| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K A Berg, W P Clarke, C Sailstad, A Saltzman, S Maayan. Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems. Molecular pharmacology. vol 46. issue 3. 1994-11-10. PMID:7935328. |
the cdnas for human 5-hydroxytryptamine (5-ht)2c and 5-ht2a receptors were stably transfected separately into parent chinese hamster ovary cells, and cell lines in which levels of transfected receptor protein expression and accumulation of inositol phosphates in response to 5-ht were comparable were chosen for study. |
1994-11-10 |
2023-08-12 |
human |
| K A Berg, W P Clarke, C Sailstad, A Saltzman, S Maayan. Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems. Molecular pharmacology. vol 46. issue 3. 1994-11-10. PMID:7935328. |
in contrast, activation of 5-ht2a receptors with either 5-ht or (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane did not alter the 5-ht1b-like response. |
1994-11-10 |
2023-08-12 |
human |
| A Lucchelli, M G Santagostino-Barbone, A Barbieri, M Tonin. A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea-pig isolated trachea. British journal of pharmacology. vol 112. issue 3. 1994-11-09. PMID:7921600. |
the 5-ht2a receptor antagonist, ketanserin (0.01, 0.1 microm) markedly depressed the first phase and shifted the second phase to the right in a parallel manner, with some depression of the 5-ht response maximum. |
1994-11-09 |
2023-08-12 |
Not clear |
| A Lucchelli, M G Santagostino-Barbone, A Barbieri, M Tonin. A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea-pig isolated trachea. British journal of pharmacology. vol 112. issue 3. 1994-11-09. PMID:7921600. |
our results suggest that neural 5-ht2a and, to a lesser extent, 5-ht3 receptor subtypes mediate the first phase of the 5-ht curve in the guinea-pig trachea. |
1994-11-09 |
2023-08-12 |
Not clear |
| A Kanamori, K Matoba, Y Yajim. Effects of sarpogrelate on serotonin-induced increases in cytosolic Ca2+ in cultured rat mesangial cells. Life sciences. vol 55. issue 18. 1994-11-04. PMID:7934648. |
the effects of the new 5-ht2a receptor antagonist sarpogrelate on the cellular action of serotonin were examined in cultured rat mesangial cells by measuring cytosolic free calcium concentration ([ca2+]i). |
1994-11-04 |
2023-08-12 |
rat |
| A Kanamori, K Matoba, Y Yajim. Effects of sarpogrelate on serotonin-induced increases in cytosolic Ca2+ in cultured rat mesangial cells. Life sciences. vol 55. issue 18. 1994-11-04. PMID:7934648. |
these results suggest that sarpogrelate and its major metabolite (m1) act as reversible and specific 5-ht2a receptor antagonists against the contractile action of platelet-derived serotonin in mesangial cells. |
1994-11-04 |
2023-08-12 |
rat |
| S T Phillips, T de Paulis, B M Baron, B W Siegel, P Seeman, H H Van Tol, H C Guan, H E Smit. Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. Journal of medicinal chemistry. vol 37. issue 17. 1994-09-22. PMID:8064797. |
5h-dibenzo[b,e][1,4]diazepine, dibenz[b,f]oxepin, and 5h-dibenzo[a,d]cycloheptene analogues of clozapine [8-chloro-11-(4-methylpiperazino)-5h- dibenzo[b,e][1,4]diazepine] were evaluated for their binding affinity to dopamine d-1, d-2, and d-4 and serotonin s-2a (5-ht2a), s-2c (5-ht2c) and s-3 (5-ht3) receptors. |
1994-09-22 |
2023-08-12 |
Not clear |
| N J Hrib, J G Jurcak, K L Burgher, P G Conway, H B Hartman, L L Kerman, J E Roehr, A T Wood. Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents. Journal of medicinal chemistry. vol 37. issue 15. 1994-09-12. PMID:7914536. |
in general, the compounds showed an affinity for dopamine d2 and serotonin 5ht2a and 5ht1a receptors. |
1994-09-12 |
2023-08-12 |
Not clear |
| S K Hemrick-Luecke, H D Snoddy, R W Fulle. Evaluation of nefazodone as a serotonin uptake inhibitor and a serotonin antagonist in vivo. Life sciences. vol 55. issue 7. 1994-08-25. PMID:8041227. |
antagonism of serotonin type 2a (5ht2a) receptors, as well as inhibition of the serotonin (5ht) uptake carrier, has been suggested to contribute to the antidepressant action of nefazodone in vivo (eison et al., 1990). |
1994-08-25 |
2023-08-12 |
mouse |
| S K Hemrick-Luecke, H D Snoddy, R W Fulle. Evaluation of nefazodone as a serotonin uptake inhibitor and a serotonin antagonist in vivo. Life sciences. vol 55. issue 7. 1994-08-25. PMID:8041227. |
1990) reporting nefazodone to be an antagonist at 5ht2a receptors, but fail to show inhibition of the 5ht uptake carrier in the same dose range. |
1994-08-25 |
2023-08-12 |
mouse |
| M Baez, L Mercurio, K Schenck, M L Cohe. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life sciences. vol 55. issue 6. 1994-08-18. PMID:8035655. |
for example, the guinea pig trachea and rat aorta markedly contract in response to serotonin via activation of 5-ht2a receptors. |
1994-08-18 |
2023-08-12 |
rat |
| M Baez, L Mercurio, K Schenck, M L Cohe. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life sciences. vol 55. issue 6. 1994-08-18. PMID:8035655. |
these data are consistent with the more profound contractile response to serotonin in guinea pig versus rat trachea and suggest that differences in tracheal contractility to serotonin correlate with the density of 5-ht2a receptor mrna. |
1994-08-18 |
2023-08-12 |
rat |
| M Baez, L Mercurio, K Schenck, M L Cohe. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life sciences. vol 55. issue 6. 1994-08-18. PMID:8035655. |
in contrast, although rat aorta contracted more dramatically to serotonin than guinea pig aorta, rat aorta possessed a similar concentration of 5-ht2a receptor specific mrna as compared to guinea pig aorta. |
1994-08-18 |
2023-08-12 |
rat |
| M Baez, L Mercurio, K Schenck, M L Cohe. Relationship between 5-HT2A receptor mRNA density and contractility in trachea and aorta from guinea pig and rat. Life sciences. vol 55. issue 6. 1994-08-18. PMID:8035655. |
these studies documenting 5-ht2a receptor mrna in rat trachea and guinea pig aorta, two tissues that do not markedly contract in response to serotonin indicate that 5-ht2a receptor mrna although present, has not resulted in a receptor capable of mediating a contractile response in these tissues. |
1994-08-18 |
2023-08-12 |
rat |
| E H Cook, K E Fletcher, M Wainwright, N Marks, S Y Yan, B L Leventha. Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. Journal of neurochemistry. vol 63. issue 2. 1994-08-12. PMID:8035173. |
primary structure of the human platelet serotonin 5-ht2a receptor: identify with frontal cortex serotonin 5-ht2a receptor. |
1994-08-12 |
2023-08-12 |
human |
| M Pompeiano, J M Palacios, G Mengo. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain research. Molecular brain research. vol 23. issue 1-2. 1994-08-08. PMID:8028479. |
distribution of the serotonin 5-ht2 receptor family mrnas: comparison between 5-ht2a and 5-ht2c receptors. |
1994-08-08 |
2023-08-12 |
rat |
| M Pompeiano, J M Palacios, G Mengo. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain research. Molecular brain research. vol 23. issue 1-2. 1994-08-08. PMID:8028479. |
because of their similarities, serotonin 5-ht2, 5-ht1c, and the recently described 5-ht2f receptors have been classified as members of the 5-ht2 receptor family, and they have been renamed 5-ht2a, 5-ht2c and 5-ht2b, respectively. |
1994-08-08 |
2023-08-12 |
rat |
| K A Berg, W P Clarke, Y Chen, B J Ebersole, R D McKay, S Maayan. 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Molecular pharmacology. vol 45. issue 5. 1994-06-23. PMID:8190100. |
this effect of 5-ht was blocked by 10 nm ketanserin as well as by 10 nm spiperone, indicating a response mediated by the 5-ht2a receptor subtype. |
1994-06-23 |
2023-08-12 |
rat |
| P H Boeijinga, H W Boddek. Serotonergic modulation of neurotransmission in the rat subicular cortex in vitro: a role for 5-HT1B receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 6. 1994-04-20. PMID:8133898. |
the responses to 5-ht were also unaffected by pretreatment with the 5-ht1a selective antagonist nan-190 (10(-6) mol/l), the 5-ht2a antagonist ketanserin (10(-6) mol/l) or the 5-ht3/5-ht4 antagonist ics 205-930 (10(-6) mol/l). |
1994-04-20 |
2023-08-12 |
rat |
| D W Bonhaus, D N Loury, L B Jakeman, Z To, A DeSouza, R M Eglen, E H Won. [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. The Journal of pharmacology and experimental therapeutics. vol 267. issue 2. 1994-01-06. PMID:8246171. |
the affinity of bimu-1 for sigma-2 binding sites (ki = 32 nm) was 200-fold greater than that for sigma-1 binding sites (ki = 6.3 microm), dopamine (d1 and d2), other serotonin (5-ht1a, 5-ht2a, 5-ht2c) and muscarinic (m1, m2, m3 and m4) receptors (ki > 10 microm). |
1994-01-06 |
2023-08-12 |
Not clear |