| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryuji Owada, Saaya Awata, Kazutomo Suzue, Hiroyasu Kanetaka, Yohei Kakuta, Kazuhiro Nakamur. Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells. Heliyon. vol 6. issue 9. 2020-09-28. PMID:32954034. |
however, detailed morphological analysis of neurons exposed to conditioned medium (cm) derived from polyq-containing microglia has not been essentially carried out. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yolandi van der Merwe, Anne E Faust, Ecem T Sakalli, Caroline C Westrick, George Hussey, Kevin C Chan, Ian P Conner, Valeria L N Fu, Stephen F Badylak, Michael B Stekete. Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function. Scientific reports. vol 9. issue 1. 2020-09-22. PMID:30837658. |
in vitro studies showed mbv suppressed pro-inflammatory signaling by activated microglia and astrocytes, stimulated rgc neurite growth, and neuroprotected rgcs from neurotoxic media conditioned by pro-inflammatory astrocytes. |
2020-09-22 |
2023-08-13 |
rat |
| Kankan Zong, Xin Liu, Zhou Sun, Lihua Piao, Yanhua Xuan, Yu Jin, Chun-Ai Cu. Macelignan inhibits the inflammatory response of microglia and regulates neuronal survival. Journal of neuroimmunology. vol 339. 2020-07-09. PMID:31838278. |
furthermore, macelignan inhibited microglial cell near neurons treated with a hypoxic conditioned medium. |
2020-07-09 |
2023-08-13 |
Not clear |
| Chuwen Li, Yaqi Bian, Yu Feng, Fan Tang, Liang Wang, Maggie Pui Man Hoi, Dan Ma, Chao Zhao, Simon Ming Yuen Le. Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization. ACS chemical neuroscience. vol 10. issue 5. 2020-05-29. PMID:30839193. |
in addition, conditioned medium (cm) experiments showed that cm from bhdpc-treated bv-2 microglia provided protections against ogd/r-induced ischemic damage in primary neurons and bend.3 ecs. |
2020-05-29 |
2023-08-13 |
mouse |
| Mengmeng Li, Dongmei Zhang, Xin Ge, Xiangyang Zhu, Yong Zhou, Yi Zhang, Xiao Peng, Aiguo She. TRAF6-p38/JNK-ATF2 axis promotes microglial inflammatory activation. Experimental cell research. vol 376. issue 2. 2020-05-26. PMID:30763583. |
inhibiting atf2 significantly decreased the expression of pro-inflammatory factors in lps-treated microglia, and alleviated neuronal apoptosis induced by the conditioned medium of activated microglia. |
2020-05-26 |
2023-08-13 |
mouse |
| Jie Li, Jingyu Zhang, Yusuo Zhang, Zichuang Wang, Yanmei Song, Shanwen Wei, Meijun He, Shoujiang You, Jia Jia, Jian Chen. TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis. Cell death & disease. vol 10. issue 5. 2020-05-19. PMID:30988281. |
traf2 expression and necroptosis were induced in mouse primary microglia treated with conditioned medium collected from neurons subject to oxygen and glucose deprivation (ogd) and in tnfα-treated mouse hippocampal neuronal ht-22 cells in the presence of the pan-caspase inhibitor z-vad. |
2020-05-19 |
2023-08-13 |
mouse |
| Stefan Gingele, Lukas Merkel, Chittappen K Prajeeth, Jessica Kronenberg, Friederike Freiin von Hoevel, Thomas Skripuletz, Viktoria Gudi, Martin Stange. Polarized microglia do not influence oligodendrocyte lineage cells via astrocytes. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 77. 2020-04-21. PMID:30716382. |
in this study, conditioned media from polarized murine microglia were used to treat astrocytes and astrocytic gene expression was analyzed by microarray for genes known to influence oligodendrocyte lineage cells. |
2020-04-21 |
2023-08-13 |
Not clear |
| M M Yurinskaya, D G Garbuz, M B Evgen'ev, M G Vinokuro. [Exogenous HSP70 and Signaling Pathways Involved in the Inhibition of LPS-Induced Neurotoxicity of Neuroblastoma Cells]. Molekuliarnaia biologiia. vol 54. issue 1. 2020-04-06. PMID:32163396. |
experiments included cell cultivation separately and transferring the conditioned medium from a-172 microglial cells to sk-n-sh neuroblastoma cells to simulate the effect of microglia treated with lps and/or hsp70. |
2020-04-06 |
2023-08-13 |
human |
| Congde Chen, Suichun Wu, Zipu Hong, Xiaoming Chen, Xiaoou Shan, Shane Fischbach, Xiangwei Xia. Chronic hyperglycemia regulates microglia polarization through ERK5. Aging. vol 11. issue 2. 2020-04-03. PMID:30684443. |
conditioned media from the m2a-polarized microglia reduced neuronal cell apoptosis in hypoxic condition, while media from m2b-like or m1-like microglia enhanced apoptosis. |
2020-04-03 |
2023-08-13 |
Not clear |
| Shuai Yuan, Zhengquan Yu, Zhuwei Zhang, Juyi Zhang, Peng Zhang, Xiang Li, Haiying Li, Haitao Shen, Gang Che. RIP3 participates in early brain injury after experimental subarachnoid hemorrhage in rats by inducing necroptosis. Neurobiology of disease. vol 129. 2020-03-24. PMID:31082470. |
additionally, we verified the presence of rip3-mediated necroptosis in an in vitro sah model of primary cultured neurons treated with conditioned medium from primary microglia activated by oxygen hemoglobin (oxyhb). |
2020-03-24 |
2023-08-13 |
rat |
| Paulo L C Coelho, Jéssika A O Amparo, Alessandra B da Silva, Karina C da Silva, Suzana Braga-de-Souza, Pedro Rocha Barbosa, Giselle P de F Lopes, Silvia L Cost. Apigenin from Croton betulaster Müll restores the immune profile of microglia against glioma cells. Phytotherapy research : PTR. vol 33. issue 12. 2020-02-20. PMID:31468624. |
treatment of c6 glioma cells with conditioned medium of microglia treated with apigenin-induced reduction of tumor migration and viability, associated with significant reduction in il-6 levels. |
2020-02-20 |
2023-08-13 |
rat |
| Jingwen Yu, Minfang Guo, Yanhua Li, Huiyu Zhang, Zhi Chai, Qing Wang, Yuqing Yan, Jiezhong Yu, Chunyun Liu, Guangxian Zhang, Ma Cunge. Astragaloside IV protects neurons from microglia-mediated cell damage through promoting microglia polarization. Folia neuropathologica. vol 57. issue 2. 2020-02-20. PMID:31556576. |
in contrast, ast-iv elevated the production of anti-inflammatory cytokine il-10 and expression of arginase 1, an m2 marker of microglia, whose conditioned medium promoted pc12 neurons survival. |
2020-02-20 |
2023-08-13 |
Not clear |
| Chao-Jun Han, Ji-Yue Zheng, Lin Sun, Hui-Cui Yang, Zhong-Qiang Cao, Xiao-Hu Zhang, Long-Tai Zheng, Xue-Chu Zhe. The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway. Acta pharmacologica Sinica. vol 40. issue 10. 2020-02-10. PMID:31015738. |
we showed that the conditioned media (cm) from gl261 glioma cells stimulated the activation of bv-2 microglia cells, evidenced by markedly increased expression of interleukin-6 (il-6), il-1β, tumor necrosis factor-α (tnf-α), ccl2 (c-c motif chemokine ligand 2) and cxcl10 (c-x-c motif chemokine 10). |
2020-02-10 |
2023-08-13 |
Not clear |
| Ahmed M Osman, Johanna Rodhe, Xianli Shen, Cecilia A Dominguez, Bertrand Joseph, Klas Blomgre. The Secretome of Microglia Regulate Neural Stem Cell Function. Neuroscience. vol 405. 2020-01-30. PMID:29101080. |
here, nscs were grown in conditioned media collected from either non-stimulated microglia, or microglia stimulated with pro- or anti-inflammatory agents. |
2020-01-30 |
2023-08-13 |
Not clear |
| Ahmed M Osman, Johanna Rodhe, Xianli Shen, Cecilia A Dominguez, Bertrand Joseph, Klas Blomgre. The Secretome of Microglia Regulate Neural Stem Cell Function. Neuroscience. vol 405. 2020-01-30. PMID:29101080. |
finally, we found that nscs differentiated in microglial conditioned media generated cells expressing the pro-inflammatory chemokine ccl2, most pronounced when differentiated in medium from the pro-inflammatory microglia subtype. |
2020-01-30 |
2023-08-13 |
Not clear |
| Sheng-Zhou Wu, Angela M Bodles, Mandy M Porter, W Sue T Griffin, Anthony S Basile, Steven W Barge. Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285800. |
results: conditioned medium from abeta-treated microglia contained elevated levels of d-serine. |
2019-11-20 |
2023-08-12 |
human |
| Si-Yeon Jeong, Raok Jeon, Yoon Kyung Choi, Joo Eun Jung, Anna Liang, Changhong Xing, Xiaoying Wang, Eng H Lo, Yun Seon Son. Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. Journal of neurochemistry. vol 136. issue 4. 2019-11-20. PMID:26603372. |
importantly, conditioned media from ogd-treated microglia increased neuronal death after ogd. |
2019-11-20 |
2023-08-13 |
Not clear |
| Si-Yeon Jeong, Raok Jeon, Yoon Kyung Choi, Joo Eun Jung, Anna Liang, Changhong Xing, Xiaoying Wang, Eng H Lo, Yun Seon Son. Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. Journal of neurochemistry. vol 136. issue 4. 2019-11-20. PMID:26603372. |
in contrast, the conditioned media from microglia treated with poly-iclc after ogd significantly protected against ogd-induced neuron death. |
2019-11-20 |
2023-08-13 |
Not clear |
| Si-Yeon Jeong, Raok Jeon, Yoon Kyung Choi, Joo Eun Jung, Anna Liang, Changhong Xing, Xiaoying Wang, Eng H Lo, Yun Seon Son. Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. Journal of neurochemistry. vol 136. issue 4. 2019-11-20. PMID:26603372. |
importantly, conditioned media from microglia treated with poly-iclc protects against ogd-induced neuron death. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rajiv Tikamdas, Sarthak Singhal, Ping Zhang, Justin A Smith, Eric G Krause, Stanley M Stevens, Sihong Song, Bin Li. Ischemia-responsive protein 94 is a key mediator of ischemic neuronal injury-induced microglial activation. Journal of neurochemistry. vol 142. issue 6. 2019-11-20. PMID:28640931. |
conditioned media (cm) from hippocampal and cortical neurons exposed to oxygen/glucose deprivation and reoxygenation induced significant activation of microglial cells as well as primary microglia, evidenced by up-regulation of inducible nitric oxide synthase, increased production of nitrite and reactive oxygen species, and increased expression of microglial markers. |
2019-11-20 |
2023-08-13 |
Not clear |