| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Li, Xi-Ming Yua. Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis. Annals of the New York Academy of Sciences. vol 1030. 2005-06-16. PMID:15659826. |
the increased macrophage apoptosis and nuclear and matrix degradation by lysosomal enzymes in atheroma may play important roles in plaque development and rupture. |
2005-06-16 |
2023-08-12 |
mouse |
| Nobuko Sakai, Ken Iseki, Shigeo Suzuki, Tetsuji Mori, Seita Hagino, Yuxiang Zhang, Sachihiko Yokoya, Yukihiko Kawasaki, Junzo Suzuki, Masato Isome, Ikuo Wada, Yoshimi Homma, Hitoshi Suzuk. Uninephrectomy induces progressive glomerulosclerosis and apoptosis in anti-Thy1 glomerulonephritis. Pathology international. vol 55. issue 1. 2005-06-14. PMID:15660699. |
it is suggested that apoptosis and extracellular matrix accumulation play an important role in the development of glomerulosclerosis. |
2005-06-14 |
2023-08-12 |
human |
| Yasunori Fujimoto, Shuichi Izumoto, Tsuyoshi Suzuki, Manabu Kinoshita, Naoki Kagawa, Kouichi Wada, Naoya Hashimoto, Motohiko Maruno, Yuji Nakatsuji, Toshiki Yoshimin. Ganglioside GM3 inhibits proliferation and invasion of glioma. Journal of neuro-oncology. vol 71. issue 2. 2005-06-14. PMID:15690123. |
gm3, the simplest ganglioside, modulates cell adhesion, proliferation and differentiation in the central nervous system and exogenously added gm3 regulates cell-cell and cell-extracellular matrix adhesion and induces apoptosis. |
2005-06-14 |
2023-08-12 |
rat |
| Laimute Taraseviciene-Stewart, Robertas Scerbavicius, Kang-Hyeon Choe, Melissa Moore, Andrew Sullivan, Mark R Nicolls, Andrew P Fontenot, Rubin M Tuder, Norbert F Voelke. An animal model of autoimmune emphysema. American journal of respiratory and critical care medicine. vol 171. issue 7. 2005-06-08. PMID:15563631. |
immunization with ecs also leads to alveolar septal cell apoptosis and activation of matrix metalloproteases mmp-9 and mmp-2. |
2005-06-08 |
2023-08-12 |
mouse |
| F Mannello, F Luchetti, E Falcieri, S Pap. Multiple roles of matrix metalloproteinases during apoptosis. Apoptosis : an international journal on programmed cell death. vol 10. issue 1. 2005-06-06. PMID:15711919. |
multiple roles of matrix metalloproteinases during apoptosis. |
2005-06-06 |
2023-08-12 |
Not clear |
| Jarrod Bailey, Alison J Tyson-Capper, Kate Gilmore, Stephen C Robson, G Nicholas Europe-Finne. Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREMalpha and CREMtau2alpha) proteins. Journal of molecular endocrinology. vol 34. issue 1. 2005-06-02. PMID:15691874. |
genes involved in regulation of cell death and apoptosis, growth and maintenance, signal transduction, physiological and developmental processes, protein kinase cascades, extracellular matrix, cytoskeleton, cell-cycle regulation, transport, and a variety of enzymes, intracellular components and nucleic acid-binding proteins have been described, many of which are involved in the modulation of myometrial activity during pregnancy and parturition. |
2005-06-02 |
2023-08-12 |
human |
| Paul M Coussens, Chas B Pudrith, Kerstin Skovgaard, Xiaoning Ren, Steven P Suchyta, Judith R Stabel, Peter M H Heegaar. Johne's disease in cattle is associated with enhanced expression of genes encoding IL-5, GATA-3, tissue inhibitors of matrix metalloproteinases 1 and 2, and factors promoting apoptosis in peripheral blood mononuclear cells. Veterinary immunology and immunopathology. vol 105. issue 3-4. 2005-06-01. PMID:15808302. |
johne's disease in cattle is associated with enhanced expression of genes encoding il-5, gata-3, tissue inhibitors of matrix metalloproteinases 1 and 2, and factors promoting apoptosis in peripheral blood mononuclear cells. |
2005-06-01 |
2023-08-12 |
cattle |
| Paul M Coussens, Chas B Pudrith, Kerstin Skovgaard, Xiaoning Ren, Steven P Suchyta, Judith R Stabel, Peter M H Heegaar. Johne's disease in cattle is associated with enhanced expression of genes encoding IL-5, GATA-3, tissue inhibitors of matrix metalloproteinases 1 and 2, and factors promoting apoptosis in peripheral blood mononuclear cells. Veterinary immunology and immunopathology. vol 105. issue 3-4. 2005-06-01. PMID:15808302. |
our results indicate that t cells within pbmcs from m. paratuberculosis-infected cows have adopted a predominant th 2-like phenotype (enhanced expression of il-5, gata 3, and possibly il-4 mrna), that cells within infected cow pbmcs may exhibit tissue remodeling deficiencies through higher expression of tissue inhibitor of matrix metalloproteinase (timp) 1 and timp2 rna and lower expression of matrix metalloproteinase (mmp) 14 rna than similar cells from healthy controls, and that cells within the pbmc population of m. paratuberculosis-infected cows are likely poised for rapid apoptosis (upregulation of cide-a, bad, tnfri, and fas). |
2005-06-01 |
2023-08-12 |
cattle |
| Shulin Xiang, Weihong Pan, Abba J Kasti. Strategies to create a regenerating environment for the injured spinal cord. Current pharmaceutical design. vol 11. issue 10. 2005-05-25. PMID:15853683. |
the strategies are classified into the following categories: penetration of the blood-brain barrier; modulation of caspase activity to reduce apoptosis; stem cells and tissue implantation; administration of neurotrophic factors, including viral vector-mediated delivery; and modulation of the extracellular matrix. |
2005-05-25 |
2023-08-12 |
Not clear |
| Filiberto Rodriguez, Frank Langer, Katherine B Harrington, Allen Cheng, George T Daughters, John C Criscione, Neil B Ingels, D Craig Mille. Alterations in transmural strains adjacent to ischemic myocardium during acute midcircumflex occlusion. The Journal of thoracic and cardiovascular surgery. vol 129. issue 4. 2005-05-19. PMID:15821645. |
normal cardiac microstructure and strains are optimized; deviations could result in apoptosis and deleterious matrix remodeling, which degenerates into global cardiomyopathy. |
2005-05-19 |
2023-08-12 |
Not clear |
| Oscar Gonzalez-Moreno, Alfonso Calvo, Bharat H Joshi, Ibane Abasolo, Pamela Leland, Zhou Wang, Luis Montuenga, Raj K Puri, Jeffrey E Gree. Gene expression profiling identifies IL-13 receptor alpha 2 chain as a therapeutic target in prostate tumor cells overexpressing adrenomedullin. International journal of cancer. vol 114. issue 6. 2005-05-16. PMID:15609296. |
examples of such genes include many involved in the formation of the cytoskeleton, cell adhesion and the extracellular matrix, as well as regulators of the cell cycle and apoptosis, cytokines and transcription factors. |
2005-05-16 |
2023-08-12 |
human |
| Mamiko Tosa, Mohammad Ghazizadeh, Hajime Shimizu, Takashi Hirai, Hiko Hyakusoku, Oichi Kawanam. Global gene expression analysis of keloid fibroblasts in response to electron beam irradiation reveals the involvement of interleukin-6 pathway. The Journal of investigative dermatology. vol 124. issue 4. 2005-05-16. PMID:15816827. |
many of the downregulated genes play roles in the enhancement of cell proliferation and extracellular matrix production, whereas several of the upregulated genes involves in the promotion of apoptosis and extracellular matrix (ecm) degradation. |
2005-05-16 |
2023-08-12 |
Not clear |
| Donald L Courter, Lucy Lomas, Marta Scatena, Cecilia M Giachell. Src kinase activity is required for integrin alphaVbeta3-mediated activation of nuclear factor-kappaB. The Journal of biological chemistry. vol 280. issue 13. 2005-05-13. PMID:15695822. |
integrin adhesion to extracellular matrix proteins protects adhesion-dependent cells from suspension-induced apoptosis. |
2005-05-13 |
2023-08-12 |
mouse |
| Monika Krampert, Wilhelm Bloch, Takako Sasaki, Philippe Bugnon, Thomas Rülicke, Eckhard Wolf, Monique Aumailley, William C Parks, Sabine Werne. Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Molecular biology of the cell. vol 15. issue 12. 2005-05-12. PMID:15371548. |
the inappropriate matrix contact of keratinocytes was accompanied by aberrant localization of beta1-integrins and phosphorylated focal adhesion kinase, as well as by increased apoptosis of wound keratinocytes. |
2005-05-12 |
2023-08-12 |
mouse |
| Kosaku Nitt. [Ectopic calcification in dialysis patients]. Clinical calcium. vol 12. issue 10. 2005-05-11. PMID:15775439. |
after degeneration and/or apoptosis of smooth muscle cells in the vascular walls, macrophage infiltration into the calcified tissues followed by production of bone matrix protein leads to the vascular calcification. |
2005-05-11 |
2023-08-12 |
Not clear |
| J H W Distler, J R Kalden, S Gray, O Distle. [Vascular changes in the pathogenesis of systemic sclerosis]. Zeitschrift fur Rheumatologie. vol 63. issue 6. 2005-05-06. PMID:15605207. |
perivascular inflammatory infiltrates and endothelial apoptosis with an impaired angiogenesis are observed in early stages of the disease, whereas later stages are characterized by an excessive accumulation of extracellular matrix proteins in the skin and various internal organs. |
2005-05-06 |
2023-08-12 |
Not clear |
| Shizhong Zheng, Anping Che. Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro. The Biochemical journal. vol 384. issue Pt 1. 2005-05-05. PMID:15320868. |
activation of ppargamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro. |
2005-05-05 |
2023-08-12 |
Not clear |
| Joel W Slaton, Gretchen M Unger, Daniel T Sloper, Alan T Davis, Khalil Ahme. Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model. Molecular cancer research : MCR. vol 2. issue 12. 2005-05-05. PMID:15634760. |
cell death was due to apoptosis and correlated with a potent down-regulation of the ck2alpha message and loss of ck2 from the nuclear matrix in the xenograft tissue as well as in cancer cells in culture. |
2005-05-05 |
2023-08-12 |
mouse |
| Joel W Slaton, Gretchen M Unger, Daniel T Sloper, Alan T Davis, Khalil Ahme. Induction of apoptosis by antisense CK2 in human prostate cancer xenograft model. Molecular cancer research : MCR. vol 2. issue 12. 2005-05-05. PMID:15634760. |
these observations accorded with several of the earlier studies indicating that loss of ck2 from the nuclear matrix is associated with induction of apoptosis. |
2005-05-05 |
2023-08-12 |
mouse |
| Zi-hui Wang, Ding Yu, Yan Chen, Jian-zhong Ha. Proteomic analysis of nuclear matrix proteins during arsenic trioxide induced apoptosis in leukemia K562 cells. Chinese medical journal. vol 118. issue 2. 2005-05-05. PMID:15667793. |
proteomic analysis of nuclear matrix proteins during arsenic trioxide induced apoptosis in leukemia k562 cells. |
2005-05-05 |
2023-08-12 |
Not clear |