| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Ishihara, K Yamada, T Hayashi, T Hasegawa, T Kameyama, T Morimasa, T Kaneyuki, T Shohmori, T Nabeshim. Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding. Biological & pharmaceutical bulletin. vol 17. issue 8. 1995-02-10. PMID:7820124. |
using in vitro autoradiography, we investigated the effects of kamikihito (kkt), a traditional chinese medicine, on specific [3h]sch23390 binding to dopamine d1 receptors and [3h]ketanserine binding to serotonin 5-ht2a receptors in the rat brain. |
1995-02-10 |
2023-08-12 |
rat |
| S Ishihara, K Yamada, T Hayashi, T Hasegawa, T Kameyama, T Morimasa, T Kaneyuki, T Shohmori, T Nabeshim. Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding. Biological & pharmaceutical bulletin. vol 17. issue 8. 1995-02-10. PMID:7820124. |
these results suggest that the changes in dopamine di and serotonin 5-ht2a receptor binding may be involved in the central effects of kkt. |
1995-02-10 |
2023-08-12 |
rat |
| J F Nash, B L Roth, J D Brodkin, D E Nichols, G A Gudelsk. Effect of the R(-) and S(+) isomers of MDA and MDMA on phosphatidyl inositol turnover in cultured cells expressing 5-HT2A or 5-HT2C receptors. Neuroscience letters. vol 177. issue 1-2. 1995-02-10. PMID:7824160. |
in all cases at both the 5-ht2a and 5-ht2c receptors, the affinities of the isomers of mdma and mda were at least 2-3 orders of magnitude less than 5-ht. |
1995-02-10 |
2023-08-12 |
Not clear |
| W Pinto, G Battagli. Comparative recovery kinetics of 5-hydroxytryptamine 1A, 1B, and 2A receptor subtypes in rat cortex after receptor inactivation: evidence for differences in receptor production and degradation. Molecular pharmacology. vol 46. issue 6. 1995-02-02. PMID:7808431. |
the present study investigates the comparative repopulation kinetics of 5-hydroxytryptamine (5-ht)1a, 5-ht1b, and 5-ht2a receptors in rat cortex homogenates after irreversible receptor inactivation by n-ethoxycarbonyl-1,2-ethoxydihydroquinoline. |
1995-02-02 |
2023-08-12 |
rat |
| M el Mansari, F Radja, A Ferron, T A Reader, E Molina-Holgado, L Descarrie. Hypersensitivity to serotonin and its agonists in serotonin-hyperinnervated neostriatum after neonatal dopamine denervation. European journal of pharmacology. vol 261. issue 1-2. 1995-01-23. PMID:8001641. |
after 6-hydroxydopamine lesion in adults, neither responsiveness to 5-ht, mcpp or doi nor the density of 5-ht1b or 5-ht2a binding were significantly different from control. |
1995-01-23 |
2023-08-12 |
rat |
| M el Mansari, F Radja, A Ferron, T A Reader, E Molina-Holgado, L Descarrie. Hypersensitivity to serotonin and its agonists in serotonin-hyperinnervated neostriatum after neonatal dopamine denervation. European journal of pharmacology. vol 261. issue 1-2. 1995-01-23. PMID:8001641. |
thus, the up-regulation of 5-ht1b, 5-ht2a and possibly 5-ht2c receptors accompanying the 5-ht hyperinnervation after neonatal but not after adult dopamine denervation was associated with increased responsiveness (it50) of neostriatal neurons to iontophoresed 5-ht and its receptor agonists. |
1995-01-23 |
2023-08-12 |
rat |
| D E Nichols, S Frescas, D Marona-Lewicka, X Huang, B L Roth, G A Gudelsky, J F Nas. 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist. Journal of medicinal chemistry. vol 37. issue 25. 1995-01-13. PMID:7996545. |
similarly, 3 and 5 produced equivalent responses at the 5-ht2a receptor as compared to 5-ht. |
1995-01-13 |
2023-08-12 |
rat |
| P Martin, F Lemonnie. [The role of type 2 serotonin receptors, 5-HT2A and 5-HT2C, in depressive disorders: effect of medifoxamine]. L'Encephale. vol 20. issue 4. 1995-01-12. PMID:7988407. |
[the role of type 2 serotonin receptors, 5-ht2a and 5-ht2c, in depressive disorders: effect of medifoxamine]. |
1995-01-12 |
2023-08-12 |
human |
| P Martin, F Lemonnie. [The role of type 2 serotonin receptors, 5-HT2A and 5-HT2C, in depressive disorders: effect of medifoxamine]. L'Encephale. vol 20. issue 4. 1995-01-12. PMID:7988407. |
concerning 5-ht2 family, it is possible that some 5-ht binding drugs properties initially attributed to 5-ht2a receptors, might well be mediated by 5-ht2c receptors. |
1995-01-12 |
2023-08-12 |
human |
| R C Ferry, C D Unsworth, R P Artymyshyn, P B Molinof. Regulation of mRNA encoding 5-HT2A receptors in P11 cells through a post-transcriptional mechanism requiring activation of protein kinase C. The Journal of biological chemistry. vol 269. issue 50. 1995-01-12. PMID:7989358. |
regulation of mrna encoding 5-ht2a receptors in p11 cells through a post-transcriptional mechanism requiring activation of protein kinase c. exposure of p11 cells to serotonin (5-ht) resulted in a transient increase in levels of 5-ht2a receptor mrna. |
1995-01-12 |
2023-08-12 |
Not clear |
| H Gozlan, A M Laporte, S Thibault, L E Schechter, F Bolaños, M Hamo. Differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on various 5-HT receptor binding sites in the rat brain. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984280. |
the effects of n-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (eedq), an alkylating agent producing irreversible blockade of various membrane bound receptors in brain, were investigated on four different types of serotonin receptors, 5-ht1a, 5-ht1b, 5-ht2a and 5-ht3, in various brain regions in the rat. |
1994-12-30 |
2023-08-12 |
rat |
| F Chaouloff, V Baudrie, I Coupr. Effects of chlorisondamine and restraint on cortical [3H]ketanserin binding, 5-HT2A receptor-mediated head shakes, and behaviours in models of anxiety. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984283. |
because restraint-induced release of 5-ht has been shown to be associated with a paradoxical increase in cortical 5-ht2a receptor binding, we have examined the influence of 5-ht synthesis/release upon cortical 5-ht2a receptor binding and 5-ht2a receptor-mediated head shakes in 3-hr restrained rats pretreated with the ganglionic blocker chlorisondamine. |
1994-12-30 |
2023-08-12 |
rat |
| S W Watts, D A Cox, B G Johnson, D D Schoepp, M L Cohe. Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis. The Journal of pharmacology and experimental therapeutics. vol 271. issue 2. 1994-12-29. PMID:7965803. |
serotonin (5-ht) contracts the guinea pig trachea through stimulation of the 5-ht2a receptor, a receptor generally linked with phosphoinositide (pi) hydrolysis. |
1994-12-29 |
2023-08-12 |
Not clear |
| S W Watts, D A Cox, B G Johnson, D D Schoepp, M L Cohe. Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis. The Journal of pharmacology and experimental therapeutics. vol 271. issue 2. 1994-12-29. PMID:7965803. |
short incubations (1-60 min) of the trachea with 5-ht (10(-4) m) to minimize possible 5-ht2a receptor desensitization did not increase pi hydrolysis, whereas carbamylcholine (10(-7) to 10(-3) m) and histamine (10(-7) to 10(-4) m) did. |
1994-12-29 |
2023-08-12 |
Not clear |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by mdl 100,907, a highly selective 5-ht2a receptor antagonist. |
1994-12-08 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
electrophysiological studies have suggested that a subpopulation of interneurons near the border of layer ii and iii in rat piriform cortex are excited by serotonin (5-hydroxytryptamine; 5-ht) via 5-ht2a (formerly 5-ht2) rather than 5-ht2c (formerly 5-ht1c) receptors. |
1994-12-08 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
in the present study, we tested a new, highly selective 5-ht2a receptor antagonist mdl 100,907 (r-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl-ethyl)]-4- piperidine-methanol, which has a 300-fold greater affinity for 5-ht2a than 5-ht1c receptors or alpha 1-adrenoceptors) on excitatory responses of interneurons to 5-ht in rat piriform cortex slices. |
1994-12-08 |
2023-08-12 |
rat |
| G J Marek, G K Aghajania. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European journal of pharmacology. vol 259. issue 2. 1994-12-08. PMID:7957607. |
these data confirm that 5-ht2a rather than 5-ht2c receptors mediate excitation by 5-ht of interneurons in the piriform cortex. |
1994-12-08 |
2023-08-12 |
rat |
| S W Watts, K W Schenck, M L Cohe. Selective desensitization of 5-hydroxytryptamine 2A receptor mediated contraction in guinea pig trachea. Canadian journal of physiology and pharmacology. vol 72. issue 5. 1994-12-02. PMID:7954073. |
5-hydroxytryptamine (serotonin, 5-ht) contracts the guinea pig trachea through stimulation of 5-ht2a receptors, an effect previously reported to rapidly desensitize. |
1994-12-02 |
2023-08-12 |
rat |
| S W Watts, K W Schenck, M L Cohe. Selective desensitization of 5-hydroxytryptamine 2A receptor mediated contraction in guinea pig trachea. Canadian journal of physiology and pharmacology. vol 72. issue 5. 1994-12-02. PMID:7954073. |
in vitro studies investigating functional desensitization of the guinea pig tracheal 5-ht2a receptor documented that 5-ht (3 x 10(-7) m) significantly (50%) but incompletely reduced subsequent tracheal maximal contraction to 5-ht. |
1994-12-02 |
2023-08-12 |
rat |