| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angela Maria Casaril, Athanasios Katsalifis, Rolf M Schmidt, Carlos Bas-Ort. Activated glia cells cause bioenergetic impairment of neurons that can be rescued by knock-down of the mitochondrial calcium uniporter. Biochemical and biophysical research communications. vol 608. 2022-04-07. PMID:35390671. |
rat primary cortical neurons were challenged with conditioned medium from mixed primary cultures of rat microglia and astrocytes that had been activated with lipopolysaccharide and atp. |
2022-04-07 |
2023-08-13 |
rat |
| Guzal Khayrullina, Zaida A Alipio-Gloria, Marc-Olivier Deguise, Sabrina Gagnon, Lucia Chehade, Matthew Stinson, Natalya Belous, Elizabeth M Bergman, Fritz W Lischka, Jeremy Rotty, Clifton L Dalgard, Rashmi Kothary, Kristen A Johnson, Barrington G Burnet. Survival motor neuron protein deficiency alters microglia reactivity. Glia. 2022-04-04. PMID:35373853. |
importantly, cell morphology and electrophysiological properties of motor neurons were altered when they were incubated with conditioned media from sma microglia. |
2022-04-04 |
2023-08-13 |
mouse |
| Natalia Salvadores, Ines Moreno-Gonzalez, Nazaret Gamez, Gabriel Quiroz, Laura Vegas-Gomez, Marcela Escandón, Sebastian Jimenez, Javier Vitorica, Antonia Gutierrez, Claudio Soto, Felipe A Cour. Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer's disease. Acta neuropathologica communications. vol 10. issue 1. 2022-03-10. PMID:35264247. |
using an in vitro model, we show that conditioned medium from aβo-stimulated microglia elicited necroptosis in neurons through activation of tnf-α signaling, triggering extensive neurodegeneration. |
2022-03-10 |
2023-08-13 |
mouse |
| Ana Isabel Sánchez-Castillo, M Rosario Sepúlveda, José Luis Marín-Teva, Miguel A Cuadros, David Martín-Oliva, Elena González-Rey, Mario Delgado, Veronika E Neubran. Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204722. |
in this review, we will discuss the application of adipose tissue-derived msc and their conditioned medium, including extracellular vesicles, in neurological disorders, their beneficial effect on microglia and the signaling pathways involved. |
2022-02-25 |
2023-08-13 |
Not clear |
| Bernarda Majc, Anamarija Habič, Metka Novak, Ana Rotter, Andrej Porčnik, Jernej Mlakar, Vera Župunski, Urša Pečar Fonović, Damijan Knez, Nace Zidar, Stanislav Gobec, Janko Kos, Tamara Lah Turnšek, Anja Pišlar, Barbara Brezni. Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163706. |
selective cathepsin x inhibitors decreased the viability of patient-derived gbm cells as well as macrophages and microglia that were cultured in conditioned media of gbm cells. |
2022-02-15 |
2023-08-13 |
human |
| Salvatore J Coniglio, Jeffrey E Segal. Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin. PloS one. vol 16. issue 11. 2021-12-03. PMID:34843542. |
we assayed cdna and protein from microglia treated with conditioned media from the murine glioma cell line gl261, and discovered that several egfr ligands including amphiregulin (areg) are strongly upregulated. |
2021-12-03 |
2023-08-13 |
human |
| Ke-Bing Chen, Min-Min Chang, Sheng-Li Wang, Yong-Xin Li, Yi-Xi Wang, Zhi-Guang Xu, Hong Wang, Bing-Cheng Zhao, Wei-Ying M. High mobility group box-1 serves a pathogenic role in spinal cord injury via the promotion of pro-inflammatory cytokines. Journal of leukocyte biology. vol 110. issue 6. 2021-11-30. PMID:34402106. |
in addition, the injured neuron-derived conditioned medium increased tnf-α secretion and the nf-κb pathway in the bv2 microglia cell line via hmgb1. |
2021-11-30 |
2023-08-13 |
Not clear |
| Saumya Mishra, Charul Rajput, Mahendra Pratap Sing. Cypermethrin Induces the Activation of Rat Primary Microglia and Expression of Inflammatory Proteins. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33230707. |
cypermethrin-treated microglia conditioned media and cells were collected to measure the expression and release of inflammatory proteins. |
2021-11-23 |
2023-08-13 |
rat |
| Saumya Mishra, Charul Rajput, Mahendra Pratap Sing. Cypermethrin Induces the Activation of Rat Primary Microglia and Expression of Inflammatory Proteins. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33230707. |
cypermethrin augmented the protein kinase c-δ (pkc-δ), inducible nitric oxide synthase (inos), phosphorylated mitogen-activated protein kinase (mapk) p38 and p42/44, matrix metalloproteinase (mmp)-3, and mmp-9 levels in the cell lysate and tumour necrosis factor-α (tnf-α) and interleukin-1β (il-1β) levels in the microglia conditioned media. |
2021-11-23 |
2023-08-13 |
rat |
| Saumya Mishra, Charul Rajput, Mahendra Pratap Sing. Cypermethrin Induces the Activation of Rat Primary Microglia and Expression of Inflammatory Proteins. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33230707. |
pre-treatment with minocycline, a microglial activation inhibitor or rottlerin, a pkc-δ inhibitor, notably reduced the release of tnf-α in the conditioned media and expression of inos protein in the microglia. |
2021-11-23 |
2023-08-13 |
rat |
| Saumya Mishra, Charul Rajput, Mahendra Pratap Sing. Cypermethrin Induces the Activation of Rat Primary Microglia and Expression of Inflammatory Proteins. Journal of molecular neuroscience : MN. vol 71. issue 6. 2021-11-23. PMID:33230707. |
while cypermethrin-treated conditioned media induced the toxicity in the rat primary neurons, minocycline or rottlerin reduced the cypermethrin treated microglia conditioned media-induced toxicity. |
2021-11-23 |
2023-08-13 |
rat |
| Zhi-Bin Ding, Qing-Xian Han, Qing Wang, Li-Juan Song, Guo-Guo Chu, Min-Fang Guo, Zhi Chai, Jie-Zhong Yu, Bao-Guo Xiao, Xin-Yi Li, Cun-Gen M. Fasudil enhances the phagocytosis of myelin debris and the expression of neurotrophic factors in cuprizone-induced demyelinating mice. Neuroscience letters. vol 753. 2021-11-22. PMID:33838256. |
in vitro, microglia with phagocytic debris exhibited enhanced expression of brain-derived neurotrophic factor (bdnf) and glial cell-derived neurotrophic factor (gdnf), and the conditioned medium promoted the maturation of oligodendrocyte precursor cells (opcs). |
2021-11-22 |
2023-08-13 |
mouse |
| Nuno L Soares, Inês Paiva, Joana Bravo, Cláudia S F Queiroga, Bernadete F Melo, Sílvia V Conde, Carlos C Romão, Teresa Summavielle, Helena L A Vieir. Carbon Monoxide Modulation of Microglia-Neuron Communication: Anti-Neuroinflammatory and Neurotrophic Role. Molecular neurobiology. 2021-11-19. PMID:34796462. |
in contrast, in the absence of inflammatory stimulus, conditioned media from co-treated microglia improved neuronal morphological complexity, which is an indirect manner of assessing neuronal function. |
2021-11-19 |
2023-08-13 |
rat |
| Xiao-Dong Chen, Jin Zhao, Xiao Yang, Bo-Wei Zhou, Zhengzheng Yan, Wei-Feng Liu, Cai Li, Ke-Xuan Li. Gut-Derived Exosomes Mediate Memory Impairment After Intestinal Ischemia/Reperfusion via Activating Microglia. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34189701. |
primary microglia were cocultured with intestinal exosomes; ht-22 cells were treated with intestinal exosomes or microglia conditioned media. |
2021-10-08 |
2023-08-13 |
mouse |
| Andrea Lopez-Lopez, Begoña Villar-Cheda, Aloia Quijano, Pablo Garrido-Gil, María Garcia-Garrote, Carmen Díaz-Ruiz, Ana Muñoz, José L Labandeira-Garci. NADPH-Oxidase, Rho-Kinase and Autophagy Mediate the (Pro)renin-Induced Pro-Inflammatory Microglial Response and Enhancement of Dopaminergic Neuron Death. Antioxidants (Basel, Switzerland). vol 10. issue 9. 2021-10-01. PMID:34572972. |
conditioned medium from (pro)renin-treated microglia increased dopaminergic cell death relative to medium from non-treated microglia. |
2021-10-01 |
2023-08-13 |
mouse |
| Han Yu, Zhihong Xu, Gaojing Qu, Huimin Wang, Lulu Lin, Xianyu Li, Xiaolin Xie, Yifeng Lei, Xiaohua He, Yun Chen, Yinping L. Hypoxic Preconditioning Enhances the Efficacy of Mesenchymal Stem Cells-Derived Conditioned Medium in Switching Microglia toward Anti-inflammatory Polarization in Ischemia/Reperfusion. Cellular and molecular neurobiology. vol 41. issue 3. 2021-09-30. PMID:32424775. |
hypoxic preconditioning enhances the efficacy of mesenchymal stem cells-derived conditioned medium in switching microglia toward anti-inflammatory polarization in ischemia/reperfusion. |
2021-09-30 |
2023-08-13 |
Not clear |
| Han Yu, Zhihong Xu, Gaojing Qu, Huimin Wang, Lulu Lin, Xianyu Li, Xiaolin Xie, Yifeng Lei, Xiaohua He, Yun Chen, Yinping L. Hypoxic Preconditioning Enhances the Efficacy of Mesenchymal Stem Cells-Derived Conditioned Medium in Switching Microglia toward Anti-inflammatory Polarization in Ischemia/Reperfusion. Cellular and molecular neurobiology. vol 41. issue 3. 2021-09-30. PMID:32424775. |
however, it remains unclear whether conditioned medium from mscs could effectively regulate the activation and polarization of microglia exposed to i/r stimulation. |
2021-09-30 |
2023-08-13 |
Not clear |
| Han Yu, Zhihong Xu, Gaojing Qu, Huimin Wang, Lulu Lin, Xianyu Li, Xiaolin Xie, Yifeng Lei, Xiaohua He, Yun Chen, Yinping L. Hypoxic Preconditioning Enhances the Efficacy of Mesenchymal Stem Cells-Derived Conditioned Medium in Switching Microglia toward Anti-inflammatory Polarization in Ischemia/Reperfusion. Cellular and molecular neurobiology. vol 41. issue 3. 2021-09-30. PMID:32424775. |
in this study, we investigated the effects of conditioned medium from bone marrow mscs (bmscs-cm) on i/r-stimulated microglia and the potential mechanism involved, as well as the way to obtain more effective bmscs-cm. |
2021-09-30 |
2023-08-13 |
Not clear |
| Yaling Xu, Lijia Yu, Ying Liu, Xiaohui Tang, Xijin Wan. Lipopolysaccharide-Induced Microglial Neuroinflammation: Attenuation by FK866. Neurochemical research. vol 46. issue 5. 2021-09-27. PMID:33713324. |
finally, conditioned medium from microglia cultures co-treated with fk866 and lps significantly increased sh-sy5y and pc12 cell viability compared with conditioned medium from microglia cultures treated with lps alone. |
2021-09-27 |
2023-08-13 |
Not clear |
| Lisha Joshi, Ioanna Plastira, Eva Bernhart, Helga Reicher, Alexander Triebl, Harald C Köfeler, Wolfgang Sattle. Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model. International journal of molecular sciences. vol 22. issue 16. 2021-09-14. PMID:34445223. |
lps upregulated atx, tlr4, and cox2 expression, amplified no production, increased neurotoxicity of microglia conditioned medium, and augmented cyto-/chemokine concentrations in the cellular supernatants. |
2021-09-14 |
2023-08-13 |
mouse |