185. issue 10. 1997-06-24. PMID:9151710. |
we now report that in vitro exposure to galectin-1 induced apoptosis of two subsets of cd4(lo) cd8(lo) thymocytes. |
1997-06-24 |
2023-08-12 |
human |
| E A Reap, K Roof, K Maynor, M Borrero, J Booker, P L Cohe. Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 11. 1997-06-19. PMID:9159145. |
thy1, cd4, cd8, and igm cells from lpr showed much lower levels of apoptosis than control cells after irradiation. |
1997-06-19 |
2023-08-12 |
mouse |
| E Peterhan. Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation. The Journal of nutrition. vol 127. issue 5 Suppl. 1997-06-13. PMID:9164274. |
via activation of nf kappa b, ros may activate viral replication, but oxidants are believed to contribute also to the loss of cd4 t cells by apoptosis. |
1997-06-13 |
2023-08-12 |
mouse |
| M G Cifone, E Alesse, L Di Marzio, B Ruggeri, F Zazzeroni, S Moretti, G Famularo, S M Steinberg, E Vullo, C De Simon. Effect of L-carnitine treatment in vivo on apoptosis and ceramide generation in peripheral blood lymphocytes from AIDS patients. Proceedings of the Association of American Physicians. vol 109. issue 2. 1997-06-03. PMID:9069583. |
in this study, we examined the effects of a short-term (5-day) intravenous treatment with l-carnitine (6 g/day) on apoptosis of cd4 and cd8 cells from 10 aids patients. |
1997-06-03 |
2023-08-12 |
Not clear |