| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Davidson, J A Stamfor. Chronic paroxetine desensitises 5-HT1D but not 5-HT1B autoreceptors in rat lateral geniculate nucleus. Brain research. vol 760. issue 1-2. 1997-10-28. PMID:9237540. |
chronic paroxetine desensitises 5-ht1d but not 5-ht1b autoreceptors in rat lateral geniculate nucleus. |
1997-10-28 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Chronic paroxetine desensitises 5-HT1D but not 5-HT1B autoreceptors in rat lateral geniculate nucleus. Brain research. vol 760. issue 1-2. 1997-10-28. PMID:9237540. |
the present study examined the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on the 5-ht1b and 5-ht1d autoreceptors controlling 5-ht efflux in slices of rat ventrolateral geniculate nucleus. |
1997-10-28 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Chronic paroxetine desensitises 5-HT1D but not 5-HT1B autoreceptors in rat lateral geniculate nucleus. Brain research. vol 760. issue 1-2. 1997-10-28. PMID:9237540. |
5-ht efflux was inhibited by cp 93129 (1 nm-10 microm) and sumatriptan (1 nm-1 microm), agonists at 5-ht1b and 5-ht1d receptors, respectively. |
1997-10-28 |
2023-08-12 |
rat |
| J J Hagan, P D Slade, L Gaster, P Jeffrey, J P Hatcher, D N Middlemis. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. European journal of pharmacology. vol 331. issue 2-3. 1997-10-27. PMID:9274976. |
these data demonstrate that 5-ht1b (formerly 5-ht(1d beta)) and not 5-ht1d (formerly 5-ht(1d alpha)) receptors mediate the hypothermic response to skf-99101h (30 mg/kg i.p.) |
1997-10-27 |
2023-08-12 |
Not clear |
| K W Johnson, J M Schaus, M M Durkin, J E Audia, S W Kaldor, M E Flaugh, N Adham, J M Zgombick, M L Cohen, T A Branchek, L A Phebu. 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs. Neuroreport. vol 8. issue 9-10. 1997-10-07. PMID:9243618. |
the serotonin (5-ht) receptor subtype mediating inhibition of neurogenic dural inflammation in guinea pigs was investigated using a series of serotonin agonists with differing affinities for the 5-ht1b, 5-ht1d and 5-ht1f receptors. |
1997-10-07 |
2023-08-12 |
human |
| C Davidson, M Ho, G W Price, B J Jones, J A Stamfor. (+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors. British journal of pharmacology. vol 121. issue 4. 1997-09-25. PMID:9208142. |
we have studied the effects of the purportedly selective 5-ht1a receptor antagonist (+)-way 100135 on electrically stimulated 5-hydroxytryptamine (5-ht) efflux in the ventrolateral geniculate nucleus (vlgn), and its affinity at human 5-ht1b and 5-ht1d receptors stably expressed in chinese hamster ovary (cho) cells. |
1997-09-25 |
2023-08-12 |
human |
| J M Zgombick, J A Bard, S A Kucharewicz, D A Urquhart, R L Weinshank, T A Branche. Molecular cloning and pharmacological characterization of guinea pig 5-HT1B and 5-HT1D receptors. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225276. |
human 5-ht1b and 5-ht1d receptors have been implicated as molecular targets for the treatment of acute migraine based upon the pharmacological actions and clinical efficacy of sumatriptan, an agonist for human 5-ht1b/1d receptors. |
1997-09-15 |
2023-08-12 |
human |
| J M Zgombick, J A Bard, S A Kucharewicz, D A Urquhart, R L Weinshank, T A Branche. Molecular cloning and pharmacological characterization of guinea pig 5-HT1B and 5-HT1D receptors. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225276. |
guinea pig 5-ht1b and 5-ht1d receptor genes were transiently expressed in cos-7 cells and their binding properties were evaluated using [3h]5-ht. |
1997-09-15 |
2023-08-12 |
human |
| J M Zgombick, J A Bard, S A Kucharewicz, D A Urquhart, R L Weinshank, T A Branche. Molecular cloning and pharmacological characterization of guinea pig 5-HT1B and 5-HT1D receptors. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225276. |
high correlations were observed between the binding affinities of serotonergic ligands for 5-ht1d binding sites measured in guinea pig cortical membranes and both cloned guinea pig 5-ht1b (r2 = 0.88) and 5-ht1d (r2 = 0.80) receptors, indicating that the development of subtype selective compounds (i.e. |
1997-09-15 |
2023-08-12 |
human |
| M E Castro, J Pascual, T Romón, C del Arco, E del Olmo, A Pazo. Differential distribution of [3H]sumatriptan binding sites (5-HT1B, 5-HT1D and 5-HT1F receptors) in human brain: focus on brainstem and spinal cord. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225278. |
differential distribution of [3h]sumatriptan binding sites (5-ht1b, 5-ht1d and 5-ht1f receptors) in human brain: focus on brainstem and spinal cord. |
1997-09-15 |
2023-08-12 |
human |
| M E Castro, J Pascual, T Romón, C del Arco, E del Olmo, A Pazo. Differential distribution of [3H]sumatriptan binding sites (5-HT1B, 5-HT1D and 5-HT1F receptors) in human brain: focus on brainstem and spinal cord. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225278. |
we report on the autoradiographic distribution of 5-ht1b, 5-ht1d and 5-ht1f receptor subtypes in human brain, focusing on the brainstem and cervical spinal cord. |
1997-09-15 |
2023-08-12 |
human |
| M E Castro, J Pascual, T Romón, C del Arco, E del Olmo, A Pazo. Differential distribution of [3H]sumatriptan binding sites (5-HT1B, 5-HT1D and 5-HT1F receptors) in human brain: focus on brainstem and spinal cord. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225278. |
we have used [3h]sumatriptan as a radioligand in the presence of suitable concentrations of 5-ct (5-carboxamidotryptamine) to define 5-ht1f receptors, and ketanserin, to discriminate between 5-ht1b and 5-ht1d receptors. |
1997-09-15 |
2023-08-12 |
human |
| X J Yu, F M Cutrer, M A Moskowitz, C Waebe. The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater. Neuropharmacology. vol 36. issue 1. 1997-08-18. PMID:9144644. |
these data suggest that sumatriptan inhibits neurogenic inflammation via 5-ht1d alpha receptors in guinea pigs and 5-ht1d beta (5-ht1b) receptors in rats. |
1997-08-18 |
2023-08-12 |
rat |
| V Audinot, S Lochon, A Newman-Tancredi, G Lavielle, M J Milla. Binding profile of the novel 5-HT1B/1D receptor antagonist, [3H]GR 125,743, in guinea-pig brain: a comparison with [3H]5-carboxamidotryptamine. European journal of pharmacology. vol 327. issue 2-3. 1997-08-18. PMID:9200567. |
ketanserin and ritanserin showed low affinity for [3h]gr 125,743 binding to guinea-pig striatal sites (k(i) = 12600 and 369 nm), suggesting that 5-ht1b (rather than 5-ht1d) receptors are predominantly labelled in this tissue. |
1997-08-18 |
2023-08-12 |
Not clear |
| H E Connor, W Feniuk, D T Beattie, P C North, A W Oxford, D A Saynor, P P Humphre. Naratriptan: biological profile in animal models relevant to migraine. Cephalalgia : an international journal of headache. vol 17. issue 3. 1997-07-31. PMID:9170336. |
naratriptan has high affinity for human recombinant 5ht1b and 5ht1d receptors (pki = 8.7 +/- 0.03 and 8.3 +/- 0.1, respectively) and causes contractions of dog isolated basilar and middle cerebral artery (ec50 values of 0.11 and 0.07 microm, respectively). |
1997-07-31 |
2023-08-12 |
human |
| G R Martin, A D Robertson, S J MacLennan, D J Prentice, V J Barrett, J Buckingham, A C Honey, H Giles, S Moncad. Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan). British journal of pharmacology. vol 121. issue 2. 1997-07-16. PMID:9154322. |
311c90 displayed high affinity at human recombinant 5-ht1d (formerly 5-ht1d alpha) and 5-ht1b (formerly 5-ht1d beta) receptors in transfected cho-k1 cell membranes (pic50 values = 9.16 +/- 0.12 and 8.32 +/- 0.09, respectively). |
1997-07-16 |
2023-08-12 |
human |
| C Davidson, J A Stamfor. Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT1B and 5-HT1D autoreceptors. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025111. |
serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-ht1b and 5-ht1d autoreceptors. |
1997-05-28 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT1B and 5-HT1D autoreceptors. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025111. |
furthermore, released 5-ht is taken up by the 5-ht transporter and may be under the influence of 5-ht1b and 5-ht1d autoreceptors. |
1997-05-28 |
2023-08-12 |
rat |
| M D Ferrar. 311C90: increasing the options for therapy with effective acute antimigraine 5HT1B/1D receptor agonists. Neurology. vol 48. issue 3 Suppl 3. 1997-04-10. PMID:9071266. |
the novel antimigraine drug 311c90 (zomig; zolmitriptan) has a high selectivity for serotonin (5ht)1 receptors, mainly 5ht1b and 5ht1d subtypes, and in preclinical studies it has been shown to act on four different sites within the trigemino-vascular system (blockade of neurogenic inflammation by inhibition of peptide release, vasoconstriction, inhibition of neuronal depolarization at peripheral sites, and effects at central sites). |
1997-04-10 |
2023-08-12 |
Not clear |
| H Saito, M Matsumoto, H Togashi, M Yoshiok. Functional interaction between serotonin and other neuronal systems: focus on in vivo microdialysis studies. Japanese journal of pharmacology. vol 70. issue 3. 1997-01-15. PMID:8935715. |
5-ht release is negatively regulated not only by somatodendritic 5-ht1a and terminal 5-ht1b (5-ht1d) autoreceptors but also by alpha 2-adrenergic and mu-opioid heteroreceptors that are located on serotonergic nerve terminals. |
1997-01-15 |
2023-08-12 |
rat |