| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvia Josefina López-Pérez, Mónica Elisa Ureña-Guerrero, Alberto Morales-Villagrá. Monosodium glutamate neonatal treatment as a seizure and excitotoxic model. Brain research. vol 1317. 2010-05-19. PMID:20043888. |
glu levels and hippocampal total content of related amino acids (asp, glu, gln, gly, tau, ala and gaba) were estimated before, immediately and after each injection. |
2010-05-19 |
2023-08-12 |
rat |
| Livea F Barbosa, Fernanda M Cerqueira, Antero F A Macedo, Camila C M Garcia, José Pedro F Angeli, Robert I Schumacher, Mari Cleide Sogayar, Ohara Augusto, Maria Teresa Carrì, Paolo Di Mascio, Marisa H G Medeiro. Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS. Biochimica et biophysica acta. vol 1802. issue 5. 2010-05-11. PMID:20097285. |
here we examined dna damage, p53 activity and apoptosis in sh-sy5y human neuroblastoma cells transfected to achieve low-level expression of either wild-type or mutant gly(93)-->ala (g93a) sod1, typical of fals. |
2010-05-11 |
2023-08-12 |
human |
| Aneta Bombalska, Alfreda Graczy. Influence of photodynamic effect on biological activity of PBR-PP complexes. Journal of photochemistry and photobiology. B, Biology. vol 98. issue 2. 2010-05-10. PMID:20079659. |
constant concentration of solubilized receptor was titrated with increasing concentration of porphyrins (ppix, hp, pp(arg)(2), hp(arg)(2), pp(gly)(2), pp(ala)(2), pp(ser)(2), pp(phe)(2)) and binding constants were calculated. |
2010-05-10 |
2023-08-12 |
Not clear |
| Xiao-Mei He, Jing Zhou, Ying Cheng, Jun Fa. [Purification and production of the extracellular 5-aminolevulinate from recombiniant Escherichia coli expressing yeast ALAS]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 23. issue 3. 2010-05-07. PMID:17578005. |
at 12h after induction at 37 degrees c, the extracellular ala production was up to 162mg per liter lb culture at initial ph 6.5 with exogenous levulinate, succinate and and glycine at the concentration of 20 mmol/l respectively. |
2010-05-07 |
2023-08-12 |
Not clear |
| Thomas Arnesen, Kristian K Starheim, Petra Van Damme, Rune Evjenth, Huyen Dinh, Matthew J Betts, Anita Ryningen, Joël Vandekerckhove, Kris Gevaert, Dave Anderso. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. Molecular and cellular biology. vol 30. issue 8. 2010-04-28. PMID:20154145. |
the human nata protein n(alpha)-terminal-acetyltransferase complex is responsible for cotranslational n-terminal acetylation of proteins with ser, ala, thr, gly, and val n termini. |
2010-04-28 |
2023-08-12 |
human |
| Carly Huitema, Lindsay D Elti. A fluorescent protein-based biological screen of proteinase activity. Journal of biomolecular screening. vol 15. issue 2. 2010-04-27. PMID:20086215. |
to establish the general utility of the screen, it was used to demonstrate that the cysteine proteinase of the hepatitis a virus, 3c(pro), prefers ile, val, or leu at the p(4) position of the cleavage sequence and gly, ser, or ala at the p'(1) position. |
2010-04-27 |
2023-08-12 |
Not clear |
| Ivan Birukou, Rachel L Schweers, John S Olso. Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin. The Journal of biological chemistry. vol 285. issue 12. 2010-04-12. PMID:20080971. |
the role of the distal histidine in regulating ligand binding to adult human hemoglobin (hba) was re-examined systematically by preparing his(e7) to gly, ala, leu, gln, phe, and trp mutants of both hb subunits. |
2010-04-12 |
2023-08-12 |
human |
| Ivan Birukou, Rachel L Schweers, John S Olso. Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin. The Journal of biological chemistry. vol 285. issue 12. 2010-04-12. PMID:20080971. |
replacing his(e7) with gly, ala, leu, or phe causes 20-500-fold increases in the rates of o(2) dissociation from either hb subunit, demonstrating unambiguously that the native his(e7) imidazole side chain forms a strong hydrogen bond with bound o(2) in both the alpha and beta chains (deltag(his(e7)h-bond) approximately -8 kj/mol). |
2010-04-12 |
2023-08-12 |
human |
| J Michael Conlon, Laurent Coquet, Thierry Jouenne, Jérôme Leprince, Hubert Vaudry, Shawichi Iwamur. Evidence from the primary structures of dermal antimicrobial peptides that Rana tagoi okiensis and Rana tagoi tagoi (Ranidae) are not conspecific subspecies. Toxicon : official journal of the International Society on Toxinology. vol 55. issue 2-3. 2010-04-08. PMID:19799928. |
similarly, the acyclic c-terminally alpha-amidated brevinin-1 peptide from r. t. okiensis (brevinin-1toa, gigsilgviakglptliswiknr.nh(2)) shows three amino acid substitutions (gly(1)-->ala, val(8)-->ala, ile(9)-->leu) compared to the ortholog from r. t. tagoi. |
2010-04-08 |
2023-08-12 |
Not clear |
| Pio D'Adamo, Sheila Ulivi, Amerigo Beneduci, Gabriele Pontoni, Giovambattista Capasso, Carmela Lanzara, Gilberto Andrighetto, Uros Hladnik, Virginia Nunes, Manuel Palacin, Paolo Gasparin. Metabonomics and population studies: age-related amino acids excretion and inferring networks through the study of urine samples in two Italian isolated populations. Amino acids. vol 38. issue 1. 2010-04-02. PMID:19067108. |
hierarchical cluster analysis has clearly identified three groups clustering the same amino acids: his, thr and ala (group one); gly and phe (group two) and a third larger one. |
2010-04-02 |
2023-08-12 |
Not clear |
| Weiqi Fu, Jianping Lin, Peilin Ce. Expression of a hemA gene from Agrobacterium radiobacter in a rare codon optimizing Escherichia coli for improving 5-aminolevulinate production. Applied biochemistry and biotechnology. vol 160. issue 2. 2010-04-01. PMID:18800199. |
then the effects of precursors (glycine and succinate) and glucose, which is an inhibitor for ala dehydratase as well as the carbon sources for cell growth, on the production of 5-aminolevulinate were investigated. |
2010-04-01 |
2023-08-12 |
Not clear |
| Jianxia Kang, Yuanli Song, Akin Sevinc, Leslie W-M Fun. Important residue (G46) in erythroid spectrin tetramer formation. Cellular & molecular biology letters. vol 15. issue 1. 2010-03-30. PMID:19756397. |
in this study, we replaced the gly residue with ala, arg or glu residues in an erythroid alpha-spectrin model protein to give g46a, g46r or g46e, respectively. |
2010-03-30 |
2023-08-12 |
Not clear |
| Xuhua Xi. The +4G site in Kozak consensus is not related to the efficiency of translation initiation. PloS one. vol 2. issue 2. 2010-03-26. PMID:17285142. |
accumulated experimental and bioinformatic evidence has suggested an alternative explanation based on amino acid constraint on the second codon, i.e., amino acid ala or gly are needed as the second amino acid in the nascent peptide for the cleavage of the initiator met, and the consequent overuse of ala and gly codons (gcn and ggn) leads to the +4g consensus. |
2010-03-26 |
2023-08-12 |
human |
| Ashley Galant, Kiani A J Arkus, Chloe Zubieta, Rebecca E Cahoon, Joseph M Je. Structural basis for evolution of product diversity in soybean glutathione biosynthesis. The Plant cell. vol 21. issue 11. 2010-03-22. PMID:19948790. |
mutation of either leu-487 or pro-488 to an ala improves catalytic efficiency using gly, but a double mutation (l487a/p488a) is required to convert the substrate preference of hgs from beta-ala to gly. |
2010-03-22 |
2023-08-12 |
Not clear |
| Renhua Sun, Heng Zheng, Zhengzhi Fang, Wenbing Ya. Rational design of aminoacyl-tRNA synthetase specific for p-acetyl-L-phenylalanine. Biochemical and biophysical research communications. vol 391. issue 1. 2010-03-15. PMID:19944076. |
tyr32 needed to be changed to non-polar amino acid with shorter side chain, val, leu, ile, gly or ala, in order to reduce steric clash and provide hydrophobic environment to acetyl on p-acetyl-l-phenylalanine. |
2010-03-15 |
2023-08-12 |
Not clear |
| Manjeet Deshmukh, Piyun Chao, Hilliard L Kutscher, Dayuan Gao, Patrick J Sink. A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity. Journal of medicinal chemistry. vol 53. issue 3. 2010-03-12. PMID:20063889. |
four cpt prodrugs were synthesized with increasing aliphatic chain length (glycine (gly) (2a), alanine (ala) (2b), aminobutyric acid (abu) (2c), and norvaline (nva) (2d)). |
2010-03-12 |
2023-08-12 |
human |
| Daniel A Kraut, Paul A Sigala, Timothy D Fenn, Daniel Herschla. Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion hole. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 5. 2010-03-05. PMID:20080683. |
to understand the paradoxical effects of these mutations and clarify the energetic importance of the tyr16 hydrogen bond, we have determined the 1.6-a resolution x-ray structure of the intermediate analogue, equilenin, bound to the tyr16ser mutant and measured the rate effects of mutating tyr16 to ser, thr, ala, and gly. |
2010-03-05 |
2023-08-12 |
Not clear |
| Bingyang Shi, Shuxiang Zhang, Meijin Guo, Yonghong Wang, Siliang Zhang, Xiaolin Sh. [Metabolic characterization of rat sertoli cell in vitro culture]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 25. issue 5. 2010-03-04. PMID:19670645. |
as the changes of amino acids during culture were concerned, glu and ala accumulated rapidly, while val, leu, ile reduced slightly and at the same time ser, arg, and gly were stable. |
2010-03-04 |
2023-08-12 |
rat |
| Daniela Valensin, Karolina Gajda, Ewa Gralka, Gianni Valensin, Wojciech Kamysz, Henryk Kozlowsk. Copper binding to chicken and human prion protein amylodogenic regions: differences and similarities revealed by Ni2+ as a diamagnetic probe. Journal of inorganic biochemistry. vol 104. issue 1. 2010-03-02. PMID:19883942. |
also chprp possesses a similar region (chprp(105-140)) containing two his (his-110 and his-124) and an identical hydrophobic tail of 15 amino acids rich in ala and gly. |
2010-03-02 |
2023-08-12 |
human |
| Janelle E Jenkins, Melinda S Creager, Randolph V Lewis, Gregory P Holland, Jeffery L Yarge. Quantitative Correlation between the protein primary sequences and secondary structures in spider dragline silks. Biomacromolecules. vol 11. issue 1. 2010-02-26. PMID:20000730. |
in this study, nuclear magnetic resonance (nmr) techniques are used to quantify the percentage of ala, gly, and ser that form both beta-sheet and helical secondary structures. |
2010-02-26 |
2023-08-12 |
spider |