| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Kulikov, D F Avgustinovich, V G Kolpakov, G B Maslova, N K Popov. 5-HT2A serotonin receptors in the brain of rats and mice hereditarily predisposed to catalepsy. Pharmacology, biochemistry, and behavior. vol 50. issue 3. 1995-08-22. PMID:7617676. |
5-ht2a serotonin receptors in the brain of rats and mice hereditarily predisposed to catalepsy. |
1995-08-22 |
2023-08-12 |
mouse |
| T Takahashi, J K Ward, S Tadjkarimi, M H Yacoub, P J Barnes, M G Belvis. 5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. American journal of respiratory and critical care medicine. vol 152. issue 1. 1995-08-10. PMID:7599849. |
the 5-ht3/4 and 5-ht3 antagonists, ics 205-930 and ondansetron, inhibited the effect of 5-ht competitively (pa2 values of 7.3 and 7.1, respectively); methiothepin (5-ht1/2c antagonist), ketanserin (5-ht2a antagonist), and gr 113808a (5-ht4 antagonist) had no effect. |
1995-08-10 |
2023-08-12 |
human |
| S C Pandey, J M Davis, G N Pande. Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. Journal of psychiatry & neuroscience : JPN. vol 20. issue 3. 1995-07-27. PMID:7786883. |
the 5-ht2a receptor subtype is the most widely studied of the 5-ht receptors in psychiatric disorders (for example, suicide, depression and schizophrenia) as well as in relation to the mechanism of action of antidepressant drugs. |
1995-07-27 |
2023-08-12 |
Not clear |
| H Pertz, S El. In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. The Journal of pharmacy and pharmacology. vol 47. issue 4. 1995-07-27. PMID:7791029. |
in-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-ht2a receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-ht contractions in rat tail artery. |
1995-07-27 |
2023-08-12 |
rat |
| H Pertz, S El. In-vitro pharmacology of sarpogrelate and the enantiomers of its major metabolite: 5-HT2A receptor specificity, stereoselectivity and modulation of ritanserin-induced depression of 5-HT contractions in rat tail artery. The Journal of pharmacy and pharmacology. vol 47. issue 4. 1995-07-27. PMID:7791029. |
sarpogrelate, (r,s)-m-1, (r)-m-1 and (s)-m-1, respectively, were competitive antagonists of 5-hydroxytryptamine (5-ht) at 5-ht2a receptors of rat tail artery with calculated pa2 values of 8.53, 9.04, 9.00 and 8.81, respectively. |
1995-07-27 |
2023-08-12 |
rat |
| J Perregaard, E K Moltzen, E Meier, C Sánche. Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. Journal of medicinal chemistry. vol 38. issue 11. 1995-07-18. PMID:7783131. |
additionally, these compounds had relatively high affinity for serotonin 5-ht1a and 5-ht2a, dopamine d2, and adrenergic alpha 1 receptors. |
1995-07-18 |
2023-08-12 |
rat |
| J Akiyoshi, A Nishizono, K Yamada, H Nagayama, K Mifune, I Fuji. Rapid desensitization of serotonin 5-HT2C receptor-stimulated intracellular calcium mobilization in CHO cells transfected with cloned human 5-HT2C receptors. Journal of neurochemistry. vol 64. issue 6. 1995-06-28. PMID:7760026. |
exposure to 5-ht, 1-(3-chlorophenyl)piperazine dihydrochloride (a 5-ht2c agonist), and 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane (a 5-ht2c and 5-ht2a agonist) resulted in increased intracellular ca2+ levels. |
1995-06-28 |
2023-08-12 |
human |
| H Y Meltze. The role of serotonin in schizophrenia and the place of serotonin-dopamine antagonist antipsychotics. Journal of clinical psychopharmacology. vol 15. issue 1 Suppl 1. 1995-05-31. PMID:7730497. |
this new strategy involves identifying drugs with strong serotonin (5-hydroxytryptamine) 5-ht2a receptor relative to dopamine d2 receptor blocking properties. |
1995-05-31 |
2023-08-12 |
Not clear |
| M Huttune. The evolution of the serotonin-dopamine antagonist concept. Journal of clinical psychopharmacology. vol 15. issue 1 Suppl 1. 1995-05-31. PMID:7730499. |
suggestions that serotonin might be involved in the cause of schizophrenia or could be a target for antipsychotic drug action began with the discovery that the antipsychotic agent clozapine is a potent serotonin 5-ht2a antagonist, as well as being a dopamine d2 antagonist. |
1995-05-31 |
2023-08-12 |
Not clear |
| M Huttune. The evolution of the serotonin-dopamine antagonist concept. Journal of clinical psychopharmacology. vol 15. issue 1 Suppl 1. 1995-05-31. PMID:7730499. |
the principle of the sdas is that the drug should be a potent serotonin 5-ht2a antagonist, with slightly less potent dopamine d2 receptor-blocking properties. |
1995-05-31 |
2023-08-12 |
Not clear |
| R Schreiber, M Brocco, V Audinot, A Gobert, S Veiga, M J Milla. (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. The Journal of pharmacology and experimental therapeutics. vol 273. issue 1. 1995-05-17. PMID:7714755. |
in this study, the involvement of serotonergic and dopaminergic receptors in the modulation of the head-twitch (htw) response to the 5-hydroxytryptamine (5-ht)2a/5-ht2c agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, was characterized in rats using novel and selective ligands at 5-ht2a, 5-ht2c, d1, d2 and 5-ht1a receptors. |
1995-05-17 |
2023-08-12 |
rat |
| A S Eison, R P Freeman, V B Guss, U L Mullins, R N Wrigh. Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat. The Journal of pharmacology and experimental therapeutics. vol 273. issue 1. 1995-05-17. PMID:7714781. |
interactions between melatonin and serotonin type 2a (5-ht2a) receptors in the regulation of the sleep-wakefulness cycle in the rat have been reported. |
1995-05-17 |
2023-08-12 |
rat |
| X Luo, D Zhang, H Weinstei. Ligand-induced domain motion in the activation mechanism of a G-protein-coupled receptor. Protein engineering. vol 7. issue 12. 1995-05-16. PMID:7716154. |
we have described recently a 3-d molecular model of the transmembrane portion of the 5-ht2a type of receptor of the neurotransmitter serotonin (5-hydroxytryptamine; 5-ht), constructed from such convergent empirical and theoretical considerations, and have used it for a computational simulation of the mechanisms of ligand-induced receptor activation and signal transduction. |
1995-05-16 |
2023-08-12 |
Not clear |
| H Canton, L Verrièle, M J Milla. Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptor-mediated phosphoinositide (PI) turnover by clozapine in the rat: a comparison to other antipsychotics. Neuroscience letters. vol 181. issue 1-2. 1995-04-27. PMID:7898773. |
competitive antagonism of serotonin (5-ht)2c and 5-ht2a receptor-mediated phosphoinositide (pi) turnover by clozapine in the rat: a comparison to other antipsychotics. |
1995-04-27 |
2023-08-12 |
rat |
| H Canton, L Verrièle, M J Milla. Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptor-mediated phosphoinositide (PI) turnover by clozapine in the rat: a comparison to other antipsychotics. Neuroscience letters. vol 181. issue 1-2. 1995-04-27. PMID:7898773. |
the antagonist actions of clozapine and several other antipsychotics at 5-hydroxytryptamine (5-ht)2a and 5-ht2c receptors were studied using the in vitro model of 5-ht-induced phosphoinositide (pi) turnover in rat choroid plexus (5-ht2c) and frontal cortex (5-ht2a). |
1995-04-27 |
2023-08-12 |
rat |
| E Fujii, K Irie, Y Uchida, F Tsukahara, T Murak. Possible role of nitric oxide in 5-hydroxytryptamine-induced increase in vascular permeability in mouse skin. Naunyn-Schmiedeberg's archives of pharmacology. vol 350. issue 4. 1995-03-07. PMID:7531292. |
the vascular permeability induced by 5-ht was inhibited by pretreatment with intraperitoneal injection of ketanserin (5-ht2a antagonist) and methysergide (5-ht1/2a antagonist), less efficiently by 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine (nan-190) (5-ht1a antagonist), but not by granisetron (5-ht3 antagonist). |
1995-03-07 |
2023-08-12 |
mouse |
| W Löscher, C Gerdes, A Richte. Lack of prophylactic or therapeutic efficacy of 5-HT2A receptor antagonists in halothane-induced porcine malignant hyperthermia. Naunyn-Schmiedeberg's archives of pharmacology. vol 350. issue 4. 1995-03-07. PMID:7845474. |
administration of 5-ht agonists which stimulate the 5-ht2a subreceptor triggers mh in susceptible pigs. |
1995-03-07 |
2023-08-12 |
Not clear |
| C M Yang, J T Hsieh, Y L Yo, R Ong, H L Tsa. 5-Hydroxytryptamine-stimulated calcium mobilization in cultured canine tracheal smooth muscle cells. Cell calcium. vol 16. issue 3. 1995-02-22. PMID:7828173. |
in contrast, 5-ht2a receptor antagonists, ketanserin and mianserin, had high affinity in antagonizing the changes in [ca2+]i response to 5-ht with pkb values of 8.3 and 8.3, respectively. |
1995-02-22 |
2023-08-12 |
Not clear |
| C M Yang, J T Hsieh, Y L Yo, R Ong, H L Tsa. 5-Hydroxytryptamine-stimulated calcium mobilization in cultured canine tracheal smooth muscle cells. Cell calcium. vol 16. issue 3. 1995-02-22. PMID:7828173. |
in conclusion, these findings indicate that the initial increase in [ca2+]i stimulated by 5-ht acting on 5-ht2a receptors is due to the release of ca2+ from internal stores, followed by the influx of external ca2+ into the cells. |
1995-02-22 |
2023-08-12 |
Not clear |
| S Ishihara, K Yamada, T Hayashi, T Hasegawa, T Kameyama, T Morimasa, T Kaneyuki, T Shohmori, T Nabeshim. Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding. Biological & pharmaceutical bulletin. vol 17. issue 8. 1995-02-10. PMID:7820124. |
effects of kamikihito, a traditional chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine d1 and serotonin 5-ht2a receptor binding. |
1995-02-10 |
2023-08-12 |
rat |