| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Séverine Vandevoorde, Christopher J Fowle. Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate. British journal of pharmacology. vol 145. issue 7. 2006-01-17. PMID:15895107. |
there is some dispute concerning the extent to which the uptake inhibitor vdm11 (n-(4-hydroxy-2-methylphenyl) arachidonoyl amide) is capable of inhibiting the metabolism of the endocannabinoid anandamide (aea) by fatty acid amide hydrolase (faah). |
2006-01-17 |
2023-08-12 |
rat |
| Antonella Brizzi, Vittorio Brizzi, Maria Grazia Cascio, Tiziana Bisogno, Rossella Sirianni, Vincenzo Di Marz. Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors. Journal of medicinal chemistry. vol 48. issue 23. 2006-01-17. PMID:16279794. |
binding studies on cb1 and cb2 receptors, anandamide membrane transporter (amt), and fatty acid amide hydrolase (faah) showed that some of the newly developed compounds have high affinity and specificity for cannabinoid cb1 and cb2 receptors. |
2006-01-17 |
2023-08-12 |
Not clear |
| Alan Saghatelian, Benjamin F Cravat. Discovery metabolite profiling--forging functional connections between the proteome and metabolome. Life sciences. vol 77. issue 14. 2006-01-05. PMID:15964030. |
we have applied dmp to study mice lacking the enzyme fatty acid amide hydrolase (faah), which degrades the endocannabinoid family of signaling lipids. |
2006-01-05 |
2023-08-12 |
mouse |
| Yong-Xin Sun, Kazuhito Tsuboi, Li-Ying Zhao, Yasuo Okamoto, Didier M Lambert, Natsuo Ued. Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. Biochimica et biophysica acta. vol 1736. issue 3. 2005-12-16. PMID:16154384. |
bioactive n-acylethanolamines including the endocannabinoid anandamide are known to be hydrolyzed to fatty acids and ethanolamine by fatty acid amide hydrolase (faah). |
2005-12-16 |
2023-08-12 |
mouse |
| Nissar A Darmani, Bryan A McClanahan, Chung Trinh, Stefania Petrosino, Marta Valenti, Vincenzo Di Marz. Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew. Neuropharmacology. vol 49. issue 4. 2005-12-07. PMID:15921709. |
of one of the major endocannabinoid metabolic enzymes, the intracellular fatty acid amide hydrolase (faah), do not significantly prevent vomiting produced by emetic doses of i.p.-administered 2-ag, cisplatin or the dopamine receptor agonist apomorphine. |
2005-12-07 |
2023-08-12 |
Not clear |
| Stefan Engeli, Jana Böhnke, Mareike Feldpausch, Kerstin Gorzelniak, Jürgen Janke, Sándor Bátkai, Pál Pacher, Judy Harvey-White, Friedrich C Luft, Arya M Sharma, Jens Jorda. Activation of the peripheral endocannabinoid system in human obesity. Diabetes. vol 54. issue 10. 2005-11-30. PMID:16186383. |
we measured circulating endocannabinoid concentrations and studied the expression of cb-1 and the main degrading enzyme, fatty acid amide hydrolase (faah), in adipose tissue of lean (n = 20) and obese (n = 20) women and after a 5% weight loss in a second group of women (n = 17). |
2005-11-30 |
2023-08-12 |
human |
| Douglas Osei-Hyiaman, Michael Depetrillo, Judith Harvey-White, Anthony W Bannon, Benjamin F Cravatt, Michael J Kuhar, Ken Mackie, Miklós Palkovits, George Kuno. Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide. Neuroendocrinology. vol 81. issue 4. 2005-10-31. PMID:16131814. |
mice deficient in fatty acid amide hydrolase (faah), the enzyme responsible for the in vivo metabolism of the endocannabinoid anandamide, have reduced levels of cart-immunoreactive nerve fibers and terminals in several brain regions implicated in appetite control, including the arcuate, dorsomedial and periventricular nuclei of the hypothalamus, the amygdala, the bed nucleus of the stria terminalis and the nucleus accumbens, and treatment of faah(-/-) mice with rimonabant, 3 mg/kg/day for 7 days, increased cart levels toward those seen in faah(+/+) wild-type controls. |
2005-10-31 |
2023-08-12 |
mouse |
| Michele K McKinney, Benjamin F Cravat. Structure and function of fatty acid amide hydrolase. Annual review of biochemistry. vol 74. 2005-09-29. PMID:15952893. |
fatty acid amide hydrolase (faah) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. |
2005-09-29 |
2023-08-12 |
human |
| Marc Steffens, Andreas Schulze-Bonhage, Rainer Surges, Thomas J Feuerstei. Fatty acid amidohydrolase in human neocortex-activity in epileptic and non-epileptic brain tissue and inhibition by putative endocannabinoids. Neuroscience letters. vol 385. issue 1. 2005-09-23. PMID:15923084. |
to further increase endocannabinoid activity, the application of faah inhibitors might be therapeutically useful in the treatment of neuronal hyperexcitability. |
2005-09-23 |
2023-08-12 |
human |
| Diane L Lynch, Patricia H Reggi. Molecular dynamics simulations of the endocannabinoid N-arachidonoylethanolamine (anandamide) in a phospholipid bilayer: probing structure and dynamics. Journal of medicinal chemistry. vol 48. issue 15. 2005-08-23. PMID:16033262. |
compound 1 has been shown to be synthesized from lipids, to interact with the membrane-embedded cannabinoid cb1 receptor, to be transported to intracellular compartments, possibly via caveolae-related endocytosis, and finally, to be degraded by fatty acid amide hydrolase (faah), an integral membrane protein which has an active site that is accessed by 1 possibly via the bilayer. |
2005-08-23 |
2023-08-12 |
Not clear |
| Diane L Lynch, Patricia H Reggi. Molecular dynamics simulations of the endocannabinoid N-arachidonoylethanolamine (anandamide) in a phospholipid bilayer: probing structure and dynamics. Journal of medicinal chemistry. vol 48. issue 15. 2005-08-23. PMID:16033262. |
the bilayer location for 1 revealed by these studies may be important for the interaction of 1 with membrane-embedded proteins such as the cannabinoid cb1 receptor and membrane-associated proteins such as faah. |
2005-08-23 |
2023-08-12 |
Not clear |
| Eva de Lago, Stefania Petrosino, Marta Valenti, Enrico Morera, Silvia Ortega-Gutierrez, Javier Fernandez-Ruiz, Vincenzo Di Marz. Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels. Biochemical pharmacology. vol 70. issue 3. 2005-08-18. PMID:15963472. |
several selective inhibitors of endocannabinoid inactivation via either the fatty acid amide hydrolase (faah) or the putative endocannabinoid transporter have been developed so far. |
2005-08-18 |
2023-08-12 |
rat |
| Eva de Lago, Stefania Petrosino, Marta Valenti, Enrico Morera, Silvia Ortega-Gutierrez, Javier Fernandez-Ruiz, Vincenzo Di Marz. Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels. Biochemical pharmacology. vol 70. issue 3. 2005-08-18. PMID:15963472. |
here, we have studied the effect in rats of a subchronic intraperitoneal treatment with three recently developed selective inhibitors of endocannabinoid uptake (vdm-11, ucm-707 and omdm-2) or with a selective faah inhibitor (n-arachidonoyl-serotonin, aa-5-ht), on the brain levels of anandamide and 2-arachidonoylglycerol (2-ag) measured by means of isotope dilution lc-ms 1, 5 and 12 h after the last treatment. |
2005-08-18 |
2023-08-12 |
rat |
| Mauro Maccarrone, Valeria Gasperi, Filomena Fezza, Alessandro Finazzi-Agrò, Antonello Ross. Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone. European journal of biochemistry. vol 271. issue 23-24. 2005-07-06. PMID:15606754. |
unlike faah, the other proteins of the endocannabinoid system are not modulated by the two hormones. |
2005-07-06 |
2023-08-12 |
human |
| Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Naohiko Uchida, Akira Nomura, Kyohei Ohtani, Makiko Kishimoto, Akiko Morio, Takaki Imamura, Ayumu Sakai, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kurod. A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. Neuroscience letters. vol 376. issue 3. 2005-05-26. PMID:15721218. |
because the pro129thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of faah and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia. |
2005-05-26 |
2023-08-12 |
human |
| Darren Fegley, Silvana Gaetani, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Daniele Piomell. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. The Journal of pharmacology and experimental therapeutics. vol 313. issue 1. 2005-05-19. PMID:15579492. |
genetic deletion of the faah gene in mice elevates brain anandamide levels and amplifies the effects of this endogenous cannabinoid agonist. |
2005-05-19 |
2023-08-12 |
mouse |
| Dale L Boger, Hiroshi Miyauchi, Wu Du, Christophe Hardouin, Robert A Fecik, Heng Cheng, Inkyu Hwang, Michael P Hedrick, Donmienne Leung, Orlando Acevedo, Cristiano R W Guimarães, William L Jorgensen, Benjamin F Cravat. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. Journal of medicinal chemistry. vol 48. issue 6. 2005-05-03. PMID:15771430. |
fatty acid amide hydrolase (faah) degrades neuromodulating fatty acid amides including anandamide (endogenous cannabinoid agonist) and oleamide (sleep-inducing lipid) at their sites of action and is intimately involved in their regulation. |
2005-05-03 |
2023-08-12 |
Not clear |
| Kazuhito Tsuboi, Yong-Xin Sun, Yasuo Okamoto, Nobukazu Araki, Takeharu Tonai, Natsuo Ued. Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15655246. |
bioactive n-acylethanolamines, including anandamide (an endocannabinoid) and n-palmitoylethanolamine (an anti-inflammatory and neuroprotective substance), are hydrolyzed to fatty acids and ethanolamine by fatty acid amide hydrolase. |
2005-04-21 |
2023-08-12 |
mouse |
| Kyle P Chiang, Alexandra L Gerber, Jack C Sipe, Benjamin F Cravat. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Human molecular genetics. vol 13. issue 18. 2005-03-15. PMID:15254019. |
reduced cellular expression and activity of the p129t mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. |
2005-03-15 |
2023-08-12 |
human |
| Kyle P Chiang, Alexandra L Gerber, Jack C Sipe, Benjamin F Cravat. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Human molecular genetics. vol 13. issue 18. 2005-03-15. PMID:15254019. |
fatty acid amide hydrolase (faah) inactivates the endogenous cannabinoid (endocannabinoid) anandamide and related lipid transmitters in vivo. |
2005-03-15 |
2023-08-12 |
human |