| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuangshuang Ye, Li Zhou, Zhemin Zho. [Thermal stability improvement for phenylalanine hydroxylase by site-directed mutagenesis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 32. issue 9. 2018-03-15. PMID:29022325. |
in proteins of thermophilic bacteria, gly is tend to be replaced by ala and lys is tend to be replaced by arg to adapt the high temperature. |
2018-03-15 |
2023-08-13 |
Not clear |
| Shuangshuang Ye, Li Zhou, Zhemin Zho. [Thermal stability improvement for phenylalanine hydroxylase by site-directed mutagenesis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 32. issue 9. 2018-03-15. PMID:29022325. |
in order to improve the thermal stability of phenylalanine hydroxylase (pah) from chromobacterium violaceum, all the gly on pah were mutated to ala and lys to arg. |
2018-03-15 |
2023-08-13 |
Not clear |
| Fobang Liu, Senchao Lai, Haijie Tong, Pascale S J Lakey, Manabu Shiraiwa, Michael G Weller, Ulrich Pöschl, Christopher J Kamp. Release of free amino acids upon oxidation of peptides and proteins by hydroxyl radicals. Analytical and bioanalytical chemistry. vol 409. issue 9. 2018-03-09. PMID:28108753. |
bovine serum albumin (bsa), ovalbumin (ova) as model proteins, and synthetic tripeptides (comprised of varying compositions of the amino acids gly, ala, ser, and met) were used for reactions with hydroxyl radicals, which were generated by the fenton reaction of iron ions and hydrogen peroxide. |
2018-03-09 |
2023-08-13 |
cattle |
| Jingwei Fan, Richen Li, Hai Wang, Xun He, Tan P Nguyen, Rachel A Letteri, Jiong Zou, Karen L Woole. Multi-responsive polypeptide hydrogels derived from N-carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs. Organic & biomolecular chemistry. vol 15. issue 24. 2018-02-08. PMID:28574067. |
statistical terpolymerizations of l-alanine (ala), glycine (gly) and l-isoleucine (ile) ncas at a 1 : 1 : 1 feed ratio initiated by monomethoxy monoamino-terminated poly(ethylene glycol) afforded a series of methoxy poly(ethylene glycol)-block-poly(l-alanine-co-glycine-co-l-isoleucine) (mpeg-b-p(a-g-i)) block polymers. |
2018-02-08 |
2023-08-13 |
Not clear |
| Tzvetan T Mihaylov, Hong Giang T Ly, Kristine Pierloot, Tatjana N Parac-Vog. Molecular Insight from DFT Computations and Kinetic Measurements into the Steric Factors Influencing Peptide Bond Hydrolysis Catalyzed by a Dimeric Zr(IV)-Substituted Keggin Type Polyoxometalate. Inorganic chemistry. vol 55. issue 18. 2018-01-31. PMID:27570876. |
peptide bond hydrolysis of several peptides with a gly-x sequence (x = gly, ala, val, leu, ile, phe) catalyzed by a dimeric zr(iv)-substituted keggin type polyoxometalate (pom), (et2nh2)8[{α-pw11o39zr(μ-oh)(h2o)}2]·7h2o (1), was studied by means of kinetic experiments and (1)h nmr spectroscopy. |
2018-01-31 |
2023-08-13 |
Not clear |
| Ryoko Tomita, Kenichiro Todoroki, Hiroshi Maruoka, Hideyuki Yoshida, Toshihiro Fujioka, Manabu Nakashima, Masatoshi Yamaguchi, Hitoshi Noht. Amino Acid Metabolomics Using LC-MS/MS: Assessment of Cancer-Cell Resistance in a Simulated Tumor Microenvironment. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 32. issue 8. 2018-01-22. PMID:27506717. |
the present method covered a linearity range of 3.6 - 1818 μm, except for gly (227 - 1818 μm), ala, asp, his (7.1 - 1818 μm each), and trp (3.6 - 909 μm). |
2018-01-22 |
2023-08-13 |
human |
| Wenwen Ding, Huanjiao Weng, Guocheng Du, Jian Chen, Zhen Kan. 5-Aminolevulinic acid production from inexpensive glucose by engineering the C4 pathway in Escherichia coli. Journal of industrial microbiology & biotechnology. vol 44. issue 8. 2018-01-01. PMID:28382525. |
following optimization of biosynthesis pathways towards coenzyme a and precursor (glycine and succinyl-coa), and downregulation of hemb expression, the production of ala was further increased to 2.81 g/l in batch-fermentation. |
2018-01-01 |
2023-08-13 |
Not clear |
| Robin Roychaudhuri, Tien-Phat V Huynh, Taylor R Whitaker, Elisabeth Hodara, Margaret M Condron, David B Teplo. A Critical Role of Ser26 Hydrogen Bonding in Aβ42 Assembly and Toxicity. Biochemistry. vol 56. issue 48. 2017-12-19. PMID:29140083. |
to study this question, we experimentally determined structure-activity relationships among aβ42 peptides in which ser26 was replaced with gly, ala, α-aminobutryic acid (abu), or cys. |
2017-12-19 |
2023-08-13 |
Not clear |
| Tsutomu Hoshino, Kazuya Nakagawa, Yukari Aiba, Daichi Itoh, Chika Nakada, Yukari Masukaw. Euphorbia tirucalli β-Amyrin Synthase: Critical Roles of Steric Sizes at Val483 and Met729 and the CH-π Interaction between Val483 and Trp534 for Catalytic Action. Chembiochem : a European journal of chemical biology. vol 18. issue 21. 2017-11-28. PMID:28875584. |
the gly and ala variants with a smaller bulk size at position 483 predominantly afforded monocyclic camelliol c, which suggested that the orientation of the (3s)-2,3-oxidosqualene substrate was not appropriately arranged in the reaction cavity as a result of the decreased bulk size, leading to failure of its normal folding into the chair-chair-chair-boat-boat conformation. |
2017-11-28 |
2023-08-13 |
Not clear |
| M Ultsch, A Braisted, H R Maun, C Eigenbro. 3-2-1: Structural insights from stepwise shrinkage of a three-helix Fc-binding domain to a single helix. Protein engineering, design & selection : PEDS. vol 30. issue 9. 2017-11-22. PMID:28475752. |
the b-domain variant bearing a gly to ala mutation (=z-domain) has been the subject of efforts to minimize a domain's size while retaining its function. |
2017-11-22 |
2023-08-13 |
human |
| Samia Elfekih, Matthew Shannon, Julien Haran, Alfried P Vogle. Detection of the Acetylcholinesterase Insecticide Resistance Mutation (G328A) in Natural Populations of Ceratitis capitata. Journal of economic entomology. vol 107. issue 5. 2017-09-22. PMID:26309287. |
wild mediterranean fruit fly specimens collected from various regions worldwide were screened for the glycine to alanine (gly->ala) point mutation (g328a) in the acetylcholinesterase enzyme, presumably causing resistance to organophosphates. |
2017-09-22 |
2023-08-13 |
drosophila_melanogaster |
| Tao Li, Wen-Tao Hou, Yuan Ruan, Bao-Dong Chen, Li-Guo Yang, Cong-Zhao Zhou, Yong-Guan Zh. Structural features of the aromatic/arginine constriction in the aquaglyceroporin GintAQPF2 are responsible for glycerol impermeability in arbuscular mycorrhizal symbiosis. Fungal biology. vol 121. issue 1. 2017-09-13. PMID:28007220. |
replacement of phenylalanine-94 (phe-94) by alanine (ala) enlarged the diameter of the ar/r constriction and resulted in an increased intracellular glycerol accumulation and thus survival rate of yeast cells at high glycerol levels, while individual or joint replacement of phe-94 and ala-234 by tryptophan and glycine induced a closed state of gintaqpf2, suggesting that the potential double gates (phe94-phe243 and arginine-249) of the ar/r constriction also likely determined solute permeability. |
2017-09-13 |
2023-08-13 |
Not clear |
| Judith Savige, Helen Storey, Hae Il Cheong, Hee Gyung Kang, Eujin Park, Pascale Hilbert, Anton Persikov, Carmen Torres-Fernandez, Elisabet Ars, Roser Torra, Jens Michael Hertz, Mads Thomassen, Lev Shagam, Dongmao Wang, Yanyan Wang, Frances Flinter, Mato Nage. X-Linked and Autosomal Recessive Alport Syndrome: Pathogenic Variant Features and Further Genotype-Phenotype Correlations. PloS one. vol 11. issue 9. 2017-08-08. PMID:27627812. |
gly>ala substitutions were underrepresented in all three genes (p< 0.0001) probably because of an association with a milder phenotype. |
2017-08-08 |
2023-08-13 |
Not clear |
| C Kaewtapee, M Eklund, M Wiltafsky, H-P Piepho, R Mosenthin, P Rosenfelde. Influence of wet heating and autoclaving on chemical composition and standardized ileal crude protein and amino acid digestibility in full-fat soybeans for pigs. Journal of animal science. vol 95. issue 2. 2017-07-19. PMID:28380613. |
autoclaving resulted in a linear decrease ( < 0.05) of trypsin inhibitor activity (tia), contents of arg, leu, ala, asp, cys, and gly as well as lys to cp ratio (lys:cp), reactive lys to cp ratio (rlys:cp), and in an increase ( < 0.05) in contents of ndf and ndin. |
2017-07-19 |
2023-08-13 |
Not clear |
| Angela Maria Amorini, Giacomo Lazzarino, Valentina Di Pietro, Stefano Signoretti, Giuseppe Lazzarino, Antonio Belli, Barbara Tavazz. Severity of experimental traumatic brain injury modulates changes in concentrations of cerebral free amino acids. Journal of cellular and molecular medicine. vol 21. issue 3. 2017-07-17. PMID:27696676. |
after 6, 12, 24, 48 and 120 hr aspartate (asp), glutamate (glu), asparagine (asn), serine (ser), glutamine (gln), histidine (his), glycine (gly), threonine (thr), citrulline (cit), arginine (arg), alanine (ala), taurine (tau), γ-aminobutyrate (gaba), tyrosine (tyr), s-adenosylhomocysteine (sah), l-cystathionine (l-cystat), valine (val), methionine (met), tryptophane (trp), phenylalanine (phe), isoleucine (ile), leucine (leu), ornithine (orn), lysine (lys), plus n-acetylaspartate (naa) were determined in whole brain extracts (n = 6 rats at each time for both tbi levels). |
2017-07-17 |
2023-08-13 |
rat |
| Angela Maria Amorini, Giacomo Lazzarino, Valentina Di Pietro, Stefano Signoretti, Giuseppe Lazzarino, Antonio Belli, Barbara Tavazz. Severity of experimental traumatic brain injury modulates changes in concentrations of cerebral free amino acids. Journal of cellular and molecular medicine. vol 21. issue 3. 2017-07-17. PMID:27696676. |
following stbi, animals showed profound, long-lasting modifications of glu, gln, naa, asp, gaba, ser, gly, ala, arg, citr, tau, met, sah, l-cystat, tyr and phe. |
2017-07-17 |
2023-08-13 |
rat |
| Xueying Zhu, Hongqi A. Theoretical insights into the properties of amino acid ionic liquids in aqueous solution. Journal of molecular modeling. vol 22. issue 7. 2017-06-16. PMID:27283444. |
this report presents a systematic investigation of the interactions of water molecule(s) with a series of amino acid cations (gly(+), ala(+), val(+), and leu(+)), halogen anions (cl(-), br(-), bf4 (-), and pf6 (-)), and clusters (glycl) n (n = 1-5). |
2017-06-16 |
2023-08-13 |
Not clear |
| Yosuke Hashimoto, Minoru Tada, Manami Iida, Shotaro Nagase, Tomoyuki Hata, Akihiro Watari, Yoshiaki Okada, Takefumi Doi, Masayoshi Fukasawa, Kiyohito Yagi, Masuo Kondo. Generation and characterization of a human-mouse chimeric antibody against the extracellular domain of claudin-1 for cancer therapy using a mouse model. Biochemical and biophysical research communications. vol 477. issue 1. 2017-05-29. PMID:27286708. |
we also constructed a mutant xi-3a2 antibody with gly, ser, and ile substituted with ala, asp, and arg at positions 236, 239, and 332 of the fc domain. |
2017-05-29 |
2023-08-13 |
mouse |
| András Szabó, Claudia Pilsak, Melinda Bence, Heiko Witt, Miklós Sahin-Tót. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. The Journal of biological chemistry. vol 291. issue 34. 2017-05-12. PMID:27358403. |
surprisingly, procela3a, which shares 92% identity with procela3b, did not form stable complexes due to the evolutionary replacement of ala(241) with gly. |
2017-05-12 |
2023-08-13 |
human |
| András Szabó, Claudia Pilsak, Melinda Bence, Heiko Witt, Miklós Sahin-Tót. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. The Journal of biological chemistry. vol 291. issue 34. 2017-05-12. PMID:27358403. |
the polymorphic nature of position 241 in both cela3a (∼4% ala(241) alleles) and cela3b (∼2% gly(241) alleles) points to individual variations in complex formation. |
2017-05-12 |
2023-08-13 |
human |