| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ladislav Senolt, Mariam Grigorian, Eugene Lukanidin, Beat A Michel, Renate E Gay, Steffen Gay, Karel Pavelka, Michel Neidhar. S100A4 (Mts1): is there any relation to the pathogenesis of rheumatoid arthritis? Autoimmunity reviews. vol 5. issue 2. 2006-04-10. PMID:16431343. |
s100a4 binds to distinct intracellular target proteins and regulates specific functions involved in tumor progression such as cell motility, proliferation and apoptosis as well as remodelling of the extracellular matrix. |
2006-04-10 |
2023-08-12 |
Not clear |
| Da-wei Guan, Rui Zhao, Yu D. [Expressions of NOS isoforms and roles of NO during skin wound healing]. Fa yi xue za zhi. vol 20. issue 4. 2006-04-07. PMID:15751659. |
nitric oxide synthase (nos) isoforms, as important factors during skin wound healing, synthesize nitric oxide (no) which may be involved in the whole event of skin wound healing and play important roles in cell proliferation, differentiation and apoptosis, angiogenesis, matrix deposits and remolding. |
2006-04-07 |
2023-08-12 |
Not clear |
| Bharat B Aggarwal, Yasunari Takada, Oommen V Oomme. From chemoprevention to chemotherapy: common targets and common goals. Expert opinion on investigational drugs. vol 13. issue 10. 2006-04-06. PMID:15461561. |
these targets include the activation of apoptosis; suppression of growth factor expression or signalling; downregulation of antiapoptotic proteins; suppression of phosphatidylinositol-3'-kinase/akt, nf-kappab, janus kinase-signal transducer and activator of transcription and activator protein-1 signalling pathways; and downregulation of angiogenesis through inhibition of vascular endothelial growth factor expression, cyclooxygenase-2, matrix metalloproteinase-9, urokinase-type plasminogen activator, adhesion molecules and cyclin d1. |
2006-04-06 |
2023-08-12 |
Not clear |
| Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato, Kusuki Nishiok. Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis. Arthritis research & therapy. vol 7. issue 4. 2006-04-06. PMID:15987493. |
transcription factor hypoxia-inducible factor (hif)-1 protein accumulates and activates the transcription of genes that are of fundamental importance for oxygen homeostasis - including genes involved in energy metabolism, angiogenesis, vasomotor control, apoptosis, proliferation, and matrix production - under hypoxic conditions. |
2006-04-06 |
2023-08-12 |
human |
| Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato, Kusuki Nishiok. Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis. Arthritis research & therapy. vol 7. issue 4. 2006-04-06. PMID:15987493. |
we investigated the levels of energy generation, cartilage matrix production, and apoptosis induction in hif-1alpha-deficient chondrocytes under normoxic and hypoxic conditions. |
2006-04-06 |
2023-08-12 |
human |
| Wei Li, Hua He, Tetsuya Kawakita, Edgar M Espana, Scheffer C G Tsen. Amniotic membrane induces apoptosis of interferon-gamma activated macrophages in vitro. Experimental eye research. vol 82. issue 2. 2006-03-31. PMID:16109408. |
in conclusion, am stromal matrix induces apoptosis of ifn-gamma activated, but not non-activated macrophages, not through the generation of no, but instead by down-regulating anti-apoptotic nf-kappab and akt-fkhr signalling pathways. |
2006-03-31 |
2023-08-12 |
mouse |
| Katalin Susztak, Amanda C Raff, Mario Schiffer, Erwin P Böttinge. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. vol 55. issue 1. 2006-03-29. PMID:16380497. |
chronic inhibition of nadph oxidase prevented podocyte apoptosis and ameliorated podocyte depletion, uae, and mesangial matrix expansion in db/db mice. |
2006-03-29 |
2023-08-12 |
mouse |
| K Breitkopf, P Godoy, L Ciuclan, M V Singer, S Doole. TGF-beta/Smad signaling in the injured liver. Zeitschrift fur Gastroenterologie. vol 44. issue 1. 2006-03-29. PMID:16397841. |
besides hepatic stellate cells (hscs), which are induced by tgf-beta to transdifferentiate to myofibroblasts and to produce extracellular matrix, hepatocytes are also strongly responsive for this cytokine, which induces apoptosis during fibrogenesis and provides growth control in regeneration processes. |
2006-03-29 |
2023-08-12 |
Not clear |
| Yao-Ching Hung, Meng-Yen Hong, G Steve Huan. Cholesterol loading augments oxidative stress in macrophages. FEBS letters. vol 580. issue 3. 2006-03-28. PMID:16414045. |
functional annotation of the differentially expressed genes indicated that apoptosis, extracellular matrix, oxidative stress, and cell proliferation was deregulated. |
2006-03-28 |
2023-08-12 |
human |
| J-F Cailhier, P Laplante, M-J Héber. Endothelial apoptosis and chronic transplant vasculopathy: recent results, novel mechanisms. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 6. issue 2. 2006-03-28. PMID:16426308. |
third, apoptosis of ec triggers extracellular matrix (ecm) proteolysis thus initiating the production of fibroproliferative/fibrogenic ecm fragments. |
2006-03-28 |
2023-08-12 |
human |
| C Marcela Díaz-Montero, Bradley W McIntyr. Acquisition of anoikis resistance in human osteosarcoma cells does not alter sensitivity to chemotherapeutic agents. BMC cancer. vol 5. 2006-03-27. PMID:15829011. |
since cell adhesion to the extracellular matrix acts as a survival factor that homeostatically maintains normal tissue architecture, it was tested whether acquisition of resistance to deadhesion-induced apoptosis (anoikis) in human osteosarcoma would result in resistance to chemotherapy. |
2006-03-27 |
2023-08-12 |
human |
| Guelaguetza Vazquez-Ortiz, Patricia Pina-Sanchez, Karla Vazquez, Alfonso Duenas, Lucia Taja, Patricia Mendoza, José A Garcia, Mauricio Salced. Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer. BMC cancer. vol 5. 2006-03-27. PMID:15989693. |
matrix metalloproteinases (mmps) and cathepsins play a central role on the enhancement of tumor-induced angiogenesis, cell migration, proliferation, apoptosis and connective tissue degradation. |
2006-03-27 |
2023-08-12 |
Not clear |
| Orla M Casey, Dermot G Morris, Richard Powell, Joseph M Sreenan, Richard Fitzpatric. Analysis of gene expression in non-regressed and regressed bovine corpus luteum tissue using a customized ovarian cDNA array. Theriogenology. vol 64. issue 9. 2006-03-23. PMID:15953631. |
the differentially expressed genes encoded enzymes involved in steroid biosynthesis and oxygen radical metabolism and proteins involved in extracellular matrix remodeling, apoptosis and cell structure. |
2006-03-23 |
2023-08-12 |
cattle |
| Orla M Casey, Dermot G Morris, Richard Powell, Joseph M Sreenan, Richard Fitzpatric. Analysis of gene expression in non-regressed and regressed bovine corpus luteum tissue using a customized ovarian cDNA array. Theriogenology. vol 64. issue 9. 2006-03-23. PMID:15953631. |
results for five of the differentially expressed genes including matrix gla protein and collagen alpha1(i) (extracellular matrix), glutathione-s-transferase alpha i (oxygen metabolism), clusterin (apoptosis) and scavenger receptor bi (steroid biosynthesis) were confirmed by northern blot analysis and found to be significantly different (p<0.01) between non-regressed and regressed cl tissue. |
2006-03-23 |
2023-08-12 |
cattle |
| Catherine M Robertson, R Todd Allen, Andrew T Pennock, William D Bugbee, David Amie. Upregulation of apoptotic and matrix-related gene expression during fresh osteochondral allograft storage. Clinical orthopaedics and related research. vol 442. 2006-03-23. PMID:16394770. |
loss of chondrocytes via apoptosis is likely a key determinant of osteochondral allograft viability during storage, whereas extracellular matrix degeneration may occur at a later stage. |
2006-03-23 |
2023-08-12 |
human |
| Hesham A Al-Mashat, Suneel Kandru, Rongkun Liu, Yugal Behl, Tesfahun Desta, Dana T Grave. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Diabetes. vol 55. issue 2. 2006-03-23. PMID:16443785. |
inhibiting apoptosis significantly improved several parameters of healing, including fibroblast density, enhanced mrna levels of collagen i and iii, and increased matrix formation. |
2006-03-23 |
2023-08-12 |
mouse |
| Mark E Obrenovich, Vincent M Monnie. Apoptotic killing of fibroblasts by matrix-bound advanced glycation endproducts. Science of aging knowledge environment : SAGE KE. vol 2005. issue 4. 2006-03-15. PMID:15673817. |
recently reported that cml-rich collagen, representing an artifically aged matrix protein, induces apoptosis in vivo and in fibroblasts. |
2006-03-15 |
2023-08-12 |
Not clear |
| Irving M Shapiro, Christopher S Adams, Theresa Freeman, Vickram Sriniva. Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth defects research. Part C, Embryo today : reviews. vol 75. issue 4. 2006-03-15. PMID:16425255. |
with respect to agents that mediate apoptosis, at the chondro-osseous junction, solubilization of mineral and hydrolysis of organic matrix constituents by septoclasts generates high local concentrations of ions, peptides, and glycans, and secreted matrix metalloproteins. |
2006-03-15 |
2023-08-12 |
Not clear |
| U Müller-Ladner, T Pa. [Pathogenesis of RA: more than just immune cells]. Zeitschrift fur Rheumatologie. vol 64. issue 6. 2006-03-14. PMID:16184347. |
in contrast to normal synovial fibroblasts or fibroblasts from patients with osteoarthritis, ra synovial fibroblasts show an upregulation of proto-oncogenes and transcription factors, which in a self-perpetuating manner mediate the expression of adhesion molecules and matrix degrading enzymes, and result in alterations in apoptosis. |
2006-03-14 |
2023-08-12 |
Not clear |
| Christophe F Chantrain, Patrick Henriet, Sonata Jodele, Hervé Emonard, Olivier Feron, Pierre J Courtoy, Yves A DeClerck, Etienne Marbai. Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases. European journal of cancer (Oxford, England : 1990). vol 42. issue 3. 2006-03-09. PMID:16406506. |
here, we discuss the possibility for mmps to contribute to pericyte recruitment at six levels: (1) direct promotion of pericyte invasion by extracellular matrix degradation; (2) stimulation of pericyte proliferation and protection against apoptosis by modification of the ecm; (3) activation of pericytes through the release of growth factor bound to the ecm; (4) transactivation of angiogenic cell surface receptor; (5) propagation of angiogenic signalling as cofactor; and (6) recruitment of bone marrow-derived stem cells. |
2006-03-09 |
2023-08-12 |
Not clear |