| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Gabbian. The myofibroblast in wound healing and fibrocontractive diseases. The Journal of pathology. vol 200. issue 4. 2003-09-16. PMID:12845617. |
myofibroblasts synthesize extracellular matrix components such as collagen types i and iii and during normal wound healing disappear by apoptosis when epithelialization occurs. |
2003-09-16 |
2023-08-12 |
Not clear |
| Mauricio J Reginato, Kenna R Mills, Jessica K Paulus, Danielle K Lynch, Dennis C Sgroi, Jayanta Debnath, Senthil K Muthuswamy, Joan S Brugg. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nature cell biology. vol 5. issue 8. 2003-09-12. PMID:12844146. |
epithelial cells must adhere to the extracellular matrix (ecm) for survival, as detachment from matrix triggers apoptosis or anoikis. |
2003-09-12 |
2023-08-12 |
Not clear |
| Pieter A van der Velden, Wieke Zuidervaart, Monique H M H Hurks, Sandra Pavey, Bruce R Ksander, Elise Krijgsman, Rune R Frants, Cornelis P Tensen, Rein Willemze, Martine J Jager, Nelleke A Grui. Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. International journal of cancer. vol 106. issue 4. 2003-09-09. PMID:12845640. |
these genes are involved in processes like angiogenesis, apoptosis, macrophage stimulation, and extracellular matrix regulation. |
2003-09-09 |
2023-08-12 |
Not clear |
| E J Macki. Osteoblasts: novel roles in orchestration of skeletal architecture. The international journal of biochemistry & cell biology. vol 35. issue 9. 2003-09-08. PMID:12798343. |
following a period of secretory activity, osteoblasts undergo either apoptosis or terminal differentiation to form osteocytes surrounded by bone matrix. |
2003-09-08 |
2023-08-12 |
Not clear |
| Yusuke Hashimoto, Takami Tomiyama, Yoshiki Yamano, Hiroshi Mor. Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis. The American journal of pathology. vol 163. issue 1. 2003-09-03. PMID:12819015. |
mutation (d472y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis. |
2003-09-03 |
2023-08-12 |
Not clear |
| D Y Kim, H W Taylor, R M Moore, D B Paulsen, D-Y Ch. Articular chondrocyte apoptosis in equine osteoarthritis. Veterinary journal (London, England : 1997). vol 166. issue 1. 2003-09-02. PMID:12788017. |
topographical distributions of chondrocyte apoptosis, cartilage matrix degeneration, and no production overlapped in equine oa cartilages, suggesting that these pathological phenomena are closely interrelated. |
2003-09-02 |
2023-08-12 |
Not clear |
| Deborah A Swartz-Basile, Lihua Wang, Yuzhu Tang, Henry A Pitt, Deborah C Rubin, Marc S Levi. Vitamin A deficiency inhibits intestinal adaptation by modulating apoptosis, proliferation, and enterocyte migration. American journal of physiology. Gastrointestinal and liver physiology. vol 285. issue 2. 2003-08-29. PMID:12711591. |
these studies indicate that vitamin a deficiency inhibits intestinal adaptation following partial small bowel resection by reducing crypt cell proliferation, by enhancing early crypt cell apoptosis, and by markedly reducing enterocyte migration rates, which may be related to changes in the expression of collagen iv and other extracellular matrix components. |
2003-08-29 |
2023-08-12 |
rat |
| Abdelkarim Sabri, Sasha G Alcott, Hasnae Elouardighi, Elena Pak, Claudia Derian, Patricia Andrade-Gordon, Kathleen Kinnally, Susan F Steinber. Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanism. The Journal of biological chemistry. vol 278. issue 26. 2003-08-20. PMID:12707281. |
of note, prolonged incubation of cardiomyocytes with cathepsin g results in the activation of caspase-3, cleavage of fak and akt, sarcomeric disassembly, cell rounding, cell detachment from underlying matrix, and morphologic features of apoptosis. |
2003-08-20 |
2023-08-12 |
mouse |
| Mònica Comalada, Marina Cardó, Jordi Xaus, Annabel F Valledor, Jorge Lloberas, Francesc Ventura, Antonio Celad. Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 9. 2003-08-13. PMID:12707320. |
like the major macrophage activator ifn-gamma, the extracellular matrix protein decorin inhibits proliferation and protects macrophages from the induction of apoptosis. |
2003-08-13 |
2023-08-12 |
mouse |
| Robert A Gatenby, Edward T Gawlinsk. The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer research. vol 63. issue 14. 2003-08-13. PMID:12873971. |
this leads to normal cell death via p53-dependent apoptosis pathways, as well as degradation of the interstitial matrix, loss of intercellular gap junctions, enhanced angiogenesis, and inhibition of the host immune response to tumor antigens. |
2003-08-13 |
2023-08-12 |
human |
| Chrishan S Samuel, Hongsheng Tian, Ling Zhao, Edward P Ament. Relaxin is a key mediator of prostate growth and male reproductive tract development. Laboratory investigation; a journal of technical methods and pathology. vol 83. issue 7. 2003-08-12. PMID:12861045. |
the marked differences in the extracellular matrix of the testis and prostate in rlx-/- males also correlated with an increase in the rate of cell apoptosis. |
2003-08-12 |
2023-08-12 |
mouse |
| H Schliephak. Prognostic relevance of molecular markers of oral cancer--a review. International journal of oral and maxillofacial surgery. vol 32. issue 3. 2003-08-11. PMID:12767868. |
tumour markers were allocated to four groups according to their function: (i) enhancement of tumour growth: cell cycle acceleration and proliferation, (ii) tumour suppression and anti-tumour defence: immune response and apoptosis, (iii) angiogenesis, (iv) tumour invasion and metastatic potential: adhesion molecules and matrix degradation. |
2003-08-11 |
2023-08-12 |
Not clear |
| Tsutomu Yoshikaw. [Alterations in sympathoadrenal system in congestive heart failure]. Nihon rinsho. Japanese journal of clinical medicine. vol 61. issue 5. 2003-08-08. PMID:12754996. |
mechanisms underlying such adverse effects involve multiple biological events including production of oxygen free radicals, cytokines, matrix metalloproteinase, apoptosis, cardiac hypertrophy, and chamber remodeling as well as energy expenditure. |
2003-08-08 |
2023-08-12 |
mouse |
| E Grimaud, F Blanchard, C Charrier, F Gouin, F Redini, D Heyman. Leukaemia inhibitory factor (lif) is expressed in hypertrophic chondrocytes and vascular sprouts during osteogenesis. Cytokine. vol 20. issue 5. 2003-08-01. PMID:12550107. |
avascular cartilage is replaced by highly vascularized bone tissue during endochondral ossification, a process involving capillary invasion of calcified hypertrophic cartilage in association with apoptosis of hypertrophic chondrocytes, degradation of cartilage matrix and deposition of bone matrix. |
2003-08-01 |
2023-08-12 |
human |
| Keiji Inoue, Masakazu Chikazawa, Satoshi Fukata, Chiaki Yoshikawa, Taro Shui. Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 2. 2003-08-01. PMID:12576464. |
the combination of tnp-470 and docetaxel inhibited intratumor neovascularization, the expression of bfgf and matrix metalloproteinases type-9 compared with controls (p < 0.005), and enhanced apoptosis in tumors compared with each therapy alone (p < 0.005). |
2003-08-01 |
2023-08-12 |
mouse |
| Keiji Inoue, Masakazu Chikazawa, Satoshi Fukata, Chiaki Yoshikawa, Taro Shui. Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 2. 2003-08-01. PMID:12576464. |
these effects are mediated, in part, by the complementary cytotoxicities of angiogenesis inhibition, down-regulation of bfgf and matrix metalloproteinases type-9, and induction of apoptosis. |
2003-08-01 |
2023-08-12 |
mouse |
| Henry O Trowbridg. Pulp biology: progress during the past 25 years. Australian endodontic journal : the journal of the Australian Society of Endodontology Inc. vol 29. issue 1. 2003-08-01. PMID:12772964. |
topics to be considered include: differentiation of odontoblasts, dentine matrix proteins, extent of odontoblast processes, pulpal stem cells, apoptosis, interstitial fluid pressure in normal and inflamed pulps, class ii antigen-presenting cells of the pulp, cytokines, antibodies, pulpal calcifications, tertiary dentine and pulpal inflammation associated with bacterial contamination of exposed dentine beneath restorations. |
2003-08-01 |
2023-08-12 |
Not clear |
| Laurent Baud, Bruno Fouqueray, Agnès Bellocq, Julie Peltie. [Calpains participate in inflammatory reaction development]. Medecine sciences : M/S. vol 19. issue 1. 2003-07-31. PMID:12836194. |
they could participate in cellular responses such as apoptosis, proliferation, extracellular matrix adhesion and motility, that have relevance to pathophysiological issues in ischemia, inflammation, repair and tumor progression. |
2003-07-31 |
2023-08-12 |
Not clear |
| Nathalie Ortega, Danielle Behonick, Dominique Stickens, Zena Wer. How proteases regulate bone morphogenesis. Annals of the New York Academy of Sciences. vol 995. 2003-07-22. PMID:12814943. |
apoptosis of the terminal hypertrophic chondrocytes, degradation of the cartilage matrix, and deposition of bone matrix by osteoblasts accompanies neovascularization of the growth plate. |
2003-07-22 |
2023-08-12 |
mouse |
| Q Yao, S Wang, A Gambotto, J C Glorioso, C H Evans, P D Robbins, S C Ghivizzani, T J Oligin. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium. Gene therapy. vol 10. issue 12. 2003-07-21. PMID:12776164. |
in a rabbit model of arthritis, intra-articular gene transfer of trail induced apoptosis in cells within the synovial lining, reduced leukocytic infiltration and stimulated new matrix synthesis by cartilage. |
2003-07-21 |
2023-08-12 |
human |