| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rex A W Marco, C Marcela Díaz-Montero, James N Wygant, Eugenie S Kleinerman, Bradley W McIntyr. Alpha 4 integrin increases anoikis of human osteosarcoma cells. Journal of cellular biochemistry. vol 88. issue 5. 2003-11-20. PMID:12616540. |
detachment of adherent cells from extracellular matrix results in induction of apoptosis ("anoikis"). |
2003-11-20 |
2023-08-12 |
human |
| Markus J Leskinen, Petri T Kovanen, Ken A Lindsted. Regulation of smooth muscle cell growth, function and death in vitro by activated mast cells--a potential mechanism for the weakening and rupture of atherosclerotic plaques. Biochemical pharmacology. vol 66. issue 8. 2003-11-20. PMID:14555226. |
furthermore, chymase can induce smc apoptosis by degrading the extracellular matrix component fibronectin necessary for smc adhesion, with subsequent disruption of focal adhesions and loss of outside-in survival signaling. |
2003-11-20 |
2023-08-12 |
Not clear |
| Elisabeth A te Velde, Benno Kusters, Cathy Maass, Rob de Waal, Inne H M Borel Rinke. Histological analysis of defective colonic healing as a result of angiostatin treatment. Experimental and molecular pathology. vol 75. issue 2. 2003-11-04. PMID:14516772. |
however, especially with respect to extracellular matrix (ecm), endothelial cell apoptosis, proliferation, or neutrophil influx, no gross differences were discerned 1 week following surgery, using histology and immunohistochemistry techniques. |
2003-11-04 |
2023-08-12 |
mouse |
| Eva C Vaquero, Mouad Edderkaoui, Kyung J Nam, Ilya Gukovsky, Stephen J Pandol, Anna S Gukovskay. Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways. Gastroenterology. vol 125. issue 4. 2003-10-30. PMID:14517801. |
normal cells die through apoptosis when detached from extracellular matrix (ecm), but the role of ecm in cancer cell survival is poorly understood. |
2003-10-30 |
2023-08-12 |
human |
| Kimihisa Ichikawa, Weimin Liu, Martin Fleck, Huangge Zhang, Limin Zhao, Toshiaki Ohtsuka, Zheng Wang, Di Liu, John D Mountz, Masahiko Ohtsuki, William J Koopman, Robert Kimberly, Tong Zho. TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis. Journal of immunology (Baltimore, Md. : 1950). vol 171. issue 2. 2003-10-23. PMID:12847280. |
in vitro tra-8 induced apoptosis of ra synovial cells and inhibited production of matrix metalloproteinases induced by pro-inflammatory cytokines. |
2003-10-23 |
2023-08-12 |
Not clear |
| M Wetzel, G A Rosenberg, L A Cunningha. Tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis. The European journal of neuroscience. vol 18. issue 5. 2003-10-23. PMID:12956705. |
tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis. |
2003-10-23 |
2023-08-12 |
rat |
| M Wetzel, G A Rosenberg, L A Cunningha. Tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis. The European journal of neuroscience. vol 18. issue 5. 2003-10-23. PMID:12956705. |
we demonstrate that both timp-3 and matrix metalloproteinase-3 (mmp-3) are constitutively expressed by primary cortical neurons in culture, and selectively modulated fas-mediated neuronal apoptosis induced by dox. |
2003-10-23 |
2023-08-12 |
rat |
| Franck Gadal, Christophe Bozic, Céline Pillot-Brochet, Sophie Malinge, Sarah Wagner, Aurélie Le Cam, Laurent Buffat, Michel Crepin, François Iri. Integrated transcriptome analysis of the cellular mechanisms associated with Ha-ras-dependent malignant transformation of the human breast epithelial MCF7 cell line. Nucleic acids research. vol 31. issue 19. 2003-10-20. PMID:14500842. |
we found 166 over- and under-expressed genes which, in the human mcf7-ras breast epithelial cell line, are involved in the different aspects of tumoral transformation such as defined signaling pathways, cellular growth, protection against apoptosis, extracellular matrix and cytoskeleton remodeling. |
2003-10-20 |
2023-08-12 |
human |
| Q Zhou, M T Nakada, C Arnold, K Y Shieh, F S Marklan. Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis. Angiogenesis. vol 3. issue 3. 2003-10-10. PMID:14517425. |
huvec adhered and spread well on immobilized contortrostatin without undergoing apoptosis, suggesting that it is the inhibition of adhesion and spreading of huvec on extracellular matrix proteins, rather than binding of contortrostatin to integrins per se, that triggers apoptosis. |
2003-10-10 |
2023-08-12 |
mouse |
| D R Brigstoc. The CCN family: a new stimulus package. The Journal of endocrinology. vol 178. issue 2. 2003-10-07. PMID:12904165. |
these proteins stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. |
2003-10-07 |
2023-08-12 |
Not clear |
| Kristin H Kain, Stacy Gooch, Richard L Klemk. Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene. vol 22. issue 38. 2003-10-07. PMID:12955086. |
inhibition of c-abl kinase activity or crk binding to abl's polyproline region prevents crk phosphorylation and apoptosis, leading to increased cell survival and invasion of the extracellular matrix. |
2003-10-07 |
2023-08-12 |
Not clear |
| Anthony J Valentijn, Anthony D Metcalfe, Jane Kott, Charles H Streuli, Andrew P Gilmor. Spatial and temporal changes in Bax subcellular localization during anoikis. The Journal of cell biology. vol 162. issue 4. 2003-10-01. PMID:12925707. |
cells can be rescued from apoptosis if they are replated onto extracellular matrix within an hour, whereas cells detached for longer could not. |
2003-10-01 |
2023-08-12 |
Not clear |
| Ronald M Bukowsk. AE-941, a multifunctional antiangiogenic compound: trials in renal cell carcinoma. Expert opinion on investigational drugs. vol 12. issue 8. 2003-09-30. PMID:12882625. |
at the molecular level, ae-941 appears to exhibit four different potential mechanisms of action: modulation of matrix proteases; inhibition of vascular endothelial growth factor binding to its receptor; induction of endothelial cell apoptosis; and stimulation of angiostatin production. |
2003-09-30 |
2023-08-12 |
Not clear |
| Maria Nataatmadja, Malcolm West, Jenny West, Kim Summers, Philip Walker, Michio Nagata, Teruo Watanab. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. vol 108 Suppl 1. 2003-09-30. PMID:12970255. |
abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. |
2003-09-30 |
2023-08-12 |
Not clear |
| Maria Nataatmadja, Malcolm West, Jenny West, Kim Summers, Philip Walker, Michio Nagata, Teruo Watanab. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. vol 108 Suppl 1. 2003-09-30. PMID:12970255. |
this study examined the relationship among the secretion of extracellular matrix proteins fibrillin, fibronectin, tenascin, and vascular smooth muscle cell (vsmc) apoptosis. |
2003-09-30 |
2023-08-12 |
Not clear |
| Maria Nataatmadja, Malcolm West, Jenny West, Kim Summers, Philip Walker, Michio Nagata, Teruo Watanab. Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm. Circulation. vol 108 Suppl 1. 2003-09-30. PMID:12970255. |
the role of matrix metalloproteinase (mmp)-2 in vsmc apoptosis was studied in ms aneurysm. |
2003-09-30 |
2023-08-12 |
Not clear |
| Denis Gingras, Dominique Boivin, Christophe Deckers, Sébastien Gendron, Chantal Barthomeuf, Richard Bélivea. Neovastat--a novel antiangiogenic drug for cancer therapy. Anti-cancer drugs. vol 14. issue 2. 2003-09-24. PMID:12569294. |
it interferes with several steps associated with the development of angiogenesis through its ability to induce endothelial cell apoptosis, and to inhibit matrix metalloproteinase activities and vascular endothelial growth factor-mediated signaling pathways, suggesting that neovastat behaves as a multifunctional antiangiogenic drug. |
2003-09-24 |
2023-08-12 |
Not clear |
| Wen-Bin Wu, Tur-Fu Huan. Activation of MMP-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosis. Experimental cell research. vol 288. issue 1. 2003-09-24. PMID:12878166. |
activation of mmp-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosis. |
2003-09-24 |
2023-08-12 |
Not clear |
| Wen-Bin Wu, Tur-Fu Huan. Activation of MMP-2, cleavage of matrix proteins, and adherens junctions during a snake venom metalloproteinase-induced endothelial cell apoptosis. Experimental cell research. vol 288. issue 1. 2003-09-24. PMID:12878166. |
we showed that the apoptosis was initiated with cell shape change and extracellular matrix degradation and occurred before cell detachment. |
2003-09-24 |
2023-08-12 |
Not clear |
| Amnon Zisman, Allan J Pantuck, Matthew H T Bui, Jonathan W Said, Randy R Caliliw, Nagesh Rao, Peter Shintaku, Frank Berger, Sanjiv S Gambhir, Arie S Belldegru. LABAZ1: A metastatic tumor model for renal cell carcinoma expressing the carbonic anhydrase type 9 tumor antigen. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941820. |
subsequent xenograft generations have conserved immunohistochemical and ultrastructural properties typical for malignant renal epithelium-derived neoplasia (vimentin+, ck-19+, ca ix+ with hypoxia-inducible factor (hif)-1 alpha constitutive expression) and have demonstrated extensive proliferation, lack of apoptosis, severe genetic alterations, and molecular expression alterations; transforming growth factor beta 1 (tgf-beta 1), hepatocyte growth factor (hgf), proto-oncogene (c-met), matrix metalloproteinase (mmp)-1, and vascular endothelial growth factor (vegf) c and d were overexpressed, whereas human epidermal growth factor receptor (her)-2, mmp-2 and mmp-9, vegf-r3, p53, and p27 were severely down-regulated, suggesting a proangiogenic environment, local invasiveness, and facilitated lymphatic metastasis. |
2003-09-24 |
2023-08-12 |
mouse |